检索结果-南通市图书馆

World Journal of Gastroenterology 2006年第20期12卷 3213-3218页

作者： Kate V Viola Charlotte Ariyan Julie Ann Sosa Department of Surgery Yale University School of MedicineNew HavenCT 06520-8062United States MD Department of Surgery Yale University School of MedicineNew HavenCT 06520-8062United States MD FACS

Outcomes assessment in surgery traditionally has included data regarding peri-operative mortality and morbidity, as well as long-term survival and recurrence in surgical oncology. However, quality of life （QOL） is another important patient-related outcome measure. QOL data can be used to tailor treatment and improve clinical outcomes by detecting physical or psychological problems in patients that otherwise might be overlooked, but which have profound implications for the effective delivery of care. We review several well-validated QOL instruments developed specifically for use in patients with gastrointestinal malignancies, including esophageal, pancreatic and colorectal cancers, and conclude that QOL assessment routinely should be included in clinical trials of novel treatments.

关键词： Gastrointestinal malignancy Quality of life Patient-related outcomes

IMPROVED WOUND HEALING AND RESULTANT SCARRING SECONDARY TO MODULATION OF WOUND HEALING CYTOKINES BY MOIST EXPOSED BURN OINTMENT

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMPROVED WOUND HEALING AND RESULTANT SCARRING SECONDARY TO M...

第十届全国烧伤创疡学术会议

作者： Bishara S.Atiyeh md FACS General Secretary Mediterranean Council for Burns and Fire DisastersMBC Clinical Professor Plastic and Reconstructive Surgery American University of Beirut Medical Center BeirutLEBANON

Objective:Moist Exposed Burn Ointment(MEB0)has been initially popularized by the Beijing Chinese Burn Center as a topical burn oint- ment capable of providing the necessary moist environment for optimal wound healing without an overlying secondary cumbersome bulky and expensive dressing. Chinese traditional medicine(CTM)is quite different from the type of medicine and approach to disease as practiced in the west. Despite its empirically time proven practices and remedies,it is difficult,however,to accept CTM without adapting it to western ways of scientific analysis and documentation and many obstacles must be overcome before adopting it in a western style medical ***:Even though the effects of MEBO have been well described in the Chinese literature,the ointment had to be sub- jected to our ways of scientific analysis and documentation before being ***- eral clinical studies were conducted to demonstrate the effect of MEB0 on primary healing of surgically repaired cutaneous wounds and on secondary healing of split thickness skin graft donor sites. Its effect on scar quality following both primary and secondary healing was also *** healing cytokine modulation by MEBO was investigated experimentally using the rabbit burn ***:Split thickness skin graft donor site wounds treated by the moisture retentive ointment had faster re- epithelialization rate than conventionally treated wounds with Sofra-Tulle or with oc- clusive Tegaderm dressings and were markedly less hyperemic and pigmented. Final cosmetic appearance as documented photographically,as well as patient’s satisfaction and preference were much superior for the MEB0 treated *** was demonstrated also that the ointment under investigation not only provided optimal and rapid re-epi- thelialization of partial thickness wounds but also resulted in faster functional cutaneous recovery as determined by TEWL(trans-epidermal water loss)*** re- suited also in bet

关键词： Wound healing moist wound healing wound healing cytokines bio-pro-active dressings

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

胸腹联合切口用于胃贲门癌

右江医学 1982年第1期 34-39页

作者： Hiroshi Akiyama Hikarn Miyazono Masahiko Tsurumaru Chiaki Hashimoto Takeshi kawamura 易少夫 md、facs、Tokyo、Japan md、Tokyo、Japan md、Tokyo、Japan md、Tokyo、Japan md、Takyo、Japan

在手术治疗胃贲门癌中,外科医生首先关心的是选择一个能快速达到病灶的切口,近年来由于使用纤维食管镜可以正确地确定责门部或食管胃连接部肿瘤的位置及其近似的大小。然而,是否打开胸腔

关键词：胸腹联合腹部切口肝衰竭手术野贵门手术区胸部食管连接部

Laparoscopic Gastrectomy with Preservation of the Vagus Nerve Accompanied by Lymph Node Dissection for Early Gastric Carcinoma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic Gastrectomy with Preservation of the Vagus Nerv...

Subcutaneous tunnel and hepatocholangio-plasty after resection for intrahepatic stones

胃癌诊治进展学习班

作者： Ichiro Uyama Yoichi Sakurai Yoshiyuki Komori Yasuko Nakamura Mitsutaka Syoji Syuhei Tonomura Ikuo Yoshida Toshihiko Masui Masahiro Ochiai Department of Surgery Fujita Health UniversitySchool of MedicineDengakugakuboKutsukake-choToyoakeAichiJapan MD Department of Surgery Fujita Health UniversitySchool of MedicineDengakugakuboKutsukake-choToyoakeAichiJapan MD FACS

Various types of function-preserving gastrectomy and limited gastrectomy have been performed in attempts to improve postoperative quality of life for early gastric *** with preservation of the vagus nerve, which is one of the noteworthy procedures, is performed in Japan to reduce occurrence of cholelithiasis and minimize loss of digestive and absorptive function. Because it is less invasive, the laparoscopic approach is used to treat early gastric *** are few reports in the English literature of laparoscopic

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 474-475页

作者： J.E.J.Krige S.J.Beningfield md facs FRCSPCS(SA) Department of SurgeryUniversity of Cape Town Health Sciences FacultyAnzio RoadObservatoryCape Town 7925South Africa FF Rad(D)(SA)Department of Radiology University of Cape Town Health Sciences Faculty Anzio RoadObservatoryCape Town 7925South Africa

The Editor welcomes submissions for possible publication in the Letters to the Editor section that consist of commentary on an article published in the Journal or other relevant issues. Letters commenting on an article published in the Journal will be considered if they are received within 6 weeks of the time the article was published. Authors of the article being commented on will be given an opportunity to offer a timely response to the letter. Authors of letters will be notified that the letter has been received. Unpublished letters cannot be returned.

关键词： Subcutaneous tunnel and hepatocholangio-plasty after resection for intrahepatic stones

What is the purpose of launching the World Journal of Otorhinolaryngology？

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology 2011年第1期1卷 1-3页

作者： Steven J Wang Department of Otolaryngology-Head and Neck Surgery University of California San Francisco CA 94115 United StatesAuthor contributions: Wang SJ solely contributed to this paper.Correspondence to: Steven J Wang MD FACS Associate Professor Department of Otolaryngology-Head and Neck Sur-gery University of California 2233 Post St PO Box 1225 San Francisco CA 94115 United States. swang@ohns.ucsf.edu

We are pleased to announce the launching of the World Journal of Otorhinolaryngology （WJO） as a new mem-ber of the World Series journal family. The WJO is a peer-reviewed open-access journal dedicated to pub-lishing original research articles, review articles, clinical studies, and case reports in all areas of otorhinolaryn-gology. Please consider submitting your research fnd-ings in otorhinolaryngology to the WJO.

关键词： Otorhinolaryngology Biomedical sciences Peer-reviewed Open-access Journal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

浙江大学学报（医学版） 2006年第1期35卷 45-49页

作者：陈斌何超劳伟峰黄学锋方炳良浙江大学医学院附属邵逸夫医院美国md Anderson癌症中心

目的:探讨在端粒酶(hTERT)启动子驱动下TRA IL基因在大肠癌细胞HT-29的表达及其杀细胞作用。方法:通过腺病毒载体系统将hTERT启动子驱动的TNF相关凋亡诱导配体(TRA IL)基因转入大肠癌细胞HT-29,流式细胞仪检测GFP/TRA IL的表达和HT-29... 详细信息

目的:探讨在端粒酶(hTERT)启动子驱动下TRA IL基因在大肠癌细胞HT-29的表达及其杀细胞作用。方法:通过腺病毒载体系统将hTERT启动子驱动的TNF相关凋亡诱导配体(TRA IL)基因转入大肠癌细胞HT-29,流式细胞仪检测GFP/TRA IL的表达和HT-29细胞凋亡率。结果:端粒酶启动子驱动的GFP/TRA IL基因和CMV启动子驱动的GFP(绿色荧光蛋白)基因在HT-29内的表达率分别达31.4%和67.0%;GFP/TRA IL基因对HT-29细胞的生长抑制率和凋亡率分别达74.2%和25.8%,与PBS和A d/CMV-GFP比差异都有显著性意义(P<0.05)。结论:端粒酶启动子驱动的GFP/TRA IL融合基因能在大肠癌细胞中有效表达;TRA IL基因对大肠癌细胞HT-29有明显的抑制生长和促凋亡作用。

关键词：肿瘤坏死因子/分析端粒,末端转移酶/遗传学肿瘤细胞,培养的蛋白质类/化学结肠直肠肿瘤/病理学基因疗法细胞凋亡

膜结合配体依赖的TRA IL抗肿瘤细胞旁观者效应

在线全文

学校读者我要写书评

暂无评论

中国病理生理杂志 2006年第8期22卷 1457-1461页

作者：黄学锋何超王达劳伟锋朱洪波毛伟芳方炳良浙江大学医学院附属邵逸夫医院肛肠外科美国md Anderson癌症中心Texas Houston 77030

目的:研究TRAIL基因抗肿瘤作用旁观者效应的发生机制。方法:腺病毒Ad/Lac-Z转染肿瘤细胞后作为标记的旁观者细胞,腺病毒Ad/g-TRAIL转染肿瘤细胞作为效应细胞,在6孔Transwell培养板上同一孔内应用隔离或混合培养旁观者细胞和效应细胞的方... 详细信息

目的:研究TRAIL基因抗肿瘤作用旁观者效应的发生机制。方法:腺病毒Ad/Lac-Z转染肿瘤细胞后作为标记的旁观者细胞,腺病毒Ad/g-TRAIL转染肿瘤细胞作为效应细胞,在6孔Transwell培养板上同一孔内应用隔离或混合培养旁观者细胞和效应细胞的方法,通过检测旁观者细胞Lac-Z酶的活性,以明确TRAIL基因旁观者效应的发生机制。结果:检测了不同来源的肿瘤细胞株,包括大肠癌细胞株DLD1和Lovo、肺癌细胞株A549、肝癌细胞株HepG2、乳腺癌细胞株mdA-MB231、卵巢癌细胞株DOV13。各株肿瘤细胞转染Ad/g-TRAIL后ELISA方法均未检测出培养液中出现可溶性TRAIL(s-TRAIL);隔离培养效应细胞与旁观者细胞,旁观者细胞的Lac-Z活性与PBS及腺病毒Ad/CMV-GFP对照组无明显差异,而混合培养组其活性明显低于对照组(Pfacs检测Sub G0/G1发现DOV13细胞在高密度生长组显著高于低密度生长组(P<0.05);荧光及相差显微镜下观察发现TRAIL转染细胞可诱导周围旁观者细胞发生凋亡而自己并不首先发生凋亡。结论:腺病毒介导的TRAIL基因的旁观者效应是通过TR IAL蛋白表达并定位于细胞膜上,通过细胞接触结合于邻近肿瘤细胞膜上的TRAIL受体而诱导旁观者肿瘤细胞的凋亡,而不是通过水解膜配体形成s-TRAIL而发生旁观者效应,这种作用是细胞接触依赖的。

关键词：基因 TRAIL 旁观者效应

在线全文

学校读者我要写书评

暂无评论

端粒酶启动子肿瘤靶向基因抗大肠癌的研究

中华普通外科杂志 2004年第8期19卷 475-477页

作者：何超陈斌张磊胡文献劳伟峰黄学锋胡晓彤方炳良浙江大学医学院附属邵逸夫医院肿瘤科杭州310016 美国md.Anderson癌症中心

目的探讨端粒酶 (hTERT)启动子驱动的肿瘤坏死因子相关凋亡诱导配体(TNF relatedapoptosis inducingligand ,TRAIL)基因在大肠癌细胞DLD1的表达及肿瘤杀伤作用。方法通过腺病毒载体系统将hTERT启动子驱动的TRAIL基因转入大肠癌细胞DLD1... 详细信息

目的探讨端粒酶 (hTERT)启动子驱动的肿瘤坏死因子相关凋亡诱导配体(TNF relatedapoptosis inducingligand ,TRAIL)基因在大肠癌细胞DLD1的表达及肿瘤杀伤作用。方法通过腺病毒载体系统将hTERT启动子驱动的TRAIL基因转入大肠癌细胞DLD1,流式细胞仪检测GFP/TRAIL的表达和DLD1细胞凋亡率。结果端粒酶启动子驱动的GFP/TRAIL基因和CMV启动子驱动的GFP(绿色荧光蛋白 )基因在DLD1内的表达率分别达 4 1 6 3%和 5 4 0 7% ;GFP/TRAIL基因对DLD1细胞的生长抑制率和凋亡率分别达 93 5 0 %和 5 6 97% ,与PBS和Ad/hTERT LacZ的差异有显著性 (P <0 0 5 )。结论端粒酶启动子驱动的GFP/TRAIL融合基因在大肠癌细胞中能够有效地表达 ;TRAIL基因对大肠癌细胞DLD1有明显的抑制生长和促凋亡作用。

关键词：端粒酶启动子基因治疗大肠癌肿瘤坏死因子凋亡诱导配体

杭白菊增强TRAIL基因诱导大肠癌细胞凋亡及机制的实验研究

在线全文

学校读者我要写书评

暂无评论

中国病理生理杂志 2006年第4期22卷 742-747页

作者：胡文献毛伟芳何超张磊黄学锋杜卫东方炳良浙江大学医学院附属邵逸夫医院肛肠外科浙江杭州310016 浙江省建工医院普外科浙江杭州310011 美国得克萨斯大学md安德森癌症中心

目的:探讨杭白菊提取液对肿瘤坏死因子相关凋亡诱导配体基因(TRAIL)抑制人大肠癌细胞株DLD-1作用的影响及其可能机制。方法:杭白菊提取液联合重组腺病毒载体(Ad)介导的TRAIL基因作用于人大肠癌细胞株DLD-1,通过倒置显微镜、MTT比色法和... 详细信息

目的:探讨杭白菊提取液对肿瘤坏死因子相关凋亡诱导配体基因(TRAIL)抑制人大肠癌细胞株DLD-1作用的影响及其可能机制。方法:杭白菊提取液联合重组腺病毒载体(Ad)介导的TRAIL基因作用于人大肠癌细胞株DLD-1,通过倒置显微镜、MTT比色法和流式细胞仪,研究分析其对DLD-1细胞抑制作用的效果。采用逆转录聚合酶链反应(RT-PCR)和流式细胞术检测杭白菊提取液作用前后DLD-1细胞TRAIL、TRAIL受体(TRAIL-Rs)mRNA以及细胞表面TRAIL蛋白表达的变化。结果:Ad/hTERT-gTRAIL对DLD-1细胞的生长抑制率和凋亡率分别为31·4%和13·5%;联合杭白菊提取液后,生长抑制率和凋亡率均显著提高,达93·1%和45·4%(P<0·05)。杭白菊提取液作用后DLD-1细胞TRAIL mRNA的表达量从作用前的0·46上调至1·01,细胞表面TRAIL蛋白表达的百分率从作用前的2·2%升高到5·0%(P<0·05)。TRAIL死亡受体(DR4、DR5)mRNA的表达量分别从0·70和0·22上调至1·10和0·83(P<0·05),而TRAIL诱骗受体(DcR1、DcR2)mRNA的表达量从0·60和1·15下调至0·19和0·78(P<0·05)。结论:杭白菊提取液联合重组腺病毒载体(Ad)介导的TRAIL基因(Ad/hTERT-gTRAIL)能有效诱导DLD-1细胞的凋亡。杭白菊提取液上调TRAIL死亡受体表达以及下调TRAIL诱骗受体的表达可能在增强TRAIL诱导的凋亡作用中起着重要作用。

关键词：杭白菊肿瘤坏死因子相关的凋亡诱导配体结直肠肿瘤细胞凋亡