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Double-antibody-based nano-biosensing systemfor the onsite monitoring of SARS-CoV-2 variants

Microsystems & Nanoengineering 2023年第4期9卷 247-262页

作者： Heba A.Hussein Ahmed Kandeil Mokhtar Gomaa Rabeay Y.A.Hassan Virology Department Animal Health Research Institute(AHRI)Agricultural Research Center(ARC)Giza 12619Egypt Biosensors Research Laboratory Zewail City of Science and Technology6th October CityGiza 12578Egypt Center of Scientific Excellence for Influenza Viruses Environmental Research DivisionNational Research CentreGiza 12622Egypt Nanoscience Program University of Science and Technology(UST)Zewail City of Science and TechnologyGiza 12578Egypt

The fast and reliable diagnosis of COVID-19 is the foremost priority for promoting public health ***, double-antibody-based immunobiosensor chips were designed, constructed, and exploited for clinicaldiagnosis. Gold nanoparticles/tungsten oxide/carbon nanotubes (AuNPs/WO3/CNTs) were used as the active workingsensor surface to support the chemical immobilization of a mixture of SARS-CoV-2 antibodies (anti-RBD-S and anti-RBD-S-anti-Llama monoclonal antibodies). The morphology and chemical functionalization of the fabricateddisposable immunochips was characterized using scanning electron microscopy (SEM), Fourier transform infrared(FTIR) spectroscopy, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). After full assayoptimization, the immunobiosensor showed a high sensitivity to detect SARS-CoV-2-S protein with limits of detectionand quantification of 1.8 and 5.6 pg/mL, respectively. On the other hand, for the SARS-CoV-2 whole virus particleanalysis, the detection and quantification limits were determined to be 5.7 and 17 pg/mL, respectively. The biosensorshowed a highly selective response toward SARS-CoV-2, even in the presence of influenza, nontargeting humancoronaviruses, and Middle East respiratory syndrome coronavirus (MERS-CoV). The immunochips exhibited distinctresponses toward the variants of concern: B.1>C.36.3>Omicron> Delta> Alpha coronavirus variants. For biosensorvalidation, twenty-nine clinical specimens were analyzed, and the impedimetric responses were positively detected fortwo Delta samples, eighteen Omicron samples, and six B.1-type samples in addition to three negative ***, the immunobiosensor was fabricated in the form of ready-to-use chips capable of sensitive detection ofvirus variants, especially variants of concern (VOC) and interest, in a specimen within 15 min. The chips providedinstantaneous detection with the direct application of clinical samples and are considered a point-of-care

关键词： system limits optimization

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A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

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Microsystems & Nanoengineering 2019年第1期5卷 356-366页

作者： Jungpyo Lee Kyungmin Ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun Il-Joo Cho Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Convergence Research Center for Diagnosis Treatmentand Care System of DementiaKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Glia-Neuron Interaction Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and TechnologyUSTYuseong-guDaejeon 34113Republic of Korea

Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain *** there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound *** addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still *** determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular ***,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial *** piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural *** designed the ultrasound transducer as an array structure to enable localized modulation in the target *** addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain *** this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied *** also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer.

关键词： neural stimulation system

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Hematite, Biotite and Cinnabar on the Face of the Turin Shroud: Microscopy and SEM-EDX Analysis

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Open Journal of Applied Sciences 2016年第9期6卷 601-625页

作者： Gérard Lucotte Thierry Derouin Thierry Thomasset Institute of Molecular Anthropology Paris France Department of Phanerogamy Natural History Museum of Paris Paris France Laboratory of Physico-Chemical Analysis UST of Compiègne Compiègne France

The Turin Shroud, recently accessible for hands-on scientific research, is now extensively investigated. Its pinkish red blood stains that seem anomalous ones are studied by modern techniques (notably by resolute optical microscopy and scanning electron microscopy coupled with energy dispersive X-ray). Exploration by these techniques of a blood stain located on the face permits us to discover some red-colour particles (hematite, biotite and cinnabar) of exogenous material in this stain. We finally characterize these red-colour particles and try to explain their presences in the blood stain. Globally, all these red-colour particles cannot explain all of the reddish appearance of the area under study.

关键词： Turin Shroud Blood Stains Face Area Hematite Biotite Cinnabar Optical Microscopy Scanning Electron Microscopy Energy Dispersive X-Ray

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Correction:High‑Performance Stainless‑Steel‑Fiber‑Reinforced Thick Ultra‑flexible Electrode Applicable to 3D Free‑Form Batteries

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Advanced Fiber Materials 2024年第6期6卷 1998-1998页

作者： Hatsey, Niguss Haregot Kim, Areum Ha, Hyunho Lee, Jin Young Oh, Minsub Kim, Kwang-Seop So, Hye-Mi Hyun, Seungmin Department of Nano-devices and Displays Korea Institute of Machinery and Materials (KIMM) Daejeon Republic of Korea Department of Nano-Mechatronics University of Science and Technology (UST) Daejeon Republic of Korea

In this article, citations to References 77–80 were missing in the text and have been added in Sect. 3.3 Discussion of the Electrochemical Results to the sentence "DRT is a useful method for analyzing the reaction kinetics and the electrochemical processes, which is often difficult to achieve with conventional EIS [77–80]". Furthermore, in the Supplementary Files the video of S1 was linked twice as S1 and S2. Supplementary video S2 was linked as S3 and the original video S3 was not linked at all. This has been corrected so that all three videos are now available. The original article has been corrected. © Donghua University, Shanghai, China 2024.

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The Kinematics Analysis of the Hydraulic Mine-clearing Mechanical Manipulator

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Defence Technology（防务技术） 2005年第1期1卷 113-116页

作者：谢庆华段红 Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu 210016 China Engineering Institution of Engineering Corps PLA USTNanjing Jiangsu 210007China No. 5311 Factory of PLA

Through analyzing the kinematics of the hydraulic manipulator operating system, according to the rules for seting up the D-H coordinate system, the generalized coordinate of the manipulator system is established. The rotating and moving joints are selected from the mechanism as joint variables. Each generalized transformation matrix of joints is worked out. The kinematics equation at the finger end of the manipulator is calculated. The obverse solution for the manipulator is gained. The geometrical operating parameters and primary technical specification of the manipulator system are simulated through the computer. The simulative result has shown that the manipulator operating system meets the working task requirements. This research provides theoretical basis for optimizing structural parameters of the manipulator operating. So it also is justified the feasibility for mechanical manipulators to be used in the engineering equipment platform of the hydraulic excavator.

关键词：液压机械手操作系统解析运动学计算仿真

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Acupoint catgut embedding for simple obesity in animal studies:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2023年第5期43卷 860-867页

作者： ZHAO HuiYan JUN Purumea LEE Chaewon HAN Chang-Hyun Korean Convergence Medical Science University of Science and Technology(UST)School of Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea KM Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea St.Johnsbury Academy Jeju 304Global edu-roDaejeong-eupSeogwipo-si 63644Republic of Kore

OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal ***:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language *** assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 ***:Twenty-four studies involving 813 animals were ***-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two ***:This systematic review suggests that ACE may be efficacious in treating ***,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.

关键词： obesity acupoint catgut embedding animal study Meta-analysis systematic review

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Picomolar-sensitiveβ-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulatedπ-elongated dioxaborine-dyes

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Bioactive Materials 2022年第7期7卷 239-248页

作者： Jusung An Peter Verwilst Hira Aziz Jinwoo Shin Sungsu Lim Ilwha Kim Yun Kyung Kim Jong Seung Kim Department of Chemistry Korea UniversitySeoul02841South Korea KU Leuven Rega Institute for Medical ResearchMedicinal Chemistry3000LeuvenBelgium Convergence Research Center for Diagnosis Treatment and Care System of DementiaBrain Science InstituteKorea Institute of Science and Technology(KIST)Seoul02792South Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792South Korea

The pathological origin of Alzheimer’s disease(AD)is still shrouded in mystery,despite intensive worldwide research *** selective visualization ofβ-amyloid(Aβ),the most abundant proteinaceous deposit in AD,is pivotal to reveal AD *** date,several small-molecule fluorophores for Aβspecies have been developed,with increasing binding *** the current work,two organic small-molecule dioxaborine-derived fluorophores were rationally designed through tailoring the hydrophobicity with the aim to enhance the binding affinity for Aβ_(1-42) fibrils-while concurrently preventing poor aqueous solubility-via biannulate donor motifs in D-π-A *** unprecedented sub-nanomolar affinity was found(K_(d)=0.62±0.33 nM)and applied to super-sensitive and red-emissive fluorescent staining of amyloid plaques in cortical brain tissue ex *** fluorophores expand the dioxaborine-curcumin-based family of Aβ-sensitive fluorophores with a promising new imaging agent.

关键词： β-Amyloid Small-molecular fluorescent probe Dioxaborine-dye Hydrophobicity tailoring Alzheimer’s disease

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Preparation of 2,5-Bis(Aminomethyl)Furan by Direct Reductive Amination of 2,5-Diformylfuran over Nickel-Raney Catalysts

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Green and Sustainable Chemistry 2015年第3期5卷 115-127页

作者： Ngoc-Thuc Le Areum Byun Yohan Han Kee-In Lee Hyungrok Kim Center for Nanocatalysts Green Chemistry and Engineering Division Korea Research Institute of Chemical Technology (KRICT) Daejeon Korea Department of Green Chemistry and Environmental Biotechnology Korea University of Science and Technology (UST) Daejeon Korea

The direct reductive amination of 2,5-diformylfuran (DFF) with ammonia to 2,5-bis(aminomethyl)furan (BAF) was demonstrated, for the first time, over the commercial type Nickel-Raney and acid treated Nickel-Raney catalysts. The effects of reaction parameters such as reaction medium, temperature and hydrogen pressure were described. The acid treated Nickel-Raney catalyst exhibited the highest BAF yield in the THF-water mixed reaction medium. The relatively higher Ni0 species composition and larger surface area of the acid treated Nickel-Raney catalyst with specific reaction conditions contributed greatly to the BAF formation. The oligomeric species, such as furanic imine trimers and tetramers confirmed by MALDI-MS analysis were presented as the intermediates of DFF reductive amination.

关键词： Reductive Amination Primary Amine 2 5-Bis(Aminomethyl)Furan 5-Diformylfuran Nickel Raney Catalyst

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Analysis and Assessment of Wind Energy Potential of Al-Hodeidah in Yemen

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Computers, Materials & Continua 2021年第11期69卷 1995-2011页

作者： Fahd N.Al-Wesabi Murad A.Almekhlafi Mohammed Abdullah Al-Hagery Mohammad Alamgeer Khalid Mahmood Majdy M.Eltahir Ali M.Al-Sharafi Amin M.El-Kustaban Department of Computer Science King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia Faculty of Computer and IT Sana’a UniversitySana’aYemen Department of Electrical Engineering–Communication Engineering Sana’a UniversityYemen Department of Computer Science College of ComputerQassim UniversitySaudi Arabia Department of Information Systems King Khalid UniversityMayahel AseerKSA Department of Computer Science College of Computers and Information TechnologyUniversity of BishaKSA Department of Electronic Faculty of EngineeringUSTSana’aYemen

Renewable energy is one of the essential elements of the social and economic development in any civilized *** use of fossil fuels and the non-renewable form of energy has many adverse effects on the most of *** the high potential of renewable energy sources in Yemen and the absence of similar studies in the region,this study aimed to examine the wind energy potential of Hodeidah-Yemen Republic by analyzing wind characteristics and assessment,determining the available power density,and calculate the wind energy extracted at different *** average wind speed of Hodeidah was obtained only for the data currently available for the five years 2005–2009(due to the current economic and the political situation in Yemen).The results show that the average wind speed in the five years is(25.2 W/m2 at 10 m,93.9 W/m2 at 30 m,and 173.5 W/m2 at 50 m).The average yearly wind power density(25.2 W/m2 at 10 m,93.9 W/m2 at 30 m and 173.5 W/m2 at 50m),and the average yearly energy density(220.8 KWh/m2/year at 10 m,822.6 KWh/m2/year at 30 m and 1519.9 KWh/m2/year at 50 m).This research is a preliminary assessment of the potential of wind energy in Hodeidah,which provides useful information for developing wind energy and an efficient wind *** to the International Wind Energy Rating criteria,the region of Hodeidah falls under‘Class 2’and is classified as‘Marginal’for most of the year.

关键词： Energy potential wind speed weibull distribution wind power density

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孔有效利用的活性炭基非对称电极膜/电容脱盐系统(英文)

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新型炭材料 2016年第4期31卷 378-385页

作者： Jiyoung Kim Dong-Hyun Peck Byungrok Lee Seong-Ho Yoon Doo-Hwan Jung Advanced Energy and Technology University of Science and Technology (UST) Yuseong-gu Daejeon 305-333 Republic of Korea New and Renewable Energy Research Division Korea Institute of Energy Research ( KIER ) Yuseong-gu Daejeon 305-343 Republic of Korea Institute for Materials Chemistry and Engineering Kyushu University Kasuga Fukuoka 816-8580 Japan

采用活性炭纤维为原料制备出膜/电容脱盐系统,提纯含氯化钠的水。OG系列活性炭纤维作为电极的活性材料,其比表面积和孔分布不同而呈现不同的活化程度。将这些材料用于膜/电容脱盐系统,评价了他们对钠离子或氯离子的脱盐性能。膜/电容实... 详细信息

采用活性炭纤维为原料制备出膜/电容脱盐系统,提纯含氯化钠的水。OG系列活性炭纤维作为电极的活性材料,其比表面积和孔分布不同而呈现不同的活化程度。将这些材料用于膜/电容脱盐系统,评价了他们对钠离子或氯离子的脱盐性能。膜/电容实验在不同操作电位窗口、含盐溶液的进料速率和浓度下进行。OG系列活性炭纤维对每种离子的脱盐效率和电吸附量来评价膜/电容性能。结果表明,BET比表面积是确保高性能的必要因素。另外,炭材料最上端的浅孔有助于活性炭纤维比表面积的充分利用。OG7A样品的孔结构适合于钠离子吸附,OG10A和OG15A适于大量孔吸附氯离子。因此,非对称电极排列施加于吸附离子的尺寸,应考虑炭材料比表面积和孔面积的有效利用,以得到高性能的膜/电容脱盐系统。

关键词：电容去离子化活性炭纤维孔尺寸氯离子和钠离子非对称电极

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