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Haplotype-resolved Chinese male genome assembly based on high-fidelity sequencing

Fundamental Research 2022年第6期2卷 946-953页

作者： Xiaofei Yang Xixi Zhao Shoufang Qu Peng Jia Bo Wang Shenghan Gao Tun Xu Wenxin Zhang Jie Huang Kai Ye Genome Institute the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061ShaanxiChina School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina moe key lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina National Institutes for food and drug Control(NIFDC) No.2Tiantan XiliDongcheng DistrictBeijing 102629China School of Automation Science and engineering Faculty of Electronic and Information EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina School of Life Science and Technology Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina Faculty of Science Leiden UniversityLeidenThe Netherlands

The advantages of both the length and accuracy of high-fidelity(HiFi)reads enable chromosome-scale haplotype-resolved genome *** this study,we sequenced a cell line named HJ,established from a Chinese Han male individual by using HiFi and *** assembled two high-quality haplotypes of the HJ genome(haplotype 1(H1):3.1 Gb,haplotype 2(H2):2.9 Gb).The continuity(H1:contig N50=28.2 Mb,H2:contig N50=25.9 Mb)and completeness(BUSCO:H1=94.9%,H2=93.5%)are substantially better than those of other Chinese genomes,for example,HX1,NH1.0,and *** comparing HJ genome with GRCh38,we reported the mutation landscape of HJ and found that 176 and 213 N-gaps were filled in H1 and H2,*** addition,we detected 12.9 Mb and 13.4 Mb novel sequences containing 246 and 135 protein-coding genes in H1 and H2,*** results demonstrate the advantages of HiFi reads in haplotype-resolved genome assembly and provide two high-quality haplotypes of a potential Chinese genome as a reference for the Chinese Han population.

关键词： Genome assembly HiFi reads Human genome Haplotype-resolved Chinese Han Mutation landscape

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Computational neuroscience:a frontier of the 21st century

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National Science Review 2020年第9期7卷 1418-1422页

作者： Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou Center for Neural Science New York University Center for Neuroscience Key Laboratory of Medical Neurobiology of the Ministry of Health of China School of Medicine Zhejiang University Department of Neuroscience and Department of Mathematics Center for the Neural Basis of Cognition University of Pittsburgh Université Claude Bernard Lyon 1 Inserm Stem Cell and Brain Research Institute U1208 Institute of Neuroscience State Key Laboratory of Neuroscience Chinese Academy of SciencesCAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Center for Brain Science and Brain-Inspired Technology Division of Arts and Sciences and NYU-ECNU Institute of Cognitive Neuroscience NYU Shanghai School of Biomedical engineering Hainan University Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics Division of Biology and Biological engineering California Institute of Technology Howard Hughes Medical Institute School of Electronics engineering and Computer Science IDG/Mc Govern Institute for Brain Research PKU-Tsinghua Center for Life SciencesPeking University College of Computer Science and Technology Zhejiang University Institute of Brain-Intelligence Science and Technology Zhangjiang Lab School of Mathematical Sciences MOE-LSCand Institute of Natural Sciences Shanghai Jiao Tong University

THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors, thoughts,emotions and consciousness. Although comprising only 2%of the total body weigh... 详细信息

关键词： NETWORKS

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Hollow CoFe-layered double hydroxide polyhedrons for highly efficient CO_(2) electrolysis

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Science China Materials 2022年第2期65卷 536-542页

作者： Miaosen Yang Jiaqiang Sun Yongji Qin Hui Yang Shusheng Zhang Xijun Liu Jun Luo School of Chemical engineering Northeast Electric Power UniversityJilin 132012China Nanchang Institute of Technology Nanchang 330044China State key laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Institute for New Energy Materials and Low-Carbon Technologies Tianjin Key Lab for Photoelectric Materials&DevicesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Materials Science and engineering Tianjin University of TechnologyTianjin 300384China College of Chemistry Zhengzhou UniversityZhengzhou 450000China moe key laboratory of New Processing Technology for Non-Ferrous Metals and Materials and Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Over the past several decades,the utilization of fossil fuels is responsible for mainly excessive atmospheric carbon dioxide(CO_(2))[1-3].Increased concentration of CO_(2)contributes to the major portion of the critical issues faced worldwide,such as global warming and drastic changes in ***,it is imperative to develop an alternative technology that is capable of providing an efficient and sustainable pathway to target the neutralization of CO_(2)level in the atmosphere.

关键词：层状双金属氢氧化物电催化二氧化碳还原法拉第二氧化碳固定多面体空心结构氢电极

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Deterministic and randomized scheduling problems under the lp norm on two identical machines

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2005年第1期6卷 20-26页

作者：林凌谈之奕何勇 Department of Mathematics State Key Lab of CAD & CG Zhejiang University Hangzhou 310027 China

Parallel machine scheduling problems, which are important discrete optimization problems, may occur in many applications. For example, load balancing in network communication channel assignment, parallel processing in large-size computing, task arrangement in flexible manufacturing systems, etc., are multiprocessor scheduling problem. In the traditional parallel machine scheduling problems, it is assumed that the problems are considered in offline or online environment. But in practice, problems are often not really offline or online but somehow in-between. This means that, with respect to the online problem, some further information about the tasks is available, which allows the improvement of the performance of the best possible algorithms. Problems of this class are called semi-online ones. In this paper, the semi-online problem P2|decr|lp (p>1) is considered where jobs come in non-increasing order of their processing times and the objective is to minimize the sum of the lp norm of every machine’s load. It is shown that LS algorithm is optimal for any lp norm, which extends the results known in the literature. Furthermore, randomized lower bounds for the problems P2|online|lp and P2|decr|lp are presented.

关键词： Semi-online Scheduling Randomization Competitive ratio

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MOF-Transformed In_(2)O_(3-x)@C Nanocorn Electrocatalyst for Efficient CO_(2)Reduction to HCOOH

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Nano-Micro Letters 2022年第10期14卷 219-234页

作者： Chen Qiu Kun Qian Jun Yu Mingzi Sun Shoufu Cao Jinqiang Gao Rongxing Yu Lingzhe Fang Youwei Yao Xiaoqing Lu Tao Li Bolong Huang Shihe Yang Guangdong key lab of Nano-Micro Material Research School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China School of Materials Science and engineering China University of PetroleumQingdaoShandong 266580People’s Republic of China Shenzhen International Graduate School Tsinghua UniversityShenzhenPeople’s Republic of China X-Ray Science Division and Joint Center for Energy Storage Research Argonne National LaboratoryLemontIL 60439USA Institute of Biomedical engineering Shenzhen Bay LaboratoryShenzhen 518107People’s Republic of China

For electrochemical CO_(2) reduction to HCOOH,an ongoing challenge is to design energy efficient electrocatalysts that can deliver a high HCOOH current density(JHCOOH)at a low *** oxide is good HCOOH production catalyst but with low *** this work,we report a unique corn design of In_(2)O_(3-x)@C nanocatalyst,wherein In_(2)O_(3-x)nanocube as the fine grains dispersed uniformly on the carbon nanorod cob,resulting in the enhanced *** performance is achieved with 84%Faradaic efficiency(FE)and 11 mA cm^(−2)JHCOOH at a low potential of−0.4 V versus *** the current density of 100 mA cm^(−2),the applied potential remained stable for more than 120 h with the FE above 90%.Density functional theory calculations reveal that the abundant oxygen vacancy in In_(2)O_(3-x) has exposed more In^(3+) sites with activated electroactivity,which facilitates the formation of HCOO**** X-ray absorp-tion spectroscopy also confirms In^(3+) as the active site and the key intermediate of HCOO*during the process of CO_(2) reduction to HCOOH.

关键词： CO_(2)reduction Indium oxide Formate Corn design Active sites

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Photo-and thermo-coupled electrocatalysis in carbon dioxide and methane conversion

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Science China Materials 2019年第10期62卷 1369-1373页

作者： Deren Yang Guoxiong Wang Xun Wang key lab of Organic Optoelectronics and Molecular engineering Department of ChemistryTsinghua UniversityBeijing 100084China State key laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

With the large-reserve discovery and exploitation of shale gas and natural gas hydrate all over the world,the production of liquid fuels and basic chemicals by replacing petroleum with abundant shale gas and natural gas hydrate has become the focus of research and development in academia and ***2 and CH4,as the main composition of shale gas and natural gas hydrate,are extremely stable and chemically inert,and thus selective activation and conversion of the two molecules remain grand challenges since the desired high-value products are more reactive than CO2 and *** to anthropogenic activities,billion tons of CO2 and CH4 are directly exhausted per year,and therefore,it is necessary to open up new routes to utilize the small molecular resource(Fig.1).

关键词：甲烷分子设计合成电催化二氧化碳热耦合化石燃料催化活化世界难题

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Damage Model of Brittle Coal-Rock and Damage Energy Index of Rock Burst

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Journal of China University of Mining and Technology 2003年第1期13卷 16-20页

作者：尹光志张东明魏作安李东伟 key lab. for the Exploitation of Southwest Resources and the Environmental Disaster Control engineering Ministry of Education Chongqing University

Based on the mechanical experiment of brittle coal-rock and the damage mechanical theory, a damage model was established. Coal-Rock damage mechanical characteristic was researched. Furthermore, interior energy transformation mechanism of rock was analyzed from the point of view of damage mechanics and damage energy release rate of brittle coal rock was derived. By analyzing the energy transformation of rock burst, a new conception, damage energy index of rock burst, was put forward. The condition of rock burst was also established.

关键词： coal-rock damage damage energy index rock burst

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Modern deep learning in bioinformatics

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Journal of Molecular Cell Biology 2020年第11期12卷 823-827页

作者： Haoyang Li Shuye Tian Yu Li Qiming Fang Renbo Tan Yijie Pan Chao Huang Ying Xu Xin Gao Cancer Systems Biology Center The China-Japan Union HospitalJilin UniversityChangchun 130033China moe key laboratory of Symbolic Computation and Knowledge engineering College of Computer Science and TechnologyJilin UniversityChangchun 130012China Department of Biology Southern University of Science and TechnologyShenzhen 518055China Computational Bioscience Research Center(CBRC) Computer Electrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou 310018China Ningbo Institute of Information Technology Application Chinese Academy of SciencesNingbo 315040China Computational Systems Biology lab Department of Biochemistry and Molecular Biology and Institute of BioinformaticsUniversity of GeorgiaAthensGA 30602USA

Deep learning(DL)has shown explosive growth in its application to bioinformatics and has demonstrated thrillingly promising power to mine the complex relationship hidden in large-scale biological and biomedical data.A number of comprehensive reviews have been published on such applications,ranging from high-level reviews with future perspectives to those mainly serving as tutorials.

关键词： has such she

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Photonic nano-device for optical signal processing

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Frontiers of Optoelectronics 2011年第3期4卷 254-263页

作者： Xinwan LI Zehua HONG Xiaomeng SUN School of Physics Electrical Information engineering Ningxia University State key laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong University

Micro/nanostructure photonic devices offer a variety of enabling properties, including low powerconsumption, cost-efficient, compact size, and *** distinctive features have been exploited in a wealth of applications ranging from telecommunication and optical interconnect to photonic network on chip. In this paper, we review two main classes of micro/nanostructure photonic devices, to provide the kinds of functions for optical signal processing.

关键词： photonic nano-device optical signal processing microano optical fiber silicon plasmonic waveguide

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Adjacent Pt Nanoparticles and Sub-nanometer WO_(x)Clusters Determine Catalytic Isomerization of C_(7)H_(16)

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CCS Chemistry 2022年第8期4卷 2639-2650页

作者： Bin Zhang Wei Zhou Jie Zhang Zirui Gao Danyang Cheng Lipeng Tang Xingwu Liu Yueqin Song Chunyang Dong Yao Xu Jie Yan Mi Peng Huizhen Liu Mark Douthwaite Meng Wang Ding Ma Beijing National laboratory for Molecular Sciences College of Chemistry and Molecular Engineering and College of Engineeringand BIC-ESATPeking UniversityBeijing 100871 Beijing National laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 petroleum Processing Research Center East China University of Science and TechnologyShanghai 200237 Cardiff Catalysis Institute School of ChemistryCardiff UniversityCardiff CF103AT

Processes for the isomerization of light alkanes have been commercialized;however,the isomerization of paraffins(C_(n)H_(2n+2),n≥7)remains a *** mesoporous tungsten-zirconia catalyst supported Pt catalysts(Pt/WZrOx),initial isomerization productivity of 5249 moli-C7/molPt/h was obtained for n-heptane reforming at 275°C and 5 bar of hydrogen.

关键词： WOx monolayers metal–acid catalysis proximity bifunctional catalysis acid quantification

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