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为全景电位计电路增加简单的禁用功能

电子设计技术 EDN CHINA 2007年第5期14卷 114-114页

作者： Lawrence Mayes malvern United Kingdom

在混音应用中．一个经常需要的功能就是将一个单声道或单通道音频源混到一个立体声场中。音频工程师所说的一个全景电位计电路是一种可从一个单声道信号产生具有标准波幅的左、右信号并能将信号的声像放在立体声场中任何位置的电路，由... 详细信息

在混音应用中．一个经常需要的功能就是将一个单声道或单通道音频源混到一个立体声场中。音频工程师所说的一个全景电位计电路是一种可从一个单声道信号产生具有标准波幅的左、右信号并能将信号的声像放在立体声场中任何位置的电路，由于声像的音量似乎与其最终位置无关，产生的左、右信号必须相加，以获得一个恒定功率的信号．

关键词：电位计电路全景信号产生禁用恒定功率单声道单通道

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一种新的肿瘤相关糖蛋白的纯化与分析

细胞与分子免疫学杂志 1987年第4期 19-19页

作者： Thomas L.Klug,Terrence F.Gerber,Vencent R.Zurawski Jr.,Norman C.LeDonne Jr,张明杰 Laboratory of Cancer Research Centoccr malvern PA 19355 Laboratory of Cancer Research Centoccr malvern PA 19355 Laboratory of Cancer Research Centoccr malvern PA 19355 Laboratory of Cancer Research Centoccr malvern PA 19355

为了从血清及悬浮组织培养上清提纯出高产量的人胃肠道相关糖蛋白抗原曾设计了一个方案。提纯的关键步骤是用单克隆抗体1116 TS-19-9进行亲和柱层析,接着使结合的蛋白诱导烷化,并进行第二次免疫亲和柱分步收集。诱导和烷化有利于打断含... 详细信息

为了从血清及悬浮组织培养上清提纯出高产量的人胃肠道相关糖蛋白抗原曾设计了一个方案。提纯的关键步骤是用单克隆抗体1116 TS-19-9进行亲和柱层析,接着使结合的蛋白诱导烷化,并进行第二次免疫亲和柱分步收集。诱导和烷化有利于打断含抗原的二硫化物稳

关键词：肿瘤相关糖蛋白粘蛋白培养上清

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浅谈北方民间服饰

设计艺术 2004年第1期 32-32页

作者：付晓英国malvern女子学院

我国北方汉族的民间服饰风格的地区差异不大，都基本沿袭了汉族的服饰传统。一般普通百姓，为了劳作方便、经济实用，日常服装体制都是上衣下裤，女子也较少着裙一衣裤非常朴素，少有绣花。

关键词：中国北方地区民间服饰设计风格款式图案形制服装体制

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人卵巢上皮癌相关抗原的分离及部分特性鉴定

细胞与分子免疫学杂志 1986年第4期 100-100页

作者： Davis H.M. 张明杰 Centor malvern PA 19355 (HMO VRZ and TLK)

鼠单克隆抗体DC125可与一种高分子量糖蛋白复合体上的一个抗原决定簇(CA125)反应,在患卵巢上皮癌妇女血清中80％以上都可检出该复合体。作者从卵巢上皮癌细胞系(OVCA4333)中分离并部分纯化了该抗原。纯化方案包括高氯酸部分收集、Separo... 详细信息

鼠单克隆抗体DC125可与一种高分子量糖蛋白复合体上的一个抗原决定簇(CA125)反应,在患卵巢上皮癌妇女血清中80％以上都可检出该复合体。作者从卵巢上皮癌细胞系(OVCA4333)中分离并部分纯化了该抗原。纯化方案包括高氯酸部分收集、Separos-4B-CL柱层析、45℃用6M尿素处理,以及在6M尿素和0.1％SDS中进行Sepharose-6B-Cl柱

关键词：卵巢上皮癌 CA 柱层析抗原

补骨脂对肝脏的双重作用:肝保护还是肝毒性?

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Acupuncture and Herbal Medicine 2024年第2期4卷 176-183,I0005页

作者：唐千茴俞沁纬 Bin Ni 江振洲张陆勇中国药科大学多靶标天然药物全国重点实验室新药筛选与药效评价中心南京 Alliance Pharma MalvernPA USA 中国药科大学药物质量与安全预警教育部重点实验室南京广东药科大学新药研发中心广州

中药补骨脂(Psoraleae Fructus)为豆科植物补骨脂Psoralea corylifolia L.的干燥成熟果实,主要包含黄酮、香豆素、单萜酚和苯并呋喃类化合物,具有免疫调节、抗氧化、雌激素样等多种药理作用,临床广泛应用于治疗骨质疏松、白癜风、银屑... 详细信息

中药补骨脂(Psoraleae Fructus)为豆科植物补骨脂Psoralea corylifolia L.的干燥成熟果实,主要包含黄酮、香豆素、单萜酚和苯并呋喃类化合物,具有免疫调节、抗氧化、雌激素样等多种药理作用,临床广泛应用于治疗骨质疏松、白癜风、银屑病等。目前,越来越多的药理研究表明,补骨脂及其活性成分在肝脏疾病以及动物模型中具有保护肝细胞、改善肝功能的作用;但随着补骨脂及其相关制剂的临床广泛应用,以及药物不良反应监测体系的完善,补骨脂及其相关制剂引发肝脏损伤的不良反应案例报道越来越多,提示补骨脂及其相关制剂对肝脏可能具有双重作用,即既具有肝脏保护作用又具有肝毒性作用。本文总结了近年来有关补骨脂中单体成分、提取物及其相关制剂的肝保护以及肝毒性作用的研究,归纳了其直接肝毒性及其在不同病理条件下对肝脏的毒/效作用及机制,以期为补骨脂及其相关制剂临床适应症的开发以及安全应用提供理论依据。

关键词：药物性肝损伤肝保护肝毒性补骨脂

Difficulties in Recruitment for a Randomised Controlled Trial of Lifestyle Intervention for Type 2 Diabetes: Implications for Diabetes Management

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Open Journal of Endocrine and Metabolic Diseases 2012年第4期2卷 53-57页

作者： George A. Jelinek Emily Hadgkiss Craig Hassed Bernard Crimmins Peter Schattner Danny Liew Rick Kausman Warrick J. Inder Siegfried Gutbrod Tracey J. Weiland Department of General Practice Faculty of Medicine Nursing and Health Sciences Monash University Clayton Australia Department of Medicine Faculty of Medicine and Health Sciences The University of Melbourne Royal Melbourne Hospital Melbourne Australia East Bentleigh General Practice Melbourne Australia Emergency Practice Innovation Centre St Vincent’s Hospital Melbourne Australia Formerly Department of Endocrinology St Vincent’s Hospital Melbourne Australia Manningham General Practice Melbourne Australia The Butterfly Foundation Malvern Australia The Gawler Foundation Yarra Junction Australia

Objective: To report our experience of attempting a randomised controlled trial of an intensive lifestyle intervention for early type 2 diabetes delivered in a residential setting. Methods: We established a trial requiring 84 participants (46 standard care and 38 intervention) to detect a 1% difference in HbA1c between intervention and control groups at 12 months, allowing for attrition. Ethics approval was obtained from Monash University. Results: The study was abandoned after five months of consistent promotion due to recruitment failure (four subjects recruited). Conclusion: It appears to be difficult for patients with diabetes to commit to a live-in period of education regarding lifestyle modification as a means of treating the illness. We recommend better education of patients and their doctors about the potential health benefits of lifestyle change to manage type 2 diabetes, and further research into novel methods of delivering lifestyle advice which are both effective and sustainable.

关键词： Type 2 Diabetes Mellitus Randomised Controlled Trial Management Lifestyle Risk Factors

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结膜松弛症的临床病例对照及组织病理学研究

世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 41-41页

作者： Francis I.C. Kim P. 宋虎平 Chatswood Grove 12-1 4 Malvern Avenue Chatswood NSW 2007 Australia Dr.

Background/aims: Conjunctivochalasis, a secondary cause of the watery eye, is frequently seen in the older age group as an elevation of the bulbar conjunctiva lying along the lateral or central lower lid margin. A prospective, interventio nal, casecontrolled clinical and histopathological study was conducted. The rele vant features of 18 patients (29 eyes) who had their conjunctivochalasis resecte d as part of the surgical management of their watery eye syndrome were examined. In the control group, tissue was obtained from an age matched series of 24 norm al subjects undergoing routine cataract surgery. Methods: 24 controls (24 specim ens) and 18 patients (29 specimens) had conjunctival strip biopsies, taken from the usual lid margin level bulbar conjunctiva in line with the inferior limbus ( controls), and the clinically apparent conjunctivochalasis (patients). These wer e submitted for histological study. Resolfs: 23 of 24 control sections demonstra ted normal conjunctival variation. Four of 29 patient specimens demonstrated a c hronic non-granulomatous conjunctivitis, while three eyes of the patient group (two patients) demonstrated features of elastosis. Of the four patients who had the inflammatory infiltrates, three had functional nasolacrimal duct obstruction s (FNLDOs) and one had a primary acquired nasolacrimal duct obstruction (PANDO). Of the two patients who had elastosis, one had an FNLDO and the other had norma l lacrimal drainage and was Jones 1 positive. Conclusion: Six of 18 patients-th at is, seven of 29 specimens of conjunctivochalasis demonstrated signs of elasto sis or of chronic non-granulomatous inflammation. Clinically, patients had a sp ectrum of aetiologies of their watery eye syndrome.

关键词：结膜松弛症病理学研究下睑缘泪溢泪液排泄系统白内障手术干预性鼻泪管阻塞肉芽肿性炎症炎性浸润

内脂素基因过表达对胰岛素抵抗大鼠胰岛素敏感性的影响

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中华医学杂志 2008年第6期88卷 365-368页

作者：孙勤李伶杨刚毅李仁哲李钶齐晓亚李生兵陈文雯刘桦唐毅 Guenther Boden 重庆医科大学附属第二医院内分泌科和脂质研究中心 400010 检验系临床生化教研室和教育部省部共建重点实验室 Department of Pediatrics University of Mississippi Medical Center 2500 North State Street Jackson Mississippim MS 39216-4505 USA Oncology Ressearch. Centocor. Inc. Malvern. Pennsylvania PA19355 USA The Division of Endocrinology/Diabetes/Metabolism and the Clinical Research Center Temple University School of Medicine Philadelphia Pennsylvania PA19140 USA

目的探讨内脂素基因过表达对高脂诱导胰岛素抵抗（IR）大鼠胰岛素敏感性的影响。方法构建大鼠内脂素基因真核表达质粒，并用该质粒转染高脂喂养诱导的IR大鼠模型。在转染前后采用两次高胰岛素-正糖钳夹技术评价大鼠胰岛素敏感性的变化... 详细信息

目的探讨内脂素基因过表达对高脂诱导胰岛素抵抗（IR）大鼠胰岛素敏感性的影响。方法构建大鼠内脂素基因真核表达质粒，并用该质粒转染高脂喂养诱导的IR大鼠模型。在转染前后采用两次高胰岛素-正糖钳夹技术评价大鼠胰岛素敏感性的变化。结果成功构建了内脂素真核表达载体pcDNA3．1内脂素。实验组大鼠在pcDNA3．1内脂素质粒注射后3d血浆内脂素水平较注射前明显升高（2．19±0．36 vs 0．98±0．27，P〈0．01）；在两次胰岛素钳夹中，pcDNA3．1内脂素质粒注射后葡萄糖输注率较注射前明显升高[（32．6±1．2）mg·kg^-1·min^-1 vs （24．0±1．2）mg·kg^-1·min^-1，P〈0．01]；总胆固醇、高密度脂蛋白胆固醇则较质粒注射前明显降低[（2．36±0．22）mmol／L vs （1．60±0．21）mmol／L和（1．41±0．24）mmol／L vs（0．88±0．11）mmol／L，均P〈0．05]；在转染前后基础血糖和胰岛素水平无明显变化。结论内脂素质粒转染使IR大鼠血浆内脂素水平升高，胰岛素敏感性增强。

关键词：内脂素胰岛素抗体正常血糖高胰岛素钳夹技术

AGENT-BASED WORKFLOW COORDINATION FOR SUPPLY CHAIN MANAGEMENT

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Transactions of Nanjing University of Aeronautics and Astronautics 2003年第1期20卷 112-117页

作者：徐琪 QIU Ro-bin 徐福缘上海理工大学管理学院上海200093中国宁夏大学计算中心银川750021中国 Department of Information Sciences Pennsylvania State University Malvern PA 19355 USA 上海理工大学管理学院上海200093中国

To align customer demand with suppliers for reducing work in process and supply costs and increasing re sp onsiveness to customer requirements, a real time collaborative supply chain mana gement system is essential. A solution to the realization of supply chain manage ment capable of timely responding to customer requirements is proposed. Workflow automation is used to manage process interaction across enterprises; Agents can be automatically invoked by supply chain workflow process and are used to pro mote the flexibility and reconfigurability by providing the mechanism in support of distributed compution in an enterprises to meet the requirements of performa nce and business dynamics. An approach that supports agent based workflow proce ss in a supply chain is proposed. And the coordination mechanism between agents is also discussed.

关键词： supply chain management workflow management multi agents coordination