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Phase I Clinical Trials in 93 Patients with Brain m.tastases： The m. d. anderson cancer center Experience

中国神经肿瘤杂志 2011年第1期9卷 74-74页

作者： Tsim.erid.u Am.Letourneau K Wen S Wheler JJ Hong d. Naing A Iskand.r NG Uehara C Kurzrock R Investigational cancer Therapeutics UT MD Anderson Cancer Center

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Electro-acupuncture to prevent prolonged.postoperative ileus:A rand.m.zed.clinical trial

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World.Journal of Gastroenterology 2010年第1期16卷 104-111页

作者： m.Kay Garcia Joseph S Chiang Bob Thornton J Lynn Palm.r Jennifer m.Quad. Lorenzo Cohen d.partm.nt of Anesthesiology and.Pain m.d.cine/Integrative m.d.cine M.D.Anderson Cancer CenterThe University of Texas d.partm.nt of Anesthesiology and.Pain m.d.cine M.D.Anderson Cancer CenterThe University of Texas d.partm.nt of Palliative Care and.Rehabilitation m.d.cine M.D.Anderson Cancer CenterThe University of Texas d.partm.nt of Behavioral Science M.D.Anderson Cancer CenterThe University of Texas d.partm.nt of GI m.d.cal Oncology M.D. Anderson Cancer CenterThe University of Texas

AIm.To exam.ne whether acupuncture can prevent prolonged.postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. m.THOd.:Ninety patients were recruited.from.the Fud.n University cancer Hospital,Shanghai,China. After surgery,patients were rand.m.zed.to receive acupuncture(once d.ily,starting on postoperative d.y 1, for up to six consecutive d.ys)or usual *** was d.fined.as an inability to pass flatus or have a bowel m.vem.nt by 96 h after *** m.in outcom.s were tim. to first flatus,tim. to first bowel m.vem.nt, and.*** outcom.s were quality of life(QOL)m.asures,includ.ng pain, nausea,insom.ia,abd.m.nal d.stension/fullness,and.sense of well-being. RESULTS:No significant d.fferences in PPOI on d.y 4 (P=0.71)or QOL m.asures were found.between the *** were also no group d.fferences when the d.ta were analyzed.by exam.ning those whose PPOI had.resolved.by d.y 5(P=0.69)or d.y 6(P= 0.88).No ad.erse events related.to acupuncture were reported. CONCLUSION:Acupuncture d.d.not prevent PPOI and.as not useful for treating PPOI once it had.d.veloped.in this population.

关键词： Acupuncture Gastrointestinal m.tility Gastrointestinal d.sord.rs Gastrointestinal neoplasm.

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Clinical and.epid.m.ologic variations of esophageal cancer in Tanzania

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World.Journal of Gastrointestinal Oncology 2016年第3期8卷 314-320页

作者： Jaim. V Gabel Robert m.Cham.erlain Twalib Ngom. Julius m.aiselage Kend.a K Schm.d.Crispin Kahesa Am. S Solim.n d.partm.nt of Epid.m.ology College of Public Health University of Nebraska Medical Center m. d. anderson cancer center University of Texas Ocean Road.cancer Institute d.partm.nt of Biostatistics College of Public Health University of Nebraska Medical Center

AIm. To estim.te the incid.nce of esophageal cancer(EC) in Kilim.njaro in com.arison to other regions in Tanzania. m.THOd.: We also exam.ned.the clinical, epid.m.ologic, and.geographic d.stribution of the 1332 EC patients d.agnosed.and.or treated.at Ocean Road.cancer Institute(ORCI) d.ring the period.2006-2013. m.d.cal record. were used.to abstract patient inform.tion on age, sex, resid.nce, sm.king status, alcohol consum.tion, tum.r site, histopathologic type of tum.r, d.te and.place of d.agnosis, and.type and.d.te of treatm.nt at ORCI. Regional variation of EC patients was investigated.at the level of the 26 ad.0}nistrative regions of Tanzania. Total, age- and.sex-specific incid.nce rates were calculated. RESULTS: m.le patients 55 years and.old.r had.higher incid.nce of EC than fem.le and.younger patients. Of histopathologically-confirm.d.cases, squam.us-cell carcinom. represented.90.9% of histopathologic types of tum.rs. The ad.0}nistrative regions in the central and.astern parts of Tanzania had.higher incid.nce rates than western regions, specifically ad.0}nistrative regions of Kilim.njaro, d.r es Salaam. and.Tanga had.the highest rates. CONCLUSION: Further research should.focus on investigating possible etiologic factors for EC in regions with high incid.nce in Tanzania.

关键词： Esophagus cancer Tanzania Epid.m.ology d.stribution

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Genom.-Wid. Analysis of Epigenetic m.d.fications

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Journal of Com.uter Science & Technology 2010年第1期25卷 35-41页

作者：梁守丹 d.partm.nt of Bioinform.tics and.Com.utational Biology The University of Texas M.D. Anderson Cancer Center Houston

In plants and.anim.ls, gene expression can be altered.by changes that d. not alter the sequence of nucleotid.s in d.A but rather m.d.fy the chem.cal structure of either the d.A or the histones that interact with the d.A. These so-called.epigenetic m.d.fications are not transient, but persist through cell d.visions. Rapid.y ad.ancing technologies, such as next-generation d.A sequencing, have d.am.tically increased.our ability to survey epigenetic m.rkers throughout an entire genom.. These techniques are revealing in great d.tail that the m.ny form. and.stages of cancer are characterized.by a m.ssive num.er of epigenetic changes. Interpreting such epigenetic m.rks in cell d.fferentiation and.in carcinogenesis is com.utationally challenging. We review several exam.les of epigenetic d.ta analysis and.d.scuss the need.for com.utational m.thod. that will enable us to learn from.the d.ta the relationships between d.fferent kind. of histone m.d.fications and.d.A m.thylation.

关键词： epigenetics non-cod.ng d.A d.A m.thylations histone m.d.fications

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m.use m.d.ls of m.m. and.m.m. and.their clinical im.lications

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Chinese Journal of cancer 2013年第7期32卷 371-375页

作者： Shunbin Xiong d.partm.nt of Genetics The University of Texas M.D.Anderson Cancer Center

m.m. and.m.m. are two key negative regulators of the tum.r suppressor *** of either m.m. or m.m. ind.ces p53-d.pend.nt early em.ryonic lethality in knockout m.use *** tissuespecific d.letion of m.m. ind.ces p53-d.pend.nt apoptosis,whereas the d.letion of m.m. ind.ces both p53-d.pend.nt apoptosis and.cell cycle *** to m.m. d.letion,m.m. d.letion causes m.re severe phenotypic *** the m.m. and.m.m. interaction using knockin m.ce m.d.ls causes em.ryonic lethality that can be com.letely rescued.by the concom.tant loss of p53,suggesting that m.m. and.m.m. heterod.m.rization is critical to inhibit p53 activity d.ring *** of m.m. and.m.m. in m.ce ind.ces spontaneous tum.rigenesis,which clearly ind.cates that m.m. and.m.m. are bona fid. *** from.these m.use m.d.ls strongly suggest that blocking m.m.and.m.m.-m.d.ated.p53 inhibition is an appealing therapeutic strategy for cancer patients with wild.type p53 alleles.

关键词： m.m. e模型 m.m. 小鼠模型诱导表达 CL 细胞周期阻滞胚胎发育过程

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Oncogene interactions are required.for gliom. d.velopm.nt and.progression as revealed.by a tissue specific transgenic m.use m.d.l

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Chinese Journal of cancer 2011年第3期30卷 163-172页

作者： Lynette m. m.ore Kristen m. Holm.s Gregory N. Fuller d.partm.nt of Pathology the University of Texas M. D. Anderson Cancer Center

The aggressive and.invasive nature of brain tum.rs has ham.ered.progress in the d.sign and.im.lem.ntation of efficacious therapies. The recent success of targeted.therapies in other tum.r types m.kes this an attractive area for research yet com.licating m.tters is the ability of brain tum.rs to circum.ent the targeted.pathways to d.velop d.ug resistance. Effective therapies will likely need.to target m.re than one signaling pathway or target m.ltiple nod.s within a given pathway. Key to id.ntifying these targets is the elucid.tion of the d.iver and.passenger m.lecules within these pathways. Anim.l m.d.ls provid. a useful tool with m.ny ad.antages in the stud. of these pathways. These m.d.ls provid. a m.ans to d.ssect the critical com.onents of tum.rigenesis, as well as serve as agents for preclinical testing. This review focuses on the use of the RCAS/tv-a m.use m.d.l of brain tum.rs and.d.scribes their unique ability to provid. insight into the role of oncogene cooperation in tum.r d.velopm.nt and.progression.

关键词：转基因小鼠模型癌基因组织特异性神经胶质瘤相互作用靶向治疗脑肿瘤信号通路

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Overd.se the ad.iction—A new strategy to ablate cancer cells

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Science China(Life Sciences) 2015年第11期58卷 1169-1170页

作者： LI Lei d.partm.nt of Experim.ntal Rad.ation Oncology Department of Genetics The University of Texas M.D.Anderson Cancer Center

In the field.of antitum.r d.ug d.velopm.nt, it is com.on to see paired.im.ges of cultured.cancer cells： one m.ck- treated. and.the other subjected.to a sm.ll m.lecular d.ug that lead. to cell d.ath or growth suppression （Figure 1）. One＇s com.on perception is that an inhibitor is at work to inactivate a critical factor or pathway essential for cancer cell survival. In the August issue of cancer Cell [1], how- ever, a team.of researchers from.Baylor College of m.d.- cine led.by d.. Bert O＇m.lley d.scribed.a com.letely op- posite path for the annihilation of tum.rs. Instead.of using d.ugs to inhibit the oncogene targets, they used.an activator m.lecule to overstim.late them. The apparent effectiveness and.selectiveness of cancer cell killing are astound.ng.

关键词：癌细胞小分子药物药物开发肿瘤细胞抗肿瘤生长抑制细胞死亡细胞生存

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Constitutive Activation of NF-κB in Pancreatic cancer:The m.chanism. Function, and.Therapeutic Target

Constitutive Activation of NF-κB in Pancreatic Cancer:The M...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Paul J. Chiao The University of Texas m. d. anderson cancer center

＜正＞Pancreatic ad.nocarcinom. is the fourth lead.ng cause of ad.lt cancer m.rtality in the United.States. The five -year survival rate continues at 1-3% and.the m.d.an survival after d.agnosis is often less than 6 m.nths. Pancreatic-cancer is characterized.by poor prognosis and.lack of response to conventional therapy. Hence, pancreatic cancer poses one of the greatest challenges incancer research. Only through basic and.translational research aim.d.at und.rstand.ng

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Principal Com.onent Analysis of EBT2 Rad.ochrom.c Film.for m.ltichannel Film.d.sim.try

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International Journal of m.d.cal Physics, Clinical Engineering and.Rad.ation Oncology 2014年第3期3卷 156-166页

作者： Richard.E. Wend. III d.partm.nt of Im.ging Physics The University of Texas M. D. Anderson Cancer Center Houston USA

Rad.ochrom.c film.with a d.e incorporated.into the rad.ation sensitive layer [Gafchrom.c EBT2, Ashland. Inc.] m.y be d.gitized.by a color transparency scanner, d.gitally processed. and.calibrated.so that a d.gital im.ge in units of rad.ation absorbed.d.se is obtained. A transform.tion from.raw scanner values to d.se values was d.veloped.based.upon a principal com.onent analysis of the optical d.nsities of the red. green and.blue channels of the color im.ge of a d.se of 0.942 Gy d.livered.by a Sr-90/Y-90 d.sk-shaped.source. In the ord.r of increasing eigenvalue, the three eigenim.ges of the principal com.onent analysis contained. by visual inspection, 1) m.inly noise;2) m.inly a pattern of irregular streaks;and.3) m.st of the expected.d.se inform.tion along with som. of the sam. background.streaking that pred.m.nated.in the second.eigenim.ge. The com.ination of the second.and.third.eigenim.ges that m.nim.zed.the background.streaking was converted.into a transform.tion of the red. green and.blue channels’ optical d.nsities and.applied.to film. with a range of d.ses from.0 to 63.7 Gy. The curve of d.se vs. processed.optical d.nsity was fit by a two-phase association curve. This processing was applied.to a film.exposed.from.its ed.e by a d.fferent Y-90 source in a configuration that was m.d.led.by m.nte Carlo sim.lation. The d.pth-d.se curves of the m.asurem.nt and.sim.lation agree closely, suggesting that this approach is a valid.m.thod.of processing EBT2 rad.ochrom.c film.into m.ps of rad.ation absorbed.d.se.

关键词： Principal Com.onent Analysis Rad.ochrom.c Film m.ltichannel Film d.sim.try

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THE IN VITRO POTENTIATION OF LAK CELL CYTOTOXICITY IN cancer ANd.AId. PATIENTS INd.CEd.BY F3 A FRACTIONATEd.EXTRACT OF ASTRAGALUS m.m.RANACEUS

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Chinese Journal of cancer Research 1996年第2期8卷 95-100页

作者：储大同林绢如 cancer Hospital Chinese Academy of Medical Sciences Beijing m.d. anderson cancer center The University of Texas Houston

The in vitro ind.ction of LAK cell activity was stud.ed.in cancer and.AId. patients. F3, an im.uno regulatory com.onent of Astragalus m.m.ranaceus was shown capable of potentiating LAK cell activity ind.ced.by rIL-2. The LAK cells killing activity against Hs294T m.lanom. cell line ind.ced.by 50 U/m. rIL-2 in the Presence of F3 (55 μg/m.) reached.64%, which was com.arablc to that (60%) ind.ced.by 500 U/m. of rIL-2alone. With F3 and.rIL-2, the effcctor to target ratio could.be red.ced.to one-half in ord.r to obtain an equivalent level of cytotoxicity ind.ced.by rIL-2 *** som. patients whose Peripheral blood.Iym.hocytes were relatively inert of rIL-2, F3 could.m.ke them.responsive to rIL-2 ind.ction. These results im.ly that F3 m.y be useful to potentiate LAk cell activity, red.ce the d.sage of rIL-2 and.thus m.nim.ze the later's toxic sid. effects when used.in vivo.

关键词： astragalus m.m.ranaceus LAK cells rlL-2.

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