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Surgeon Perspectives on Anastomotic Leaks and FluidAI’s StreamTM Platform: Integrating Qualitative Insights for Technological Innovation

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Surgical Science 2024年第8期15卷 492-500页

作者： Olivia Rennie Manaswi Sharma Nour Helwa Department of Clinical Affairs FluidAI Medical (Formerly NERv Technology Inc.) Kitchener Canada Faculty of Medicine University of Toronto Toronto Canada

Purpose: This article investigates the critical importance of integrating surgeons’ direct input into the development of innovative technologies that address gaps in surgical care, inc.uding those aimed at reducing anastomotic leaks (AL), a major complication in gastrointestinal surgery. While traditional quantitative research methods are prevalent, they often overlook the invaluable insights of the surgeons who manage these complications firsthand. Subjects and Methods: This study employs a qualitative approach, utilizing semi-structured interviews with 40 surgeons from various specialties, inc.uding general, bariatric, colorectal, trauma, hepato-biliary, and thoracic surgery. The interviews were designed to probe the needs of surgeons, challenges currently faced, and gaps in clinical practice, research, and technology for detection and/or management of AL. The data were analyzed using thematic analysis, which revealed significant gaps in current technologies for early detection and prevention of leaks. Results: Surgeons expressed strong interest in FluidAI’s Stream™ Platform, a non-invasive medical device designed to monitor postoperative drainage fluid in real-time, providing continuous data on AL risk. The ability of this platform to offer early prediction through pH and electrical conductivity analysis was particularly appealing to participants, who emphasized the importance of timely interventions in improving patient outcomes. The study’s findings highlight not only the clinical challenges but also the emotional toll that AL takes on surgeons, underlining the need for innovations that are both data-driven and humanistic. Conclusion: By centering surgeons’ perspectives, this research advocates for a human-centered approach to technological advancement, ensuring that new tools are both clinically effective and aligned with the real-world needs of surgical practitioners.

关键词： Anastomotic Leaks Surgeon Perspectives Postoperative Complications Qualitative Inquiry Technological Innovation

COMPARATIVE EXTRACTION OF METAL CATIONS FROM SULPHATE MEDIUM WITH CYANEX 272 AND A MIXED ALKYL PHOSPHINIC ACID BLEND （ODDPA）

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COMPARATIVE EXTRACTION OF METAL CATIONS FROM SULPHATE MEDIUM...

LINGO-1-Fc蛋白对低钾诱导小脑颗粒神经元凋亡的保护作用

International Solvent Extraction Conference 2005

作者： B.Jakovljevic C.Bourget J.Hillhouse M.Humeniuk D.Nucciarone CYTEC Industries inc. Phosphine and Phosphorus Specialties Niagara Falls Canada CYTEC Industries inc. Phosphine and Phosphorus Specialties Niagara Falls Canada CYTEC Industries inc. Phosphine and Phosphorus Specialties Niagara Falls Canada CYTEC Industries inc. Phosphine and Phosphorus Specialties Niagara Falls Canada CYTEC Industries inc. Phosphine and Phosphorus Specialties Niagara Falls Canada

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生物化学与生物物理进展 2006年第4期33卷 336-342页

作者：赵湘辉金卫林 MI Sha 鞠躬第四军医大学神经科学研究所西安710032 上海交通大学神经科学研究所上海200240 Department of Discovery Biology Biogen Idec Inc. 14 Cambridge Center Cambridge Massachusetts 02142 USA

髓鞘抑制因子Nogo-A、mag和OMgp通过共同的受体信号复合物NgR/p75NTR(或者TROY)发挥对中枢神经纤维再生的抑制作用.新近克隆的跨膜蛋白LINGO-1是该信号途径的另一个重要组成成分和调节分子.LINGO-1特异表达于中枢神经系统,神经元上的LIN... 详细信息

髓鞘抑制因子Nogo-A、mag和OMgp通过共同的受体信号复合物NgR/p75NTR(或者TROY)发挥对中枢神经纤维再生的抑制作用.新近克隆的跨膜蛋白LINGO-1是该信号途径的另一个重要组成成分和调节分子.LINGO-1特异表达于中枢神经系统,神经元上的LINGO-1被证明参与调节中枢神经再生的抑制信号,而少突胶质细胞表达的LINGO-1分子参与负调节少突胶质细胞的髓鞘化过程.为探讨LINGO-1分子在神经元凋亡过程中的作用,利用包含LINGO-1分子胞外段LRR和IgC2结构域的Fc融合蛋白作为功能性拮抗剂,研究LINGO-1对低钾诱导的小脑颗粒神经元凋亡的保护作用.利用成熟的Hoechst标记凋亡细胞的方法,观察到经LINGO-1-Fc蛋白预处理2h能够显著阻止小脑颗粒神经元的凋亡.仅包括LRR结构域的GST-LINGO-1与LINGO-1-Fc蛋白,虽同样具有与颗粒神经元的结合活性,但是GST-LINGO-1不能有效地阻止低钾诱导的细胞凋亡.这些结果提示,LINGO-1-Fc蛋白能够阻止低钾诱导的小脑颗粒神经元凋亡,并且这种作用可能是IgC2结构域依赖的.

关键词： LINGO-1 小脑颗粒神经元凋亡保护作用

The landscape of investigator‐initiated oncology trials conducted in China's Mainland during the past decade(2010–2019)

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Cancer Innovation 2023年第1期2卷 79-90页

作者： Ye Cao Lin‐Miao Ye Zhong Fan Wei Yang Li‐Ying Chen Yun Mei De‐Ying He Wen‐Jin Mo Department of Clinical Research State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‐sen University Cancer CenterGuangzhouChina Department of Clinical Research Jieyang People's HospitalJieyangChina Department of Pediatrics the First Affiliated HospitalSun Yat‐sen UniversityGuangzhouChina Department of Clinical Trials AI Innovations Yidu Tech Inc.BeijingChina Information Service Department Guangzhou Yushi Medicinal Technology Co.Ltd.GuangzhouChina

The number of clinical trials conducted in China's Mainland,inc.uding investigator‐initiated trials(IITs),has inc.eased rapidly in recent ***,there are few data on the characteristics of cancer‐related *** performed a comprehensive analysis of the landscape of cancer‐related IITs in China's Mainland in the past *** cancer‐related IITs registered on two clinical trial registries in the United States(***,***)and China's Mainland(***,ChiCTR)from 2010 to 2019 were *** were reviewed manually to validate classification,subcategorized by cancer type,and stratified by design characteristics to facilitate comparison across cancer types and with other specialties.A total of 8199 cancer‐related IITs were *** number of trials registered annually inc.eased over time,especially in the last 5 *** interventional studies were predominant,randomized double‐blind studies accounted for only 8%of *** the past decade,the trend for interventional studies conducted with different drugs inc.eased year on year,although the inc.ease in hormonal therapy IITs was not ***,cancerrelated IITs were unevenly geographically distributed,with half concentrated in the economically developed cities Shanghai,Beijing,and *** also found an inc.ease in registration before participant enrollment(64.9%for trials in conducted in 2015–2019 vs.40.2%in 2010–2014,pinc.ease in targeted therapy[17.8%vs.14.2%,p=0.004],immune checkpoint inhibitor therapy[6.6%vs.0.0%,p<0.001],and immune cell therapy[9.6%vs.4.5%,p<0.001]).Details of cancer‐related IITs conducted during the past decade illustrate the merits of oncology research

关键词： cancer investigator‐initiated trials landscape clinicaltrials.gov ***

magnetic sphinc.er augmentation: Optimal patient selection and referral care pathways

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World Journal of Gastrointestinal Endoscopy 2019年第8期11卷 472-482页

作者： F Paul Buckley Benjamin Havemann Amarpreet Chawla Department of Surgery and Perioperative Care Dell Medical SchoolThe University of Texas at AustinAustinTX 78712United States Austin Gastroenterology Bee CaveTX 78738United States Department of Health Economics and Market Access Ethicon Inc.(Johnson and Johnson)CincinnatiOH 45242United States

Outcomes associated with magnetic sphinc.er augmentation (MSA) in patients with gastroesophageal reflux disease (GERD) have been reported,however the optimal population for MSA and the related patient care pathways have not been *** Minireview presents evidence that describes the optimal patient population for MSA,delineates diagnostics to identify these patients,and outlines opportunities for improving GERD patient care *** publications from MEDLINE/EMBASE and guidelines were identified from *** experts contextualized the evidence based on clinical *** optimal MSA population may be the 2.2-2.4% of GERD patients who,despite optimal medical management,continue experiencing symptoms of heartburn and/or uncontrolled regurgitation,have abnormal pH,and have intact esophageal function as determined by high resolution *** work-ups inc.ude ambulatory pH monitoring,high-resolution manometry,barium swallow,and *** patients may present with a range of typical or atypical *** addition to primary care providers (PCPs) and gastroenterologists (GIs),other specialties involved may inc.ude otolaryngologists,allergists,pulmonologists,among *** diagnostic testing is required to ascertain surgical necessity for *** referral pathways for GERD management are *** exist for enabling patients,PCPs,GIs,and surgeons to act as a team in developing evidence-based optimal care plans.

关键词： Gastroesophageal reflux disease Surgery magnetic sphinc.er augmentation Referral pathways

Safety and Performance of Harmonic®HD 1000i Shears in Thoracoscopic Procedures: A Retrospective Study

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Open Journal of Thoracic Surgery 2022年第2期12卷 33-42页

作者： Seong Yong Park Subin Lim Dong Kyu Kim Jason R. Waggoner Paula P. Veldhuis Giovanni A. Tommaselli Department of Thoracic and Cardiovascular Surgery Samsung Medical Center Sungkyunkwan University School of Medi-cine Seoul Republic of Korea Real-World Evidence Team ALYND Yonsei University Health System Seoul Republic of Korea Department of Family Medicine Yonsei University College of Medicine Seoul Republic of Korea Ethicon Inc. Cincinnati OH USA

Background: Ultrasonic energy devices are utilized for transection, inc.sion, and hemostasis in traditional open and laparoscopic procedures. The Harmonic HD 1000i Shears, designed to deliver a precise amount of thermal energy during tissue transection and vessel sealing, has been utilized in many specialties. This study aimed to confirm real-world safety and performance of the Harmonic device in two thoracoscopic procedures: lobectomy and segmentectomy. Methods: The primary endpoint of this retrospective, observational, single-arm study was rate of post-operative blood transfusions related to study device or procedure. Secondary endpoints inc.uded occurrence of intra- and post-operative adverse events (AEs) or complications device- or procedure-related, and rate of required additional hemostatic measures. Adults inc.uded those who underwent thoracoscopic lobectomy or segmentectomy where HD 1000i shears were used while excluding those where additional advanced energy devices were used. The study was conducted at Severance Hospital, Yonsei University Health System, South Korea from May 1, 2018, to November 30, 2020. Results: Subjects inc.uded n = 766 lobectomies (mean age 63.79, 52% male) and n = 215 segmentectomies (mean age 63.19, 54% male). Estimated blood loss was 50 mL (0 min, 3200 max) and 20 mL (0 min, 800 max), intraoperative transfusion rate 0.001% and 0%, intraoperative complication/AE rate 1% and 2%, and post-operative complication/AE rate 9% and 4% in the lobectomy and segmentectomy groups, respectively. Median operative times were 108 min. (35 min, 395 max) for lobectomies and 105 min. (32 min, 574 max) for segmentectomies. Conclusion: Given the low rate of blood loss and intra- and post-operative complication/AE rates, HD 1000i can be used confidently for thoracoscopic pulmonary resection in adults.

关键词： Harmonic HD 1000i Shears Lobectomy Segmentectomy Ultrasonic Energy Device

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微功耗清洁能源存贮系统

电源世界 2012年第3期 21-32页

作者：郭隆李嘉明郁百超豪德千网水平电池有限公司 TRI-mag INC.美国三磁电子公司湖北省电力信息通信公司

微功耗清洁能源存贮系统包括DC/DC、AC/DC、DC/AC三种功率变换器,每种变换都采用微功耗电力电子变换技术,实现了清洁能源的高品质、高效率的存贮和并网,该微功耗清洁能源存贮系统最大特点是,只要把输入功率中极小部份进行功率变换,就可... 详细信息

微功耗清洁能源存贮系统包括DC/DC、AC/DC、DC/AC三种功率变换器,每种变换都采用微功耗电力电子变换技术,实现了清洁能源的高品质、高效率的存贮和并网,该微功耗清洁能源存贮系统最大特点是,只要把输入功率中极小部份进行功率变换,就可以得到全部输出功率,即输入功率中极大部份既不必进行实际的功率变换,也不必通过磁芯变压器或电感传递,直接到达输出端,成为输出功率,器件都工作在工频,不产生EMI干扰,因此功耗极小而寿命极长,输出正弦波不失真,安全可靠,节能环保,成本、体积、重量、功耗都是传统贮能系统的1/10。

关键词：电能存贮系统微功耗存贮和并网

Urgent Need of Continuing Medical Education:The Key for Patient Awareness of Labor Epidural Analgesia-A Survey of Chinese Perinatal Care Providers

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Maternal-Fetal Medicine 2021年第3期3卷 169-175页

作者： Peishan Zhao Ling-Qun Hu Chunyuan Liu Huiling Li Anna Huang Shuwei Yang Zhenyu Cai Department of Anesthesiology and Perioperative Medicine Tufts Medical CenterBostonMA 02111USA Department of Anesthesiology The Ohio State University Wexner Medical CenterColumbusOH 43210USA Department of Anesthesiology Chongqing Liangping County People's HospitalChongqing 405200China Department of Obstetrics and Gynecology The People's HospitalPeking University School of MedicineBeijing 100044China Mailman School of Public Health Columbia UniversityNew YorkNY 10032USA ApgarCARE International Inc.Xi’anShaanxi 710075China Department of Obstetrics and Gynecology Aviation General Hospital of China Medical UniversityBeijing 100012China

Objective:This survey was designed to understand the misconceptions about labor ***:This voluntary and anonymous online survey on *** was conducted from September 1st,2015 to January 1st,2016 via mainly WeChat groups dedicated to perinatal healthcare providers in *** questionnaire inc.uded items inquiring the knowledge and opinions about labor epidural analgesia related to maternal complications,baby safety,and effect on *** surveys were excluded from the data *** data was presented as percentages and a Chi-square test or Fisher's exact test,as appreciate,was used to quantitatively compare the ***:A total of 1412 respondents completed surveys with 42.9%(606/1412)of them being anesthesiologists,35.1%(495/1412)being obstetricians,11.8%(167/1412)being midwives,3.7%(52/1412)being labor and delivery nurses,and 6.5%(92/1412)being hospital administrators and *** study revealed a lack of knowledge in labor pain *** 82.4%(1164/1412)of respondents were familiar with labor epidural analgesia,8.9%(126/1412)did not know how it works,and 1.1%(15/1412)never heard it in a multiple-choice *** three main groups(anesthesiologists,obstetricians,and midwives/labor and delivery nurses)were chosen for *** among these three groups concerning five questions in the three main concerns were evaluated using a statistical significance of Pspecialties to improve evidence-based medical practices as these misconceptions have existed for over 10 years in the medical *** of public awareness fueled by misconceptions related to labor epidural analgesia may be associated with a lack of professional *** knowledge in professionals needs to be disseminated to the public in order to dispel possible misconceptions and rumors about labor epidural

关键词： Education,medical,continuing Labor epidural analgesia Patient awareness Questionnaire