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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

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Frontiers of Medicine 2023年第3期17卷 527-533页

作者： Kevin M.Veen Grigorios Papageorgiou Casper F.Zijderhand Mostafa M.Mokhles Jasper J.Brugts Olivier C.Manintveld Alina A.Constantinescu Jos A.Bekkers Johanna J.Makkenberg Ad J.J.CBogers Kadir Caliskan Department of Cardiothoracic Surgery Erasmus MC3000 CA RotterdamThe Netherlands Department of Biostatistics Erasmus MC3000 CA RotterdamThe Netherlands Department of Cardiology Erasmus MC3000 CA RotterdamThe Netherlands

In this study,we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation(TR),taking into account its dynamic nature,after biatrial orthotopic heart transplant(OHT).All consecutive adult patients undergoing biatrial OHT(1984−2017)with an available follow-up echocardiogram were ***-models were used to model the evolution of *** mixed-model was inserted into a Cox model in order to address the association of the dynamic TR with *** total,572 patients were included(median age:50 years,males:74.9%).Approximately 32% of patients had moderate-to-severe TR immediately after ***,this declined to 11%on 5 years and 9% on 10 years after surgery,adjusted for survival *** mechanical support was associated with less TR during follow-up,whereas concurrent LV dysfunction was significantly associated with more TR during *** at 1,5,10,20 years was 97%±1%,88%±1%,66%±2% and 23%±2%,*** presence of moderate-to-severe TR during follow-up was associated with higher mortality(HR:1.07,95%CI(1.02–1.12),p=0.006).The course of TR was positively correlated with the course of creatinine(R=0.45).TR during follow-up is significantly associated with higher mortality and worse renal ***,probability of TR is the highest immediately after OHT and decreases ***,it may be reasonable to refrain from surgical intervention for TR during earlier phase after OHT.

关键词： orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation

Enrichment and immobilization of macromolecular analytes on a porous membrane utilizing permeation drag

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Journal of Pharmaceutical Analysis 2018年第3期8卷 187-193页

作者： Pedram Madadkar Rahul Sadavarte Raja Ghosh Department of Chemical Engineering Mc Master University

Enrichment and immobilization of analytes by chemical bonding or physical adsorption is typically the first step in many commonly used analytical techniques. In this paper, we discuss a permeation drag based technique as an alternative approach for carrying out location-specific immobilization of macro- molecular analytes. Fluorescein isothiocyanate （FITC） labeled macromolecules and their complexes were enriched near the surface of ultrafiltration membranes and detected by direct visual observation and fluorescence imaging. The level of macromolecule enrichment at the immobilization sites could be controlled by manipulating the filtration rate and thereby the magnitude of permeation drag. Higher enrichment as indicated by higher fluorescence intensity was observed at higher filtration rates. Also, larger macromolecules were more easily enriched. The feasibility of using this technique for detecting immunocomplexes was demonstrated by carrying out experiments with FITC labeled bovine serum al- bumin （FITC-BSA） and its corresponding antibody. This permeation drag based enrichment technique could potentially be developed further to suit a range of analytical applications involving more sophis- ticated detection methods.

关键词： Macromolecule Enrichment Immobilization Concentration polarization Permeation draglmmunoassay Membrane Ultrafiltration

Inflammatory bowel disease and airway diseases

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World Journal of Gastroenterology 2016年第34期22卷 7735-7741页

作者： Maria Vutcovici Paul Brassard Alain Bitton Division of Gastroenterology Mc Gill University Health CentreMontreal General Hospital Division of Clinical Epidemiology Mc Gill University Health Centre Department of Medicine Mc Gill University

Airway diseases are the most commonly described lung manifestations of inflammatory bowel disease(IBD). However,the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases. Recent evidence of IBD occurrence among patients with airway diseases and the higher than estimated prevalence of subclinical airway injuries among IBD patients support the hypothesis of a two-way association. Future research efforts should be directed toward further exploration of this association,as airway diseases are highly prevalent conditions with a substantial public health impact.

关键词： Inflammatory bowel disease Ulcerative colitis Asthma Chronic obstructive pulmonary disease Crohn’s disease

Transcranial magnetic stimulation to understand pathophysiology and as potential treatment for neurodegenerative diseases

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Translational Neurodegeneration 2015年第1期4卷 184-195页

作者： Zhen Ni Robert Chen Division of Neurology Krembil Neuroscience Centre and Toronto Western Research InstituteUniversity Health NetworkUniversity of TorontoTorontoONCanada mc-411 Toronto Western Hospital399 Bathurst StreetTorontoON M5T 2S8Canada

Common neurodegenerative diseases include Parkinson’s disease(PD),Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS)and Huntington’s disease(HD).Transcranial magnetic stimulation(TMS)is a noninvasive and painless method to stimulate the human ***-and paired-pulse TMS paradigms are powerful ways to study the pathophysiological mechanisms of neurodegenerative *** evoked potential studied with single-pulse TMS is increased in PD,AD and ALS,but is decreased in *** in motor cortical excitability in neurodegenerative diseases may be related to functional deficits in cortical circuits or to compensatory *** or even absence of short interval intracortical inhibition induced by paired-pulse TMS is common in neurodegenerative diseases,suggesting that there are functional impairments of inhibitory cortical *** short latency afferent inhibition in AD,PD and HD may be related to the cortical cholinergic deficits in these *** plasticity tested by paired associative stimulation or theta burst stimulation is impaired in PD,AD and *** TMS(rTMS)refers to the application of trains of regularly repeating TMS ***-frequency facilitatory rTMS may improve motor symptoms in PD patients whereas low-frequency inhibitory stimulation is a potential treatment for levodopa induced *** delivered both to the left and right dorsolateral prefrontal cortex improves memory in AD *** motor cortical stimulation in low frequency may be useful for HD ***,the effects of treatment with multiple sessions of rTMS for neurodegenerative diseases need to be tested in large,sham-controlled studies in the future before they can be adopted for routine clinical practice.

关键词： Alzheimer’s disease Amyotrophic lateral sclerosis Huntington’s disease Parkinson’s disease Transcranial magnetic stimulation

SARS-CoV-2-specific T-cells in unexposed humans:presence of cross-reactive memory cells does not equal protective

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Signal Transduction and Targeted Therapy 2020年第1期5卷 635-636页

作者： Rory D.de Vries Department Viroscience Erasmus MCRotterdamthe Netherlands

Using human blood samples obtained from pre-pandemic donors,a recent article by Mateus et *** Science provided new evidence that SARS-CoV-2-reactive T-cells in unexposed donors are indeed HCoV-specific T-cells.1 The rapid global spread of coronavirus disease 2019(COVID-19),caused by the newly-emerged coronavirus SARS-CoV-2,has led to millions of infections with substantial morbidity and mortality.2 Different clinical manifestations of COVID-19 have been observed:asymptomatic infections,mild self-limiting disease,acute respiratory distress syndrome and *** determinants underlying disease severity currently remain elusive;since severe patients often present with immune hyperresponsiveness,it is speculated that the host’immune response could be a contributing factor to severe disease.

关键词： protective distress reactive

Comparison of long-term outcome between patients aged 〈 65 years vs. ≥ 65 years after atrial fibrillation ablation

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Journal of Geriatric Cardiology 2017年第9期14卷 569-574页

作者： Zsuzsanna Kis Anna ME Noten Mihran Martirosyan Astrid A Hendriks Rohit Bhagwandien Tamas Szili-Torok Department of Cardiology Erasmus MC University Medical Center Rotterdam the Netherlands

Background Atrial fibrillation （AF） is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to com-pare the long-term outcome data of patients 〈 65 years vs.≥ 65 years who underwent catheter ablation （CA） for drug-refractory AF. MethodsConsecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completeda five-year of follow-up were divided into two groups： patients aged 〈 65 years into group 1, and patients aged ≥ 65 into group 2. Long-termoutcome data concerning mortality, thromboembolic events （TE） and success rates were compared between these groups. Results A totalnumber of 390 patients were included, group 1 contained 310 patients, and 80 patients in group 2. In group 2, patients had more often impairedrenal function （P 〈 0.001） and thyroid disease （P = 0.047）. A total of fifteen patients died during the 6.63 ± 2.1 years of follow-up, with a sig-nificantly higher incidence in the older group （8/80 vs. 7/310 patients, P = 0.004）. The majority of fatal outcome was due to cancerous dis-eases in both groups. No difference was observed concerning the long-term TE rate （12/310 vs. 4/80 patients, P = 0.75）. Rhythm controlfailed in 25.9% of the patients, with no difference between the groups： 26.4% in group 1 vs. 23.7% in group 2 （P = 0,67）, ConclusionsDespite growing prevalence of AF in aging population, the elderly patients are underrepresented in CA procedures. Similar clinical successand TE complication rate are observed between the age-groups. Our data suggest more liberal criteria might be applied while selecting pa-tients for AF ablation.

关键词： Atrial fibrillation Catheter ablation Clinical outcome The elderly Thromboembolic complication

DIABETIC INTERSTITIAL GLUCOSE IN THE SKIN TISSUE BY ATR-FTIR SPECTROSCOPY VERSUS CAPILLARY BLOOD GLUCOSE

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Journal of Innovative Optical Health Sciences 2010年第2期3卷 81-90页

作者： NATALJA SKREBOVA EIKJE mc Professional OU Voistluse 23/25-35TallinnEstonia

Recently introduced horizontal attenuated total reflectance(HATR)Fourier transform infrared(FTIR)spectroscopy for real-time assessment and continuous monitoring of glucose biomolecules in the skin tissue directly on the patients might appear a promising alternative to interpret the activity of interstitial glucose metabolism in vivo by means of evaluating the dynamics of changes of glucose concentrations in interstitial fluid(IF).In the present study,in vivo spectra by ATR-FTIR spectroscopy were obtained post-prandially during a 120–180-minute continuous monitoring in three patients with type 2 diabetes and compared to pre-prandial *** all patients with diabetes interstitial glucose levels at 1030 and 1041cm^(−1) reflected the best relationship with blood *** lag time(LT)required for glucose to diffuse from the capillary to epidermal skin tissue was calculated between 0 and 60 minutes at all measured glucose *** showed intra-and inter-subject variations of each glucose biomolecule,pointing to similarities and differences among interstitial glucose metabolism of the ***,the findings suggest that HATR-FTIR spectroscopy might have the potential for clinical interpretation of activity of glucose metabolism for diagnosis,management,and treatment of patients with diabetes.

关键词： ATR-FTIR spectroscopy skin interstitial glucose diabetes.

Effects of foundation rocking and uplifting on displacement amplification factor

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 511-525页

作者： Mohammad Khanmohammadi Vahid Mohsenzadeh School of Civil Engineering University of Tehran Department of Civil Engineering Mc Master University

Prediction of displacement demand to assess seismic performance of structures is a necessary step where nonlinear static procedures are *** such predictions have been well established in literature for fixed-base structures,fewer bodies of researches have been carried out on the effect of rocking and uplifting of shallow foundations supported by soil,on such *** paper aimed to investigate the effect of soil structure interaction on displacement amplification factor C1 using the beam on nonlinear Winkler foundation concept.A practical range of natural period,force reduction factors,and wide range of anticipated behavior from rocking,uplifting and hinging are considered and using thousands nonlinear time history analysis,displacement amplification factors are *** results indicate that the suggested equations in current rehabilitation documents underestimate displacement demands in the presence of foundation rocking and ***,using regression analyses,new equations are proposed to estimate mean values of C1.

关键词： soil-structure interaction rocking and uplifting foundations displacement amplification factor

WiSeREmulator: An Emulation Framework for Wireless Structural Health Monitoring

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Tsinghua Science and Technology 2015年第4期20卷 317-326页

作者： Rajat Khanda Rong Zheng Gangbing Song Department of Electrical Eng. University of Houston Department of Computing and Software Mc Master University

Many competing approaches exist in evaluating sensor network solutions differing by levels of ease of use, cost, control, and realism. Existing work concentrates on simulating network protocols or emulating processing units at the machine cycle level. However, little has been done to emulate the sensors and the physical environments that they monitor. The main contribution of this work is the design of WiserEmulator, an emulation framework for structural health monitoring, which gracefully balances the trade-offs between realism, controllability, and cost. WiserEmulator consists of two main components -- a testbed of wireless sensor nodes and a software emulation environment. To emulate the excitation and response of piezo-electric transducers, as well as the wave propagation inside concrete structures, the COMSOL Multi-Physics software was utilized. Digitized sensing output from COMSOL was played back via a multi-channel Digital-to-Analog Converter （DAC） connected to the wireless sensor testbed. In addition to the emulation of concrete structures, WiSeREmulator also allows users to choose pre- stored data collected from field experiments and synthesized data. A user-friendly Graphical User Interface （GUI） was developed that facilitates intuitive configurations of experimental settings, control of the on-set and progression of the experiments, and real-time visualization of experimental results. We have implemented WiSeREmulator in MATLAB. This work advances the state of the art in providing low cost solutions to evaluating Cyber Physical Systems such as wireless structural health monitoring networks.

关键词： structure health monitoring cyber physical systems emulater