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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo Chikako Harada Takayuki Harada Visual research project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Model-based estimation of above-ground biomass in the miombo ecoregion of Zambia

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Forest Ecosystems 2016年第4期3卷 258-274页

作者： James Halperin Valerie LeMay Emmanuel Chidumayo Louis Verchot Peter Marshall Department of Forest Resources Management The University of British Columbia 2424 Main Mall Vancouver BC V6T 1Z4 Canada makeni savanna research project P.O. Box 50323 Ridgeway Lusaka Zambia International Center for Tropical Agriculture Km 17 Recta Cali-Palmira Apartado Aereo 6713 Cali 763537. Colombia

Background：Information on above-ground biomass（AGB） is important for managing forest resource use at local levels,land management planning at regional levels,and carbon emissions reporting at national and international *** many tropical developing countries,this information may be unreliable or at a scale too coarse for use at local *** is a vital need to provide estimates of AGB with quantifiable uncertainty that can facilitate land use management and policy development ***-based methods provide an efficient framework to estimate ***：Using National Forest Inventory（NFI） data for a^1,000,000 ha study area in the miombo ecoregion,Zambia,we estimated AGB using predicted canopy cover,environmental data,disturbance data,and Landsat 8 OLI satellite *** assessed different combinations of these datasets using three models,a semiparametric generalized additive model（GAM） and two nonlinear models（sigmoidal and exponential）,employing a genetic algorithm for variable selection that minimized root mean square prediction error（RMSPE）,calculated through *** compared model fit statistics to a null model as a baseline estimation *** bootstrap resampling methods,we calculated 95% confidence intervals for each model and compared results to a simple estimate of mean AGB from the NFI ground plot ***：Canopy cover,soil moisture,and vegetation indices were consistently selected as predictor *** sigmoidal model and the GAM performed similarly;for both models the RMSPE was -36.8 tonnes per hectare（i.e.,57% of the mean）.However,the sigmoidal model was approximately 30% more efficient than the GAM,assessed using bootstrapped variance estimates relative to a null *** selecting the sigmoidal model,we estimated total AGB for the study area at 64,526,209 tonnes（＋/- 477,730）,with a confidence interval 20 times more precise than a simple designbased ***：Our findings demonstrate that NFI

关键词： National Forest Inventory Above-ground biomass Miombo REDD+ Generalized additive model Nonlinear model Landsat 8 OLI

Radio Direction Finding Method to Mitigate Tsunami Risk in Sierra Leone

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Advances in Geological and Geotechnical Engineering research 2023年第2期5卷 64-75页

作者： Valentino Straser Daniele Cataldi Gabriele Cataldi Faculty of Agriculture University of MakeniFatima CampusMakeni00232Sierra Leone Group Radio Emission project LarianoRome00076Italy

In this study,the Radio Direction Finding method is proposed for the detection of electromagnetic signals,in the VLF band,to try to anticipate the occurrence of potentially destructive geophysical *** experimentation concerns the interception of electromagnetic anomalies in Sierra Leone,in the five-day time window,associated with seismic events that could potentially generate *** area of investigation is Sierra Leone,whose coastline is subjected to tidal wave hazards triggered by earthquakes generated in the Mid-Atlantic *** Sierra Leone is not affected by recurrent earthquakes,there is nevertheless a low probability,estimated at 2 percent,of the occurrence of destructive earthquakes in the next 50 *** in estimates,the risk of rogue and potentially damaging waves is estimated to strike the Sierra Leone coast at least once in the next 10 *** Radio Direction Finding experiment carried out continuously 24/7,has shown a close relationship between increased radio-anomalies,in the frequencies of 6,000 Hz,a time window between electromagnetic anomaly detection and the imminence of an earthquake,and higher frequency times for the risk of earthquake occurrence in the Mid-Atlantic Ridge.

关键词： Tsunami Radio direction finding Destructive earthquakes Mid-Atlantic ridge Sierra Leone

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

Weather Events Associated with Strong Earthquakes and Seismic Swarms in Italy

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Advances in Geological and Geotechnical Engineering research 2023年第3期5卷 39-54页

作者： Valentino Straser Daniele Cataldi Gabriele Cataldi University makeni Department of Agriculture Fatima CampusMakeni00000Sierra Leone Group Radio Emissions project LarianoRome00076Italy

This study discusses the possible relationship between potentially destructive seismic events,earthquake swarms,and intense weather events occurring in the same epicentral zone at time intervals ranging from one day to a few *** objective of the present study is,therefore,to analyze the interaction between the lithosphere,atmosphere,and ionosphere in order to propose,prospectively,a new hydro-climatic model to be applied not only in Italy,where this research was carried *** study concerns some of the most intense Italian earthquakes starting from 1920,with the destructive event in Lunigiana,in North Western Apennines,until the recent earthquake swarm that hit the Emilia-Romagna region followed,as in the cases analyzed in this research,by strong atmospheric *** recurrence associating seismic events with atmospheric precipitation allows us to propose some hypotheses about the triggering *** tectonically stressed areas,during pre-seismic and seismic phases,the release of gases from the ground and electrical charges near active faults is *** is hypothesized that water condensation nuclei are carried by radon gas on atmospheric gases,also originating from cosmic rays in the upper atmosphere,generated by air ionization.

关键词： Extreme hydro-climatic events Earthquakes Radon gas Earthquake swarms Atmospheric precipitation

Role of animal models in glaucoma research

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Neural Regeneration research 2020年第7期15卷 1257-1258页

作者： Atsuko Kimura Takahiko Noro Takayuki Harada Visual research project Tokyo Metropolitan Institute of Medical Science

Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of *** is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys).

关键词： elevated degeneration drugs

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

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Nano research 2025年第1期18卷 50-75页

作者： Jingwen Yu Yunliang Liu Naiyun Liu Yaxi Li Yuanyuan Cheng Peng Cao Yixian Liu Xinya Yuan Xinyue Zhang Haitao Li Institute for Energy research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

Spectroscopic investigation confirms retaining the pristine nature of single-walled carbon nanotubes on dissolution in aniline

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Frontiers of Materials Science 2017年第3期11卷 276-283页

作者： Somdutta SINGHA Swapankumar GHOSH project Management Division CSIR-Central Glass & Ceramic Research Institute Kolkata-700032 India

Carbon nanotubes in all forms are very much insoluble in both organic and inorganic solvents due to its high agglomeration and entangled morphology. General methods for dissolution of single-walled carbon nanotubes （SWNTs） are mostly associated with complexation or polymerization or addition of macromolecules which change the physical or chemical properties of SWNTs and the pristine nature of SWNTs is lost. Dissolution of SWNTs in a solvent like aniline is practiced here which is a very simple reaction method. Here aniline is capable to form a SWNT-aniline charge transfer complex without attachment of macromolecules or polymer which is also soluble in other organic solvents. Solvation of SWNTs by this method is also capable of maintaining the similarity between the structure of SWNTs before and after the dissolution, which means that the pristine nature of SWNTs is preserved. Formation of charge transfer complex in this reaction has been proven by UV-Vis/NIR absorption and photoluminescence spectroscopy. Raman spectroscopy and electron microscopy （FESEM and TEM） are the evidences for protection of the pristine nature of SWNTs even after high-temperature complexation reaction with aniline and also after solubilization in organic solvents.

关键词： single-walled carbon nanotubes aniline dissolution organic solvent spectroscopy