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Orbital reconstruction:From simple materials to bioengineered solutions

Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 98-105页

作者： maria Cervatiuc Eldor Jonnazarov Doston Farhodovich Shukuraliev mehrob Islomidinovich Yatimov Abdullo Hudoydodovich Bobobegov Sukhrobjon Solijonovich Tuychiev Husan Bahtiyorovich Juraev Suhrob Tulqinovich Khidiraliev makhmudjon Burhonovich muratov Sherali Chorshanbeevich Uralov Dilshod Uralovich Yuldashov muslihiddin Ahmadovich Rahimov Ruslan Usmonjonovich Ghoziev Idibek Shamsidinovich mainusov Department of Oncology Radiotherapy and Plastic SurgeryI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Ophthalmology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia c Avicenna Tajik state medical university(ATSmU) Dushanbe 734003Tajikistan Tajik National university(TNU) Dushanbe 734025Tajikistan Pacific state medical university(PSmU) Vladivostok 690002Russia

Orbital fractures are a frequent and serious problem for practicing ophthalmologists. The complexity of the pathology is explained by the combined nature of the injuries(often associated with craniofacial injuries), multistage treatments, results that are often unsatisfactory, and a wide range of complaints about functional and cosmetic limitations. Over the years, significant progress has been made in the field of orbital reconstruction,allowing the transition from traditional methods using simple materials to innovative bioengineering *** evolution has been driven by advances in surgical technologies, imaging techniques, and biomaterials aimed at optimizing the restoration of the shape and function of the orbital region. Traditional approaches are based on the use of autologous tissues such as bone grafts and muscle flaps, which provide biocompatibility and natural integration, but have limitations in terms of customization and accessibility. The advent of patient-specific implants and 3D printing technology has revolutionized the reconstruction of the orbit, allowing implants to be precisely adapted to a patient's anatomy. Biocompatible materials, such as porous polyethylene, titanium, and silicone, have become the basis for orbital reconstruction, ensuring durability and compatibility while minimizing long-term complications. Bioengineered solutions hold promise for further advancements in orbital reconstruction. We searched Pub med, Cyberleninka, and other verified databases for published articles on orbital reconstruction reported in the literature between 1960 and January 2024. In this article, we consider the advantages and disadvantages of each category of reconstruction materials and provide up-to-date information on the methods for modifying their properties using modern processing technologies.

关键词： Orbital reconstruction Bioengineered solutions Biomaterials Patient-specific implants minimally invasive surgery

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Porous Shish-Kebab Structure Prepared from Oriented UHmWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey V.maksimkin Nataliya A.Sipyagina Tarek Dayyoub Alena N.malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry V.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National university of Science and Technology"mISIS"moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHmWPE) films, which provided special conditions for the crystallization of dissolved UHmWPE macromolecules on the surface of oriented UHmWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEm) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHmWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHmWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHmWPE Supercritical CO_(2) Porous shish-kebab structure

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Garg incontinence scores: New scoring system on the horizon to evaluate fecal incontinence. Will it make a difference?

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World Journal of Gastroenterology 2024年第3期30卷 204-210页

作者： Petr Tsarkov Inna Tulina Parvez Sheikh Darya D Shlyk Pankaj Garg Department of Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Oncologic Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Colorectal Surgery Saifee HospitalMumbai 400004MaharashtraIndia Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia

The main aim of this opinion review is to comment on the recent article published by Garg et al in the World Journal of Gastroenterology 2023;29:4593–*** authors in the published article developed a new scoring system,Garg incon-tinence scores(GIS),for fecal incontinence(FI).FI is a chronic debilitating disease that has a severe negative impact on the quality of life of the *** IV criteria define FI as multiple episodes of solid or liquid stool passed into the clothes at least twice a *** associated social stigmatization often leads to significant under-reporting of the condition,which further impairs *** important point is that the complexity and vagueness of the disease make it difficult for the patients to properly define and report the magnitude of the problem to their *** to this,the management becomes even more *** issue is resolved up to a considerable extent by a scoring *** were several scoring systems in use for the last three *** prominent of them were the Cleveland Clinic scoring system or the Wexner scoring system,*** Hospital or Vaizey’s scores,and the FI severity ***,there were several shortcomings in these scoring *** the opinion review,we tried to analyze the strength of GIS and compare it to the existing scoring *** main pitfalls in the existing scoring systems were that most of them gave equal weightage to different types of FI(solid,liquid,flatus,etc.),were not comprehensive,and took only the surgeon’s perception of FI into *** GIS,almost all shortcomings of previous scoring systems had been addressed:different weights were assigned to different types of FI by a robust statistical methodology;the scoring system was made comprehensive by including all types of FI that were previously omitted(urge,stress and mucus FI)and gave priority to patients’rather than the physicians’perceptions while developing the scoring *** to this,GIS in

关键词： Fecal incontinence Scoring system Urge Stress Flatus

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morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第11期30卷 1524-1532页

作者： Yi-Fan Chang Jia-Jing Li Tao Liu Chong-Qing Wei Li-Wei ma Vladimir N Nikolenko Wei-Long Chang Department of Gastrointestinal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia

Autophagy is a cellular catabolic process characterized by the formation of double-membrane *** electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation.A large number of studies have shown that autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal(GI)***,the role of autophagy in GI diseases remains *** article focuses on the morphological and biochemical characteristics of autophagy in GI diseases,in order to provide new ideas for their diagnosis and treatment.

关键词： Autophagy morphological study Biochemical characteristics Subcellular structure Transmission electron microscopy Gastrointestinal diseases

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Cardiovascular disease mortality and air pollution in countries with different socioeconomic status

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Chronic Diseases and Translational medicine 2024年第3期10卷 247-255页

作者： Nikolai Khaltaev Svetlana Axelrod Global Non-Communicable Diseases Platform Global Alliance against Chronic Respiratory DiseasesGenevaSwitzerland Institute for Leadership and Health management I.M.Sechenov First Moscow State University(Sechenov University)MoscowRussia

Background Cardiovascular diseases(CVDs)account for 17.9 million deaths *** risk factors increase the risk of dying from *** pollution is not included in this risk calculation since the appreciation of air pollution as a modifiable risk factor is still *** purpose of this study was to analyze CVD mortality attributed to air pollution in all World Health Organization WHO member states and demonstrate the association of CVD mortality with air pollution depending on countries'income *** The CVD death rate was calculated by dividing the number of deaths by the total *** proportion of the population with primary reliance on clean fuels and technologies for cooking was calculated as an indicator of household air *** annual mean concentration of fine particulate matter≤2.5µg/m^(3) and≤10.0µg/m^(3) to which the population is exposed was used as an indicator of ambient air *** There is a gradual increase in CVD mortality attributed to air pollution from high-income countries(HICs)to low-income countries(LICs).Household air pollution is the major cause of CVD mortality in *** heart disease mortality attributed to ambient air pollution in all countries is higher than stroke mortality attributed to ambient air *** LIC,mortality from stroke is attributed to household air pollution of 39.27±14.47,which is more than twice the stroke mortality attributed to ambient air pollution at 18.60±5.64,t=7.17,pmponent of the CVD preventive strategy,along with lifestyle modifications and effective disease management.

关键词： ambient air pollution cardiovascular disease household air pollution low-income countries World Health Organization

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Changes in renal function and morphological variations of kidney diseases in rheumatoid arthritis patients

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Asian Journal of Urology 2024年第2期11卷 304-310页

作者： Yan Tang Yuliya Varavko Raisa Aringazina Irina menshikova College of medical Technology Yongzhou Vocational Technical CollegeYongzhouChina Department of Internal Diseases Propaedeutics Irkutsk State Medical UniversityIrkutskRussian Federation Department of Internal Diseases No.1 Non-Commercial Joint-Stock Society“West Kazakhstan Marat Ospanov Medical University”AktobeKazakhstan Department of Hospital Therapy No.1 I.M.Sechenov First Moscow State Medical University of Ministry of Health of Russian Federation(Sechenov University)MoscowRussian Federation

Objective:Rheumatoid nephropathy is one of the most severe extra-articular manifestations of rheumatoid arthritis(RA)associated with a very unfavorable *** study aimed to identify changes in renal function and morphological variations of kidney diseases in RA ***:The study enrolled patients(126 patients)between 18 and 55 years of age with a confirmed active RA of more than 12 *** patient underwent the following range of laboratory and instrumental research methods:general clinical analysis of blood and urine,performing urinalysis according to Nechiporenko method;determining daily proteinuria;determining the blood content of glucose,urea,creatinine,uric acid,total bilirubin,liver transaminase level,ionogram,lipidogram,and coagulogram;determining the blood content of rheumatoid factor,anti-streptolysin O,and C-reactive protein;and X-ray of the joints of hands and *** function was examined by estimating glomerular filtration rate,tubular reabsorption index,and renal functional *** studying the morphological changes in the kidneys under ultrasound examination,renal biopsy was performed in 31 patients with RA with urinary syndrome(proteinuria more than 0.3 g per day and hematuria).Results:Nephropathy in RA is characterized by impaired renal function and manifested by an increased blood creatinine and a decrease in glomerular filtration rate and renal functional *** morphological variations of nephropathy at RA,mesangial proliferative glomerulonephritis prevails,accounting for 48.4%of *** disorders include the secondary amyloidosis(29.0%of patients),tubulointerstitial nephritis(16.1%),membranous glomerulonephritis(3.2%),and focal-segmental glomerulosclerosis(3.2%).Conclusion:Kidney damage is a common systemic manifestation of RA with a long and active course,a major nephropathy trigger.

关键词： Rheumatoid nephropathy Secondaryrenal amyloidosis mesangial proliferative glomerulonephritis Renal functional reserve

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A rare case of cardiac and ophthalmic manifestations of meningococcal septicemia

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World Journal of Emergency medicine 2024年第4期15卷 328-330页

作者： Svetlana Rachina Anastasia Shchendrygina Heshan Radeesha de Silva Svetlana Tarasenko Nadezhda mukhina Irina Komarova Ludmila Fedina Elena Burmistrova Elvira martens Sergey Sidorenko Vladimir Gostev Dmitry Polev Alina Saitova Lyudmila Kraeva Nikita Goncharov Irina Zvetkova Department of Hospital Therapy I M Sechenov First Moscow State Medical UniversityMoscow 119048Russia Outpatient Clinic#64 Moscow 119048Russia Department of Cardiology City Clinical Hospital n.a.S.S.YudinMoscow 119048Russia Department of medical microbiology and molecular Epidemiology Pediatric Research and Clinical Center for InfectiousDiseasesSaint Petersburg 197022Russia Department of medical microbiology North-Western State Medical University Named After I.I.MechnikovSaintPetersburg 191015Russia Department of Epidemiology Saint-Petersburg Pasteur InstituteSaint Petersburg 197101Russia

Acute pericarditis is usually a self-limiting disorder that commonly occurs due to viral etiology or unexplained *** pericarditis(mP)is a remarkably uncommon clinical entity that manifests as a complication during the acute or convalescent phase of meningococcal ***,its occurrence within the context of meningococcal septicemia has also been *** report a rare case of a previously healthy male patient who developed both acute pericarditis and uveitis as a presentation of meningococcal septicemia,with no characteristic skin rashes or meningeal signs.

关键词： acute Acute rare

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Large-scale error-tolerant programmable interferometer fabricated by femtosecond laser writing

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Photonics Research 2024年第3期12卷 I0028-I0040页

作者： ILYA KONDRATYEV VERONIKA IVANOVA SUREN FLDZHYAN ARTEm ARGENCHIEV NIKITA KOSTYUCHENKO SERGEY ZHURAVITSKII NIKOLAY SKRYABIN IVAN DYAKONOV mIKHAIL SAYGIN STANISLAV STRAUPE ALEXANDER KORNEEV SERGEI KULIK Quantum Technology Centre and Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia Russian Quantum Center Moscow 121205Russia Laboratory of Quantum Engineering of Light South Ural State UniversityChelyabinsk 454080Russia

We introduce a programmable eight-port interferometer with the recently proposed error-tolerant architecture capable of performing a broad class of *** interferometer has been fabricated with femtosecond laser writing,and it is the largest programmable interferometer of this kind to *** have demonstrated its advantageous error tolerance by showing an operation in a broad wavelength range from 920 to 980 nm,which is particularly relevant for quantum photonics due to efficient photon sources existing in this wavelength *** work highlights the importance of developing novel architectures of programmable photonics for information processing.

关键词： interferometer laser femtosecond

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Olefin Polymerization Behavior of Titanium(IV) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim F.magomedov Svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia V.Nelyubina Evgenii K.Golubev maria D.Evseeva Viktor G.Vasil'ev Galina G.Nikiforova mikhail I.Buzin Vyacheslav S.Bogdanov Boris m.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(mmAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(m_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHmWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(IV) (Co)polymerization Al/mg co-catalyst Ultra-high molecular weight polyethylene

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Characteristics of gut microbiota in anastomotic leakage patients in cold zones post-colorectal cancer surgery: A high-throughput sequencing and propensity-score matching study

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Frigid Zone medicine 2024年第2期4卷 120-128页

作者： Yuliuming Wang Yukun Zhang Yu Cao Weiyuan Zhang ming Liu Guiyu Wang Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200433China Department of Faculty Surgery No.2 I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of General Surgery The fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Objective:The study aimed to explore the association between gut microbiota and anastomotic leakage(AL)after surgery in colorectal cancer(CRC)patients from a frigid zone,based on high-throughput ***:A total of 98 CRC patients admitted to the Second Affiliated Hospital of Harbin medical university from July 2018 to February 2019,who met the inclusion criteria,were *** these,10 patients were diagnosed as *** propensity-score matching of baseline characteristics,10 patients from the anastomotic leakage group(AG)and 10 patients from the normal group(NG)were finally included in this *** samples were collected,and total DNA was extracted for high-throughput sequencing and bioinformatic ***:Alpha diversity analysis showed no significant difference between the two groups,while beta diversity analysis revealed significant differences in principal *** microbiota were classified as Proteobacteria at the phylum level(P=0.021).At the genus level,the abundances of Streptococcus(P=0.045),Citrobacter(P=0.008)and Klebsiella(P=0.002)were significantly different between the two *** analysis indicated that these genera contributed most to the differences between the ***:The characteristics of the gut microbiota in the AG and NG were significantly different,and these differences might be associated with AL in CRC patients from frigid zones.

关键词： colorectal cancer anastomotic leakage gut microbiota

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