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Successful treatment with hysteroscopy for infertility due to isthmocele and hydrometra secondary to cesarean section: A case report

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World Journal of Clinical Cases 2019年第6期7卷 753-758页

作者： Luis Pablo López Rivero miguel Jaimes Felipe Camargo Esther López-Bayghen Instituto de Infertilidad y Genética méxico sc Departamento de Toxicología Centro de Investigación de Estudios

BACKGROUND An isthmocele is a scar defect in the uterine wall due to a cesarean section. Its prevalence is unknown,but it has been associated with secondary ***,we present a case where the patient suffered from an isthmocele that was associated with persistent hydrometra,which developed during in vitro *** SUmmARY The patient underwent hysteroscopic surgery,which successfully resolved the isthmocele as well as the hydrometra. Afterward,two high-quality,euploid embryos,determined by morphological assessment and pre-implantation genetic diagnostic testing,were transferred. This resulted in uterine pregnancy,as determined byserum β-human chorionic gonadotropin levels on day 14(180 m U/mL) and ultrasound-confirmed presence of a gestational sac with a positive embryocardia at week 6. The pregnancy reached 36 wk without any complications,and the product was born in good health. We report a successful isthmocele treatment in a patient with secondary infertility,in which the isthmocele was the cause of persistent *** Hydrometra caused by secondary cesarean is an infertility factor,which can be corrected by hysteroscopy plus ablation of the isthmocele.

关键词： In vitro fertilization Isthmocele Hydrometra Case report

Soil loss and displacement by heavy equipment in forest road subgrading projects

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International Journal of Sediment Research 2009年第2期24卷 227-235页

作者： Aidin PARSAKHOO Seyed Ataollah HOSSEINI majid LOTFALIAN Hamid JALILVAND m.sc. Student of Forest Engineering Faculty of Natural ResourcesMazandaran University Department of Forestry Faculty of Natural ResourcesMazandaran University

Forest soil is an important component of the natural environment,and is a primary medium for many biological activities. In this study,soil loss and displacement by excavator and bulldozer(heavy equipments) were measured on cut and fills slopes of forest roads located in mazandaran province,Iran. The volumes of soil losses were estimated by prismoidal analyses of cut and fill slopes deformation between two time treatments(under subgrading and two years later) in slope classes of 30-50% and 50-70%. Weights of soil losses were calculated by multiplying the volumes of soil losses(cm3) to the general bulk density(1.3g/cm3) . Soil displaced area by heavy equipment was evaluated according to earth working width. Results indicated that heavy equipment has significant effect on deformation of cut slope gradient and fill slope length(pmed in different slope classes. The average soil loss by excavator and bulldozer were 160.35 t/ha·yr and 429.09 t/ha·yr,respectively. moreover,the soil displaced area during the subgrading process by bulldozer was greater than excavator in both two slope classes(pment in forest roads can be reduced by applying powerful excavators in subgrading project,especially in steep terrains.

关键词： Soil losses Soil displacement Heavy equipment Forest road Subgrading

mechanical Properties of a Wood Flour-PET Composite Through Computational Homogenisation

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Computers, materials & Continua 2021年第6期67卷 4061-4079页

作者： P.Pesante K.Saavedra G.Pincheira m.sc.in mechanical Engineering Faculty of EngineeringUniversidad de Talca CampusCuricóChile Department of Industrial Technologies Faculty of EngineeringUniversidad de Talca CampusCuricóChile

This work proposes to study the effective elastic properties(EEP)of a wood-plastic composite(WPC)made from polyethylene terephthalate(PET)and Chilean Radiate pine’s wood our,using nite element simulations of a representative volume element(RVE)with periodic boundary *** are validated through a static 3-point bending test,with specimens obtained by extruding and *** effect of different weight fractions,space orientations and sizes of particles are here *** predictions are empirically conrmed in the sense that composites with more wood our content and bigger size,have higher elastic ***,these results are very sensitive to the orientation of *** and Reuss mean-eld homogenisation approaches are also given as upper and lower *** tests evidence that exural strengths and ultimate tensile elongations decrease respect to 100%PET,but these properties can be enhanced considering particle-size distributions instead of a xed size of wood our.

关键词： Wood-plastic composite periodic homogenisation mechanical properties experimental validation

Surgical and nutritional interventions for endometrial receptivity:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12295-12304页

作者： Dinorah Hernández-melchor Cecilia Palafox-Gómez Ivan madrazo Ginna Ortiz America Padilla-Viveros Esther López-Bayghen science Technology and Society ProgramCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Clinical Research Instituto Regenera SCMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMéxico City 07360CDMXMéxico Investigación Clínica Instituto de Infertilidad y Genética México SCINGENESMéxico City 05320CDMXMéxico Departamento de Toxicología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMéxico

BACKGROUND Polycystic ovary syndrome(PCOS)is an endocrine disease that combines metabolic,reproductive,and psychological *** disorders and impaired endometrial receptivity in PCOS can cause *** resistance(IR)is a pathological state of inadequate response to insulin that affects reproduction in PCOS,as damage caused by IR at the endometrial level becomes an obstacle for embryo *** IR resulted in spontaneous pregnancies in PCOS patients,indicating that metabolic corrections improve endometrial *** stem-cell treatment has also corrected endometrial quality and lead to pregnancies in patients with Asherman’s *** propose a combination of nutritional intervention with the surgical placement of stem cells to improve endometrial quality to achieve pregnancy in a PCOS patient undergoing in vitro fertilization(IVF)*** SUmmARY After two failed IVF cycles,a metabolic intervention,consisting of a ketogenic diet with daily consumption of 50 g of carbohydrates(CH),was indicated until *** Syndrome was assessed using the Harmonizing Definition(3 of 5 pathologies:Central obesity,hypertension,hyperglycemia,hypertriglyceridemia,and dyslipidemia),and the Homeostatic model Assessment of IR(HOmA-IR)was used to measure the level of *** IR improved,endometrial quality ***,two day 5-thawed embryos(euploid,donated oocyte–partner's sperm)failed to implant,suggesting endometrial quality improvement was ***,transmyometrial implantation of mesenchymal stem cells from the stromal vascular fraction of adipose tissue was performed to enrich the endometrial stem cell *** endometrial mean thickness for embryo transfer(6.9 mm)was achieved three months after stem cell treatment and continuous dietary control of *** euploid-day 5-thawed embryos(donated oocyte–partner's sperm)were transferred,and embryo implantation was confirmed on day 14 byβ-hCG s

关键词： Polycystic ovarian syndrome Insulin resistance Nutritional intervention Endometrial quality Stem cell treatment Case report

Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury

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Neural Regeneration Research 2023年第7期18卷 1457-1462页

作者： Hannah mmcCoy Rachel Polcyn Naren LBanik Azizul Haque Department of microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Administration medical Center CharlestonSCUSA

Spinal cord injury(scI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no *** and Drug Administration-approved ***,a multifunctional glycolytic enzyme upregulated after scI,promotes pro-and anti-inflammatory events and regulates functional recovery in *** is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway ***-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in *** surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated *** here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following ***,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase *** combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following *** role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neu

关键词： cathepsin X ENOblock enolase glia mitogen-activated protein kinase/extracellular signal-regulated kinase neurodegeneration neuroinflammation phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B Rho-associated protein kinase spinal cord injury

Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice:involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms

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Neural Regeneration Research 2022年第1期17卷 185-193页

作者： mushfiquddin Khan Fei Qiao Pavan Kumar S.m.Touhidul Islam Avtar K.Singh Jeseong Won Inderjit Singh Department of Pediatrics Medical University of South CarolinaCharlestonSCUSA Department of Pathology and Laboratory medicine Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson VA medical Center CharlestonSCUSA

Spinal cord injury(scI)is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal(4-HNE),a reactive aldehyde,formed by scI-induced metabolic dysregulation of membrane *** aldehyde load causes redox alteration,neuroinflammation,neurodegeneration,pain-like behaviors,and locomotion *** scavenging of reactive aldehydes results in limited improved motor and sensory *** this study,we targeted the activity of mitochondrial enzyme aldehyde dehydrogenase 2(ALDH2)to detoxify 4-HNE for accelerated functional recovery and improved pain-like behavior in a male mouse model of contusion scI.N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide(Alda-1),a selective activator of ALDH2,was used as a therapeutic tool to suppress the 4-HNE *** was induced by an impactor at the T9–10 vertebral *** animals were initially treated with Alda-1 at 2 hours after injury,followed by once-daily treatment with Alda-1 for 30 consecutive *** function was evaluated by the Basso mouse scale,and pain-like behaviors were assessed by mechanical allodynia and thermal ***2 activity was measured by enzymatic assay.4-HNE protein adducts and enzyme/protein expression levels were determined by western blot analysis and histology/*** resulted in a sustained and prolonged overload of 4-HNE,which parallels with the decreased activity of ALDH2 and low functional ***-1 treatment of scI decreased 4-HNE load and enhanced the activity of ALDH2 in both the acute and the chronic phases of ***,the treatment with Alda-1 reduced neuroinflammation,oxidative stress,and neuronal loss and increased adenosine 5′-triphosphate levels stimulated the neurorepair process and improved locomotor and sensory ***,the results provide evidence that enhancing the ALDH2 activity by Alda-1 treatment of scI mice suppresses the 4-HNE load that attenuates neuroinfl

关键词： 4-hydroxy-trans-2-nonenal Alda-1 ALDH2 Basso mouse scale score functional recovery mitochondrial function neuroinflammation neuroprotection pain spinal cord injury

The characteristics of multi-source mobility datasets and how they reveal the luxury nature of social distancing in the U.S. during the COVID-19 pandemic

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International Journal of Digital Earth 2021年第4期14卷 424-442页

作者： Xiao Huang Zhenlong Li Yuqin Jiang Xinyue Ye Chengbin Deng Jiajia Zhang Xiaoming Li Department of Geosciences University of ArkansasFayettevilleARUSA Department of Geography University of South CarolinaColumbiaSCUSA Landscape Architecture and Urban Planning Texas A&M UniversityCollege StationTXUSA Department of Geography State University of New York at BinghamtonBinghamtonNYUSA Department of Epidemiology and Biostatistics University of South CarolinaColumbiaSCUSA Department of Health Promotion Educationand BehaviorUniversity of South CarolinaColumbiaSCUSA

This study reveals the human mobility from various sources and the luxury nature of social distancing in the U.S during the COVID-19 pandemic by highlighting the disparities in mobility dynamics from lower-income and upper-income *** collect,process,and compute mobility data from four different *** further design a Responsive Index(RI)based on the time series of mobility change percentages to quantify the general degree of mobility-based responsiveness to COVID-19 at the *** *** find statistically significant positive correlations in the RI between either two data sources,revealing their general similarity,albeit with varying Pearson’s r *** the similarity,however,mobility from each source presents unique and even contrasting characteristics,in part demonstrating the multifaceted nature of human *** results suggest that counties with higher income tend to react more aggressively in terms of reducing more mobility in response to the COVID-19 *** states present a positive difference in RI between their upper-income and lower-income counties,where diverging patterns in time series of mobility changes percentages can be *** findings shed light on not only the characteristics of multi-source mobility data but also the mobility patterns in tandem with the economic disparity.

关键词： COVID-19 mobility responsive index visualization big data

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

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Cellular & molecular Immunology 2018年第5期15卷 458-469页

作者： Hannah m.Knochelmann Connor J.Dwyer Stefanie R.Bailey Sierra m.Amaya Dirk m.Elston Joni m.mazza-mc.Crann Chrystal m.Paulos Department of microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Dermatology and Dermatologic Surgery Medical University of South CarolinaCharlestonSCUSA

The balance between Th17 cells and regulatory T cells(Tregs)has emerged as a prominent factor in regulating autoimmunity and ***17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer,though their role in carcinogenesis is less well *** are required for self-tolerance and defense against autoimmunity and often correlate with cancer *** review addresses the importance of a functional homeostasis between these two subsets in health and the consequences of its disruption when these forces collide in ***,we discuss the ability of Th17 cells to mediate cancer regression in immunotherapy,including adoptive transfer and checkpoint blockade therapy,and the therapeutic possibilities of purposefully offsetting the Th17/Treg balance to treat patients with cancer as well as those with autoimmune diseases.

关键词： autoimmunity cancer immunotherapy Th17 Treg

Slc7a5 regulation of neural development

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Neural Regeneration Research 2021年第10期16卷 1994-1995页

作者： Aidan m.Sokolov David m.Feliciano Department of Biological sciences Clemson UniversityClemsonSCUSA

membrane transport proteins are appreciated for their ability to transport molecules across biological membranes and have received a renewed focus for their role in nervous system *** such group of transporters are members of the solute carrier(SLC)*** transporters shuttle various molecules,including neurotransmitters,fatty acids,amino acids,and inorganic *** such,they play an integral role in supplying cells with essential *** example is that amino acids are transported by SLC family ***7a5 is a SLC family member that transports essential amino acids important for neuronal development,as well as other biological molecules including thyroid hormones T3,T4,and ***7a5 forms a heterodimer with Slc3a2 that facilitates the subcellular distribution of *** acids including leucine,glutamine,and arginine support cell growth by activating the protein kinase,mammalian target of rapamycin complex 1(mTORC1)(Liu et al.,2020).Consistent with this notion is that Slc7a5 transport of amino acids regulates mTORC1 activity in numerous cell types(Nicklin et al.,2009).A recent manuscript expands upon these findings to demonstrate that Slc7a5 plays a previously unrecognized and critical role in the regulation of mTORC1 activity and neuron development(Sokolov et al.,2020).

关键词： inorganic solute notion