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Viscoelastic Evaluation of Different Hyaluronic Acid Based Fillers Using Vibrational Optical Coherence Tomography

Materials Sciences and Applications 2019年第5期10卷 423-431页

作者： Frederick H. Silver Ruchit G. Shah Nikita Kelkar Dominick Benedetto Dale DeVore Justin Cohen Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway NJ USA OptoVibronex LLC Mt. Bethel Pa USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ USA Center for Advanced Eye Care Vero Beach FL USA DV consulting Chelmsford MA USA Glasgold Group Princeton NJ USA

Hylauronic acid (HA) is used as a viscoelastic in Ophthalmology during cataract surgery based on its high viscosity at rest, its ability to shear thin and dissipate energy during phacoemulsification. However, these properties of HA solutions would make them susceptible to migration when used as dermal filler materials. In this study, we apply a new technique termed vibrational optical coherence tomography (VOCT) to compare the physical properties of different HA solutions and fillers used in facial aesthetics. Results presented in this study suggest that HA solutions and HA dermal fillers have markedly different physical properties. HA solutions are highly viscoelastic with high % viscous losses while fillers tend to have lower viscous energy dissipation properties. Clinical observations suggest that the high loss fillers are injected more superficially in the face where tension and internal and external forces are more likely minimized giving tissue of the hands and lips more volume and allowing more natural movement. In contrast, the lower loss gels that are used to lift tissue, generally have a higher G’, and are injected deeper into the face where injection and internal forces are likely to be higher. It is concluded that HA filler gel design can be optimized by use of VOCT to evaluate the % viscous energy loss both in vitro and in vivo.

关键词： Hyaluronic Acid Injectable Filler Dermal Filler Plastic Surgery Cosmetic Surgery Viscoelastic Mechanical Properties Facial Surgery Optical Coherence Tomography Vibrational Optical Coherence Tomography

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无人植保机施药雾滴空间质量平衡测试方法

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农业工程学报 2016年第11期32卷 54-61页

作者：王昌陵何雄奎王潇楠 Jane.Bonds Andreas.Herbst 王志国潘海洋何正泽中国农业大学理学院北京100193 Bonds consulting Group llc Panama City Florida 32408USA Institute for Chemical Application Technology of JKI Messeweg 11/12 D-38104 BraunschweigGermany 安阳全丰航空植保科技有限公司安阳455001 珠海绿卫士航空植保技术有限公司珠海519085 洛克希德(武汉)无人机科学研究院有限公司武汉430070

为了研究精准作业参数(速度、高度)下的无人植保机施药雾滴空间分布和下旋气流场特性,该文提出了一种无人机施药雾滴空间质量平衡测试试验方法,并且使用该方法对3种无人机进行了田间实际试验研究,结果表明:该方法可以有效获得准确飞行... 详细信息

为了研究精准作业参数(速度、高度)下的无人植保机施药雾滴空间分布和下旋气流场特性,该文提出了一种无人机施药雾滴空间质量平衡测试试验方法,并且使用该方法对3种无人机进行了田间实际试验研究,结果表明:该方法可以有效获得准确飞行速度和高度下无人机施药雾滴空间分布情况和下旋气流场分布情况,在平均风速1.7 m/s、平均气温31.5℃、平均相对湿度34.1%的条件下,飞行高度2.5 m、速度5.0 m/s时,3WQF80-10型无人机喷雾作业雾滴在上风向部、顶部、下风向部和底部的平均分布比例为4.4%,2.3%,50.4%和43.7%;CG-Q60S型无人机雾滴在4个方向上平均分布比例为2.5%,1.5%,43.2%和52.8%;LXD8-3WD10型无人机雾滴在4个方向上平均分布比例为1.9%,2.0%,21.9%和74.7%。雾滴空间质量平衡分布规律符合下旋气流场分布规律,无人机下旋气流风场的测量是分析雾滴在空间不同部位分布的重要手段。研究结果可为低空低量无人植保机施药技术研究和建立无人植保机低空低量施药田间雾滴沉积与飘失测试标准提供参考。

关键词：机械化农药流场无人机雾滴空间质量平衡测试沉积分布

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更好地平衡模内流动

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现代塑料 2014年第7期 44-44页

作者： Jim Frankland Frankland Plastics consulting llc.

如果挤出模头设计正确，且能满足聚合物性质和产量方面的要求，那么此模头应该无需调整即可挤出所需的产品。

关键词：内流动平衡模头设计聚合物挤出

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冠层推拨装置对喷杆喷雾机雾滴飘失与沉积特性的影响

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植物保护 2021年第1期47卷 68-73页

作者：王士林李雪雷哓晖顾炀 HERBST Andreas BONDS Jane 吕晓兰江苏省农业科学院农业设施与装备研究所南京210014 农业农村部长江中下游设施农业工程重点实验室南京210014 Institute for Chemical Application Technology of JKI Braunschweig D-38104Germany Bonds consulting Group llc Panama City Florida 32408USA

喷杆喷雾机具有作业效率高、雾滴覆盖率高、沉积分布均匀、防治效果好等优点,是目前大田作物最主要的施药机具。但受作物冠层遮挡和侧风等气象条件的影响,导致喷杆喷雾机作业时雾滴难以穿透到植株中下部并伴随飘失。为改善喷杆喷雾机喷... 详细信息

喷杆喷雾机具有作业效率高、雾滴覆盖率高、沉积分布均匀、防治效果好等优点,是目前大田作物最主要的施药机具。但受作物冠层遮挡和侧风等气象条件的影响,导致喷杆喷雾机作业时雾滴难以穿透到植株中下部并伴随飘失。为改善喷杆喷雾机喷雾雾滴在作物冠层的穿透性并降低飘移量,本文优化设计了一种适用于大田作物的喷杆喷雾机冠层推拨装置。并分别使用两种喷头(标准扇形雾喷头ST110-02、射流喷头IDK120-02)对该装置的减飘性和在小麦上的沉积特性进行了对比试验。结果表明:该冠层推拨装置对标准扇形雾喷头ST110-02的减飘效果强于射流喷头IDK120-02,其减飘效果分别为59.0%和9.5%;冠层推拨装置可以提高药液的沉积率,对于ST110-02喷头可增加18.0%,IDK120-02喷头增加了8.6%;同时该推拨装置对小麦植株的推拨作用增加了雾滴向冠层中下方的穿透效果,有利于药液在植株上的均匀沉积。

关键词：喷杆喷雾机推拨装置飘失雾滴沉积

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评估多材料回收用螺杆的设计

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现代塑料 2020年第6期 28-28页

作者： Jim Frankland Frankland Plastics consulting LLC Jim Frankland

由于许多塑料产品是用熔点差异很大的多种材料制成的,因此在回收这些产品时必须仔细考虑螺杆设计。当前,塑料回收越来越受到关注,必须想方设法来避免在回收共挤出或共注射成型部件时出现的加工问题。许多塑料产品是用几种不同的聚合物... 详细信息

由于许多塑料产品是用熔点差异很大的多种材料制成的,因此在回收这些产品时必须仔细考虑螺杆设计。当前,塑料回收越来越受到关注,必须想方设法来避免在回收共挤出或共注射成型部件时出现的加工问题。许多塑料产品是用几种不同的聚合物层组成,以提供特殊的性能,比如阻隔性、光泽度、颜色和耐磨性等,这些聚合物层非常薄,在设计回收用螺杆时必须予以考虑,对于半结晶聚合物尤其如此。

关键词：聚合物层塑料产品半结晶聚合物共注射成型螺杆设计光泽度共挤出材料回收

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Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers Robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin Blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina Attia Steven Bollipo Alastair D.Smith Bradley Freilich Robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver consulting llc New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health llc MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

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Part A: The Development of mI SMART, a Nurse-Led Technology Intervention for Multiple Chronic Conditions

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Open Journal of Nursing 2016年第4期6卷 303-308页

作者： Jennifer A. Mallow Laurie A. Theeke Rebecca Walls Elliott Theeke Brian K. Mallow School of Nursing West Virginia University Morgantown West Virginia USA Milan Puskar Health Right Morgantown West Virginia USA Sovern Run LLC Albright West Virginia USA

Background: The treatment of Multiple Chronic Conditions (mcc) is complex for both patients and providers. Used as integrated tools, technology may decrease complexity, remove the barrier of distance to obtain care, and improve outcomes of care. A new platform that integrates multiple technologies for primary health care called mI SMART (Mobile Improvement of Self-Management Ability through Rural Technology) has been developed. The purpose of this paper is to present to development of mI SMART, a nurse-led technology intervention for treating for mcc in primary care. Methods: The creation of mI SMART was guided by the model for developing complex nursing interventions. The model suggests a process for building and informing interventions with the intention of effectiveness, sustainability, and scalability. Each step in the model builds from and informs the previous step. Results: The process resulted in the integrated technologies of mI SMART. The system combines a HIPAA compliant, web-based, structure of mHealth sensors and mobile devices to treat and monitor multiple chronic conditions within an existing free primary care clinic. The mI SMART system allows patients to track diagnoses, medications, lab results, receive reminders for self-management, perform self-monitoring, obtain feedback in real time, engage in education, and attend visits through video conferencing. The system displays a record database to patients and providers that will be integrated into existing Electronic Health Records. Conclusion: By using the model for developing complex nursing interventions, a multifaceted solution to clinical problems was identified. Through modeling and seeking expert review, we have established a sustainable and scalable integrated nurse-led intervention that may increase access and improve outcomes for patients living in rural and underserved areas. The first trial of mI SMART has been completed and evaluated for feasibility, acceptability, and effectiveness in per

关键词： Multiple Chronic Conditions mHealth Telehealth Health Disparities Nursing Informatics

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Human photosynthesis, the ultimate answer to the long term mystery of Kleiber’s law or E = M<sup>3/4</sup>: Implication in the context of gerontology and neurodegenerative diseases

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Open Journal of Psychiatry 2013年第4期3卷 408-421页

作者： Gjumrakch Aliev Arturo Solís-Herrera Yi Li Yury G. Kaminsky Nikolay N. Yakhno Vladimir N. Nikolenko Andrey A. Zamyatnin Jr. Valery V. Benberin Sergey O. Bachurin Department of Anatomy First Moscow State Medical University Moscow Russian Federation Department of Neurological Disorders First Moscow State Medical University Moscow Russian Federation Institute of Physiologically Active Compounds Russian Academy of Sciences Chernogolovka Russian Federation Medical Center of the Administration of the President of the Republic of Kazakhstan Astana Kazakhstan Russian Academy of Sciences Institute of Theoretical and Experimental Biophysics Pushchino Russian Federation “GALLY” International Biomedical Research consulting llc San Antonio USA Human Photosynthesis Study Center Pulgas Pandas Sur México Institute of Molecular Medicine First Moscow State Medical University Moscow Russian Federation Department of Human Sciences Texas A&M University-Kingsville Kingsville USA

Kleiber’s Law or E = M3/4 is a mathematical expression known since 1932 that outlines the relationship between mass (biomass) and the use of energy. It is compelling because it supports a long standing observation that larger animals appear to use energy more efficiently than smaller ones. For example, an elephant’s weight is 200,000 times of a mouse, but uses only about 10,000 fold energy;thus a cat, having a mass of about 100 times of a mouse, only spends roughly 33 fold energy. In other words, the bigger you are, the less energy per gram of tissue you actually need to stay alive. Many facts pertaining to animal size call for a rational explanation. This paper takes into account that the fascinating relationship between mass and energy use for any living thing is governed strictly by a mathematical universal formula across all living species, operating in the tiniest of bacteria to the biggest of whales and sequoia tress. For the first time, we report a capacity for the mammal eukaryotic cell to split, break or dissociate water molecules through melanin. Even though E = M3/4 was discovered eight decades ago, no proper satisfactory explanation exists. Nevertheless, our multiyear detailed study on the “Human Photosynthesis” or first found in the human retina and later in all eukaryotic cells, may finally unravel this mystery, namely, the bigger you are the more surface area you have to absorb electromagnetic radiation and the more potential exists to use that electromagnetic radiation spectra to perform work. We propose a future application of this theory in the context of human diseases, especially age-related disorders, such as retinopathy, cerebrovascular and Alzheimer disease and these implications may not only foster a better understanding of the pathobiology of these devastating diseases but also develop much more effective therapies in the foreseeable future.

关键词： Human Photosynthesis Kleiber’s Law Geriatrics Gerontology Cardio- and Cerebrovascular Diseases Neurodegeneration Alzheimer Disease Retinopathy

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Dougherty博士与光敏剂Photofrin

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中国激光医学杂志 2019年第5期28卷 288-291页

作者：黄正 Stuart L Marcus Ron R Allison 福建师范大学医学光电科学与技术教育部重点实验室和福建省光子技术重点实验室福州市350007 SLM Clinical Development consulting LLC.New YorkUSA Carolina Radiation Medicine North CarolinaUSA

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动... 详细信息

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动力疗法的光敏剂,目前仍在欧美和亚洲部分国家和地区使用。他的工作也是现代光动力医学的一个重要里程碑。根据Dougherty本人以及和他共事过的美国同事提供的资料,本文对Dougherty博士和Photofrin研发过程中的一些重要历史人物和事件做一回顾性介绍。

关键词：癌症研究所光动力 Photofrin 光敏剂肿瘤光动力疗法

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Circulating Tumor Cell Cultures as a Predictive Marker during Salvage Therapy of Refractory Merkel Cell Carcinoma with Chemotherapy and Electron Beam Radiation

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Journal of Cancer Therapy 2013年第7期4卷 1162-1166页

作者： Sreekanth Donepudi Susan A. Reisinger John R. McGregor Shweta Tharkar Suzanne Samlowski Daniel Ostler Shirley Shen Wolfram E. Samlowski 21st Century Radiation Oncology Las Vegas USA Comprehensive Cancer Centers of Nevada Las Vegas USA Genomics Core Facility of UNLV Las Vegas USA LMC Pathology Las Vegas USA TrueCells LLC Las Vegas USA

Metastatic Merkel Cell carcinoma (mcc) is a highly unusual and aggressive skin cancer that presents as a small, pink to violet skin lesion and metastasizes early in its growth. Metastatic mcc is generally treated with small cell lung cancer chemotherapy regimens, because the tumor consists of neuroendocrine cells, but patients generally do not have durable responses. The pathogenesis of mcc has recently been attributed to the Merkel Cell polyoma virus. This virus activates the cellular retinoblastoma oncoprotein and cell cycle machinery, triggering continual cellular proliferation. A 77-year-old man developed extensive mcc metastases, involving more than one fourth of his scalp and numerous cervical lymph nodes. Following failure of initial chemotherapy and radiation, effective palliation was achieved by using a sequence of electron-beam radiotherapy, low dose gemcitabine, and etoposide, resulting in significant periods of tumor regression and prolonged survival. A novel circulating tumor cell (CTC) culture assay was performed on four separate clinic visits during the treatment period. Tumor colonies were cultured from the patient’s peripheral blood and CTC colony counts were correlated with clinical treatment response. Not only did the patient respond to palliative cell cycle directed chemotherapy and electron beam radiation, but we demonstrated that CTC can be cultured from peripheral blood of mcc patients and serve as a predictive marker to monitor treatment response.

关键词： Merkel Cell Carcinoma Chemotherapy Radiotherapy Circulating Tumor Cells CTC Culture

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