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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

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Neural Regeneration Research 2024年第9期19卷 2010-2018页

作者： Yan Wang Dai Li Lan Zhang Zhenyu Yin Zhaoli Han Xintong Ge Meimei Li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang Xiong Han Gao Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina Tianjin Geriatrics institute Tianjin Medical University General HospitalTianjinChina Tianjin neurological institute Tianjin Medical University General HospitalTianjinChina

We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain ***,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains *** this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of *** found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum ***,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured ***,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly *** findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum ***,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

关键词： apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-124-3p neuron repetitive mild traumatic brain injury X-box binding protein 1

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Investigation on Strengthening Mechanism of China Low-Activation Ferrite Steel upon Thermo-Mechanical Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 373-387页

作者： Dongtian Yang Liangyin Xiong Hongbin Liao Guoping Yang Xiaoyu Wang Shi Liu institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials science and Engineering University of Science and Technology of ChinaShenyang110016China Center for Fusion science Southwestern Institute of PhysicsChengdu610041China

The objective of this study was to investigate the influence of strengthening mechanisms on the high-temperature mechanical properties of China low-activation ferrite(CLF-1)steel,which underwent thermodynamic design and thermo-mechanical treatment(TMT).The microstructure characterization in the normalized and tempered condition and the TMT condition was carried out using optical microscopy,X-ray diffractometer,and scanning electron microscopy with electron backscatter ***-resolution transmission electron microscopy was employed to determine the crystallographic structures of precipitated *** results indicated that the addition of Ti led to an increase in the allocation of C in MC phase and an enhancement in the content of MC *** to CLF-P steel in the normalized and tempered condition,a 1.5-fold increase in dislocation density and an order of magnitude improvement in MX phase density were achieved after *** formation of high-density nano-scale MC phases during TMT played a significant role in precipitation strengthening due to their favorable coherent relationship with the matrix and low interfacial free *** excellent high-temperature mechanical properties observed in CLF-P steel after TMT can be attributed to the combined effects of precipitation strengthening,dislocation strengthening,and lath strengthening.

关键词： China low-activation ferrite(CLF-1)steel Thermo-mechanical treatment MC phase Crystallographic structure Strengthening mechanism

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A combined computational/experimental study of anode-concerned voltage drop in aqueous primary Mg-air batteries

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Journal of Magnesium and Alloys 2024年第5期12卷 1854-1866页

作者： Wen Xu Min Deng Darya Snihirova Linqian Wang Yulong Wu Sviatlana V.Lamaka Mikhail L.Zheludkevich Daniel Hoche institute of Surface science Helmholtz-Zentrum Hereon21502 GeesthachtGermany School of Materials science and Engineering Hebei University of Technology300000TianjinChina institute for Materials science Faculty of EngineeringKiel University24143 KielGermany

The voltage drop appearing at Mg anode-electrolyte interface is a critical issue for the battery power and energy density of aqueous primary Mg-air *** respective voltage loss is typically assigned to the deposits layer forming on the anode surface during *** this work,we experimentally and computationally investigate the critical factors affecting the voltage drop at Mg anode towards a deeper understanding of the contribution of deposit and its growth.A two-dimensional(2D)mathematical model is proposed to compute the voltage drop of Mg-0.15Ca wt.%alloy(Mg-0.15Ca)by means of a semi-empirical formulas and experiments-based modification model,considering the effect of discharge current density,the negative difference effect(NDE)and surface deposits layer *** model is utilized to simulate the discharge potential of the anode at predefined experimental current *** computed voltage drop(half-cell voltage)is in good agreement with the experimental *** applicability of the mathematical model is successfully validated on the second material(namely high-purity Mg).

关键词： Aqueous Mg-air battery Voltage drop NDE Charge transfer Deposits-related resistances

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A review of understanding electrocatalytic reactions in energy conversion and energy storage systems via scanning electrochemical microscopy

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Journal of Energy Chemistry 2024年第4期91卷 155-177页

作者： Jihye Park Jong Hwan Lim Jin-Hyuk Kang Jiheon Lim Ho Won Jang Hosun Shin Sun Hwa Park Interdisciplinary Materials Measurement institute Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Material science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement science University of Science and TechnologyDaejeon 34113Republic of Korea

To address climate change and promote environmental sustainability,electrochemical energy conversion and storage systems emerge as promising alternative to fossil fuels,catering to the escalating demand for *** optimal energy efficiency and cost competitiveness in these systems requires the strategic design of electrocatalysts,coupled with a thorough comprehension of the underlying mechanisms and degradation behavior occurring during the electrocatalysis *** electrochemical microscopy(SECM),an analytical technique for studying surface electrochemically,stands out as a powerful tool offering electrochemical *** possesses remarkable spatiotemporal resolution,enabling the visualization of the localized electrochemical activity and surface *** review compiles crucial research findings and recent breakthroughs in electrocatalytic processes utilizing the SECM methodology,specifically focusing on applications in electrolysis,fuel cells,and metal–oxygen batteries within the realm of energy conversion and storage *** with an overview of each energy system,the review introduces the fundamental principles of SECM,and aiming to provide new perspectives and broadening the scope of applied research by describing the major research categories within SECM.

关键词： Scanning electrochemical microscopy Electrocatalyst Electrocatalysis Water splitting Fuel cell Metal-oxygen battery

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Molecular Dynamics Simulation of Shock Response of CL-20 Co-crystals Containing Void Defects

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Defence Technology（防务技术） 2024年第1期31卷 364-374页

作者： Changlin Li Wei Yang Qiang Gan Yajun Wang Lin Liang Wenbo Zhang Shuangfei Zhu Changgen Feng State Key Laboratory of Explosion science and Technology Beijing Institute of TechnologyBeijing 100081China School of Materials science&Engineering Beijing Institute of TechnologyBeijing 100081China

To investigate the effect of void defects on the shock response of hexanitrohexaazaisowurtzitane(CL-20)co-crystals,shock responses of CL-20 co-crystals with energetic materials ligands trinitrotoluene(TNT),1,3-dinitrobenzene(DNB),solvents ligands dimethyl carbonate(DMC) and gamma-butyrolactone(GBL)with void were simulated,using molecular dynamics method and reactive force *** is found that the CL-20 co-crystals with void defects will form hot spots when impacted,significantly affecting the decomposition of molecules around the *** degree of molecular fragmentation is relatively low under the reflection velocity of 2 km/s,and the main reactions are the formation of dimer and the shedding of nitro *** existence of voids reduces the safety of CL-20 co-crystals,which induced the sensitivity of energetic co-crystals CL-20/TNT and CL-20/DNB to increase more *** has occurred under the reflection velocity of 4 km/s,energetic co-crystals are easier to polymerize than solvent co-crystals,and are not obviously affected by *** results show that the energy of the wave decreases after sweeping over the void,which reduces the chemical reaction frequency downstream of the void and affects the detonation performance,especially the solvent co-crystals.

关键词： CL-20 co-crystals Molecular dynamics simulation Reactive forcefield Impact response Hot spot Void defect

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Cobalt phosphide-based composites as anodes for lithium-ion batteries:From mechanism,preparation to performance

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Particuology 2024年第5期88卷 11-31页

作者： Bo Lan Yishan Wang Jialei Lu Dongdong Liu Chuncheng Wei Xueqian Zhang Xiaoxiao Huang Guangwu Wen School of Materials science and Engineering Shandong University of TechnologyZibo255000China School of Materials science and Engineering Harbin Institute of TechnologyHarbin150001China School of Materials science and Engineering Harbin Institute of TechnologyWeihai264209China

With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition metal phosphides,especially cobalt phosphide(CoP)composites,have become a research hotspot for LIBs anode materials in recent years due to their high theoretical specific capacity,low polarization,and suitable voltage *** review first systematically discusses the lithium storage mechanism and preparation methods of CoP in current ***,the applications of CoP anode materials in LIBs are categorically reviewed,including the composites of CoP with various types of carbon materials and ***,the challenges and future development directions of CoP anode materials are summarized to provide guidance for further improving the lithium storage performance of CoP and its practical applications.

关键词： CoP Composites Preparation Anodes Lithium-ion batteries

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In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes

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Stroke & Vascular Neurology 2024年第1期9卷 8-17,I0001-I0033页

作者： Yu Tian Mengxing Wang Yuesong Pan Xia Meng Xingquan Zhao Liping Liu Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese institute for Brain Research BeijingChina National Center for neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for neurological Diseases BeijingChina

Introduction It remains unclear whether enlarged perivascular spaces(EPVS)predict poor clinical outcomes in patients with acute ischaemic stroke(AIS)or transient ischaemic attack(TIA).Method Data were obtained from the Third China National Stroke Registry *** estimated EPVS in basal ganglia(BG)and centrum semiovale(CSO)using a semiquantified scale(Grade from 0 to 4).Using Cox and logistic regression analyses,the associations of EPVS with 3-month and 1-year adverse outcomes(including recurrent stroke,ischaemic stroke,haemorrhagic stroke,combined vascular event,disability and mortality)were *** analyses of any association of cerebral small vessel disease at baseline and development of a small arterial occlusion(SAO)were *** Among 12603 patients with AIS/TIA,median age was 61.7±11.6 years,and 68.2%were *** adjusting for all potential confounders,frequent-to-severe BG-EPVS was associated with a decreased risk of recurrent ischaemic stroke(HR 0.71,95%CI 0.55 to 0.92,p=0.01)but an increased risk of haemorrhagic stroke(HR 1.99,95%CI 1.11 to 3.58,p=0.02)at 1 year after AIS/TIA,compared with none-to-mild *** with frequent-to-severe CSO-EPVS had a decreased risk of disability(OR 0.76,95%CI 0.62 to 0.92,p=0.004)and all-cause death(HR 0.55,95%CI 0.31 to 0.98,p=0.04)within 3-month but not 1-year follow-ups,compared with those with none-to-mild *** analyses showed that both BG-EPVS(HR 0.43,95%CI 0.21 to 0.87,p=0.02)and CSO-EPVS(HR 0.58,95%CI 0.35 to 0.95,p=0.03)were associated with a decreased risk of subsequent ischaemic stroke in patients with SAO during 1-year *** BG-EPVS increased the risk of haemorrhagic stroke in patients already with AIS/TIA within 1 ***,caution is recommended when selecting antithrombotic agents for secondary stroke prevention in patients with AIS/TIA and more severe BG-EPVS.

关键词： patients haemorrhagic prevention

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Robust asymmetric Cherenkov radiation in tilted anisotropic medium

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science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 46-51页

作者： Shuwen Xue Yadong Xu Linkang Han Zhi Ning Chen Qiaoliang Bao Shan Zhu Huanyang Chen institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyJiujiang Research InstituteXiamen UniversityXiamen 361005China School of Physical science and Technology Institute of Theoretical and Applied PhysicsSoochow UniversitySuzhou 215006China Department of Electrical and Computer Engineering National University of SingaporeSingapore 8117583Singapore institute of Energy Materials science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Cherenkov radiation(CR)is available for a wide variety of terahertz(THz)radiation sources,but its efficiency is deeply affected by intrinsic *** find that if the tilted angle(α)of anisotropic material and radiation angle(θ)meet the condition ofθ+α=π/2,the intensity of radiation fields for the charged particle bunch(CPB)moving from left to right cannot be influenced by intrinsic losses,which means long-distance radiation can be ***,we observe an asymmetric CR when the CPB moves from the opposite *** addition,we select natural van der Waals(vd W)materialα-MoO3as an example,further confirming that the radiation field can reach the far field and the asymmetric CR radiation can also be *** wonderful properties with long-distance radiation will extend the application of CR to a certain extent for future design and fabrication.

关键词： asymmetric Cherenkov radiation intrinsic losses long-distance radiation

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A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

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science China(Information sciences) 2024年第2期67卷 118-143页

作者： Guang-Ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Center for Control science and Technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems

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A multilayer network diffusion-based model for reviewer recommendation

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Chinese Physics B 2024年第3期33卷 700-717页

作者：黄羿炜徐舒琪蔡世民吕琳媛 institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China institute of Dataspace Hefei Comprehensive National Science CenterHefei 230088China Big Data Research Center University of Electronic Science and Technology of ChinaChengdu 611731China School of Computer science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Cyber science and Technology University of Science and Technology of ChinaHefei 230026China

With the rapid growth of manuscript submissions,finding eligible reviewers for every submission has become a heavy *** systems are powerful tools developed in computer science and information science to deal with this ***,most existing approaches resort to text mining techniques to match manuscripts with potential reviewers,which require high-quality textual information to perform *** this paper,we propose a reviewer recommendation algorithm based on a network diffusion process on a scholar-paper multilayer network,with no requirement for textual *** network incorporates the relationship of scholar-paper pairs,the collaboration among scholars,and the bibliographic coupling among *** results show that our proposed algorithm outperforms other state-of-the-art recommendation methods that use graph random walk and matrix factorization and methods that use machine learning and natural language processing,with improvements of over 7.62%in recall,5.66%in hit rate,and 47.53%in ranking *** work sheds light on the effectiveness of multilayer network diffusion-based methods in the reviewer recommendation problem,which will help to facilitate the peer-review process and promote information retrieval research in other practical scenes.

关键词： reviewer recommendation multilayer network network diffusion model recommender systems complex networks

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