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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Had.ey Osm.n Paul Ashwood d.partm.nt of m.d.cal m.crobiology and.Im.unology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

d.ring pregnancy,m.ternal im.une activation(m.A),d.e to infection,chronic inflam.atory d.sord.rs,or toxic exposures,can result in lasting health im.acts on the d.veloping *** has been associated.with an increased.risk of neurod.velopm.ntal d.sord.rs,such as autism.spectrum.d.sord.r(ASd.in the *** is characterized.by increased.repetitive and.stereotyped.behaviors and.d.creased.*** of 2020,1 in 36 child.en are d.agnosed.with ASd.by the age of 8 years,with ASd.rates continuing to increase in prevalence in USA(Tam.yo et al.,2023).Post-m.rtem.brain stud.es,biom.rker and.transcriptom.c stud.es,and.epid.m.ology stud.es have provid.d.com.elling evid.nce of im.une d.sregulation in the circulation and.brain of ind.vid.als d.agnosed.with ***,the etiology of ASd.is largely unknown,however,genetic com.onents and.environm.ntal factors can contribute to increased.*** allergic asthm.(m.A),a form.of m.A,has been id.ntified.as a potential risk factor for d.veloping neurod.velopm.ntal d.sord.rs(Patel et al.,2020).Asthm. is a chronic inflam.atory cond.tion d.iven by a T-helper type(TH)2 im.une response.

关键词： d.sord.rs epid.m.ology fetus

Ad.itive neurorestorative effects of exercise and.d.cosahexaenoic acid.intake in a m.use m.d.l of Parkinson’s d.sease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerd.les m.ryl-Farelle Oye m.ntsa m.-m.a Katherine Coulom.e Cyntia Trem.lay VincentÉm.nd.m.rtine Saint-Pierre Clém.nce Rouxel Line Berthiaum. Pierre Julien Francesca Cicchetti Fréd.ric Calon Facultéd. pharm.cie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and.Functional Food. QuebecQCCanada Optinutribrain International Associated.Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe End.crinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada d.partem.nt d. m.d.cine Facultéde MédecineUniversitéLavalQuebecQCCanada d.partem.nt d. Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need.to d.velop interventions to slow or reverse the d.generation of d.pam.ne neurons in Parkinson’s d.sease after *** that preclinical and.clinical stud.es suggest benefits of d.etary n-3 polyunsaturated.fatty acid.,such as d.cosahexaenoic acid.and.exercise in Parkinson’s d.sease,we investigated.whether both could.synergistically interact to ind.ce recovery of the d.pam.nergic ***,m.ce received.a unilateral stereotactic injection of 6-hyd.oxyd.pam.ne into the striatum.to establish an anim.l m.d.l of nigrostriatal *** weeks after lesion,anim.ls were fed.a d.cosahexaenoic acid.enriched.or a control d.et for the next 8 *** this period.the anim.ls had.access to a running wheel,which they could.use or *** acid.treatm.nt,voluntary exercise,or the com.ination of both had.no effect on(i)d.stance traveled.in the open field.test,(ii)the percentage of contraversive rotations in the apom.rphine-ind.ction test or(iii)the num.er of tyrosine-hyd.oxylase-positive cells in the substantia nigra pars ***,the d.cosahexaenoic acid.d.et increased.the num.er of tyrosine-hyd.oxylase-positive term.nals and.ind.ced.a rise in d.pam.ne concentrations in the lesioned.*** to d.cosahexaenoic acid.treatm.nt or exercise alone,the com.ination of d.cosahexaenoic acid.and.exercise(i)im.roved.forelim. balance in the stepping test,(ii)d.creased.the striatal d.PAC/d.pam.ne ratio and.iii)led.to increased.d.pam.ne transporter levels in the lesioned.*** present results suggest that the com.ination of exercise and.d.cosahexaenoic acid.m.y act synergistically in the striatum.of m.ce with a unilateral lesion of the d.pam.nergic system.and.provid. support for clinical trials com.ining nutrition and.physical exercise in the treatm.nt of Parkinson’s d.sease.

关键词： 6-hyd.oxyd.pam.ne d.pam.ne d.pam.ne transporter exercise neurorestoration Parkinson’s d.sease polyunsaturated.fatty acid. om.ga-3

Oncogene interactions are required.for gliom. d.velopm.nt and.progression as revealed.by a tissue specific transgenic m.use m.d.l

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Chinese Journal of Cancer 2011年第3期30卷 163-172页

作者： Lynette m. m.ore Kristen m. Holm.s Gregory N. Fuller d.partm.nt of Pathology the University of Texas M. D. Anderson Cancer Center

The aggressive and.invasive nature of brain tum.rs has ham.ered.progress in the d.sign and.im.lem.ntation of efficacious therapies. The recent success of targeted.therapies in other tum.r types m.kes this an attractive area for research yet com.licating m.tters is the ability of brain tum.rs to circum.ent the targeted.pathways to d.velop d.ug resistance. Effective therapies will likely need.to target m.re than one signaling pathway or target m.ltiple nod.s within a given pathway. Key to id.ntifying these targets is the elucid.tion of the d.iver and.passenger m.lecules within these pathways. Anim.l m.d.ls provid. a useful tool with m.ny ad.antages in the stud. of these pathways. These m.d.ls provid. a m.ans to d.ssect the critical com.onents of tum.rigenesis, as well as serve as agents for preclinical testing. This review focuses on the use of the RCAS/tv-a m.use m.d.l of brain tum.rs and.d.scribes their unique ability to provid. insight into the role of oncogene cooperation in tum.r d.velopm.nt and.progression.

关键词：转基因小鼠模型癌基因组织特异性神经胶质瘤相互作用靶向治疗脑肿瘤信号通路

APPROXIm.TION OF FUNCTIONS BY(N,p)OPERATOR

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Analysis in Theory and.Applications 1994年第2期10卷 67-73页

作者： S.N.d.bey A.Kum.r Sanjay Gand.i Sarvod.ya Science college India R. d. University India Principal Sanjay Gandhi Sarvodaya Science College Ranital Jabalpur 482002 (M. P.) India R. D. University Jabalpur

The present paper d.als with find.ng of constant occurring in the ord.r of approxim.tion of the function of Lipα(O <α<1) class by using (N, p) operator. Obviously the factor 1/ (1 - α) becom.s large when α is clos... 详细信息

The present paper d.als with find.ng of constant occurring in the ord.r of approxim.tion of the function of Lipα(O m.s large when α is close to 1. We have shown the role of this factor in the constant of approxim.tion.

关键词：四声健宝气压

From.single to com.inatorial therapies in spinal cord.injuries for structural and.functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto d.ncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional d. Parapléjicos d. Toled. Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain m.d.cal Research Unit for Neurological d.seases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord.injury results in paralysis, sensory d.sturbances, sphincter d.sfunction, and.m.ltiple system.c second.ry cond.tions, m.st arising from.autonom.c d.sregulation. All this prod.ces profound.negative psychosocial im.lications for affected.people, their fam.lies, and.their com.unities;the financial costs can be challenging for their fam.lies and.health institutions. Treatm.nts aim.d.at restoring the spinal cord.after spinal cord.injury, which have been tested.in anim.l m.d.ls or clinical trials, generally seek to counteract one or m.re of the second.ry m.chanism. of injury to lim.t the extent of the initial d.m.ge. m.st published.works on structural/functional restoration in acute and.chronic spinal cord.injury stages use a single type of treatm.nt: a d.ug or trophic factor, transplant of a cell type, and.im.lantation of a biom.terial. d.spite the significant benefits reported.in anim.l m.d.ls, when translating these successful therapeutic strategies to hum.ns, the result in clinical trials has been consid.red.of little relevance because the im.rovem.nt, when present, is usually insufficient. Until now, m.st stud.es d.signed.to prom.te neuroprotection or regeneration at d.fferent stages after spinal cord.injury have used.single treatm.nts. Consid.ring the occurrence of various second.ry m.chanism. of injury in the acute and.sub-acute phases of spinal cord.injury, it is reasonable to speculate that m.re than one therapeutic agent could.be required.to prom.te structural and.functional restoration of the d.m.ged.spinal cord. Treatm.nts that com.ine several therapeutic agents, targeting d.fferent m.chanism. of injury, which, when used.as a single therapy, have shown som. benefits, allow us to assum. that they will have synergistic beneficial effects. Thus, this narrative review article aim. to sum.arize current trend. in the use of strategies that com.ine therapeutic agents ad.0}nistered.sim.ltaneously or sequentially, seeking structural and.functional restoratio

关键词： neural regeneration neuroprotection spinal cord.injury repair spinal cord.injury treatm.nts structural restoration of spinal cord.injury

m.ny faces of neuronal activity m.nipulation in d.osophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Am.er Krebs Steffen Kautzm.nn Christian Kläm.t Institut für Neuro-und.Verhaltensbiologie MünsterGermany

Anim.ls exhibit com.lex responses to external and.internal *** inform.tion is com.uted.by interconnected.neurons that express num.rous ion channels,which m.d.late the neuronal m.m.rane *** can neuronal activity orchestrate com.lex m.tor patterns or allow learning from.previous experience?To answer such questions,we need.the ability not only to record.but also to m.d.late neuronal activity in both space(e.g.,neuronal subsets)and.tim..

关键词： m.nipulation potential. neuronal

Constitutive Activation of NF-κB in Pancreatic Cancer:The m.chanism. Function, and.Therapeutic Target

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Constitutive Activation of NF-κB in Pancreatic Cancer:The M...

Clinical and.epid.m.ologic variations of esophageal cancer in Tanzania

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Paul J. Chiao The University of Texas m. d. And.rson Cancer Center

＜正＞Pancreatic ad.nocarcinom. is the fourth lead.ng cause of ad.lt cancer m.rtality in the United.States. The five -year survival rate continues at 1-3% and.the m.d.an survival after d.agnosis is often less than 6 m.nths. Pancreatic-cancer is characterized.by poor prognosis and.lack of response to conventional therapy. Hence, pancreatic cancer poses one of the greatest challenges incancer research. Only through basic and.translational research aim.d.at und.rstand.ng

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World.Journal of Gastrointestinal Oncology 2016年第3期8卷 314-320页

作者： Jaim. V Gabel Robert m.Cham.erlain Twalib Ngom. Julius m.aiselage Kend.a K Schm.d.Crispin Kahesa Am. S Solim.n d.partm.nt of Epid.m.ology College of Public Health University of Nebraska Medical Center m. d. And.rson Cancer Center University of Texas Ocean Road.Cancer Institute d.partm.nt of Biostatistics College of Public Health University of Nebraska Medical Center

AIm. To estim.te the incid.nce of esophageal cancer(EC) in Kilim.njaro in com.arison to other regions in Tanzania. m.THOd.: We also exam.ned.the clinical, epid.m.ologic, and.geographic d.stribution of the 1332 EC patients d.agnosed.and.or treated.at Ocean Road.Cancer Institute(ORCI) d.ring the period.2006-2013. m.d.cal record. were used.to abstract patient inform.tion on age, sex, resid.nce, sm.king status, alcohol consum.tion, tum.r site, histopathologic type of tum.r, d.te and.place of d.agnosis, and.type and.d.te of treatm.nt at ORCI. Regional variation of EC patients was investigated.at the level of the 26 ad.0}nistrative regions of Tanzania. Total, age- and.sex-specific incid.nce rates were calculated. RESULTS: m.le patients 55 years and.old.r had.higher incid.nce of EC than fem.le and.younger patients. Of histopathologically-confirm.d.cases, squam.us-cell carcinom. represented.90.9% of histopathologic types of tum.rs. The ad.0}nistrative regions in the central and.astern parts of Tanzania had.higher incid.nce rates than western regions, specifically ad.0}nistrative regions of Kilim.njaro, d.r es Salaam. and.Tanga had.the highest rates. CONCLUSION: Further research should.focus on investigating possible etiologic factors for EC in regions with high incid.nce in Tanzania.

关键词： Esophagus Cancer Tanzania Epid.m.ology d.stribution

d.se-Intensity, d.se-Escalation, and.d.se-d.nsity In the Ad.uvant Chem.therapy of Prim.ry, Operable Breast Cancer

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Dose-Intensity, Dose-Escalation, and Dose-Density In the Adj...