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A further review of the genetic and phenotypic nature of diabetes mellitus

Case Reports in Clinical Medicine 2013年第9期2卷 538-553页

作者： Graham Wilfred Ewing Igor Gennadyevich Grakov mimex inc Sochi Russia Montague Healthcare Mulberry House Nottingham England

Background: The organs in the body function in coherent organ networks. These organ networks are commonly known as physiological systems. Blood Glucose, Blood Pressure and pH exhibit the characteristics of neurally regulated Physiological Systems. Any medical condition, such as diabetes, has origins which are due to systemic dysfunction. This influences the genetic expression of proteins and the rate at which such expressed proteins subsequently react. increased levels of acidity influence the levels of available minerals, protein conformation, and hence the rate at which expressed proteins such as insulin and leptin react or function. This is particularly significant in diabetes etiology where a deficiency of insulin and insulin-“resistance” are significant features of type 1 and type 2 diabetes. Proteins such as Insulin absorb and emit light. Moreover, the spectrum and intensity of the bioluminescence emitted from glycated proteins (which are more significantly bioluminescent) influence colour perception. Accordingly, changes to the diabetic’s colour perception can be used as the basis of a cognitive screening technique which is able to quantify the influence of genotype and phenotype. This may have significant advantages over current biomarker techniques which are not able to satisfactorily determine the earliest onset of?diabetes or distinguish between the symptomatic and presymptomatic onset of diabetes. Such methodology, based upon the properties of proteins, i.e. effectively, the rate at which proteins are expressed and the rate at which such expressed proteins subsequently react, allows the clinician to quantify genotype and phenotype and may contribute to a greater understanding of the processes responsible for what are commonly known as type 1 and type 2 diabetes. The aim of this article is to highlight the limitations of the current techniques used to diagnose diabetes and to highlight, at least from the theoretical perspective, the significance of the au

关键词： Autonomic Nervous System (ANS) Physiological Systems Mathematical Modelling Blood Glucose Diabetes Genotype Phenotype Sensory Input Visual Perception Colour Perception

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EFFECT OF A PROPELLER AND GAS DIFFUSION ON BUBBLE NUCLEI DISTRIBUTION IN A LIQUID

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Journal of Hydrodynamics 2012年第6期24卷 809-822页

作者： HSIAO Chao-Tsung CHAHINE Georges L. DYNAFLOW INC.

A multi-bubble dynamics code accounting for gas diffusion in the liquid and through the bubble wall was developed and used to study the modification of a bubble nuclei population dynamics by a propeller. The propeller flow field was obtained using a Reynolds-Averaged Navier-Stokes （RANS） solver and bubble nuclei populations were propagated in this field. The numerical procedure enabled establishment of the possibility of production behind the propeller of relatively large visible bubbles starting from typical ocean nuclei size distributions. The resulting larger bubbles are seen to cluster in the blade wakes and tip vortices. Parametric investigations of the initial nuclei size distribution, the dissolved gas concentration, and the cavitation number were conducted to ide- ntify their effects on bubble entrainment and the resultant void fractions and bubble distribution modifications downstream from the propeller. Imposed synthetic turbulence-like fluctuations unto the average RANS flow field were also used to study the effect averaging in the RANS procedure has on the results.

关键词： gas diffusion bubble entrainment propeller

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High-quality aluminum turbocharger impellers produced by thixocasting

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1786-1791页

作者： G.WALLACE A.P.JACKSON S.P.MIDSON Q.ZHU Aluminum Complex Components Inc The Midson Group Inc. Cummins Turbo Techno logies

The thixocasting process was chosen to produce the impellers as it is capable of producing castings with extremely high internal *** cut from the DC cast bars are re-heated to the semi-solid casting temperature, and a specially-designed runner and gating system is used to prevent oxide from the surface of the slugs from becoming incorporated into the *** technology used to produce the semi-solid impellers is described in *** semi-solid cast impellers, produced from an Al-Si-Mg-Cu alloy, are heat treated to the T6 *** from testing are presented demonstrating that the impellers are free of porosity and other internal *** mechanical property and fatigue data are presented showing that the semi-solid impellers have better properties than impellers produced by conventional casting and similar properties to forged and machined impellers.A short study is also described which identified suitable processing parameters to minimize hot tearing in the complex-shaped turbocharger impellers semi-solid cast from alloy *** surfaces of the impellers were examined using penetrant testing, and the results of modifying processing parameters on the propensity for surface cracking are *** aging study was performed to identify optimum mechanical strength.

关键词： semi-solid casting turbocharger impeller fatigue properties alloy 201

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On the radiative and thermodynamic properties of the cosmic radiations using COBE FIRAS instrument data: Ⅲ. Galactic far-infrared radiation

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Research in Astronomy and Astrophysics 2015年第7期15卷 939-952页

作者： Anatoliy I Fisenko Vladimir Lemberg ONCFEC inc.

Using the three-component spectral model describing the FIRAS average continuum spectra, the exact analytical expressions for thermodynamic and radiative functions of Galactic far-infrared radiation are obtained. The COBE FIRAS instrument data in the 0.15-2.88 THz frequency interval at the mean temperatures of T1= 17.72 K, T2= 14 K and T3= 6.73 K are used for calculating the radiative and thermodynamic functions, such as the total radiation power per unit area, total energy density, total emissivity, number density of photons, Helmholtz free energy density, entropy density, heat capacity at constant volume and pressure for the warm,intermediate-temperature and very cold components of the Galactic continuum spectra. The generalized Stefan-Boltzmann law for warm, intermediate-temperature and very cold components is constructed. The temperature dependence of each component is determined by the formula IS-B（T） = σ′ T6. This result is important when we construct the cosmological models of radiative transfer that can be applied inside the Galaxy. Within the framework of the three-component spectral model, the total number of photons in our Galaxy and the total radiation power（total luminosity） emitted from a surface of the Galaxy are calculated. Their values are N6Gtotal= 1.3780 × 108 and I3Gtotal（T） = 1.0482 × 106 W. Other radiative and thermodynamic properties of the Galactic far-infrared radiation（photon gas） of the Galaxy are calculated. The expressions for astrophysical parameters, such as the entropy density/Boltzmann constant and number density of the Galactic far-infrared photons are obtained. We assume that the obtained analytical expressions for thermodynamic and radiative functions may be useful for describing the continuum spectra of the far-infrared radiation for other galaxies.

关键词： Galaxy: general -- galaxies: general

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Challenges of mining the first right-handed longwall panel in a new reserve block in Pittsburgh Seam

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International Journal of Mining Science and Technology 2019年第1期29卷 145-149页

作者： Jun Lu Greg Hasenfus CONSOL Energy inc.

In this paper, the mining experience and challenges for the first right-handed longwall panel in the Pittsburgh Seam are introduced. The longwall headgate T-junction experienced very high face convergence(up to 61 cm), accompanied by roof sag, floor heave, and rib loading. The headgate convergence was so large that, in a few places, it threatened longwall retreat and ultimately required the bottom to be re-graded. Different underground instruments, such as a roof scope, de-gas drill, tell-tale, laser meter,and borehole pressure Cell(BPC), were employed to explore the roof geology and to monitor the entry convergence and the stress changes in the pillar. In addition, the impact of other geologic factors, such as large overburden depth, laminated sandstone roof geology, soft floor, and large headgate equipment,were also analyzed. Subsequently, geotechnical solutions were provided to avoid or mitigate the impact of these challenging geologic factors.

关键词： Coal mining Horizontal stress Ground control Roof convergence

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EXPERIMENTAL AND NUMERICAL INVESTIGATION OF BUBBLE AUGMENTED WATERJET PROPULSION

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Journal of Hydrodynamics 2012年第5期24卷 635-647页

作者： CHOI Jin-Keun SINGH Sowmitra HSIAO Chao-Tsung CHAHINE Georges L DYNAFLOW inc. JessupMarylandUSA

This contribution presents experimental and numerical investigations of the concept jet propulsion augmentation using bubble injection. A half-3D （D-shaped cylindrical configuration to enable optimal visualizations） divergent-convergent nozzle was designed, built, and used for extensive experiments under different air injection conditions and thrust measurement schemes. The design, optimization, and analysis were conducted using numerical simulations. The more advanced model was based on a two-way coupling between an Eulerian description of the flow field and a Lagrangian tracking of the injected bubbles using our Surface Averaged Pressure （SAP） model. The numerical results compare very favorably with nozzle experiments and both experiments and simulations validation the thrust augmentation concept. For a properly designed nozzle and air injection system, air injection produces net thrust augmentation, which increases with the rate of bubble injection. Doubling of thrust was measured for a 50% air injection rate. This beneficial effect remains at 50% after account for liquid pump additional work to overcome increased pressure by air injection.

关键词： waterjet propulsion bubble dynamics multi-phase flow

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Fatman： Building Reliable Archival Storage Based on Low-Cost Volunteer Resources

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Journal of Computer Science & Technology 2015年第2期30卷 273-282页

作者：覃安胡殿明刘俊杨文君谭待 Baidu inc. Beijing 100193 China

We present Fatman, an enterprise-scale archival storage based on volunteer contribution resources from underutilized web servers, usually deployed on thousands of nodes with spare storage capacity. Fatman is specifically designed for enhancing the utilization of existing storage resources and cutting down the hardware purchase cost. Two major concerned issues of the system design are maximizing the resource utilization of volunteer nodes without violating service level objectives （SLOs） and minimizing the cost without reducing the availability of archival system. Fatman has been widely deployed on tens of thousands of server nodes across several datacenters, providing more than 100 PB storage capacity and serving dozens of internal mass-data applications. The system realizes an efficient storage quota consolidation by strong isolation and budget limitation, to maximally support resource contribution without any degradation on host-level SLOs. It novelly improves data reliability by applying disk failure prediction to minish failure recovery cost, named fault-aware data management, dramatically reduces the mean time to repair （MTTR） by 76.3% and decreases file crash ratio by 35% on real-life product workload.

关键词： volunteer storage failure prediction, failure recovery, reliability, archival storage

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The Radio Technologies in City Emergency Response System

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China Communications 2008年第4期5卷 99-103页

作者： David Lum Motorola inc

Ⅰ. WHAT’S CERSThe City Emergency Response System (CERS) is a comprehensive system that provides the emergency relief and services for the citizen through an integrated communication and IT platform. With CERS, the

关键词： The Radio Technologies in City Emergency Response System

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A Low-cost and High Efficiency Architecture of AES Crypto-engine

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China Communications 2008年第2期5卷 8-15页

作者： Z.F.Zhao D.Y.Yu L.Li Vinno Technologies inc

The growing market of WPAN has led to an increasingdemand of security measures and devices forprotecting the user data transmitted over the *** Encryption Standards(AES)isthe basic security approach for *** meet thelow cost,low power feature and high security demandof WPAN,a low cost,high efficient AES coreis proposed in this *** achieve low cost,methods of integration and resource sharing are usedin designing a very low-complexity architecture,especially in(inverse)byte substitution(inv)SubBytes)modules and(inverse)mix column(inv)MixColumn)modules,*** more,AESEncryptor and Decryptor is integrated into a fullfunctional *** very low-cost andhigh efficiency AES core of IEEE 802.15.4-2006 isdesigned and emulated on Xilinx *** show that this kind of design can be used inresource critical applications,such as smart card,PDA and mobile phones.

关键词： AES S-box Sub-Byte WPAN

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Neurodegenerative diseases are a function of matrix breakdown:how to rebuild extracellular matrix and intracellular matrix

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Neural Regeneration Research 2018年第7期13卷 1185-1186页

作者： Greg Maguire Bio Regenerative Sciences Inc.Neo GenesisInc.

Matrix within cells,the cytoskeleton,and that which surrounds cells,the extracellular matrix（ECM）,are connected to one another through a number of receptors including those in primary cilia,serving as an important chemical and physical signaling system：Mechanical forces generated through the matrix play a critical role in determining the form and function of tissues（Hughes et al.,2018）.

关键词： ECM Neurodegenerative diseases are a function of matrix breakdown:how to rebuild extracellular matrix and intracellular matrix

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