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Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul Madley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee M Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson Michael Lundberg Daniel Berglind Neil M Davies Brian K Lee Cecilia Magnusson Dheeraj Rai Department of Global Public Health Karolinska InstitutetStockholmSweden Medical Research Council Integrative epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK centre for Academic Mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Department of epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Development Pennsylvania State UniversityState CollegePAUSA Department of Clinical Neuroscience Karolinska InstitutetStockholmSweden centre for epidemiology and Community Medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample Mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,p<0.001)—a correlation that was more pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,p<0.001).Findings from Mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

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State of the Art of Lifecourse Cohort Establishment

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China CDC weekly 2024年第14期6卷 300-304页

作者： Shaoqing Dai Ge Qiu Yuchen Li Shuhan Yang Shujuan Yang Peng Jia School of resource and Environmental Sciences Wuhan UniversityWuhan CityHubei ProvinceChina International Institute of Spatial Lifecourse Health(ISLE) Wuhan UniversityWuhan CityHubei ProvinceChina mrc epidemiology Unit University of CambridgeCambridgeUK Department of Geography The Ohio State UniversityColumbusOHUSA West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu CitySichuan ProvinceChina Hubei Luojia Laboratory Wuhan CityHubei ProvinceChina School of Public Health Wuhan UniversityWuhan CityHubei ProvinceChina Renmin Hospital Wuhan UniversityWuhan CityHubei ProvinceChina

The global rise in non-communicable diseases(NCDs)presents significant public health *** managing and preventing NCDs necessitates a thorough understanding of their causes and progression,which can be achieved through a lifecourse approach to determine past exposures’impact before NCD ***,this approach requires robust backing from data,specifically lifecourse cohort data,which are generally *** overcome this obstacle,three primary strategies have been employed to establish such cohorts:active follow-up cohorts,registry-based datasets,and technology-based data collection and simulation methods.

关键词： diseases overcome obstacle

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Healthy life expectancy with cardiovascular disease among Chinese rural population based on the prospective cohort study

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Journal of Geriatric Cardiology 2024年第8期21卷 799-806页

作者： Feng JIANG Xiao-Tian LIU Ze HU Wei LIAO Shuo-Yi LI Rui-Fang ZHU Zhen-Xing MAO Jian HOU Sohail Akhtar Fayaz Ahmad Tahir Mehmood Chong-Jian WANG Department of epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Mathematics and Statistics The University of HaripurHaripurPakistan School of Natural Sciences National University of Sciences and TechnologyIslamabadPakistan

BACKGROUND Limited research has explored the impact of cardiovascular disease(CVD)on healthy life expectancy(HLE)especially in resource-limited *** study aimed to investigate the association between CVD and HLE in Chinese rural *** This study included 11,994 participants aged 45 years and older from the baseline and follow-up surveys of the Henan rural cohort *** status was measured via a Visual Analogue *** multistate Markov model was applied to estimate the association between CVD and transitions in health,unhealthiness and ***-specific total life expectancy,HLE and unhealthy life expectancy were calculated by the multistate life table *** During a mean follow-up time of 3.85(3.84–3.86)years,there were 588 deaths *** individuals with CVD,the risk of switching from health to unhealthiness status was increased by 71%[hazard ratio(HR)=1.71,95%CI:1.42–2.07],the chance of recovery was reduced by 30%(HR=0.70,95%CI:0.60–0.82).Men aged 45 years without CVD could gain an extra 7.08(4.15–10.01)years of HLE and lose 4.00(1.60–6.40)years of unhealthy life expectancy compared to their peers with CVD,*** corresponding estimates among women were 8.62(5.55–11.68)years and 5.82(2.59–9.04)years,*** This study indicated that CVD was significantly associated with poorer health status and lower HLE among Chinese rural *** is an important public health policy to adopt targeted measures to reduce the CVD burden and enhance the quality of life and HLE in resource-limited areas.

关键词： Healthy cardiovascular life

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Spatial Dynamics of Chickenpox Outbreaks in Rapidly Developing Regions:Implications for Global Public Health

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Biomedical and Environmental Sciences 2024年第7期37卷 687-697页

作者： Li Wang Miaomiao Wang Chengdong Xu Peihan Wang Meiying You Zihan Li Xinmei Chen Xinyu Liu Xudong Li Yuanyuan Wang Yuehua Hu Dapeng Yin College of Geography and Environmental Science Henan UniversityKaifeng 475001HenanChina State Key Laboratory of resources and Environmental Information System Institute of Geographic Science and Natural Resource ResearchChinese Academy of SciencesBeijing 100101BeijingChina Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475001HenanChina Office of epidemiology Chinese Center for Disease Control and PreventionBeijing 102206BeijingChina University of Chinese Academy of Sciences(UCAS) Beijing 100101BeijingChina Weifang Municipal Center for Disease Control and Prevention Weifang 261061ShandongChina Hainan Center for Disease Control and Prevention Haikou 570203HainanChina

Objective The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to ***,certain factors influencing local chickenpox outbreaks have not been ***,we examined the relationship between spatial clustering,heterogeneity of chickenpox outbreaks,and socioeconomic factors in Southern *** We assessed chickenpox outbreak data from Southern China between 2006 and 2021,comprising both relatively fast-growing parts and slower sub-regions,and provides a representative sample of many developing *** analyzed the spatial clustering attributes associated with chickenpox outbreaks using Moran’s I and local indicators of spatial association and quantified their socioeconomic determinants using Geodetector q *** There were significant spatial heterogeneity in the risk of chickenpox outbreaks,with strong correlations between chickenpox risk and various factors,particularly demographics and living ***,interactive effects among specific are factors,such as population density and per capita residential building area,percentage of households with toilets,percentage of rental housing,exhibited q statistics of 0.28,0.25,and 0.24,*** This study provides valuable insights into the spatial dynamics of chickenpox outbreaks in rapidly developing regions,revealing the socioeconomic factors affecting disease *** implications extend the formulation of effective public health strategies and interventions to prevent and control chickenpox outbreaks in similar global contexts.

关键词： Chickenpox Spatial dynamics Socioeconomic factors

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Leisure-time physical activity and all-cause mortality and cardiovascular disease in adults with type 2 diabetes:Cross-country comparison of cohort studies

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Journal of Sport and Health Science 2024年第2期13卷 212-221页

作者： Jakob Tarp Mengyun Luo Miguel Adriano Sanchez-Lastra Knut Eirik Dalene Borja del Pozo Cruz Mathias Ried-Larsen Reimar Wernich Thomsen Ulf Ekelund Ding Ding Department of Clinical epidemiology Aarhus University&Aarhus University HospitalAarhus 8200Denmark Prevention Research Collaboration Sydney School of Public HealthThe University of SydneyCamperdownNSW 2006Australia Charles Perkins centre the University of SydneyCamperdownNSW 2050Australia Department of Sports Medicine Norwegian School of Sports SciencesOslo 0806Norway Department of Special Didactics Faculty of Education and Sports SciencesUniversity of VigoPontevedra 36005Spain Well-Move Research Group Galicia Sur Health Research Institute(IIS Galicia Sur)SERGAS-UVIGOVigo 36213Spain Department of Chronic Diseases Norwegian Institute of Public HealthOslo 0473Norway centre for Active and Healthy Ageing Department of Sports Science and Clinical BiomechanicsUniversity of Southern DenmarkOdense 5230Denmark Faculty of Education University of CadizCadiz 11519Spain Biomedical Research and Innovation Institute of Cadiz(INiBICA)Research Unit Puerta del Mar University HospitalUniversity of CadizCadiz 11009Spain The centre of Inflammation and Metabolism&the centre for Physical Activity Research RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark

Purpose:This study aimed to quantify the dose-response association and the minimal effective dose of leisure-time physical activity(PA)to prevent mortality and cardiovascular disease in adults with type 2 ***:Cross-country comparison of 2 prospective cohort studies including 14,913 and 17,457 population-based adults with type 2 diabetes from the UK and *** leisure-time PA was self-reported and categorized by metabolic equivalent hours per week(MET-h/week)according to World Health Organization recommendations:none,below recommendation(>0-7.49 MET-h/week);at recommended level(7.5-14.9 MET-h/week);above recommendation(>15 MET-h/week).Mortality and cardiovascular disease data were obtained from national ***:During a median follow-up of 12.4 and 9.7 years,in the UK and China cohorts,repectively,higher levels of leisure-time PA were inversely associated with all-cause(1571 and 2351 events)and cardiovascular mortality(392 and 1060 events),mostly consistent with a linear dose-response *** below,at,and above recommendations,compared with no activity,yielded all-cause mortality hazard ratios of0.94(95%confidence interval(95%CI):0.79-1.12),0.90(95%CI:0.74-1.10),and 0.85(95%CI:0.70-1.02)in British adults and 0.87(95%CI:0.68-1.10),0.88(95%CI:0.74-1.03),and 0.77(95%CI:0.70-0.85)in Chinese *** with cardiovascular mortality were more pronounced in British adults(0.80(95%CI:0.58-1.11),0.75(95%CI:0.52-1.09),and 0.69(95%CI:0.48-0.97))but less pronounced in Chinese adults(1.06(95%CI:0.76-1.47),1.01(95%CI:0.80-1.28),and 0.79(95%CI:0.69-0.92)).PA at recommended levels was not associated with lower rates of major adverse cardiovascular events(2345 and 4458 events).Conclusion:Leisure-time PA at the recommended levels was not convincingly associated with lower mortality and had no association with risk of major adverse cardiovascular events in British or Chinese adults with type 2 ***-time PA above current recom

关键词： Complications epidemiology Exercise Prevention

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Developing fertility control for rodents: a framework for researchers and practitioners

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Integrative Zoology 2024年第1期19卷 87-107页

作者： Giovanna MASSEI Jens JACOB Lyn A.HINDS Botstiber Institute for Wildlife Fertility Control Department of Environment and GeographyUniversity of YorkHeslingtonYorkUK Rodent Research Institute for Epidemiology and Pathogen DiagnosticsJulius Kühn–Institute(JKI)Federal Research Institute for Cultivated PlantsMünsterGermany CSIRO Health and Biosecurity CanberraACTAustralia

Fertility control is often heralded as a humane and effective technique for management of overabundant wildlife,including *** intention is to reduce the use of lethal and inhumane methods,increase farm productivity and food security as well as reduce disease transmission,particularly of *** developed a framework to guide researchers and stakeholders planning to assess the effectiveness of a potential contraceptive agent for a particular *** guidelines describe the overarching research questions which must be sequentially addressed to ensure adequate data are collected so that a contraceptive can be registered for use in broad-scale rodent *** framework indicates that studies should be undertaken iteratively and,at times,in parallel,with initial research being conducted on(1)laboratory-based captive assessments of contraceptive effects in individuals;(2)simulation of contraceptive delivery using bait markers and/or surgical sterilization of different proportions of afield-based or enclosure population to determine how population dynamics are affected;(3)development of mathematical models which predict the outcomes of different fertility control scenarios;and(4)implementation of large-scale,replicated trials to validate contraceptive efficacy under various management-scalefield *** some circumstances,fertility control may be most effective when integrated with other methods(*** culling).Assessment of non-target effects,direct and indirect,and the environmental fate of the contraceptive must also be *** fertility control for a species is a resource-intensive commitment but will likely be less costly than the ongoing environmental and economic impacts by rodents and rodenticides in many contexts.

关键词： captive studies field applications modeling oral contraceptive delivery population management rodents

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Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

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Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu Zequn Lu Yimin Cai Bin Li Ying Zhu Xiangpan Li Yongchang Wei Shaokai Zhang Jianbo Tian Xiaoping Miao Department of epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China Research Center of Public Health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China Department of Cancer epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China Department of epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

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What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis:Correct Chemotherapy Regimen and Patient Compliance are the Key

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Biomedical and Environmental Sciences 2024年第9期37卷 1086-1090页

作者： Igor Mokrousov Tatiana Vinogradova Marine Dogonadze Maria Vitovskaya Natalia Zabolotnykh Sergei Chekrygin Anna Vyazovaya Laboratory of Molecular epidemiology and Evolutionary Genetics St.Petersburg Pasteur InstituteSt.Petersburg197101Russia Henan International Joint Laboratory of Children’s Infectious Diseases Children’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s Hospital Zhengzhou Children’s HospitalZhengzhou 450012HenanChina St.Petersburg Research Institute of Phthisiopulmonology St.PetersburgRussia resource Center Bio-bank Center Research Park of St.Petersburg State UniversitySt.PetersburgRussia

Despite well-known limitations,mice remain useful as model animals to study tuberculosis(TB)pathogenesis,the basic immune response,the extent of lung pathology as well as efficacy of new drugs against Mycobacterium tuberculosis[1,2].There are four routes of tuberculosis infection in mice:aerosol generation and exposition,intravenous injection,intranasal administration,and subcutaneous administration[3].

关键词： tuberculosis drugs injection

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Demographic determinants of risk,colon distribution and density scores of diverticular disease

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World Journal of Gastroenterology 2011年第8期17卷 1009-1017页

作者： Mark Golder Irina Chis Ster Pratusha Babu Amita Sharma Muhammad Bayat Abdulkadir Farah centre for Academic Surgery Institute of Cell and Molecular Science Barts and the London School of Medi-cine and Dentistry Queen Mary University mrc centre for Paediatric epidemiology and Biostatistics University College Department of Radiology University Hospital Lewisham

AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760 whites,62 Asians,44 black africans(BAs),and 134 other blacks(OBs).Risks and diverticula density of left-sided DD(LSDD) and rightsided-component DD(RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic ***:Four hundred and forty-seven patients had DD(322 LSDD and 125 RSCDD).Adjusted risks:(1) LSDD:each year increase in age increased the odds by 6%(95% CI:5-8,SE:0.8%,P < 0.001);Asians:odds ratio(OR):0.23(95% CI:0.10-0.53,SE:0.1,P ≤ 0.001) and OBs:OR:0.25(95% CI:0.14-0.43,SE:0.07,P ≤ 0.001) appeared protected vs Whites;(2) RSCDD:each year increase in age increased the odds by 4%(95% CI:2-6,SE:1%,P < 0.001);females were 0.60 times(95% CI:0.40-0.90,SE:0.12,P = 0.01) less likely than males to have RSCDD;BAs were 3.51 times(95% CI:1.70-7.24,SE:1.30,P < 0.001) more likely than Whites to have RSCDD;and(3) DD density scores:each year increase in age increased the odds of highdensity scores by 4%(95% CI:1-6,SE:1%,P < 0.001);RSCDD was 2.77 times(95% CI:1.39-3.32,SE:0.67,P < 0.001) more likely to be of high density than *** further signif icant differences were found in the adjusted ***:Right colonic DD might be more common and has higher diverticula density in the west than previously *** appear predisposed to DD,whereas other ethnic differences appear conserved following migration.

关键词： Diverticular disease Migration Barium enema Ethnicity Colon distribution Risk

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Cervical cancer prevention in China: where are we now, and what's next?

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Cancer Biology & Medicine 2024年第3期21卷 213-217页

作者： Huijiao Yan Qiankun Wang Youlin Qiao School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Cancer epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

关键词： prevention Cervical epidemiology

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