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Glymphatic function and its influencing factors in different glucose metabolism states

World Journal of Diabetes 2024年第7期15卷 1537-1550页

作者： Bin Tian Chen Zhao Jia-Li Liang Hui-Ting Zhang Yi-Fan Xu Hui-Lei Zheng Jia Zhou Jiang-Nian Gong Shu-Ting Lu Zi-San Zeng department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina magnetic resonance Research Collaboration Siemens HealthineersGuangzhou 510620Guangdong ProvinceChina magnetic resonance Research Collaboration Siemens Healthineers Ltd.Wuhan 430071Hubei ProvinceChina department of Health Management The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well *** To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states,the present study employed diffusion tensor imaging along the perivascular space(DTI-ALPS)*** Sample size was calculated using the pwr package in R *** crosssectional study enrolled 22 patients with normal glucose metabolism(NGM),20 patients with prediabetes,and 22 patients with type 2 diabetes mellitus(T2DM).A 3.0T magnetic resonance imaging was used to evaluate the function of the glymphatic *** mini-mental state examination(MMSE)was used to assess general cognitive *** DTI-ALPS index of bilateral basal ganglia and the mean DTI-ALPS index was ***,the correlation between DTI-ALPS and clinical features was *** The left-side,right-side,and mean DTI-ALPS index in the T2DM group were significantly lower than that in the NGM *** right-side DTI-ALPS and mean DTI-ALPS index in the T2DM group were significantly lower than those in the prediabetes ***-ALPS index lateralization was not *** MMSE score in the T2DM group was significantly lower than that in the NGM and prediabetes *** controlling for sex,the left-side DTI-ALPS and mean DTI-ALPS index in the prediabetes group were positively correlated with 2-hour postprandial blood glucose level;the left-side DTI-ALPS index was negatively correlated with total cholesterol and low-density lipoprotein *** right-side DTI-ALPS and mean DTI-ALPS index were negatively correlated with the glycosylated hemoglobin level and waist-to-hip ratio in the prediabetes *** left-side,right-side,and mean DTI-ALPS index in the T2DM group were positively correlated with *** left-side and mean DTIALPS index in the T2DM group were negatively

关键词： Glymphatic system Prediabetes Type 2 diabetes mellitus magnetic resonance imaging Diffusion tensor imaging along the perivascular space

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Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The affiliated Changzhou Second People’s hospital of Nanjing medical university Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China department of Radiology First Hospital of China Medical UniversityShenyang 110002China department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of magnetic resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing medical university Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

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White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study

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Congenital Heart Disease 2024年第3期19卷 279-291页

作者： Yang Hua Jinyu Sun Yuxuan Lou Hao Zhang Jing Shi Wei Sun department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China

Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and ***,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged *** retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk ***:226 patients with migraine and PFO were consecutively initially *** factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model *** discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration ***:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of *** magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML *** regression screened out potential variables and subsequent multivariate analysisﬁnally identiﬁed age,mean platelet volume,andﬁbri-nogen(FIB)as independent predictive factors of *** area under the ROC curve(AUC)was ***-mer-Lemeshow test and calibration curve veriﬁed a consistency between the predicted and actual ***:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.

关键词： White matter lesion migraine patent foreman ovale nomogram predictive model

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T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da Zheng Qiao-Yi Huang Qi-Ming Huang Xiao-Ting Ke Kai Ye Shu Lin Jian-Hua Xu department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina department of Computed Tomography/magnetic resonance Imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported *** a non-invasive model to predict the differentiation grade of CRC is of great *** To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July *** were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 *** were delineated layer by layer on high-resolution *** absolute shrinkage and selection operator regression was applied to screen for radiomic *** and clinical models were constructed using the multilayer perceptron(MLP)*** radiomic features and clinically relevant variables(selected based on a significance level of P<0.05 in the training set)were used to construct radiomics-clinical *** performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULTS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic *** different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic *** AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation *** AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation *** clinical model achieved an AUC of 0.7

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging

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Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： Yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei Yi Xu Ling Wang Yi Xia Xu Qi Huanping Mei Xueqiang Xu Huijuan Mao Changying Xing Ningning Wang department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the *** present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in *** early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of *** one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal *** diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the *** changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and ***,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary *** the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal *** focal infection ultimately resolved during the subsequent three ***-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

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Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin Xiao-Qi Kong Ya-Juan Zhu Zong-Xin Chen Xi-Ming Wang Cai-Hua Xu Jin-Xian Pu Jian-Quan Hou Yu-Hua Huang Fu-Hai Ji Chen Huang department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The first affiliated hospital of Soochow university(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

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CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen Kang Yang department of Neurology and Institute of Neurology of first affiliated hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The first affiliated hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

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Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis

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Chinese Chemical Letters 2024年第8期35卷 413-417页

作者： Tian Feng Yun-Ling Gao Di Hu Ke-Yu Yuan Shu-Yi Gu Yao-Hua Gu Si-Yu Yu Jun Xiong Yu-Qi Feng Jie Wang Bi-Feng Yuan School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China department of Radiation and medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Key Laboratory of magnetic resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China university of Chinese Academy of Sciences Beijing 101408China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China Phase I Clinical Trial Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Sleep deprivation(SD)is a widespread issue that disrupts the lives of millions of *** effects ini-tiate as changes within neurons,specifically at the DNA and RNA level,leading to disruptions in neuronal plasticity and the dysregulation of various cognitive functions,such as learning and *** acid epigenetic modifications that could regulate gene expression have been reported to play crucial roles in this ***,there is a lack of comprehensive research on the correlation of SD with nucleic acid epigenetic *** the current study,we aimed to systematically investigate the landscape of modifications in DNA as well as in small RNA molecules across multiple tissues,including the heart,liver,kidney,lung,hippocampus,and spleen,in response to chronic sleep deprivation(CSD).Using liquid chromatography-tandem mass spectrometry(LC-MS/MS)analysis,we characterized the dynamic changes in DNA and RNA modification profiles in different tissues of mice under CSD ***,we ob-served a significant decrease in the level of 5-methylcytosine(5mC)and a significant increase in the level of 5-hydroxymethylcytosine(5hmC)in the kidney in CSD *** RNA modifications,we observed an overall increased trend for most of these significantly changed modifications across six tis-sues in CSD *** study sheds light on the significance of DNA and RNA modifications as crucial epigenetic markers in the context of CSD-induced stress.

关键词： Sleep deprivation Epigenetics Mass spectrometry DNA modification RNA modification Small RNA

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Relative exchangeable copper， a high-quality biomarker for differentiation of Traditional Chinese Medicine syndrome in Wilson’s disease

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Journal of Traditional Chinese Medicine 2024年

作者： DING Yufeng YANG Wenming CHENG Yuan YANG Yulong ZHU Jun LU Yachun FANG Xiang ZHANG Jing department of Neurology， The first affiliated hospital of Anhui university of Traditional Chinese Medicine department of Clinical Laboratory， the first affiliated hospital of Anhui university of Traditional Chinese Medicine

Objective: To investigate the value of relative exchangeable copper (REC) in diagnosing Wilson’s disease (WD) and to determine its significance in the differentiation of Traditional Chinese Medicine (TCM) syndrome. Methods: A total of 78 patients with WD were recruited on the same day of the medical visit， and among them， 32 were suffering from non-WD (N-WD) and 37 were heterozygous ATP7B carriers (HC) enrolled as controls. Molecular genetic testing was performed for diagnosing WD and HC. Additionally， REC levels in different TCM syndromes were investigated. The correlation between REC and serum ceruloplasmin (Cp)， serum copper oxidase (CO)， and 24-h urinary copper was analyzed using the Global Assessment Scale and Unified Wilson’s Disease Rating Scale and the significance of REC in WD diagnosis was investigated. Resting-state functional magnetic resonance imaging was used to assess the clinical symptoms of WD and analyze its severity in different TCM syndromes. Results: REC determination helped in significantly distinguishing patients with N-WD or HC from those with WD with a cut-off of 21.15%. Furthermore， the comparative analysis of REC ratios among different TCM syndromes showed markedly high REC levels in the dampness-heat internal accumulation syndrome group. Additionally， the seed-based functional connectivity value from the putamen to the cerebellum was signi?cantly correlated with TCM syndromes. Conclusion: REC level is a high-quality biomarker for diagnosing WD that effectively reflects disease severity and plays an essential role in deciding on treatment strategies and prognosis. Furthermore， REC levels are closely related to TCM syndromes in WD; thus， it is a potential objective quantitative indicator for distinguishing TCM syndromes in WD.

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The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary

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Genes & Diseases 2024年第3期11卷 39-42页

作者： Haoyu Ruan Zhe Wang Xuemei Tang Qiong Zhan Kun Chen Lu Gao Ming Guan department of Laboratory Medicine Huashan HospitalFudan UniversityShanghai 200040China department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China department of Physiology Naval Medical UniversityShanghai 200433China department of Oncology Huashan HospitalFudan UniversityShanghai 200040China

Cancer of unknown primary(CUP)is a rare disease characterized by metastases in which the primary tumor is of unknown *** cerebrospinal fluid(CSF)tumor microenvironment of CUP is still unknown.A Chinese male was diagnosed with leptomeningeal metastases from CUP(CUP-LM)based on the following medical examination results:partial leptomeningeal enhancement by brain magnetic resonance imaging,few malignant cells of diverse morphology in CSF,and no abnormalities or lymphadenopathy by systemic examination.

关键词： metastases cerebrospinal fluid

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