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LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun Jia Fugen Shangguan Shiwei Gong Linhua Lan Zhiyin Song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang Carolyn K.Suzuki Zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission key laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China key laboratory of Ministry of Education for TCM Viscera-State theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China key laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei key laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State key laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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Multiple flux difference effect in the lattice hydrodynamic model

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Chinese Physics B 2012年第2期21卷 210-217页

作者： Wang Tao Gao Zi-You Zhao Xiao-Mei moe key laboratory for urban transportation complex systems theory and Technology Beijing Jiaotong UniversityBeijing 100044China College of Automation&Electronic Engineering Qingdao University of Science&TechnologyQingdao 266042China

Considering the effect of multiple flux difference, an extended lattice model is proposed to improve the stability of traffic flow. The stability condition of the new model is obtained by using linear stability theory. The theoretical analysis result shows that considering the flux difference effect ahead can stabilize traffic flow. The nonlinear analysis is also conducted by using a reduetive perturbation method. The modified KdV （mKdV） equation near the critical point is derived and the kink antikink solution is obtained from the mKdV equation. Numerical simulation results show that the multiple flux difference effect can suppress the traffic jam considerably, which is in line with the analytical result.

关键词： flux difference lattice hydrodynamic model traffic flow mKdV equation

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Mixed traffic flow modeling near Chinese bus stops and its applications

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Journal of Central South University 2012年第9期19卷 2697-2704页

作者：杨小宝四兵锋环梅 key laboratory for urban transportation complex systems theory and Technology of Ministry of Education(Beijing Jiaotong University)

To determine how bus stop design influences mixed traffic operation near Chinese bus stops,a new theoretical method was developed by using additive-conflict-flows *** procedure was extended from homogeneous traffic flow to mixed traffic *** on the procedure and queuing theory,car capacity and speed models were proposed for three types of bus stops including curbside,bus bay and bicycle *** effects of various combinations of bus stop type,traffic volume,bus dwell time,and berth number on traffic operations were *** results indicate that traffic volume,bus dwell time and berth number have negative effects on traffic operations for any type of bus *** different types of bus stops,at car volumes above approximately 200 vehicles per hour,the bus bay and bicycle detour designs provide more benefits than the curbside *** traffic volume increases,the benefit firstly increases in uncongested conditions and then decreases in congested *** reaches the maximum at car volumes nearly 1 100 vehicles per *** results can be used to aid in the selection of a preferred bus stop design for a given traffic volume in developing countries.

关键词： mixed traffic flow bus stop road capacity speed bicycles

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Photon orbits and phase transition for Letelier AdS black holes immersed in perfect fluid dark matter

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Chinese Physics C 2024年第6期48卷 247-259页

作者： Ashima Sood Md Sabir Ali J.K.Singh Sushant G.Ghosh Department of Mathematics Netaji Subhas University of TechnologyNew Delhi-110078India Centre for Theoretical Physics Jamia Millia IslamiaNew Delhi 110025India Department of Physics Mahishadal Raj CollegePurba MedinipurWest Bengal721628India Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China key laboratory of Quantum theory and Applications of moe Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&key laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We obtain an exact solution for spherically symmetric Letelier AdS black holes immersed in perfect fluid dark matter(PFDM).Considering the cosmological constant as the positive pressure of the system and volume as its conjugate variable,we analyze the thermodynamics of our black holes in the extended phase *** to the background clouds of strings parameter(a)and the parameter endowed with PFDM(β),we analyze the Hawking temperature,entropy,and specific ***,we investigate the relationship between the photon sphere radius and phase transition for the Letelier AdS black holes immersed in *** the analysis,with a particular condition,non-monotonic behaviors are found between the photon sphere radius,impact parameter,PFDM parameter,temperature,and *** can regard the changes in both the photon sphere radius and impact parameter before and after phase transition as the order parameter;their critical exponents near the critical point are equal to the same value,1/2,similar to that in ordinary thermal *** indicates that a universal relation of gravity may exist near the critical point for a black hole thermodynamic system.

关键词： AdS black holes perfect fluid dark matter Letelier spacetime photon orbit extended phase space thermodynamics correlation of photon orbit and thermodynamics

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Dynamic System for Solving Saddle Point Problems in Hilbert Spaces and Its Application to Neural Computing

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Tsinghua Science and Technology 2011年第3期16卷 315-319页

作者：沈喜生王晓芳柴跃廷 moe key laboratory for urban transportation complex systems theory and Technology Beijing Jiaotong University Department of Automation Tsinghua University School of Business Renmin University of China

This paper studies the existence and uniqueness of solutions and the stability and convergence of a dynamic system for solving saddle point problems （SPP） in Hilbert spaces. The analysis first converts the SPP into a problem of searching for equilibriums of a dynamic system using a criterion for solutions of the SPP, then shows the existence and uniqueness of the solutions by creating a positive function whose Fréchet derivative is decreasing along any solution. The construction of positively invariant subsets gives the global stability and convergence of this dynamic system, that is, the dynamic system globally converges to some exact solution of the SPP. Finally, the paper also shows that the obtained results can be applied to neural computing for solving SPP.

关键词： global stability saddle point problems (SPP) minimax problem

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Evolution of suspension bridge structural systems,design theories,and shape-finding methods:A literature survey

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Journal of Traffic and transportation Engineering(English Edition) 2024年第2期11卷 225-244页

作者： Wenming Zhang Genmin Tian Yupeng Chen key laboratory of Concrete and Pre-stressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China State key laboratory of Safety Durability and Healthy Operation of Long Span BridgesSoutheast UniversityNanjing 210096China

Modern suspension bridges exhibit a trend of lighter structures,more diversified structural forms,and longer spans,the latter already exceeding two *** performance under dead and live loads depends on their structural and main cable systems,while cablesupported bridges especially rely on the design analysis and construction control of the main *** literary survey systematically analyzes the research progress and state-ofthe-art status quo in the structural systems and design theories of suspension bridges,focusing on the structural systems,main cable shape analyses,live load effect analyses,and emerging lucrative research *** than 100 reliable references have been surveyed.(1)Multi-span or multi-main cable schemes appeal to increasing attention,which may become a better choice in terms of structural systems in scenarios with extremely long spans and heavy *** cable layouts,such as spatial main cables and hybrid cable-stayed suspension systems have also become feasible approaches for enhancing structural stiffness.(2)The shape-finding analysis during the construction phase is more complex and has more essential factors than that of the completed bridge *** theories combining analytical methods and finite element methods are more suitable for the shape-finding analysis of complex cable systems than any single theory of the two,especially for novel cable systems.(3)The live load effect analysis methods based on traditional deflection theory or modified/improved deflection theories still have wide applications,but the refined theory of treating hangers as discrete members is also constantly developing,which is expected to provide new ideas for more complex structural analysis under the different types of live loads and their distribution forms.

关键词： Suspension bridges Structural system Cable analysis Shape-finding analysis Construction control and calculation Live load effect

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Exploring hidden-charm and hidden-strange hexaquark states from lattice QCD

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 30-37页

作者： Hang Liu Jinchen He Liuming Liu Peng Sun Wei Wang Yi-Bo Yang Qi-An Zhang INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Maryland Center for Fundamental Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland 20742USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Southern Center for Nuclear-Science theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China CAS key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing 100049/Hangzhou 310024China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Beihang UniversityBeijing 102206China

Based on five different ensembles of newly generated(2+1)-flavor configurations with pion mass of approximately mπ■(140-310)MeV,we present a lattice analysis of hidden-charm and hidden-strange hexaquarks with the quark content■.The correlation matrices of two types of operators with JPC=0++,0-+,1++and 1--are simulated to extract the masses of the hexaquark candidates,which are subsequently extrapolated to the physical pion mass and continuum *** results indicate that ground state masses are below the■threshold and provide a characteristic signal for the experimental discovery of hexaquark candidates,which may enrich the versatile structure of multiquarks;moreover,it is an indispensable step to decipher the nonperturbative nature of the fundamental interactions of quarks and gluons.

关键词： quantum chromodynamics lattice QCD multiquark states

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Work-function effect of Ti_(3)C_(2)/Fe-N-C inducing solid electrolyte interphase evolution for ultra-stable sodium storage

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Nano Research 2024年第8期17卷 7163-7173页

作者： Huicong Xia Lingxing Zan Hongliang Dong Yifan Wei Yue Yu Jinfu Shu Jia-Nan Zhang Chong-Xin Shan key laboratory of Advanced Energy Catalytic and Functional Material Preparation of Zhengzhou College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China key laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China key laboratory of Chemical Reaction Engineering of Shaanxi Province College of Chemistry and Chemical EngineeringYan’an UniversityYan’an 716000China Center for High Pressure Science and Technology Advanced Research PudongShanghai 201203China key laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

In the quest to enhance the efficiency of sodium-ion batteries,the dynamics of solid electrolyte interphase(SEI)formation are of paramount *** SEI layer’s integrity is integral to the charge–discharge efficiency and the overall longevity of the ***,a novel two-dimensional Ti_(3)C_(2) fragments enmeshed on iron-nitrogen-carbon(Fe-N-C)nanosheets(Ti_(3)C_(2)/Fe-NC)has been *** electrode features a matrix which has been shown to expedite SEI layer formation through the facilitation of selective anion adsorption,thus augmenting battery *** functional theory calculation reveals that the SEI evolution energy of NaPF6 at the Ti_(3)C_(2)/Fe-N-C interface is 0.81 eV,significantly lower than the Ti_(3)C_(2)(1.23 eV).This process is driven by the electron transportation from Ti_(3)C_(2) to Fe-N-C substrate,facilitated by their work-function difference,leading to the formation of ferromagnetic Fe species,which possesses Fe 3d d_(xz)d_(z)2 orbitals and undergoes hybridization with theπandσorbitals of NaF,creating a key intermediate during *** process diminishes the antibonding energy and attenuates the orbital interaction with NaF,thus reducing the activation energy and improving the SEI formation reaction ***,it leads to the creation of multi-interface SEI characterized by high-throughput ion transport and an efficient reaction network.

关键词： Ti_(3)C_(2)/Fe-N-C heterostructure work-function electron interaction solid electrolyte interphase sodium storage

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Optimization of Empty Pallets Dispatching Based on Different transportation Modes

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Journal of systems Science and Information 2017年第2期8卷 97-110页

作者： Kang ZHOU Shiwei HE Rui SONG Weichuan YIN Lingyan CHENG School of Traffic and transportation Beijing Jiaotong University moe key laboratory for urban transportation complex systems theory and Technology Beijing Jiaotong University

In the pallet pool system, the differentiation of palletized freight volumes in different regions and seasonal transport of certain goods lead to the imbalance of pallets distribution among regions. It is necessary to improve the utilization of pallets through dispatching. The paper analyzes the factors which affect empty pallets dispatching, it includes carbon emission, transportation time and pallet type based on the pallet pool mode of enterprise alliance. On this basis, the optimization model is established with the goal of minimum total dispatching cost. Then, according to the different influences of railway and highway in transportation cost, the dispatching scheme is analyzed and the transportation mode of empty pallets dispatching is determined. Considering the characteristics of model, Cplex is used to solve it. Finally, a case is used to verify the feasibility and superiority of reasonable empty pallets dispatching in different transportation modes, and the transport characteristics of two transportation modes are analyzed. Moreover, the costs of pallets leasing and dispatching are compared.

关键词： freight dispatching optimization ILOG Cplex pallets pallet pool stochastic constraint

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Topological-based bottleneck analysis and improvement strategies for traffic networks

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Science China(Technological Sciences) 2009年第10期52卷 2814-2822页

作者： JianJun Wu ZiYou Gao HuiJun Sun State key laboratory of Rail Traffic Control and Safety (Beijing Jiaotong University) Beijing 100044 China School of Traffic and transportation Beijing Jiaotong University Beijing 100044 China moe key laboratory for urban transportation complex systems theory and Technology Beijing Jiaotong University Beijing 100044 China

A method is proposed to find key components of traffic networks with homogenous and heterogeneous topologies, in which heavier traffic flow is transported. One component, called the skeleton, is the minimum spanning tree (MST) based on the zero flow cost (ZCMST). The other component is the infinite incipient percolation cluster (IIC) which represents the spine of the traffic network. Then, a new method to analysis the property of the bottleneck in a large scale traffic network is given from a macroscopic and statistical viewpoint. Moreover, three effective strategies are proposed to alleviate traffic congestion. The significance of the findings is that one can significantly improve the global transport by enhancing the capacity in the ZCMST with a few links, while for improving the local traffic property, improving a tiny fraction of the traffic network in the IIC is effective. The result can be used to help traffic managers prevent and alleviate traffic congestion in time, guard against the formation of congestion bottleneck, and make appropriate policies for traffic demand management. Meanwhile, the method has very important theoretical significance and practical worthiness in optimizing traffic organization, traffic control, and disposal of emergency.

关键词： traffic congestion user equilibrium assignment heterogeneous and homogenous networks

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