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肝移植

德国医学 1999年第3期16卷 165-168页

作者： T.Berg W.-O.Bechstein A.R.Mller P.Neuhaus U.Hopf 彭小楚 Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie Universittsklinik CharitCampus Virchow-klinikumHumboldt-UniversittAugusten Burger platz 1D-13353 BerlinGermany 襄樊市护士学校

直至1998年全世界250个移植中心进行肝移植已愈10000例。当前在德国每年肝移植约为650～700例。在Charit campus Virchow-临床医院的移植中心及其它几个移植中心近年来1年生存率已愈90％、5年生存率已愈80％。头孢菌素A及Tacrolimus(FK506)

关键词：肝移植手术适应证免疫抑制 PBC PSC AIH

A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

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World Journal of Gastroenterology 2006年第25期12卷 4033-4037页

作者： Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat Biochemistry and Molecular Biotechnology Laboratory Division of PHT S.K.University of Agricultural Sciences and Technology of KashmirShalimar CampusSrinagarKashmirIndia Department of Biotechnology University of Kashmir SrinagarKashmirIndia Department of Psychiatry Government Medical College SrinagarKashmirIndia Broad Institute of Harvard and mit 320 Charles St CambridgeMA-02141United States Department of Surgery Government Medical College SrinagarKashmirIndia Department of Pathology Government Medical College SrinagarKashmirIndia

瞄准：为了系统地检验风险因素的关联的程度，例如年龄，与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法：所有情况(n = 51 ) 并且控制(n = 15... 详细信息

瞄准：为了系统地检验风险因素的关联的程度，例如年龄，与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法：所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症，疾病在癌症的家庭历史上包括了信息，与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果：(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%)，那没与个人和 clinicopathological 参数的年龄相关，但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 )，在消费的一个未知地点，和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 )，红 chillies ( CD = 20.2 )，热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论：我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前，在人种上的食道的癌症病人之中，克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素，特别热的咸茶，肉，烤的面包和“ Hakh ”的继续的暴露有关，那富于 nitrosoamines 和家庭癌症历史。

关键词： p53基因食道癌饮食习惯治疗

Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 1592-1600页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi Singapore-mit Alliance for Research and Technology SMART Singapore 138602Singapore Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Massachusetts Institute of Technology CambridgeMA 02139USA Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz Institute HI-ErN Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany National University of Singapore Singapore 119077Singapore

Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global ***,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box *** Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical *** the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the *** a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods.

关键词： knowledge network enable

Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

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Nano Research 2020年第9期13卷 2323-2331页

作者： Chun Xu Lan Xiao Yuxue Cao Yan He Chang Lei Yin Xiao Wujin Sun Samad Ahadian Xueting Zhou Ali Khademhosseini Qingsong Ye School of Dentistry The University of QueenslandHerstonQLD4006Australia Center for Minimally Invasive Therapeutics(C-mit) University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Institute of Health and Biomedical Innovation Queensland University of TechnologyKelvin Grove CampusBrisbane4006Australia School and Hospital of Stomatology Wenzhou Medical Universityy Wenzhou 325035China Department of Oral and Maxillofacial Surgery Massachusetts General Hospital and Harvard School of Dental MedicineBostonMA 02114USA Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072t Australia Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Chemical and Biomolecular Engineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Radiological Sciences University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Terasaki Institute for Biomedical Innovation Los AngelesCA90095USA Present address:Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430060China

Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules,such as bone morphogenetic proteins,are desired for bone ***,we report the development of mesoporous silica rods with large cone-shaped pores(MSR-CP)to load and deliver large protein *** is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated ***,bone morphogenetic proteins 2(BMP-2)loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal *** vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration *** study provides a potential strategy for the design of drug delivery systems for bone regeneration.

关键词： mesoporous silica rod bone regeneration cone shaped pores morphogenetic proteins 2(BMP-2)delivery osteoimmunomodulation

Evolution of enhanced innate immune evasion by SARS-CoV-2

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四川生理科学杂志 2021年第10期43卷 1695-1695页

作者： Lucy G Thorne Division of Infection and Immunity University College London London WC1E 6BT United Kingdom Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG) San Francisco CA 94158 USA Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai New York NY 10029 USA Quantitative Biosciences Institute (QBI) University of California San Francisco San Francisco CA 94158 USA J. David Gladstone Institutes San Francisco CA 94158 USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco CA 94158 USA Howard Hughes Medical Institute San Francisco CA 94158 USA Division of Advanced Therapies National Institute for Biological Standards and Control South Mimms UK Cardiovascular Research Institute University of California - San Francisco San Francisco CA 94158 USA Division of Virology Department of Pathology University of Cambridge Addenbrooke’s Hospital Hills Road Cambridge CB2 2QQ UK Epithelial Stem Cell Biology & Regenerative Medicine laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT UK Institute of Immunity & Transplantation Division of Infection & Immunity UCL Pears Building London NW3 2PF UK mit Computer Science and Artificial Intelligence Laboratory Cambridge MA 02139 USA Broad Institute of mit and Harvard Cambridge MA 02142 USA European Molecular Biology Laboratory (EMBL) European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge UK Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY 10029 USA The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY 10029 USA Department of Medicine Division of Infectious Diseases Icahn School of Medicine at Mount Sinai New York NY 10029 USA Department of Pathology Molecular and Cell-Based Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA

Emergence of SARS-CoV-2 variants of concern(VOCs)suggests viral adaptation to enhance human-to-human transmission1,*** much effort has focused on characterisation of spike changes in VOCs,mutations outside spike likely contribute to *** we used unbiased abundance proteomics,phosphoproteomics,RNAseq and viral replication assays to show that isolates of the Alpha(B.1.1.7)variant3 more effectively suppress innate immune responses in airway epithelial cells,compared to first wave *** found that Alpha has dramatically increased subgenomic RNA and protein levels of N,Orf9b and Orf6,all known innate immune *** of Orf9b alone suppressed the innate immune response through interaction with TOM70,a mitochondrial protein required for RNA sensing adaptor MAVS ***,the activity of Orf9b and its association with TOM70 was regulated by *** propose that more effective innate immune suppression,through enhanced expression of specific viral antagonist proteins,increases the likelihood of successful Alpha transmission,and may increase in vivo replication and duration of *** importance of mutations outside Spike in adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the Delta and Omicron N/Orf9b regulatory regions.

关键词： outside likely alone

全球城市交通出行方式和出行目的地选择对新型冠状病毒传播的影响

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Science Bulletin 2022年第6期67卷 588-592,M0003页

作者：朱瑞 Luc Anselin Michael Batty Mei-Po Kwan 陈旻骆威程涛 Che Kang Lim Paolo Santi 程澄顾秋实 Man Sing Wong 张凯闾国年 Carlo Ratti Department of Land Surveying and Geo-Informatics the Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China Senseable City Laboratory Future Urban Mobility IRGSingapore-MIT Alliance for Research and TechnologySingapore 138602Singapore Center for Spatial Data Science Division of the Social SciencesUniversity of ChicagoChicago IL 60637USA School of Geography Science Nanjing Normal UniversityNanjing 210023China Centre for Advanced Spatial Analysis Faculty of the Built EnvironmentUniversity College LondonLondon WC1E 6BTUK Department of Geography and Resource Management the Chinese University of Hong KongHong KongChina Institute of Space and Earth Information Science the Chinese University of Hong KongHong KongChina Department of Human Geography and Spatial Planning Utrecht UniversityUtrecht 3584 CSNetherlands State Key Laboratory Cultivation Base of Geographical Environment Evolution Nanjing 210023China Department of Geography National University of SingaporeSingapore 117570Singapore SpaceTimeLab Department of CivilEnvironmental and Geomatic EngineeringUniversity College LondonLondon WC1E 6BTUK Department of Clinical Translational Research Singapore General HospitalSingapore 169856Singapore Division of Clinical Immunology and Transfusion Medicine Department of Laboratory MedicineKarolinska InstitutetStockholm 17177Sweden Senseable City Laboratory Department of Urban Studies and PlanningMassachusetts Institute of TechnologyCambridgeMA 02139USA Istituto di Informatica e Telematica del CNR Pisa 56124Italy Department of System Science Institute of High Performance Computing Agency for ScienceTechnology and ResearchSingapore 138632Singapore Department of Tourism Studies School of HumanitiesSoutheast UniversityNanjing 210096China

城市交通出行方式和出行目的地的选择与新型冠状病毒的传播具有关联性.本研究基于2020年2~12月期间,苹果和谷歌公司记录的全球58个城市的交通出行报告,通过多变量时间序列分析,研究了城市交通出行行为对每日确诊病例的影响.研究发现,在... 详细信息

城市交通出行方式和出行目的地的选择与新型冠状病毒的传播具有关联性.本研究基于2020年2~12月期间,苹果和谷歌公司记录的全球58个城市的交通出行报告,通过多变量时间序列分析,研究了城市交通出行行为对每日确诊病例的影响.研究发现,在全球尺度,与出行目的地相关的行为活动对每日确诊病例的贡献最大,其次是传染源和出行方式.在三类出行方式中,开车是最安全的通勤方式.而在一些大城市,步行的风险显著提高.虽然公众对乘坐公共交通比较担心,但该出行方式在部分城市反而是相对安全的.在六类出行目的地中,与车站和工作地相关的活动对疫情的传播贡献最大,而与药店和公园相关的活动对疫情传播的贡献最小.同时发现,建城区人口密度和口罩使用率在不同时期对病毒传播的影响具有差异性.该研究有助于为交通出行政策的制定提供依据,有助于市政在控制和预防病毒流行的同时保持城市开放.

关键词：多变量时间序列疫情传播出行方式谷歌公司交通出行病毒传播出行行为大城市

Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton mit Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

Feedstock choice,pyrolysis temperature and type influence biochar characteristics:a comprehensive meta-data analysis review

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Biochar 2020年第4期2卷 421-438页

作者： James A.Ippolito Liqiang Cui Claudia Kammann Nicole Wrage‑Mönnig Jose MEstavillo Teresa Fuertes‑Mendizabal Maria Luz Cayuela Gilbert Sigua Jeff Novak Kurt Spokas Nils Borchard Department of Soil and Crop Sciences Colorado State UniversityFort Collins 80523USA School of Environmental Science and Engineering Yancheng Institute of Technology9 Yingbin AvenueYancheng 224051China Department of Applied Ecology Geisenheim UniversityVon‑Lade‑Straße 165366 GeisenheimGermany Faculty of Agricultural and Environmental Sciences Grassland and Fodder SciencesUniversity of RostockJustus‑von‑Liebig‑Weg 618059 RostockGermany Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Apdo.64448080 BilbaoSpain Department of Soil and Water Conservation and Waste Management CEBAS-CSICCampus Universitario de Espinardo30100 MurciaSpain United States Department of Agriculture Agriculture Research ServiceCoastal Plains Research Center2611 West Lucas StreetFlorenceSC 29501USA United States Department of Agriculture Agriculture Research ServiceSoil and Water Management Research UnitUniversity of Minnesota439 Borlaug Hall1991 Buford CircleSt.PaulMN 29501USA Natural Resources Institute Finland(Luke) Latokartanonkaari 900790 HelsinkiFinland

Various studies have established that feedstock choice,pyrolysis temperature,and pyrolysis type influence final biochar physicochemical ***,overarching analyses of pre-biochar creation choices and correlations to biochar characteristics are severely ***,the objective of this work was to help researchers,biochar-stakeholders,and practitioners make more well-informed choices in terms of how these three major parameters influence the final biochar *** approximately 5400 peer-reviewed journal articles and over 50,800 individual data points,herein we elucidate the selections that influence final biochar physical and chemical properties,total nutrient content,and perhaps more importantly tools one can use to predict biochar’s nutrient *** on the large dataset collected,it appears that pyrolysis type(fast or slow)plays a minor role in biochar physico-(inorganic)chemical characteristics;few differences were evident between production *** temperature,however,affects biochar’s longevity,with pyrolysis temperatures>500℃ generally leading to longer-term(i.e.,>1000 years)*** pyrolysis temperatures also led to biochars containing greater overall C and specific surface area(SSA),which could promote soil physico-chemical ***,based on the collected data,it appears that feedstock selection has the largest influence on biochar *** surface area is greatest in wood-based biochars,which in combination with pyrolysis temperature could likely promote greater changes in soil physical characteristics over other feedstock-based ***-and other grass-based biochars appear to have cation exchange capacities greater than other biochars,which in combination with pyrolysis temperature could potentially lead to longer-term changes in soil nutrient *** collected data also suggest that one can reasonably predict the availability of various biochar nutrients(e.g.,N,P

关键词： Biochar Total elemental analysis Plant-available elemental analysis Physico-chemical characteristics·Meta-analysis

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst mit & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院