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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina school of Basic medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical school of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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A case report of cutaneous larva migrans in Argentina

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 81-82页

作者： Javier Bava Lucia G Gonzalez Celeste M Seley Gisela P Lopez Alcides Troncoso Infectious Diseases "Francisco J mui" Department of Microbiology ParasitologyInfectious Diseases and Tropical MedicineSchool of MedicineBuenos Aires University

Cutaneous larva migrans(CLM) represents the most common tropically acquired *** is caused by infection with hookworm larvae in tropical and sub-tropical areas,and people who have a history of foreign travel and of walking barefoot on sandy soil or beaches are at a high risk of getting infected with *** diagnosis is usually made on the basis of the typical appearance of the lesion,intense itching and history of foreign *** is a common parasitic skin disease that can be easily prevented by wearing 'protective' footwear.A case of CLM is described in this article.

关键词： Cutaneous larva migrans Epidermal parasitic skin diseases Dog faeces Hookworm larvae Protective footwear

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Toward Practical Solid-State Lithium−Sulfur Batteries: Challenges and Perspectives

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Accounts of Materials Research 2021年第10期2卷 869-880页

作者： Saneyuki Ohno Wolfgang G.Zeier Department of Applied Chemistry Graduate School of EngineeringKyushu University819-0395 FukuokaJapan Institute of Inorganic and Analytical Chemistry University of Münster48149 MünsterGermany Helmholtz Institut münster Forschungszentrum JülichD-48149 MünsterGermany

CONSPECTUS:The energy density of the ubiquitous lithium-ion batteries is rapidly approaching its theoretical *** go beyond,a promising strategy is the replacement of conventional intercalation-type materials with conversion-type materials possessing substantially higher *** the conversion-type cathode materials,sulfur constitutes a cost-effective and earth-abundant element with a high theoretical capacity that has a potential to be game-changing,especially within an emerging solid-state battery *** of nonflammable solid electrolytes that improves battery safety and boosts the energy density,as lithium metal anodes are also *** long-standing inherent problem of conventional lithium−sulfur batteries,arising from the reaction intermediates dissolved in liquid electrolytes,can be eliminated with inorganic solid ion *** particular,the highly conducting and easily processable lithium-thiophosphates have successfully enabled the lab-scale solid-state lithium−sulfur cells to achieve close-to-theoretical *** applications requiring safe,energy-dense,lightweight batteries,solid-state lithium−sulfur batteries are an ideal choice that could surpass conventional lithium-ion batteries.

关键词： battery lithium boost

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Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae

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Journal of Environmental Sciences 2016年第9期28卷 153-164页

作者： Jia Du Shutao Wang Hong You Zhongqiang Liu school of municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China school of Marine Science and Technology Harbin Institute of Technology at Weihai Weihai 264209 China school of public health Jia Mu Si Uniuersity Jiamusi 154007 China The Second Middle school of Funing at Qinhuangdao Qinhuangdao 066300 China

Perfluorooctane sulfonate（PFOS） and ZnO nanoparticles（nano-ZnO） are widely distributed in the ***,the potential toxicity of co-exposure to PFOS and nano-ZnO remains to be fully *** test investigated the effects of co-exposure to PFOS and nano-ZnO on the hypothalamic–pituitary–thyroid（HPT） axis in *** embryos were exposed to a combination of PFOS（0.2,0.4,0.8 mg/L） and nano-ZnO（50 mg/L）from their early stages of life（0–14 days）.The whole-body content of TH and the expression of genes and proteins related to the HPT axis were *** co-exposure decreased the body length and increased the malformation rates compared with exposure to PFOS ***-exposure also increased the triiodothyronine（T3） levels,whereas the thyroxine（T4）content remained *** with the exposure to PFOS alone,exposure to both PFOS（0.8 mg/L） and nano-ZnO（50 mg/L） significantly up-regulated the expression of corticotropin-releasing factor,sodium/iodidesymporter,iodothyronine deiodinases and thyroid receptors and significantly down-regulated the expression of thyroid-stimulating hormone,thyroglobulin（TG）,transthyretin（TTR） and thyroid *** protein expression levels of TG and TTR were also significantly down-regulated in the co-exposure *** addition,the expression of the thyroid peroxidase gene was unchanged in all *** results demonstrated that PFOS and nano-ZnO co-exposure could cause more serious thyroid-disrupting effects in zebrafish than exposure to PFOS *** results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO.

关键词： nano-ZnO PFOS zebrafish thyroid hormone HPT axis

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Journey through the birth, growth and maturity of X-ray astronomy

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Research in Astronomy and Astrophysics 2019年第10期19卷 1-16页

作者： Prahlad Chandra Agrawal mu-DAE Centre of Excellence in Basic Sciences Mumbai University Campus at Vidhyanagari

In this biographical account, I recall my scientific journey that began in 1961 when I joined as a Physics Trainee in the BARC Training school and after one year course was admitted in TIFR as a Research Associate. During 1962–1967, I worked on determination of the He^3 /He^4 ratio in cosmic rays using a gas Cerenkov counter and also used a scintillation + solid Cerenkov detector to measure flux of protons and helium nuclei in primary cosmic rays. I also developed a large area scintillation-Cerenkov detector with a spark chamber between them for measuring charge composition of primary cosmic rays. I joined the X-ray astronomy programme in 1967 initiated by Prof. B. V. Sreekantan and played a leading role in developing a balloon borne hard X-ray instrument for studying time variability and energy spectra of cosmic X-ray sources. We carried out a series of balloon experiments and studied temporal intensity variation and energy spectra of X-ray objects like Sco X-1, Cyg X-1, etc. Results on rapid intensity changes and spectra appeared in a series of publications based on which I obtained a Ph.D. degree in 1972. Immediately afterwards, I joined Prof. Gordon Garmire at Caltech as a Research Fellow (a post-doctoral position) to work with him on the low energy component of HEAO A-2 experiment. The instrument was developed and successfully realised. Working on this satellite experiment was a thrilling experience which exposed me to the technical complexities of space instruments. The HEAO-1 satellite was launched in 1978. During 1978–1979, Guenter Riegler and I, working at JPL, reported detection of intense soft X-rays from several classes of extragalactic and Galactic objects like new BL Lacs, a new AM Her binary, coronal X-rays from active stars, etc. After returning to TIFR, I developed a rocket experiment with K. P. Singh to map the spatial and spectral distribution of the Soft Diffuse X-ray Background. At the same time, I also designed 15 cm deep Xenon filled Proportio

关键词： TIFR-X-ray Astronomy by balloons-rockets and satellites-Indian Astronomy Satellite ASTROSAT

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Stress perceptions of nurses serving in home healthcare services during the COVID-19 pandemic:A qualitative research

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Journal of Acute Disease 2023年第2期12卷 73-79页

作者： Arzu Karakaya Mehmet Ucar Department of Psychiatric Nursing MuşAlparslan UniversityVocational School of Health ServicesMuşTurkey Department of Public Health Nursing MuşAlparslan UniversityVocational School of Health ServicesMuşTurkey

Objective:To investigate the stress perceptions of nurses serving in home healthcare services during ***:This study was qualitative research with a phenomenological *** were collected and recorded through in-depth interviews with 6 nurses working in muşState Hospital,Home Healthcare Services Unit using a form consisting of 12 questions on an online platform between May 2021 and July *** audio recordings were transcribed by the researcher and content analysis was performed by creating codes,categories,and ***:The interviews yielded 10 categories and 59 *** codes were addressed under the theme of"COVID-19 pandemic".Under this main theme,nurses expressed the problems they experienced in issues such as stress,support mechanisms,and family and social problems during *** mentioned that they experienced high stress in this process,as well as social isolation and negative thoughts of society about them and that they could not spare time for themselves and their ***:Nurses working in home healthcare services frequently express negativities such as high stress,isolation from society,and increased ***,actions should be taken to raise awareness of society on these issues,increase the number of personnel,conduct more research,and share the results with the public.

关键词： Home Healthcare Services COVID-19 Nurse Stress Social isolation Workload

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DNA methyltransferases in hematological malignancies

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Journal of Genetics and Genomics 2020年第7期47卷 361-372页

作者： Nguyet-Minh Hoang Lixin Rui Department of medicine University of Wisconsin School of Medicine and Public HealthMadisonWI53792USA Carbone Cancer Center University of Wisconsin School of Medicine and Public HealthMadisonWI53792USA

DNA methyltransferases(DNMTs)are an evolutionarily conserved family of DNA methylases,transferring a methyl group onto the fifth carbon of a cytosine *** mammalian DNMT family includes three major members that have functional methylation activities,termed DNMT1,DNMT3A,and ***3A and DNMT3B are responsible for methylation establishment,whereas DNMT1 maintains methylation during DNA *** evidence demonstrates that regulation of DNAmethylation by DNMTs is critical for normal *** DNA methylation due to DNMT dysregulation and mutations is known as an important molecular event of hematological malignancies,such as DNMT3A mutations in acute myeloid *** this reviewwe first describe the basic methylation mechanisms of DNMTs and their functions in lymphocyte maturation and differentiation,We then discuss the current understanding of DNA methylation heterogeneity in leukemia and lymphoma to highlight the importance of studying DNA methylation *** also discuss DNMT mu-tations and pathogenic roles in human leukemia and *** summarize the recent understanding of how DNMTs interact with transcription factors or cofactors to repress the expression of tumor suppressor *** highlight current clinical studies using DNMT inhibitors for the treatment of these hematological malignancies.

关键词： DNA methyltransferases Leukemia Lymphoma Tumor suppressor DNA methylation

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