检索结果-南通市图书馆

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer

cancer Biology & Medicine 2019年第2期16卷 234-246页

作者： Rebecca Carter Azadeh Cheraghchi-Bashi Adam Westhorpe Sheng Yu Yasmin Shanneik Elena Seraia Djamila Ouaret Yasuhiro Inoue Catherine Koch Jenny Wilding Daniel Ebner Anderson J. Ryan Francesca M. Buffa Ricky A. Sharma NIHR University College London Hospitals Biomedical Research Centre/ UCL cancer Institute University College London London WC1E 6DD UK NIHR Oxford Biomedical Research Centre Department of Oncology University of Oxford Oxford 0X1 2JD UK Computational Biology and Integrative Genomics University of Oxford Oxford 0X1 2JD UK NDM Research Building Nuffield Department of Medicine University of Oxford Oxford 0X1 2JD UK Weatherall Institute of Molecular Medicine John Radcliffe Hospital University of Oxford Oxford 0X1 2JD UK Mie University Graduate School of Medicine Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Edobashi 2-174 Tsu Japan Departme nt of Biology Massachusetts In stitute of Tech no logy Cambridge Massachusetts 02142 USA Target Discovery Institute National Phenotypic Screening Centre Nuffield Department of Medicine University of OxfordOxford 0X1 2JD UK CRUK & mrc Oxford Institute for Radiation Oncology University of Oxford Oxford 0X1 2JD UK

Objective: Patients with BRAF-mutant colorectal cancer(CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF ***: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were validated in a 16-cell line panel of human CRC cell lines, using clonogenic survival assays and xenograft models in ***: Most consistently identified hits were drugs targeting cell growth/proliferation or DNA damage repair. The most effective class of drugs that radiosensitised wild-type and mutant cell lines was PARP inhibitors. In clonogenic survival assays, talazoparib produced a radiation enhancement ratio of 1.9 in DLD1(BRAF-wildtype) cells and 1.8 in RKO(BRAF V600 E) cells. In DLD1 xenografts, talazoparib significantly increased the inhibitory effect of radiation on tumour growth(P ≤ 0.01).Conclusions: Our method for screening large drug libraries for radiosensitisation has identified PARP inhibitors as promising radiosensitisers of colorectal cancer cells with wild-type and mutant BRAF backgrounds.

关键词： Radiosensitizer colorectal cancer PARP inhibitor radiotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessing the welfare of genetically altered mice

引用

中国比较医学杂志 2007年第3期17卷 146-146页

作者： Wells D J Playle L C Enser W E j Flecknell P A Gardiner M A Holland j Howard B RT Hubrecht R Humphreys K R Jackson IJ Lane N Maconochie M Mason G Morton D B Raymond R Robinson V Smith J A Watt N Department of Cellular and Molecular Neuroscience Imperial College Faculty of Medicine UK National Centre for the Replacement Refinement and Reduction of Animals in Research UK Harlan UK Ltd UK Comparative Biology Centre University of Newcastle UK mrc Mary Lyon Centre UK mrc National Institute forMedical Research UK Medical School University of Sheffield UK Universities Federation for Animal Welfare UK GlaxoSmithKline UK mrc Human Genetics unit UK Royal Society for the Prevention of Cruelty toAnimals UK Department of Biology and Environmental Science University of Sussex UK University ofGuelph Canada Medical School University of Birmingham UK cancer Research UK UK Boyd Group UK Home Office Dundee UK

In 2003, under the auspices of the main UK funders of biological and biomedical research, a working group was established with a remit to review potential welfare issues for genetically altered (GA) mice, to summarize current practice, and to recommend contemporary best practi。ce for welfare assessments。The working group has produced a report which makes practical recommendations for GA mouse welfare assessment and dissemination of welfare information between establishments using a 'mouse passport'。The report can be found at www。nc3rs, org。uk/GAmice and www。lal。org。uk/gaa and includes templates for the recommended welfare assessment scheme and the mouse passport。An overview is provided below。

关键词：鼠动物福利评价实验动物遗传

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune checkpoint inhibitors in cancer therapy

引用

The Journal of Biomedical Research 2018年第5期32卷 317-326页

作者： Eika S.Webb Peng Liu Renato Baleeiro Nicholas R.Lemoine Ming Yuan Yaohe Wang Center for Molecular Oncology Barts Cancer Institute Queen Mary University of London EC1M 6BQ UK Sino-British Research Centre for Molecular Oncology National Center for International Research in Cell and Gene Therapy Zhengzhou University School of Basic Medical Sciences Academy of Medical Sciences Zhengzhou UniversityZhengzhou Henan 450002 China

In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4（CTLA-4） and programmed cell death protein 1（PD-1） which have been shown to have potent immunomodulatory effects through their function as negative regulators of T cell activation. CTLA-4, through engagement with its ligands B7-1（CD80） and B7-2（CD86）, plays a pivotal role in attenuating the activation of naive and memory T cells. In contrast, PD-1 is primarily involved in modulating T cell activity in peripheral tissues via its interaction with PD-L1 and PD-L2. The discovery of these negative regulators of the immune response was crucial in the development of checkpoint inhibitors. This shifted the focus from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses.

关键词： checkpoint inhibitor CTLA-4 PD-1 immunotherapy cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

指导性集体锻炼对治疗中的早期乳腺癌妇女的益处:实用性随机对照试验

引用

英国医学杂志中文版 2007年第4期10卷 210-213页

作者： Nanette Mutrie Anna M Campbell Fiona Whyte Alex McConnachie Carol Emslie Laura Lee Nora Kearney Andrew Walker Diana Ritchie 方桦（译）王燕（校） Department of Sport Culture and the ArtsStrathclyde UniversityGlasgow G13 1PP Nursing and Midwifery School University of GlasgowGlasgow G12 8LW Robertson Centre for Biostatistics University of Glasgow G12 8QQ mrc Social and Public Health Sciences unit Glasgow G12 8RZ cancer Care Research Centre Department of Nursing and MidwiferyUniversity of StirlingStirling FK9 4LA Beatson Oncology Centre Glasgow G11 6NT 不详

目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中... 详细信息

目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中177位完成6个月随访。干预与常规护理相对照,干预组予12周指导性集体锻炼加常规护理。主要结果评价癌症治疗功能评价(FACT)问卷、贝克抑郁问卷、正性和负性情绪量表、体重指数、7日体力活动回忆问卷、12分钟步行实验和肩关节活动度评估。结果对基线值、研究中心、基线治疗和参加干预试验时的年龄进行校正后,综合效应模型的评估结果(干预组减对照组)显示第12周时:12分钟步行距离为129米(95%可信区间83～176),1周的中等强度活动时间182分钟(75～289),肩关节活动度2.6(1.6～3.7),乳腺癌特定的生活质量量表2.5(1.0～3.9),正性情绪4.0(1.8～6.3)。初步结果未发现干预锻炼对生活质量综合量表(FACT-G)有影响。随访6个月后,大多数效果维持不变,并且在乳腺癌特定的生活质量上得到改善。尚未有不良反应的报道。结论在12周干预锻炼结束时以及6个月后,指导性集体锻炼均显示出机体功能和心理上的获益。因此临床医生应该鼓励患者活动,决策者们应该考虑把体育锻炼纳入到癌症康复服务中来。试验注册号当前对照试验 ISRCTN12587864[***]。

关键词：随机对照试验早期乳腺癌体育锻炼治疗功能集体妇女生活质量量表医疗卫生服务体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Colorectal neoplasm:Magnetic resonance colonography with fat enema-initial clinical experience

引用

World Journal of Gastroenterology 2007年第40期13卷 5371-5375页

作者： Shuai Zhang Jun-Wei Peng Qiang-Ying Shi Feng Tang Min-Guo Zhong Department of Radiology Fudan University Cancer Hospital Depatment of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Surgery Fudan University CancerHospital Department of Oncology Shanghai Medical CollegeFudan University Shanghai 200032 China

瞄准：为颜色的察觉作为一个方法与胖灌肠估计磁性的回声 colonography 表面的瘤。方法：连续 22 个病人在结肠镜检查前与胖灌肠经历了先生 colonography。有倒置恢复顺序的 T1 加权的三维的快宠坏的坡度回响以前在背卧位与病人一起被... 详细信息

瞄准：为颜色的察觉作为一个方法与胖灌肠估计磁性的回声 colonography 表面的瘤。方法：连续 22 个病人在结肠镜检查前与胖灌肠经历了先生 colonography。有倒置恢复顺序的 T1 加权的三维的快宠坏的坡度回响以前在背卧位与病人一起被获得并且在 Gadopentetate Dimelumine 管理以后的 75 s。在哪儿由， pre 和柱子先生花冠图象与单个呼吸抓住被获得让大约 20 s 盖住全部冒号。先生 colonographs 和病人的质量是到脂肪的忍耐造影剂被调查。先生 colonography 识别的 Colorectal 瘤与在结肠镜检查上识别的那些相比，检测损害的敏感因此是计算的。结果：没有镇静和痛觉缺失，有胖灌肠的先生 colonography 很好被容忍。120 (90.9%) 从 132，结肠的片断很好被扩张并且仅仅 1 (0.8%) 结肠的片断是差的扩张。在对比改进扫描以后，在正常的结肠的墙和腔之间的吝啬的 contrast-to-noise 比率(CNR ) 价值是 18.5 +/- 2.9 当吝啬的 CNR 在颜色之间珍视时，表面的瘤和腔是 20.2 +/- 3.1。由磁性的回声 colonography， 35 个瘤(敏感 74.3%) 中的 26 个被检测。然而， mrc 的敏感是 95.5%(22 中的 21 个) 为比 10 公里大的瘤并且 55.6%(9 中的 5 个) 为 5-10 公里瘤。结论：有胖灌肠的先生 colonography 和有倒置恢复顺序的 T1 加权的三维的快宠坏的坡度回响在检测颜色是可行的比 10 大的表面的瘤公里。

关键词：消化系疾病灌肠液病理检查磁共振成像

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues

引用

Bone Research 2020年第3期8卷 286-299页

作者： Jiajia Xu Dongqing Li Ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert J.Tower Leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris Jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.James Departments of Pathology Johns Hopkins UniversityBaltimore 21205 MDUSA Department of Microbiology Wuhan University School of Basic Medical of ScienceWuhanHubeiP.R.China Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningP.R.China Departments of Orthopaedics Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Plastic Surgery Johns Hopkins UniversityBaltimore 21205 MDUSA Departments of Autopsy Service Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Radiology and Radiological Science bonBaltimore 21205 MDUSA UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center Los AngelesCA 90095USA Center for Cardiovascular Science and mrc Center for Regenerative Medicine University of EdinburghEdinburghUK

Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming ***,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic ***146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal *** CD146+CD31—CD45 cells retained canonical features of pericytes/*** pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not *** analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal ***,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor *** sum,human skeletal and soft tissue pericytes differ in their basal abilities to form *** exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell ***,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering.

关键词： CD146 CXCR4 pericyte

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

英国早期乳腺癌治疗的差异

引用

英国医学杂志中文版 2021年第4期24卷 190-192页

作者： David Dodwell Yasmin Jauhari Toral Gathani David Cromwell Melissa Gannon Karen Clements Kieran Horgan 邱鹏飞(译) 王微丽(译) 石志强(译) 张宏艳(校) Nuffield Department of Population Health University of OxfordOxfordUK Clinical Effectiveness unit Royal College of Surgeons of EnglandLondonUK cancer Epidemiology unit Nuffield Department of Population HealthUniversity of Oxford Department of Surgery Oxford University Hospitals NHS Foundation TrustOxfordUK Department of Health Services Research and Policy London School of Hygiene and Tropical MedicineUK Public Health England Birmingham UK Department of Breast Surgery St James′s University HospitalLeedsUK 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) 乳腺外科一病区解放军总医院第五医学中心肿瘤学部

在英国,大约七分之一的女性会罹患乳腺癌。尽管乳腺癌发病率仍呈.上升趋势,但病死率却逐年下降,10年生存率约为80%1。这种生存的提高很大程度,上得益于近几十年来乳腺癌早期诊断和治疗的进步,但仍有提升的空间。据报道,英国75岁以下人... 详细信息

在英国,大约七分之一的女性会罹患乳腺癌。尽管乳腺癌发病率仍呈.上升趋势,但病死率却逐年下降,10年生存率约为80%1。这种生存的提高很大程度,上得益于近几十年来乳腺癌早期诊断和治疗的进步,但仍有提升的空间。据报道,英国75岁以下人群乳腺癌病死率为(13~32)人/10万人2,但整体乳腺癌生存率仍然低于美国和澳大利亚等国家3。

关键词：乳腺癌七分之一澳大利亚生存率早期诊断和治疗病死率

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

预后及预后研究：是什么，为什么，以及如何做？

引用

英国医学杂志中文版 2009年第5期12卷 303-307页

作者： Karel G M Moons Patrick Royston Yvonne Vergouwe Diederick E Grobbee Douglas GAltman 周久顺(译) 张孔来(校) Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht Netherlands mrc Clinical Trials unit London NW1 2DA Centre for Statistics in Medicine University of Oxford Oxford OX2 6UD 北京协和医科大学流行病学教研室

当医生们在预测转归时，他们往往很少进行具体的研究。这篇文章是Karel Moons和他的同事们系列文章中的第一篇，旨在阐述预后研究的重要性。

关键词：预后预后研究医生肿瘤病因

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Breast cancer Risk Genes-Association Analysis in More than 113,000 Women

引用

四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数

引用

环境与职业医学 2014年第11期31卷 898-903页

作者： Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉张伊人金泰廙 Health Canada OttawaOntarioCanada Brigham Young University mrc-PHE Centre for Environment and Health School of Public HealthImperial College London School of Public Health University of Washington Institute for Health Metrics and Evaluation Global Alliance for Clean Cookstoves Harvard School of Public Health Harvard University U.S. Environmental Protection Agency Research Triangle Park School of Population and Public Health University of British ColombiaVancouverBritish ColumbiaCanada mrc-PHE Centre for Environment and Health King’s College London University of California BerkeleyBerkeleyCaliforniaUSA School of Medicine University of CaliforniaSan FranciscoSan FranciscoCaliforniaUSA School of Medicine University of CaliforniaBerkeleyBerkeleyCaliforniaUSA Department of Public Health and Policy University of Liverpool School of Public Health Fudan University Exposure Epidemiologyand Risk ProgramDepartment of Environmental HealthHarvard School of Public Health World Health Organization Institute of Population Health University of OttawaOttawaOntarioCanada American cancer Society AtlantaGeorgiaUSA Health Effects Institute BostonMassachusettsUSA

[背景]评估由于环境空气中细颗粒物（PM2.5）长期暴露引起的疾病负担,需要了解相对风险度（RR）函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.... 详细信息

[背景]评估由于环境空气中细颗粒物（PM2.5）长期暴露引起的疾病负担,需要了解相对风险度（RR）函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数：缺血性心脏病（IHD）、脑血管疾病（脑卒中）、慢性阻塞性肺病（COPD）和肺癌（LC）。建立急性下呼吸道感染（ALRI）发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染（AAP）、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟（AS）等研究的RR信息,拟合综合暴露-反应（IER）模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数（PAFs）。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为：IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。

关键词：细颗粒物环境空气污染风险函数全球疾病负担相对风险慢性阻塞性肺病全球环境缺血性心脏病颗粒物质烟草烟雾

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：