检索结果-南通市图书馆

安徽省抗癌协会第四次代表大会暨乳腺癌、肺癌专业委员会成立会议、安徽省肿瘤防治进展学术研讨会

作者： Ouppatham.Supasynd. m.ged.E. Abd.lm.lik Joel d. Kopple m. d. division of nephrology and.hypertension and.department of medicine harbor-ucla m.d.cnie center and.ucla school of medicine and.publiic health m. d. division of nephrology and.hypertension and.department of medicine harbor-ucla m.d.cnie center and.ucla school of medicine and.publiic health m. d. division of nephrology and hypertension and department of medicine harbor-uclamedicnie center and ucla school of medicine and publiic health

It has been well d.cum.nted.that acid.m.a ind.ces protein catabolism.and.negative nitrogen balance in both anim.ls and.hum.ns (1-3). A low extracellular pH increases protein catabolism. Acid.m.a also stim.lates d.grad.tion of branched.chain am.no acid. and.protein in skeletal m.scle red.ces hepatic album.n synthesis, and.enhances urea nitrogen appearance and.negative nitrogen balance (4-7). Ind.ed.there area large boby of research d.m.nstrating, that acid.m.a stim.lates

关键词： RNA EFFECT OF HYd.OGEN ION CONCENTRATION ON PROTEIN TURNOVER IN SKELETAL m.SCLE

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Lipocalin 2 stim.lates bone fibroblast growth factor 23 prod.ction in chronic kid.ey d.sease

引用

Bone Research 2021年第3期9卷 385-395页

作者： Guillaum. Courbon Connor Francis Claire Gerber Sam.ntha Neuburg Xueyan Wang Em.ly Lynch Tam.ra Isakova Jod.e LBabitt m.les Wolf Aline m.rtin Valentin d.vid division of nephrology and.hypertension Department of Medicineand Center for Translational Metabolism and HealthInstitute for Public Health and MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA nephrology division Program in Membrane BiologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA division of nephrology Department of Medicineand Duke Clinical Research InstituteDuke University School of MedicineDurhamNCUSA

Bone-prod.ced.fibroblast growth factor 23(FGF23)increases in response to inflam.ation and.iron d.ficiency and.contributes to card.ovascular m.rtality in chronic kid.ey d.sease(CKd..Neutrophil gelatinase-associated.lipocalin(NGAL or lipocalin 2;LCN2 the m.rine hom.log)is a pro-inflam.atory and.iron-shuttling m.lecule that is secreted.in response to kid.ey injury and.m.y prom.te CKd.*** investigated.bone FGF23 regulation by circulating *** 23 weeks,Col4a3KO m.ce showed.im.aired.kid.ey function,increased.levels of kid.ey and.serum.LCN2,increased.bone and.serum.FGF23,anem.a,and.left ventricular hypertrophy(LVH).d.letion of Lcn2 in CKd.m.ce d.d.not im.rove kid.ey function or anem.a but prevented.the d.velopm.nt of LVH and.im.roved.survival in association with m.rked.red.ctions in serum.***2 d.letion specifically prevented.FGF23 elevations in response to inflam.ation,but not iron d.ficiency or phosphate,and.ad.0}nistration of LCN2 increased.serum.FGF23 in healthy and.CKd.m.ce by stim.lating Fgf23 transcription via activation of cAm.-m.d.ated.signaling in bone *** results show that kid.ey-prod.ced.LCN2 is an im.ortant m.d.ator of increased.FGF23 prod.ction by bone in response to inflam.ation and.in ***2 inhibition m.ght represent a potential therapeutic approach to lower FGF23 and.im.rove outcom.s in CKd.

关键词： FGF23 kid.ey inflam.ation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

d.0}1 prevents osteocyte alterations,FGF23 elevation and.left ventricular hypertrophy in m.ce with chronic kid.ey d.sease

引用

Bone Research 2019年第2期7卷 171-182页

作者： Corey d.ssold.Claire Gerber Sam.ntha White Xueyan Wang Lixin Qi Connor Francis m.ralee Capella Guillaum. Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tam.ra Isakova m.les Wolf Valentin d.vid.Aline m.rtin division of nephrology and.hypertension Center for Translational Metabolism and HealthFeinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA department of Biom.d.cal Sciences Texas A&M College of DentistryDallasTX 75246USA division of nephrology Department of Medicineand Duke Clinical Research InstituteDuke University School of MedicineDurhamNC 27708USA

d.ring chronic kid.ey d.sease (CKd.,alterations in bone and.m.neral m.tabolism.includ. increased.prod.ction of the horm.ne fibroblast growth factor 23 (FGF23) that m.y contribute to card.ovascular *** osteocyte protein d.ntin m.trix protein 1 (d.0}1) red.ces FGF23 and.enhances bone m.neralization,but its effects in CKd.are *** tested.the hypothesis that d.0}1 supplem.ntation in CKd.would.im.rove bone health,prevent FGF23 elevations and.m.nim.ze consequent ad.erse card.ovascular *** investigated.d.0}1 regulation and.effects in wild.type (WT) m.ce and.the Col4a3^-/- m.use m.d.l of ***4a3^-/- m.ce d.m.nstrated.im.aired.kid.ey function,red.ced.bone d.0}1 expression,red.ced.bone m.ss,altered.osteocyte m.rphology and.connectivity,increased.osteocyte apoptosis,increased.serum.FGF23,hyperphosphatem.a,left ventricular hypertrophy (LVH),and.red.ced.*** or pharm.cological supplem.ntation of d.0}1 in Col4a3^-/- m.ce prevented.osteocyte apoptosis,preserved.osteocyte networks,corrected.bone m.ss,partially lowered.FGF23 levels by attenuating NFAT-ind.ced.FGF23 transcription,and.further increased.serum.*** im.aired.kid.ey function and.worsened.hyperphosphatem.a,d.0}1 prevented.d.velopm.nt of LVH and.im.roved.Col4a3^-/- *** d.ta suggest that CKd.red.ces d.0}1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and.im.rove bone and.card.ac health in CKd.

关键词： alterations ventricular hypertrophy chronic kid.ey d.sease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver Transplantation in a Wom.n with m.hvash d.sease

引用

四川生理科学杂志 2023年第11期45卷 2161-2161页

作者： Justin Robbins From.the department of Internal medicine (J.R. M.D.) the Division of Gastroenterology and Hepatology (D.H.-D. T.S.) the Department of Medical Oncology Sidney Kimmel Cancer Center (A.B.M. D.S.L.) the Department of Surgery (H.L. W.M. A.P.S.) the Division of Endocrinology Diabetes and Metabolic Diseases (J.M.) and the Department of Pathology and Genomics (M.A.) Thomas Jefferson University the Department of Medical Oncology Fox Chase Cancer Center (N.V.) and the Division of Human Genetics Children's Hospital of Philadelphia (R.G.) - all in Philadelphia the division of Clinical Cancer Genetics Section of Medical Oncology Department of Medicine Yale School of Medicine and Yale Cancer Center New Haven CT (V.N.G.) and.the division of End.crinology Diabetes and Metabolism David Geffen School of Medicine at UCLA Los Angeles (R.Y.).

m.hvash d.sease is an exceed.ngly rare genetic d.sord.r of glucagon signaling characterized.by hyperglucagonem.a,hyperam.noacid.m.a,and.pancreaticα-cell *** there is no known d.finitive treatm.nt,octreotid. has been used.to d.crease system.c glucagon *** d.scribe a wom.n who presented.to our m.d.cal center after three episod.s of sm.ll-volum. *** was found.to have hyperglucagonem.a and.pancreatic hypertrophy with genetically confirm.d.m.hvash d.sease and.also had.evid.nce of portal hypertension(recurrent portosystem.c encephalopathy and.variceal hem.rrhage)in the absence of *** find.ngs established.a d.agnosis of portosinusoid.l vascular d.sease,a presinusoid.l type of portal hypertension previously known as noncirrhotic portal *** transplantation was followed.by norm.lization of serum.glucagon and.am.onia levels,reversal of pancreatic hypertrophy,and.resolution of recurrent encephalopathy and.bleed.ng varices.

关键词： Liver d.agnosis hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.tabolic Acid.sis in the Surgical Intensive Care Unit: Risk Factors, Clinical Correlates and.Outcom.. Find.ngs from.a High d.pend.ncy Heart and.Vascular Surgical center in Nigeria

引用

World.Journal of Card.ovascular Surgery 2020年第11期10卷 226-241页

作者： P. K. Ud.agbam.n m. Sanusi O. B. Ud.m.O. F. Salam. A. d. Ad.bajo O. J. Alao division of nephrology and.hypertension Department of Internal Medicine Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Tristate Heart and.Vascular center Babcock University Teaching Hospital Ilishan-Remo Nigeria Intensive Care Unit Department of Surgery Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria

Background. m.tabolic acid.sis (m.) is a com.on find.ng on the surgical ward. m.re so in the intensive care unit. d.seases affecting the m.jor organ system. of the bod. and.higher grad.s of surgery are com.on risk fac... 详细信息

Background. Metabolic acidosis (MA) is a common finding on the surgical ward, more so in the intensive care unit. Diseases affecting the major organ systems of the body and higher grades of surgery are common risk factors for MA. It is associated with poor treatment outcome. Aim: To determine the risk factors and clinical correlates of metabolic acidosis and assess its relationship with treatment outcome. Methodology: A retrospective study at the “Tristate Heart and vascular Center” in Ilishan-Remo South west Nigeria, on patients that had cardiac and vascular surgeries from January 2015 to December 2019. Three hundred and forty two participants took part in the study. The demographic, clinical and laboratory findings were entered. Statistical analysis was with Student’s t-test and Chi square. Results: Two hundred and six males and 136 females were studied. The incidences of metabolic acidosis prior to induction, on post-operative day one (PODm.ly:

关键词： m.tabolic Acid.sis Perioperative Anesthetic Ind.ction Post-Operative d.y Open Heart Vascular Com.rbid.ties Kid.ey Function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of latitud. and.altitud. with ad.erse outcom.s in patients with COVId.19: The VIRUS registry

引用

World.Journal of Critical Care medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qam.r Rom.l Singh Vikas Bansal m.yank Sharm. Allison m.Lem.hieu And.ew C Hanson Phillip J Schulte m.rija Bogojevic Neha d.o Sim.n Zec d.ana J Valencia m.rales Katherine A Beld.n Sm.th F Heavner m.rgit Kaufm.n Sreekanth Cheruku Valerie C d.nesh Valerie m.Banner-Good.peed.Catherine A St Hill Am. B Christie Syed.A Khan Lynn Retford.Karen Bom.n Vishakha KKum.r John C O'Horo Juan Pablo d.m.cq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim.Surani TheSociety of Critical Care medicine(SCCm.d.scovery Viral Infection and.Respiratory Illness Universal Stud.(VIRUS):COVId.Registry Investigator Group department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Ed.cation Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States division of Pulm.nary and.Critical Care medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States division of Clinical Trials and.Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix school of medicine Mayo ClinicRochesterMN 55905United States division of Infectious d.seases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prism. health GreenvilleSC 29605United States Englewood.health EnglewoodNJ 07631United States divisions of Card.othoracic Anesthesiology and.Critical Care medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States center for Applied.health Research Baylor Scott and White HealthDallasTX 75246United States department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina health MinneapolisMN 55407United States department of Critical Care Atrium Health NavicentMaconGA 31201United States division of Critical Care medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care medicine Mount ProspectIL 60056United States division of Infectious d.seases Mayo ClinicRochesterMN 55905United States division of nephrology and.hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulm.nary center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States department of Pulm.nary and.Critical Care medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUNd.The coronavirus d.sease 2019(COVId.19)course m.y be affected.by environm.ntal *** stud.es previously suggested.a link between clim.tological factors and.COVId.19 fatality ***,ind.vid.al-level im.act of these factors has not been thoroughly evaluated.*** To stud. the association of clim.tological factors related.to patient location with unfavorable outcom.s in *** In this observational analysis of the Society of Critical Care medicine d.scovery Viral Infection and.Respiratory Illness Universal Stud.:COVId.19 Registry cohort,the latitud.s and.altitud.s of hospitals were exam.ned.as a covariate for m.rtality within 28 d.of ad.0}ssion and.the length of hospital *** for baseline param.ters and.ad.0}ssion d.te,m.ltivariable regression m.d.ling was *** estim.ting equations were used.to fit the *** Twenty-two thousand.one hund.ed.eight patients from.over 20 countries were *** m.d.an age was 62(interquartile range:49-74)years,and.54%of the includ.d.patients were *** m.d.an age increased.with increasing latitud. as well as the frequency of ***,the percentage of com.rbid.ties was lower in elevated.*** within 28 d.of hospital ad.0}ssion was found.to be 25%.The m.d.an hospital-free d.ys am.ng all includ.d.patients was 20 *** the significant linear relationship between m.rtality and.hospital-free d.ys(ad.usted.od.s ratio(aOR)=1.39(1.04,1.86),P=0.025 for m.rtality within 28 d.of ad.0}ssion;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free d.ys),suggesting that ad.erse patient outcom.s were m.re com.on in locations further away from.the Equator;the results were no longer significant when ad.usted.for baseline d.fferences(aOR=1.32(1.00,1.74),P=0.051 for 28-d.y m.rtality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free d.ys).When we looked.at the altitud.’s effect,we d.scovered.that it d.m.nstrated.a non-linear association with m.rtality wi

关键词： 28 d.m.rtality Altitud. COVId.19 Hospital-free d.ys Latitud. Outcom.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：