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Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice

Food Science and Human Wellness 2024年第2期13卷 946-960页

作者： Yunting Xie Linlin Cai Zhiji Huang Kai Shan Xinglian Xu Guanghong Zhou Chunbao Li Key Laboratory of Meat Processing and Quality Control MOEKey Laboratory of Meat ProcessingMARAJiangsu Innovative Center of Meat ProductionProcessing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

To determine the effects of plant-based meat analogues on the metabolic health and the possible mechanisms,mice were fed with a real pork diet(AP),a real beef diet(AB),a plant-based pork analogue diet(PP)and plant-based beef analogue diet(PB)for 68 *** with real meat,the plant-based meat analogues increased food and energy intake,body weight,white fat and liver weight and caused adipocyte hypertrophy,hepatic lipid droplet accumulation,and inflammatory responses in *** revealed that plantbased meat analogues altered the composition of serum metabolites,which regulated lipid metabolism *** PB diet upregulated gene expression related to lipid synthesis,lipolysis and adipocyte differentiation while the PP diet upregulated expression of lipolysis-related genes but downregulated expression of adipocyte differentiation-related genes in white adipose ***,both PP and PB diets upregulated lipid influx-and synthesis-related genes but downregulated lipid oxidation-related genes in *** specific metabolite biomarkers may affect fat accumulation mainly by direct lipid metabolism pathways or indirect amino acid metabolism,protein digestion and absorption,bile secretion,aminoacyl-tRNA biosynthesis,neuroactive ligand-receptor interaction and ABC transporters *** findings provide a new insight into understanding the differences in nutritional functions of meat and plant-based meat analogues.

关键词： Meat analogues Metabolomics Lipid metabolism Adipose tissue dysfunction Ectopic fat deposition

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Encoding innumerable charge density waves of FeGe into polymorphs of LiFe6Ge6

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 130-136页

作者： Yilin Wang School of Emerging technology University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China New Cornerstone Science Laboratory University of Science and Technology of China

Kagome metals exhibit rich quantum states by the intertwining of lattice,charge,orbital and spin degrees of ***,a novel charge density wave （CDW） ground state was discovered in kagome magnet FeGe and was revealed to be driven by lowering magnetic energy via large ***,based on DFTcalculations,we show that such mechanism will yield infinitely many metastable CDWs in FeGe due to different ways to arrange the Ge1-dimerization in enlarged ***,utilizing these metastable CDWs,innumerable polymorphs of kagome magnet LiFe6Ge6can be stabilized by filling Li atoms in the voids right above/below the dimerized Ge1-sites in the CDW *** polymorphs are very stable due to the presence of magnetic-energy-saving mechanism,in sharp contrast to the non-magnetic “166” kagome *** this way,a one-to-one mapping of the metastable CDWs of FeGe to stable polymorphs of LiFe6Ge6is *** one hand,the fingerprints of these metastable CDWs,i.e.,the induced in-plane atomic distortions and band gaps,are encoded into the corresponding stable polymorphs of LiFe6Ge6,such that further study of their properties becomes *** the other hand,such innumerable polymorphs of LiFe6Ge6offer great degrees of freedom to explore the rich physics of magnetic kagome *** thus reveal a novel connection between the unusually abundant CDWs and structural polymorphism in magnetic kagome materials,and establish a new route to obtain structural polymorphism on top of CDW states.

关键词： kagome magnet unconventional charge density wave structural polymorphism magnetic energy saving

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A Novel Disturbance Observer Based Fixed-Time Sliding Mode Control for Robotic Manipulators With Global Fast Convergence

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 661-672页

作者： Dan Zhang Jiabin Hu Jun Cheng Zheng-Guang Wu Huaicheng Yan IEEE Zhejiang university of technology Guangxi Normal university Zhejiang university the East China university of Science and technology

This paper proposes a new global fixed-time sliding mode control strategy for the trajectory tracking control of uncertain robotic ***,a fixed-time disturbance observer(FTDO) is designed to deal with the adverse effects of model uncertainties and external disturbances in the manipulator *** an adaptive scheme is used and the adaptive FTDO(AFTDO) is developed,so that the priori knowledge of the lumped disturbance is not ***,a new non-singular fast terminal sliding mode(NFTSM) surface is designed by using an arctan function,which helps to overcome the singularity problem and enhance the robustness of the *** on the estimation of the lumped disturbance by the AFTDO,a fixed-time non-singular fast terminal sliding mode controller(FTNFTSMC)is developed to guarantee the trajectory tracking errors converge to zero within a fixed *** settling time is independent of the initial state of the *** addition,the stability of the AFTDO and FTNFTSMC is strictly proved by using Lyapunov ***,the fixed-time NFESM(FTNFTSM) algorithm is validated on a 2-link manipulator and comparisons with other existing sliding mode controllers(SMCs) are *** comparative results confirm that the FTNFTSMC has superior control performance.

关键词： Disturbance observer(DO) fixed-time non-singular sliding mode control robotic manipulator trajectory tracking

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HEN:a novel hybrid explainable neural network based framework for robust network intrusion detection

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Science China(Information Sciences) 2024年第7期67卷 72-90页

作者： Wei WEI Sijin CHEN Cen CHEN Heshi WANG Jing LIU Zhongyao CHENG Xiaofeng ZOU School of Computer Science and Engineering Xi'an University of TechnologyShaanxi Key Laboratory for Network Computing and Security Technology School of Computer Science and technology Wuhan University of Science and Technology School of Future technology South China University of Technology Shenzhen Research Institute of Hunan university School of Computer Science Hunan University of Technology and Business Institute for Infocomm Research (I2R) Agency for Science Technology and Reseach (A*STAR)

With the rapid development of network technology and the automation process for 5G, cyberattacks have become increasingly complex and threatening. In response to these threats, researchers have developed various network intrusion detection systems(NIDS) to monitor network traffic. However, the incessant emergence of new attack techniques and the lack of system interpretability pose challenges to improving the detection performance of NIDS. To address these issues, this paper proposes a hybrid explainable neural network-based framework that improves both the interpretability of our model and the performance in detecting new attacks through the innovative application of the explainable artificial intelligence(XAI)method. We effectively introduce the Shapley additive explanations(SHAP) method to explain a light gradient boosting machine(Light GBM) model. Additionally, we propose an autoencoder long-term short-term memory(AE-LSTM) network to reconstruct SHAP values previously generated. Furthermore, we define a threshold based on reconstruction errors observed during the training phase. Any network flow that surpasses the specified threshold is classified as an attack flow. This approach enhances the framework's ability to accurately identify attacks. We achieve an accuracy of 92.65%, a recall of 95.26%, a precision of 92.57%,and an F1-score of 93.90% on the dataset NSL-KDD. Experimental results demonstrate that our approach generates detection performance on par with state-of-the-art methods.

关键词： explainable artificial intelligence light gradient boosting machine machine learning network intrusion detection Shapley additive explanation hybrid explainable neural network (HEN)

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Passivation remediation of weakly alkaline Cd-contaminated soils using combined treatments of biochar and sepiolite

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Ecological Processes 2024年第1期13卷 40-52页

作者： Yuxin Zhang Shan Gao Hongtao Jia Tao Sun Shunan Zheng Shihang Wu Yuebing Sun Key Laboratory of Original AgroEnvironmental Pollution Prevention and Control Ministry of Agriculture and Rural Affairs (MARA)/Tianjin Key Laboratory of Agro-Environment and Agro-Product Safety Agro–Environmental Protection InstituteMARA College of Resources and Environment Sciences Xinjiang Agricultural University Rural Energy and Environment Agency Ministry of Agriculture and Rural Affairs

Background Cadmium(Cd) pollution in agricultural soils has become a priority environmental concern globally. A reasonable application of passivators is critical to address the problem. In this study, we examined the remediation effects of rice husk biochar(r BC) and sepiolite(Sep) as single and combined(r BC + Sep) treatments on Cd pollution in a weakly alkaline soil using three maize cultivars(Liyu 16, Zhengdan 958, and Sanbei 218) as test crops. We also explained the mechanisms involved in the remediation *** The pseudo-second-order kinetic equation and Langmuir model could well describe the adsorption process of r BC + Sep for Cd2+. Compared with the control treatment(CK), soil available Cd concentration decreased by 29.51–36.34% under r BC + Sep treatment(p 0.05).Conclusions The application of 0.2% r BC + 0.5% Sep composite passivation material to weakly alkaline Cd-contaminated soil can effectively reduce the Cd concentration of soil and maize.

关键词： Cd Rice husk biochar Sepiolite Passivation restoration Weakly alkaline soil Maize

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A hybrid WUDT-NAFnet for simultaneous source data deblending

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Petroleum Science 2024年第3期21卷 1649-1659页

作者： Chao-Fan Ke Shao-Huan Zu Jun-Xing Cao Xu-Dong Jiang Chao Li Xing-Ye Liu Key Laboratory of Earth Exploration and Information technology of Ministry of Education Chengdu University of Technology State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology College of Geophysics Chengdu University of Technology

Simultaneous source technology,which reduces seismic survey time and improves the quality of seismic data by firing more than one source with a narrow time interval,is compromised by the massive blended ***,deblending algorithms have been developed to separate this ***,deep learning(DL)has been proved its great potential in suppressing the *** most popular DL method employs neural network as a filter to attenuate the blended noise in an iterative estimation and subtraction framework(IESF).However,there are still amplitude distortion and blended noise residual problems,especially when dealing with weak signal submerged in strong *** address these problems,we propose a hybrid WUDT-NAFnet,which contains two *** first network is a wavelet based U-shape deblending transformer network(WUDTnet),incorporated into IESF as a robust regularization term to iteratively separate the blended *** second network is a nonlinear activate free network(NAFnet)designed to recover the event amplitude and further suppress the weak noise residual in *** the hybrid network,the blended noise can be separated purposefully and *** using synthetic and field seismic data demonstrate that the WUDTNAFnet outperforms traditional curvelet transform(CT)based method and the deblending transformer(DT)model in terms of ***,for field applications,the data augmentation method of bicubic interpolation is applied to mitigate the feature difference between synthetic and field ***,the trained network exhibits strong signal preservation ability in numerical field example without requiring additional training.

关键词： Simultaneous-source Deblending Deep learning Transformer

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A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

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Science China(Information Sciences) 2024年第2期67卷 118-143页

作者： Guang-Ren DUAN Center for Control Theory and Guidance technology Harbin Institute of Technology Center for Control Science and technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems

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A compact route for efficient production of high-purity β-Ga2O3 powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou Gao-Jie Chen Liang Xu Zhi-Jun Shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of Technology Low-Carbon Research Institute Anhui University of Technology

The present study has proposed a compact process for the production of high-purity β-Ga2O3powder by simply using gallium metal and water as the raw materials. The process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product of β-Ga2O3. Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization. X-ray diffractometer（XRD）, scanning electron microscopy（SEM）, thermogravimetryDdifferential scanning calorimetry（TG-DSC） and X-ray photoelectron spectroscopy（XPS） were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH to β-Ga2O3by calcination. Chemical analysis of the final product of β-Ga2O3obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry（ICP-MS）, and the results showed that the contents of the representative impurities such as Ni, Cu, In, Mn, Co, Zn and Cr are obviously lower than the requirement of 5N β-Ga2O3standard, exhibiting excellent application prospect of the proposed process to produce high-purity β-Ga2O3.

关键词： Calcination Hydrothermal synthesis Purity Reaction mechanism β-Ga2O3

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Phytochemical analysis, antioxidant, acetylcholinesterase, and α-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese Medicine 2024年第3期44卷 496-504页

作者： Naila Sher Mushtaq Ahmed Nadia Mushtaq Department of Biotechnology University of Science and Technology Department of Botany University of Science and Technology

OBJECTIVE:To investigate the effects of Hippeastrum hybridum（HH） as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase（α-amylase） and acetylcholinesterase（AChE）.METHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be（78.52±0.69） mg GAE/g,（2.01±0.04） mg RUE/g,and（58.12±0.23） mg TAE/g of plant extract respectively.28.02%±0.02% alkaloid and 2.02%±0.05% saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50（50%inhibition） of（151.01±0.13）(HH),（79.01±0.04）(Ascorbic acid) for ferric reducing,（91.48±0.13）(HH),（48.02±0.11）(Ascorbic acid) against Ammonium molybdenum,（156.02±0.31）(HH),（52.38±0.21）(Ascorbic acid) against DPPH,136.01±0.21（HH）,52.02±0.31（Ascorbic acid） against H2O2,and 154.12±0.03（HH）,（40.05±0.15）(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition of α-amylase(Vmaxremained constant and Km increases from 10.65 to84.37%) while Glucophage caused the un-competitive type of inhibition i-e both Km and Vmaxdecreased from40.49 to 69.15%and 38.86 to 69.61%*** Ki,（inhibition constant）;KI,（dissociation constant）,Km,（Michaelis-Menten constant）,and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while Vmaxdecreases from 60.5%to74.1%.The calculated Ki,KI,Km,and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidants,Alzheimer‘s and T

关键词： Hippeastrum hybridum acetylcholinesterase alpha-amylase antioxidant phytochemicals

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Optically levitated micro gyroscopes with an MHz rotational vaterite rotor

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Microsystems & Nanoengineering 2024年第3期10卷 219-227页

作者： Kai Zeng Xiangming Xu Yulie Wu Xuezhong Wu Dingbang Xiao College of Intelligence Science and technology National University of Defense TechnologyChangsha 410073China College of Information and Communication National University of Defense TechnologyWuhan 430000China Key Laboratory of Satellite Navigation technology National University of Defense TechnologyChangsha 410073China

The field of levitated optomechanics has experienced significant advancements in manipulating the translational and rotational dynamics of optically levitated particles and exploring their sensing *** concept of using optically levitated particles as gyroscopes to measure angular motion has long been explored but has not yet been proven either theoretically or *** this study,we present the first rotor gyroscope based on optically levitated high-speed rotating *** gyroscope is composed of a micrometer-size ellipsoidal vaterite particle that is driven to rotate at MHz frequencies in a vacuum *** an external angular velocity is input,the optical axis deviates from its initial position,resulting in changes in the frequency and amplitude of the rotational *** analyzing these changes,the angular velocity of the input can be accurately detected,making it the smallest rotor gyroscope in the *** angular rate bias instability of the gyroscope is measured to be 0.08°/s and can be further improved to as low as 10^(−9)°/h theoretically by cooling the motion and increasing the angular moment of the levitated *** work opens a new application paradigm for levitated optomechanical systems and may pave the way for the development of quantum rotor gyroscopes.

关键词： particles. rotational angular

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