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EMT transcription factors activated circuits:A novel tool to study EMT dynamics and its therapeutic implications

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Synthetic and Systems Biotechnology 2024年第1期9卷 1-10页

作者： Tianying Chen Wangyue Jia Bo Zhang Hanqi Xie Qiong Wu moe key laboratory of bioinformatics Center for Synthetic and System BiologySchool of Life SciencesTsinghua UniversityBeijing100084China

The epithelial mesenchymal transition(EMT)plays significant roles in the progression of cancer and fibrotic ***,this process is reversible,resulting in mesenchymal epithelial transition(MET),which plays an important role in cancer *** is a lack of methods to trace and target EMT cells using synthetic biology circuits,which makes it difficult to study the cell fate or develop targeted *** this study,we introduced responsive EMT sensing circuits,which sense the EMT using specific promoters that respond to transcription factors typical of EMT activation(EMT-TFs).The transcriptional strength of EMT-sensing promoters decreased more than 13-fold in response to the overexpression of the ***,the NOT gate circuits were built by placing the tetR transcription repressor under the control of EMT sensing promoters and expressed an output signal using the constitutive CMV promoter modified with tetO sites This circuit is named EMT sensing and responding *** the EMT transcription factors was present,we observed a 5.8-fold signal increase in the ***,we successfully distinguished mesenchymal breast cancer cells from epithelial cancer cells and repressed the proliferation of EMT tumor cells using our *** EMT sensing and responding circuits are promising tools for the identification of EMT cells,which is crucial for EMT-related disease therapy and investigating the mechanisms underlying the reversible EMT process.

关键词： Epithelial mesenchymal transition Synthetic biology Tumor killing

Rapid and controllable in-situ self-assembly of main-group metal nanofilms for highly efficient CO_(2)electroreduction to liquid fuel in flow cells

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Nano Research 2024年第6期17卷 5718-5725页

作者： Miao Wang Huaizhu Wang Yaoda Wang Junchuan Liang Mengfei Zhu Jiarui Li Zuoxiu Tie Zhong Jin State key laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic ChemistryMOE Key Laboratory of High Performance Polymer Materials and TechnologyJiangsu Key Laboratory of Advanced Organic MaterialsTianchang New Materials and Energy Technology Researc

The electrocatalytic reduction of CO_(2)is a promising pathway to generate renewable fuels and ***,its advancement is impeded by the absence of electrocatalysts with both high selectivity and ***,we present a scalable in-situ thermal evaporation technique for synthesizing series of Bi,In,and Sn nanofilms on carbon felt(CF)substrates with a high-aspect-ratio *** resulting main-group metal nanofilms exhibit a homogeneously distributed and highly exposed catalyst surface with ample active sites,thereby promoting mass transport and ad-/desorption of reaction *** from the unique fractal morphology,the Bi nanofilms deposited on CF exhibit optimal catalytic activities for CO_(2)electroreduction among the designed metal nanofilms electrodes,with the highest Faradaic efficiency of 96.9%for formate production at−1.3 V *** hydrogen electrode(RHE)in *** an industrially relevant current density of 221.4 mA·cm−2 in flow cells,the Bi nanofilms retain a high Faradaic efficiency of 81.7%at−1.1 V(***)and a good long-term stability for formate ***,a techno-economic analysis(TEA)model shows the potential commercial viability of electrocatalytic CO_(2)conversion into formate using the Bi nanofilms *** results offer a green and convenient approach for in-situ fabrication of stable and inexpensive thin-film catalysts with a fractal structure applicable to various industrial settings.

关键词： CO_(2)electroreduction non-noble metal nanofilms flow cells efficiency and selectivity techno-economic analysis

Self-Powered Piezo-Supercapacitors Based on ZnO@Mo-Fe-MnO2 Nanoarrays

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Energy & Environmental Materials 2024年第4期7卷 304-314页

作者： Luo Sun Zhiguo Ye Xinyuan Peng Shaojie Zhuang Duosheng Li Zhong Jin School of Materials Science and Engineering Nanchang Hangkong University State key laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic Chemistry MOE Key Laboratory of High Performance Polymer Materials and Technology Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University

The development of self-charging supercapacitor power cells （SCSPCs） has profound implications for smart electronic devices used in different ***,we epitaxially electrodeposited Mo-and Fe-codoped MnO2films on piezoe... 详细信息

关键词： MnO2 piezoelectric self-charging supercapacitors ZnO nanoarray

Chemical modification of barite for improving the performance of weighting materials for water-based drilling fluids

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Petroleum Science 2024年第1期21卷 551-566页

作者： Li-Li Yang Ze-Yu Liu Shi-bo Wang Xian-Bo He Guan-Cheng Jiang Jie Zhang moe key laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and ProspectingChina University of Petroleum(Beijing)Changping DistrictBeijing102249China moe key CNPC Drilling Research Institute Changping DistrictBeijing102206China

With increasing drilling depth and large dosage of weighting materials,drilling fluids with high solid content are characterized by poor stability,high viscosity,large water loss,and thick mud cake,easier leading to reservoir damage and wellbore *** this paper,micronized barite(MB)was modified(mMB)by grafting with hydrophilic polymer onto the surface through the free radical polymerization to displace conventional API barite *** suspension stability of water-based drilling fluids(WBDFs)weighted with API barite:mMB=2:1 in 600 g was significantly enhanced compared with that with API barite/WBDFs,exhibiting the static sag factor within 0.54 and the whole stability index of *** viscosity and yield point reached the minimum,with a reduction of more than 40%compared with API barite only at the same *** multi-stage filling and dense accumulation of weighting materials and clays,filtration loss was decreased,mud cake quality was improved,and simultaneously it had great reservoir protection performance,and the permeability recovery rate reached 87%.In addition,it also effectively improved the lubricity of *** sticking coefficient of mud cake was reduced by 53.4%,and the friction coefficient was ***,mMB can serve as a versatile additive to control the density,rheology,filtration,and stability of WBDFs weighted with API barite,thus regulating comprehensive performance and achieving reservoir protection *** work opened up a new path for the productive drilling of extremely deep and intricate wells by providing an efficient method for managing the performance of high-density WBDFs.

关键词： Drilling fluids Weighting materials Filtration control Reservoir protection Stability property

Interplant communication:an emerging battlefield in plant-aphid-virus interactions

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Science China(Life Sciences) 2024年第5期67卷 1069-1071页

作者： Yunjing Wang Qian Gong Yule Liu moe key laboratory of bioinformatics and Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China

Plants constantly face threats from various organisms,including pathogens and *** the pathogens,plant viruses are obligate intracellular parasites that infect plants and cause serious crop yield losses.

关键词： plant Plants communication

Legacy and emerging per-and polyfluoroalkyl substances(PFAS) in the atmosphere: A comprehensive review

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Science China Technological Sciences 2024年第10期67卷 3032-3050页

作者： QIAO BiTing SONG DongBao CHEN Hao YAO YiMing SUN HongWen moe key laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai University

With long-term production and widespread application, per-and polyfluoroalkyl substances(PFAS) have been detected in various media worldwide, including the atmosphere. Since the gradual restriction and phase-out of C8perfluoroalkyl acids(PFAAs), environmental contamination by emerging PFAS substitutes such as short-chain PFAA homologues, perfluoroether carboxylic, and sulfonic acids has been reported. Although there has been extensive monitoring of emerging PFAS substitutes in the aquatic environment, few studies have conducted target analysis and nontarget screening(NTS) of emerging unknown PFAS in the atmosphere over the past decade. To fill the gap, this review focused on emerging PFAS in the atmosphere in addition to legacy PFAS. The reported sampling, pretreatment, and instrumental analysis methods for target analysis and NTS of both neutral and ionic PFAS in the atmosphere are summarized, along with the advantages and current limitations of different sampling and NTS methods for PFAS in the atmosphere. The global levels, composition, and spatiotemporal distribution characteristics of legacy and emerging PFAS in the atmosphere are summarized and their transport, transformation, and dry/wet deposition are elucidated. The review highlights the importance of developing and applying the all-in-one strategy integrating target, suspect screening, and NTS to gain insights into emerging PFAS in the atmosphere and provide a reference for future research.

关键词： emerging PFAS atmosphere nontarget screening spatiotemporal distribution fate

pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： Jing-Yuan Xiang Wen-Long Zhang He-Ting Li Ya-Ning He Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Numerical Study on Heat Transfer and Frictional Resistance of Two Types of Molten Salts in Straight Channels and Supercritical Carbon Dioxide in Airfoil Channels

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Journal of Thermal Science 2024年第4期33卷 1443-1457页

作者： WANG Yanquan LU Yuanwei GAO Qi LI Feng MA Yancheng WANG Yuanyuan WU Yuting moe key laboratory of Enhanced Heat Transfer and Energy Conservation Beijing Key Laboratory of Heat Transfer and Energy ConversionBeijing University of TechnologyBeijing100124China

Molten salt and supercritical carbon dioxide(sCO_(2))are considered to be one of the most promising combined heat transfer refrigerants for third-generation solar thermal power *** evaluate the potential of chloride salts and carbonates in third-generation solar thermal power generation,this paper uses molten salts and sCO_(2)as the working media of printed circuit board heat exchangers(PCHE),and uses numerical simulation to study the heat transfer and friction of PCHE channels with different molten salts and sCO_(2),and establishes predictive correlations respectively.A local heat transfer and friction study was conducted on the sCO_(2)side of the airfoil channel,and it was found that the inlet mass flow rate has a significant impact on it,while the inlet temperature has a relatively small impact.A comprehensive comparison was made between the heat transfer and friction of two molten salts,and the comprehensive performance of chloride salts was 70%-80%higher than that of *** results indicate that the potential of chloride salts in third-generation solar thermal power generation is much greater than that of carbonates.

关键词： third generation solar thermal power generation sCO_(2) PCHE molten salt

Effects of baffle position in serpentine flow channel on the performance of proton exchange membrane fuel cells

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Chinese Journal of Chemical Engineering 2024年第5期69卷 250-262页

作者： Guodong Xia Xiaoya Zhang Dandan Ma moe key laboratory of Enhanced Heat Transfer and Energy Conservation Beijing Key Laboratory of Heat Transfer and Energy ConversionBeijing University of TechnologyBeijing 100124China

This study used a three-dimensional numerical model of a proton exchange membrane fuel cell with five types of channels:a smooth channel(Case 1);eight rectangular baffles were arranged in the upstream(Case 2),midstream(Case 3),downstream(Case 4),and the entire cathode flow channel(Case 5)to study the effects of baffle position on mass transport,power density,net power,***,the effects of back pressure and humidity on the voltage were *** showed that compared to smooth channels,the oxygen and water transport facilitation at the diffusion layer-channel interface were added 11.53%-20.60%and 7.81%-9.80%at 1.68 A·cm^(-2)by adding *** closer the baffles were to upstream,the higher the total oxygen flux,but the lower the flux uniformity the worse the water *** oxygen flux of upstream baffles was 8.14%higher than that of downstream baffles,but oxygen flux uniformity decreased by 18.96%at 1.68 A·cm^(-2).The order of water removal and voltage improvement was Case 4>Case 5>Case 3>Case 2>Case *** power of Case 4 was 9.87%higher than that of the smooth *** the Case 4,when the cell worked under low back pressure or high humidity,the voltage increments were *** potential increment for the back pressure of 0 atm was 0.9%higher than that of 2 atm(1 atm=101.325 kPa).The potential increment for the humidity of 100%was 7.89%higher than that of 50%.

关键词： Proton exchange membrane fuel cell Baffle position Mass transfer Net power Uniformity Voltage increment