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Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

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Infectious Diseases of Poverty 2019年第4期8卷 96-97页

作者： Akintunde Sowunmi Godwin Ntadom Kazeem Akano Folasade O.Ibironke Adejumoke I.Ayede Chimere Agomo Onikepe A.Folarin Grace O.Gbotosho Christian Happi Stephen Oguche Henrietta U.Okafor Martin Meremikwu Philip Agomo William Ogala Ismaila Watila Olugbenga Mokuolu Finomo Finomo Joy C.Ebenebe Nma Jiya Jose Ambe Robinson Wammanda George Emechebe Wellington Oyibo Francis Useh Temitope Aderoyeje Titilope M.Dokunmu Omobolaji T.Alebiosu Sikiru Amoo Oluwabunmi K.Basorun Olubunmi A.Wewe Chukwuebuka Okafor Odafe Akpoborie Bayo Fatunmbi Elsie O.Adewoye Nnenna M.Ezeigwe Ayoade Oduola Antimalarial Therapeutic Efficacy Monitoring Group National Malaria Elimination ProgrammeThe Federal Ministry of HealthAbujaNigeria Department of Pharmacology and Therapeutics University of IbadanIbadanNigeria 不详

Background:The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies(ACTs). This post analyses is aimed to evaluate changes in early treatment response markers 10 years after the adoption of ACTs as first-line treatments of uncomplicated falciparum malaria in ***: At 14 sentinel sites in six geographical areas of Nigeria, we evaluated treatment responses in 1341 children under 5 years and in additional 360 children under 16 years with uncomplicated malaria enrolled in randomized trials of artemether-lumefantrine versus artesunate-amodiaquine at 5-year interval in 2009-2010 and 2014-2015 and at 2-year interval in 2009-2010 and 2012-2015, respectively after deployment in ***: Asexual parasite positivity 1 day after treatment initiation (APPD1) rose from 54 to 62% and 2 days after treatment initiation from 5 to 26% in 2009-2010 to 2014-2015(P=0.002 and P 75 000 μl^-1, haematocrit > 27% 1 day post-treatment initiatiortreatment with artemether-lumefantrine and enrolment in 2014-2015 independently predicted APPD1. In paralle , Kaplan-Meier estimated risk of recurrent infections by day 28 rose from 8 to 14% (P=0005) and from 9 to 15%(P=0.02) with artemether-lumefantrine and artesunate-amodiaquine, respectively. Mean asexual parasitaemia half-life increased significantly from 1.1 h to 1.3h within 2 years (P<0.0001).Conclusions:These data indicate declining parasitological responses through time to the two ACTs may be due to emergence of parasites with r

关键词： Declining responsiveness Falciparum malaria Children Artemisinin-based combination treatment Nigeria

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Factors associated with risk of malaria infection among pregnant women in Lagos, Nigeria

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Infectious Diseases of Poverty 2013年第1期2卷 152-159页

作者： Chimere O Agomo Wellington A Oyibo ANDI Centre of Excellence for malaria Diagnosis International MalariaMicroscopy Training and RDT QA ProgrammeWHO/TDR/FIND Malaria Specimen Bank SiteDepartment of Medical Microbiology and ParasitologyCollege of MedicineUniversity of LagosIdi-ArabaLagosNigeria malaria Research Laboratory Nigerian Institute of Medical ResearchPMB 2013YabaLagosNigeria

Background:Pregnant women living in an area of stable malaria transmission such as Lagos,Nigeria,have been identified as being at an increased risk of the effects of malaria *** this area,most of the infections are asymptomatic which means they are overlooked and untreated much to the detriment of the mother and her *** reality of scaled-up malaria interventions with long-lasting insecticide treated nets,vector control,artemisinin combination therapy(ACT)and intermittent preventive treatment of malaria pregnancy(IPTp)using sulphadoxine pyrimethamine(SP)is that it is also essential to determine the risk factors at play in these kinds of *** study was aimed at identifying the factors associated with risk of malaria infection in pregnant women in Lagos,Southwest ***:Demographic information and malaria prevention practices of the pregnant women studied were captured using structured *** was used to establish malaria infection,species identification and parasite *** risk and multivariate logistic regression analysis were used to compare factors associated with malaria in pregnant ***:malaria microscopy details,demographic information and malaria prevention practices of the pregnant women were obtained using a structured *** prevalence of malaria using peripheral blood from 1,084 pregnant women that participated in the study was 7.7%.Plasmodium falciparum(***)was seen in 95.2%of the cases as either mixed infection with ***(3.6%)or as a mono infection(91.6%).malaria preventive practices associated with a significant reduction(Pmalaria infection was the use of insecticide sprays(RR=0.36,95 C.I.0.24-0.54),and the combined use of insecticide spray and insecticide-treated nets(ITN)(RR=6.53,95%C.I.0.92-46.33).Sleeping under ITN alone(RR=1.07,95%C.I.0.55-2.09)was not associated with significant reduction in malaria infection among the study participan

关键词： malaria Pregnancy Risk factors Insecticide spray Maternal age malaria in pregnancy in Lagos

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Therapeutic efficacy and effects of artesunate-amodiaquine and artemetherlumefantrine on malaria-associated anaemia in Nigerian children aged two years and under

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Infectious Diseases of Poverty 2016年第1期5卷 622-635页

作者： Akintunde Sowunmi Kazeem Akano Adejumoke I.Ayede Godwin Ntadom Elsie O.Adewoye Bayo Fatunmbi Temitope Aderoyeje Department of Pharmacology and Therapeutics University of IbadanIbadanNigeria Institute for Medical Research and Training University of IbadanIbadanNigeria Department of Paediatrics University of IbadanIbadanNigeria malaria elimination programme Federal Ministry of HealthAbujaNigeria Department of Physiology University of IbadanIbadanNigeria World Health Organization Regional Office for the Western PacificPhnom PenhCambodia Department of Clinical Pharmacology University College HospitalIbadanNigeria

Background:Artemisinin-based combination therapies are recommended as first-line treatments for uncomplicated falciparum malaria,but there is little evaluation of their efficacy and effects on uncomplicated malaria-associated anaemia in children aged 2 years and ***:Parasitological efficacy and effects on malaria-associated anaemia were evaluated in 250 malarious children aged 2 years and under,and efficacy was evaluated in 603 malarious children older than two but younger than 5 years of age following treatment with artesunate-amodiaquine(AA)or artemether-lumefantrine(AL).Kinetics of the disposition of parasitaemia following treatment were evaluated using a non-compartment ***-appearing anaemia(LAA)was diagnosed using the following criteria:clearance of parasitaemia,fever and other symptoms occurring within 7 days of starting treatment,adequate clinical and parasitological response on days 28–42,haematocrit(HCT)≥30%at 1 and/or 2 weeks,a fall in HCT toelimination half-time of 1 *** half-times were similar for both *** children aged 2 years and under who were anaemic at presentation,the mean anaemia recovery time was 12.1 days(95%CI 10.6–13.6,n=127),which was similar for both *** asymptomatic LAA occurred in 11 childr

关键词： Falciparum malaria malaria-related anaemia Young children Artemisinin-based combination therapies Nigeria

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Emerging Food-borne Pathogens

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Biomedical and Environmental Sciences 2001年第1期14卷 44-52页

作者： JRGEN SCHLUNDT programme of Food Safety

The epidemiology of foodborne diseases is changing. While in many developing nations the efficient treatment of diarrhoeal diseases through oral rehydration has probably led to the prevention of many food related deaths, the underlying problems have not been solved. In these countries, the disease incidence of food_and waterborne disease is still increasing, and now data from other parts of the world indicate that new foodborne pathogens have emerged as important public health problems. Over the last two decades, bacterial infections caused by Campylobacter and enterohaemorrhagic Escherichia coli have emerged, well_recognized pathogens, such as Salmonella enteritidis, have increased dramatically in disease incidence and important foodborne pathogens have become increasingly resistant to antimicrobial agents. The future strategy for prevention of foodborne disease should be founded in scientifically based evaluations of the whole food production chain ‘from farm to table’, including a description of the most important (risk) factors. Epidemiological studies of outbreaks as well as sporadic cases should be aimed at a better understanding of these factors. In terms of public health importance of the problem, the focus should be on the size of the problem, and the potential for improvement. The indications are that both in developed and developing countries there is significant potential for an improvement of the situation. With this aim in mind, international effort should focus on scientific assessments of the potential for risk reduction under different regional conditions.

关键词： public health prevention of developing countries Escherichia coli food production the world

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Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu Xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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Immediate assessment of performance of medical laboratory scientists following a 10-day malaria microscopy training programme in Nigeria

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Global Health Research and Policy 2017年第1期2卷 30-36页

作者： Bolatito Aiyenigba Abiodun Ojo Adolor Aisiri Justus Uzim Oluwole Adeusi Halima Mwenesi FHI360 Nigeria AbujaNigeria malaria Consortium Nigeria AbujaNigeria FHI360 Washington DC DurhamUSA

Background:Rapid and precise diagnosis of malaria is an essential element in effective case management and control of *** microscopy is used as the gold standard for malaria diagnosis,however results remain poor as positivity rate in Nigeria is consistently over 90%.The United States President’s malaria Initiative(PMI)through the malaria Action Program for States(MAPS)supported selected states in Nigeria to build capacity for malaria *** study demonstrates the effectiveness of in-service training on malaria microscopy amongst medical laboratory ***:The training was based on the World Health Organization(WHO)basic microscopy training *** 10-day training utilized a series of didactic lectures and examination of teaching slides using a CX 21 Olympus binocular *** 108 medical laboratory scientists trained from 2012 to 2015 across five states in Nigeria supported by PMI were included in the *** of the training using a pre-and post-test method was based on written test questions;reading photographic slide images of malaria parasites;and prepared ***:There was a significant improvement in the mean written pre-and post-tests scores from 37.9%(95%CI 36.2-39.6%)to 70.7%(95%CI 68.4-73.1%)(pmalaria microscopy.

关键词： malaria Microscopy Training Nigeria

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Estimates of three classical summations on the spaces F_p^(α,q)(R^n)(0 < p ≤ 1)

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Applied Mathematics(A Journal of Chinese Universities) 2014年第3期29卷 329-338页

作者： GAO Gui-lian ZHONG Yong School of Science Hangzhou Dianzi University Postdoctoral programme of Economics and Management School of Wuhan University Postdoctoral programme of China Great Wall Asset Management Corporation

We obtain the boundedness on Fp^α,q（R^n）for the Poisson summation and Gauss summation. Their maximal operators are proved to be bounded from Fp^α,q（R^n）to L∞（R^n）For the maximal operator of the Bochner-Riesz ... 详细信息

关键词： Poisson summation Gauss summation Bochner-Riesz summation Triebel-Lizorkin space.

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Species richness and adaptive capacity in animal communities:lessons from China

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Integrative Zoology 2008年第2期3卷 95-100页

作者： John MACKINNON EU-China Biodiversity programme BeijingChina

Climate change is already threatening the long-term viability of many important protected areas, and as globalwarming accelerates this will increase. Lowered water tables, melting permafrost, changing vegetation zones, combinedwith the fragmentary distribution of wilderness areas, will cause a wave of local extinctions as species fail toadapt to changing conditions in time or fail to move as climate zones advance across the face of the *** can predict and even model likely scenarios, but can we do anything to help safeguard valuable biodiversityor must we passively document Earth’s changes and accept these losses? Studies of the extraordinary speciesrichness of the Hengduan Mountains and the Qionglai Mountain ranges of South-West China and of theChangbaishan Mountains in North-East China give us some optimism. This paper provides an explanation for thehigh species richness in these ranges and identifies design principles that can be used in the selection of protectedareas or in the revision of existing protected area boundaries to enhance their ecological resilience and allow themto maintain higher levels of biological diversity under conditions of climate change or other disturbance.

关键词： adaptive capacity biodiversity richness Changbaishan Hengduan Qionglai

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Combination treatment of bisphosphonate(pamidronate) and Quercus infectoria semipurified fraction promotes proliferation and differentiation of osteoblast cell via expression of Osterix and Runx2 marker

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Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 261-267页

作者： Abdullah Amira Raudhah Hapidin Hermizi Abdullah Hasmah Biomedicine programme School of Health Sciences Universiti Sains Malaysia Environmental and Occupational Health programme School of Health Sciences Universiti Sains Malaysia

Objective:To understand the effects of combination treatment of pamidronate with isolated Quercus infectoria semi-purified fraction(Qlsm-F)on human foetal osteoblast cell model(hFOB1.19 cell line)through assessment of Runt related transcription fraction-2(Runx2)and Osterix(Osx).Methods:The isolation and purification of QIsm-F were conducted by chromatographic *** order to assess relative efficacy of QIsm-F to the osteoblast model,the determination of half maximal effective concentration(EC_(50))was performed by MTT *** 1.19 cells were cultured in DMEM F-12 and supplemented with 10%fetal bovine serum along with 1%penicillin-streptomycin incubated in 5%CO_2 at 37℃.Expression of Runx2 and Osx was assessed through western blotting and confirmed with immunofluorescence ***:Results of western blot analysis and immunofluorescence staining demonstrated that compared to hFOB 1.19 cells treated with single individual treatment of QIsm-F and control groups,levels of Runx2 and Osx were elevated with higher fluorescence intensity and more rapid proliferation in hFOB 1.19 cells treated with combined treatment of QIsm-F and ***:The finding demonstrates the synergistic effect between osteoporotic drug pamidronate and established *** combination treatment helps increase the efficiency of pamidronate acting on osteoblast cells by stimulating osteoblast proliferation and differentiation via expression of Runx2 and Osx.

关键词： Pamidronate Runx2 Osterix Osteoblast Quercus infectoria semi-purified fraction

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The role of the T follicular helper cells in allergic disease

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Cellular & Molecular Immunology 2012年第5期9卷 386-389页

作者： DM Kemeny Department of Microbiology and Immunology programme National University of Singapore Singapore

T follicular helper （Tfh） cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 （Th2） effector cells.

关键词： allergy asthma IgE follicular helper T cells

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