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Perihepatic adhesions: An unusual complication of hemolysis, elevated liver enzymes and low platelet syndrome

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World Journal of Gastroenterology 2014年第26期20卷 8726-8728页

作者： Margot M Koeneman Ger H Koek Marc Bemelmans Louis L Peeters Department of Obstetrics and Gynecology Maastricht University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineMaastricht University Medical Center Department of Surgery Maastricht University Medical Center

We present a case of symptomatic perihepatic adhesions,which developed after a pregnancy complicated by hemolysis,elevated liver enzymes and low platelet(HELLP)syndrome,in which a subcapsular liver hematoma *** patient presented with complaints of persistent,severe right-sided upper abdominal *** complaints developed gradually,one year after a pregnancy that had been complicated by HELLP syndrome with a subcapsular liver *** hematoma had resolved *** upperabdominal magnetic resonance imaging revealed a density between liver and diaphragm at the site of the former subcapsular hematoma,suspect of perihepatic *** presence of perihepatic adhesions was confirmed during a laparoscopy and treated by adhesiolysis in the same *** adhesions may have developed in response to the degradation process of the subcapsular liver hematoma during conservative *** case of perihepatic adhesions may therefor be the first presentation of a long term sequel of subcapsular liver hematoma in HELLP syndrome.

关键词： Hemolysis elevated liver enzymes and low platelet syndrome Liver Haematoma Long-term effects Adhesions Tissue

Applications of Blockchain Technology in marketing—A systematic review of marketing technology companies

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Blockchain(Research and Applications) 2021年第3期2卷 79-87页

作者： Valerio Stallone Martin Wetzels Michael Klaas Zurich University of Applied Sciences Theaterstrasse 178401WinterthurSwitzerland maastricht University 6200MD Maastrichtthe Netherlands

Given the emerging nature of integrating Blockchain Technology(BCT)into several business fields concerning the interaction between companies and their customers,this study aims to investigate the applications of BCT in marketing through an accurate procedure of locating,selecting and analyzing existing companies using BCT in marketing.A sample that consists of 800 companies was identified using web-scraping *** data set was collected from initial coin offerings(ICO)websites as well as from an existing,older landscape of *** data set was then intensively analyzed in order to be categorized into five fields of marketing *** and ecommerce outgrew the other fields of social&relationship,content&experience and data in absolute numbers,revealing the focus of practitioners in the past as well as gaps for the *** authors provided future directions for researchers on and development of tools to systematically generate knowledge and improve the application of BCT and the work of practitioners in marketing.

关键词： Blockchain Marketing Blockchain applications Blockchain in marketing

Alternatives for large-scale production of cultured beef: A review

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Journal of Integrative Agriculture 2015年第2期14卷 208-216页

作者： Matilda S M Moritz Sanne E L Verbruggen Mark J Post Department of Physiology Maastricht UniversityMaastricht 6229 ER The Netherlands Department of Physics Chemistry and Biology Linkping UniversityLinkping SE-581 83 Sweden

Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today＇s 2-dimensional（2D） standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef.

关键词： cultured beef microcarriers aggregated cells packed bed bioreactor cell culture

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Magnetically responsive nanofibrous ceramic scaffolds for on-demand motion and drug delivery

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Bioactive Materials 2022年第9期7卷 372-381页

作者： Yonggang Zhang Jiaping Li Pamela Habibovic Department of Instructive Biomaterials Engineering Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands Department of Complex Tissue Regeneration Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands

Smart biomaterials,featuring not only bioactivity,but also dynamic responsiveness to external stimuli,are desired for biomedical applications,such as regenerative medicine,and hold great potential to expand the boundaries of the modern clinical ***,a magnetically responsive three-dimensional scaffold with sandwich structure is developed by using hydroxyapatite(HA)nanowires and ferrosoferric oxide(Fe_(3)O_(4))nanoparticles as building *** magnetic HA/Fe_(3)O_(4) scaffold is fully inorganic in nature,but shows polymeric hydrogel-like characteristics including a 3D fibrous network that is highly porous(>99.7%free volume),deformable(50%deformation)and elastic,and tunable *** magnetic HA/Fe3O4 scaffold has been shown to execute multimodal motion upon exposure to an external magnetic field including shape transformation,rolling and *** addition,we have demonstrated that the magnetic scaffold can serve as a smart carrier for remotely controlled,on-demand delivery of compounds including an organic dye and a ***,the magnetic scaffold has exhibited good biocompatibility,supporting the attachment and proliferation of human mesenchymal stromal cells,thereby showing great potential as smart biomaterials for a variety of biomedical applications.

关键词： Hydroxyapatite Magnetic Responsive Drug delivery Cell culture

Ontology-based Access Control for FAIR Data

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Data Intelligence 2020年第1期2卷 66-77,304,305页

作者： Christopher Brewster Barry Nouwt Stephan Raaijmakers Jack Verhoosel Data Science Department at TNO Kampweg 55Soesterberg 3769 DEThe Netherlands Institute of Data Science Maastricht UniversityMaastricht 6229 ERThe Netherlands

This paper focuses on fine-grained,secure access to FAIR data,for which we propose ontology-based data access *** policies take into account both the FAIR aspects of the data relevant to access(such as provenance and licence),expressed as metadata,and additional metadata describing *** this tripartite approach(data,associated metadata expressing FAIR information,and additional metadata about users),secure and controlled access to object data can be *** yields a security dimension to the“A”(accessible)in FAIR,which is clearly needed in domains like security and *** domains need data to be shared under tight controls,with widely varying individual access *** this paper,we propose an approach called Ontology-Based Access Control(OBAC),which utilizes concepts and relations from a data set's domain *** argue that ontology-based access policies contribute to data reusability and can be reconciled with privacy-aware data access *** illustrate our OBAC approach through a proof-of-concept and propose that OBAC to be adopted as a best practice for access management of FAIR data.

关键词： Access control Semantic technology Ontology Security FAIR

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Effects of endothelin ETA receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure

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Acta Pharmacologica Sinica 2006年第11期27卷 1417-1422页

作者： Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON Thomas UNGER Clinic of Cardiology Christian-Albrechts-University of Kiel24105 KielGermany Institute of Pharmacology Christian-Albrechts University of Kiel24105 KielGermany Department of Pathology University of MaastrichtMaastrichtthe Netherlands

Aim:To investigate whether the endothelin ETAreceptor blocker provides similarbenefit on cardiac remodeling and survival in a hypertensive rat model of chronicheart failure（CHF）.Methods:Male stroke-prone spontaneously hypertensive（SHR-SP）rats were subjected to permanent ligation of the left coronary artery andwere treated for 6 weeks with the endothelin ETAreceptor blocker LU 135252(***-1.d-1)starting 24 h after ligation or ***-operated rats servedas normal *** mean arterial blood pressure（MAP）,heart rate（HR）,leftventricular end-diastolic pressure（LVEDP）,left ventricular contractility(LVdp/dtmax),left ventricular inner diameter（LVD）and circumference（LVC）,septalthickness,left ventricular interstitial collagen content（ICC）and heart weight（HW）were measured at the end of the ***:Compared with the untreatedgroup,LU 135252 tended to increase HW（1.43±0.03 vs 1.38±0.04 g;P>0.05）,increased LVD（7.65±0.24 mm vs 6.58±0.14 mm;P0.05）,reduced LVEDP（144mmHg vs 27±4 mmHg;P<0.05）andimproved LV dp/dtmax（4230±450 mmHg/s vs 1950±400 mmHg/s;P<0.05）;survivalwas not prolonged significantly（13% vs 11%;P=NS）.Conclusion:In this hyper-tensive rat model of CHF,chronic endothelin ETA receptor blockade with LU 135252improves cardiac hemodynamics,however,it does not affect long-term survivaland worsens cardiac ***,endothelin ETAreceptor antagonists areunlikely to have an important role in the management of patients with CHF.

关键词： myocardial infarction heart failure endothelin ET_A receptor antagonism LU 135252 cardiac remodeling ventricular function SHR-SP rats

Role of imaging in predicting response to neoadjuvant chemotherapy in gastric cancer

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World Journal of Gastroenterology 2014年第7期20卷 1650-1656页

作者： Robert Michael Kwee Thomas Christian Kwee Department of Radiology Maastricht University Medical Center6229 HX MaastrichtThe Netherlands Department of Radiology University Medical Center Utrecht3584 CX UtrechtThe Netherlands

With the proven overall benefit of neoadjuvant chemotherapy in patients with locally advanced gastric cancer,there has come a need to discriminate responders from *** this article,the current role of anatomical and molecular imaging in the prediction of response to neoadjuvant therapy in gastric cancer is outlined and future prospects are discussed.

关键词： Gastric cancer Neoadjuvant therapy Chemotherapy Response Imaging

An optimized medial parapatellar approach to the goat medial femoral condyle

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Animal Models and Experimental Medicine 2021年第1期4卷 54-58页

作者： Pieter P.W.van Hugten Ralph M.Jeuken Alex K.Roth Saskia Seeldrayers Peter J.Emans Laboratory for Experimental Orthopedics Department of Orthopedic SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands Laboratory Animal Facility Maastricht UniversityMaastrichtThe Netherlands

Goats or sheep are the preferred animal model for the preclinical evaluation of cartilage repair techniques due to the similarity of the goat stifle joint to the human *** medial femoral condyle of the stifle joint is the preferred site for the assessment of articular cartilage repair,as this is the primary location for this type of lesion in the human *** surgical exposure of the medial femoral condyle is paramount to obtain reproducible results without surgical *** applying the standard human medial arthrotomy technique on the goat stifle joint,there are some key aspects to consider in order to prevent destabilization of the extensor apparatus and subsequent postoperative patellar dislocations with associated animal *** paper describes a modified surgical technique to approach the medial femoral condyle of the caprine stifle *** modified technique led to satisfactory exposure without postoperative incidence of patellar luxations and no long-term adverse effects on the joint.

关键词： approach arthrotomy cartilage condyle goats

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Local digital lending development and the incidence of deprivation in Kenya

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Financial Innovation 2023年第1期9卷 2856-2881页

作者： Godsway Korku Tetteh University of Strathclyde 16 Richmond StreetGlasgowUK UNU‑MERIT Maastricht UniversityMaastrichtThe Netherlands

In the developing world,vulnerable communities often lack access to regular income sources to cope with unforeseen *** advancements in financial technology have enabled microcredit to be delivered via digital *** digital credit may quicken remote access to consumer credit without the need for collateral,little is known about its contribution to the welfare of underserved *** study examines the effects of local digital lending development on deprivation and explores the implications of these effects on rural *** results show a negative association between local digital lending development and food deprivation on one hand and health deprivation on the *** evidence suggests that local digital lending development can reduce the probability of food and health ***,the evidence reveals that inhabitants of rural communities benefit more from digital lending *** study recommends the decentralization of financial inclusion policies as a pathway to promote digital lending at the local level.

关键词： Microfinance Fintech Digital lending Deprivation