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Polybrominated biphenyl exposure and thyroid function tests in electronic waste dismantling and general population of Chinese adults

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Emerging Contaminants 2024年第1期10卷 72-79页

作者： Shijie Wang Jingxi Jin Zhitong Zhang Chen Guo Zhigang Li Jicheng Hu Ying Wang Yongjie Wei Jun Jin College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijing 100191China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Engineering Research Center of Food Environment and public health Beijing 100081China Center for Global health School of Public HealthNanjing Medical UniversityChina

This study aimed to determine the concentration of 35 PBB(polybrominated biphenyls)congeners in the human serum of residents from an electronic waste(e-waste)dismantling area compared to a control area in ***,four thyroid hormones,namely FT3,FT4,TSH,and TRH,were also *** findings revealed that the total PBB concentrations(sum of the 35 PBB congeners)ranged from 47.1 to 1360 ng/g lipid in the e-waste area and 105–1980 ng/g lipid in the control ***-1 and BB-10 were the dominant congeners in both study areas,followed by *** to the e-waste dismantling area,the control area samples had a significantly higher concentration of less-brominated(Br1–3)PBBs,including the concentrations of less-brominated congeners such as BB-1,BB-4,BB-9,and BB-10,which were significantly higher than those in the e-waste dismantling ***,more-brominated hexabromobiphenyl congeners BB-153,BB-154 and BB-155 were found in samples from the e-waste dismantling area at significantly higher concentrations than in the control area.E-waste dismantling areas have released historically produced commercial PBB products,but equally not negligible is the exposure of the general population to newly produced PBB *** concentrations in the e-waste dismantling area samples decreased with increasing age,while they increased with increasing age in the control area ***,stepwise multiple regression analysis showed a significant association between BB-103 concentrations and thyroid hormone *** addition,BB-103 has the potential to interfere with the binding of T3 and thyroid hormone receptors(TR).Given these findings,the research on human exposure of PBB and the relationships between the PBB and thyroid hormones should be studied further.

关键词： Polybrominated biphenyls Human serum E-waste Thyroid hormone Human exposure

Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2024年第10期30卷 1405-1419页

作者： Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang International school of public health and One health Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Medical Laboratory Science and Technology College Harbin Medical University-Daqing CampusDaqing 163000Heilongjiang ProvinceChina Department of Laboratory Diagnosis Qiqihar Tuberculosis Control CenterQiqihar 161000Heilongjiang ProvinceChina Department of public health University of CopenhagenCopenhagen 1353Denmark Department of public health University of Southern DenmarkOdense 5000Denmark

BACKGROUND Ulcerative colitis is a chronic inflammatory disease of the colon with an unknown *** sphingomyelinase(alk-SMase)is specifically expressed by intestinal epithelial cells,and has been reported to play an anti-inflammatory ***,the underlying mechanism is still *** To explore the mechanism of alk-SMase anti-inflammatory effects on intestinal barrier function and oxidative stress in dextran sulfate sodium(DSS)-induced *** Mice were administered 3%DSS drinking water,and disease activity index was determined to evaluate the status of *** permeability was evaluated by gavage administration of fluorescein isothiocyanate dextran,and bacterial translocation was evaluated by measuring serum *** epithelial cell ultrastructure was observed by electron *** blotting and quantitative real-time reverse transcription-polymerase chain reaction were used to detect the expression of intestinal barrier proteins and mRNA,*** oxidant and antioxidant marker levels were analyzed using commercial kits to assess oxidative stress *** Compared to wild-type(WT)mice,inflammation and intestinal permeability in alk-SMase knockout(KO)mice were more severe beginning 4 d after DSS *** mRNA and protein levels of intestinal barrier proteins,including zonula occludens-1,occludin,claudin-3,claudin-5,claudin-8,mucin 2,and secretory immunoglobulin A,were significantly reduced on 4 d after DSS *** observations revealed progressive damage to the tight junctions of intestinal epithelial ***,by day 4,mitochondria appeared swollen and ***,compared to WT mice,serum malondialdehyde levels in KO mice were higher,and the antioxidant capacity was significantly *** expression of the transcription factor nuclear factor erythroid 2-related factor 2(Nrf2)in the colonic mucosal tissue of KO mice was significantly decr

关键词： Alkaline sphingomyelinase Intestinal mucosal barrier Antioxidant capacity Dextran sulfate sodium-induced colitis nuclear factor erythroid 2-related factor 2

Control and Stabilization of Chaotic System Based on Linear Feedback Control Method

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Wuhan University Journal of Natural Sciences 2024年第3期29卷 284-292页

作者： WEI Xingmin LI Dekui school of public health Gansu University of Chinese MedicineLanzhou 730000GansuChina

In this paper, two kinds of chaotic systems are controlled respectively with and without time-delay to eliminate their chaotic behaviors. First of all, according to the first-order approximation method and the stabilization condition of the linear system, one linear feedback controller is structured to control the chaotic system without time-delay, its chaotic behavior is eliminated and stabilized to its equilibrium. After that, based on the first-order approximation method, the Lyapunov stability theorem, and the matrix inequality theory, the other linear feedback controller is structured to control the chaotic system with time-delay and make it stabilized at its equilibrium. Finally, two numerical examples are given to illustrate the correctness and effectiveness of the two linear feedback controllers.

关键词： chaotic system without time-delay chaotic system with time-delay stabilization linear feedback control method

A Data-Driven Real-Time Trajectory Planning and Control Methodology for UGVs Using LSTMRDNN

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1292-1294页

作者： Kaiyuan Chen Runqi Chai Runda Zhang Zhida Xing Yuanqing Xia Guoping Liu Vanke school of public health Institute for Healthy ChinaTsinghua UniversityBeijing 100084 school of Automation Beijing Institute of TechnologyBeijing 100081 Department of Electronic and Electrical Engineering Southern University of Science and TechnologyShenzhen 518055China

Dear Editor,This letter presents a novel data-driven trajectory planning and control scheme for the unmanned ground vehicles(UGVs).A recent work[1]has demonstrated the effectiveness of approximating the optimal state ... 详细信息

关键词： LSTM UGV neural

Direct Analysis of Whole Blood by a Disposable Monolithic Column Mass Spectrometry Analysis Kit

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Chinese Journal of Chemistry 2024年第10期42卷 1073-1078页

作者： Wenxin Wang Jin Han Yutong Zheng Haijie Wang Chengbiao Zhu Yongyi Li Yuqi Feng Zhenwei Wei Xiangyu Wang College of Chemistry and Molecular Science Wuhan UniversityWuhanHubei 430072China school of public health Wuhan UniversityWuhanHubei 430072China schoolof Bioengineering and health Wuhan Textile UniversityWuhanHubei 430200China

A monolithic column-based mass spectrometry(MS)analysis kit was prepared for whole blood analysis with *** kit is disposable and can be used for purification,storage,transportation and direct analysis of whole *** kit mainly consists of a capillary for quantitative microsampling,a cation exchange monolithic column for purification and storage,and a syringe for loading *** kit is very friendly to various users that one can easily siphon the blood in the kit followed by rapid *** established a quantitative method using the kit with a limit detection as low as 0.33 nmol/L,and achieved more than five orders of magnitude enhancement in sensitivity compared to direct nanoelectrospray ionization MS *** column can avoid analyte exposure to environment,which helps the storage of the sample for laboratory *** relative standard deviation of immediate blood analysis and storage blood analysis within 10 d was less than 10%.This method has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2μL rat *** results indicate that this disposable kit does have the potential to achieve highly sensitive quantitative MS analysis in biological samples,which is expected to become a cost-effective and powerful tool for in vitro diagnostics.

关键词： Clinical Ms Whole blood analysis Porous polymers Matrix isolation Trace analysis

Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： Xiao-Min Li Junchao Jia Danting Yang Jiali Jin Junkuo Gao school of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport *** strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton ***,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced ***,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism

Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

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Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang Department of Nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic *** model ApoE^(-/-)mice were orally administered with *** F1-7 for 12 *** probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory *** widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after *** F1-7 *** analysis proved that ALC was associated with atherosclerotic inflammatory *** using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB ***,our results revealed that *** F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： Tongyu Zhang Yingxi Zhu Xiaochen Wang Danyang Chong Haiquan Wang Dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang Meng Wang Kin Fai Ho Tao Wang Shuncheng Lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina school of public health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism