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Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart

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Journal of Pharmacy and Pharmacology 2015年第7期3卷 316-330页

作者： Ana P. Silva Jose Carlos C. L. S. Filho Joaquim S. da Costa Junior Walter J. Pelaez Martin S. Faillace Alexandre de B. Falcao Ferraz Jorge M. David Rivelilson M. Freitas Post-Graduate in Biotechnology Northeast Biotechnology Network Federal University of Piaui Teresina 64048-901 PI Brazil Department of Computer Science North Union of Parana Londrina 86041-140 Brazil Department of Chemistry Federal Institute of Piaui Teresina Piaui 64000-040 Brazil INFIQC-CONICET. Department of Physicalchemistry Faculty of Chemical Sciences National University of C6rdoba C6rdobaX5OOOHUA Argentina Laboratory of Genetic Toxicology Lutheran University of BraziL Canoas 92425-900 RS Brazil Institute of Chemistry Federal University of Bahia Salvador Bahia 40170-290 Brazil

The major constituent from the hexane extract of the seeds ofP. insignis is GFC （garcinielliptone FC）. Doses of 25, 50 and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline （vehicle） and orally administered for 30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes, demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weight gain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore, no differences in weight and macroscopic structure of the brain, liver, kidney, lung, heart and spleen between groups of male and female adult mice were observed after treatment. During the periods of treatment, GFC produced no significant changes on haematological and biochemical parameters in male and female mice treated with all doses used. The aim of this study was to investigate the toxicological potential of GFC through behavioral, hematological, biochemical and morphological parameters in animals in order to ensure the safe use ofPlatonia insignis in folk medicine.

关键词： Platonia insignis clusiaceae polyisoprenylated benzophenones biochemical analyses toxicity.

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