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BCL-6 and EZH2 cooperate to epigenetically repress anti-inflammatory miR-142-3p/5p in lupus CD4+T cells

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Cellular & Molecular Immunology 2021年第2期18卷 504-505页

作者： Amr H.Sawalha Division of Rheumatology Department of PediatricsChildren’s Hospital of PittsburghUniversity of PittsburghPittsburghPAUSA Division of Rheumatology and Clinical Immunology Department of MedicineUniversity of PittsburghPittsburghPAUSA lupus Center of Excellence University of Pittsburgh School of MedicinePittsburghPAUSA

Epigenetics plays an important role in the pathogenesis of several autoimmune diseases.1,2,3 Indeed,a large body of evidence implicates abnormal T cell DNA methylation patterns in the pathogenies of lupus,a prototypical autoimmune systemic disease.4,5 Specific DNA methylation marks have been associated with clinical subsets of lupus patients,6,7,8 while others,such as methylation levels in apoptosis genes,might explain differences in disease susceptibility between ethnicities.9 Furthermore,demethylation of the IFI44L gene locus has recently been described as a novel promising highly sensitive and specific diagnostic tool in lupus.

关键词： lupus EZH2 autoimmune

Risk factors for clinical coronary events in patients with SLE:a multicentre case-control study

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Risk factors for clinical coronary events in patients with S...

Broad spectrum of interferon-related nephropathies-glomerulonephritis,systemic lupus erythematosus-like syndrome and thrombotic microangiopathy:A case report and review of literature

The 8th International Congress on SLE

作者： Sahena Haque Donna Taylor-Fesler Caroline Gordon Veronica Toescu David Isenberg Anisur Rahman Aubrey Bell Peter Lanyon Neil McHugh David GI Scott Paul Emery Lee Suan Teh Jacqueline Andrews Hazem Youssef Bridget Griffiths John McLaren Ian Bruce The University of Manchester Oxford RoadManchesterMI3 910 The University of Manchester Oxford RoadManchesterMI3 910 British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group The University of Manchester Oxford RoadManchesterM139HJ British Isles Lupus Assessment Group BSR Lupus Special Interest Group

＜正＞Purpose:To identify risk factors（RF）for clinical coronary heart disease（CHD）in SLE and to study the role of traditional RF,SLE disease distribution,serology and therapy. Methods:This was a multicentre case,control *** recruited 48 SLE patients with verified clinical CHD （myocardial infarction or angina pectoris）and 78 SLE

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World Journal of Nephrology 2019年第7期8卷 109-117页

作者： Iacopo Gianassi Marco Allinovi Leonardo Caroti Lino Calogero Cirami Nephrology Dialysis and Transplantation Unit Careggi University Hospital

BACKGROUND Interferons(IFNs)are characterized by a wide range of biological effects,which justifies their potential therapeutic use in several pathologies,but also elicit a wide array of adverse effects in almost every organ *** them,renal involvement is probably one of the most complex to *** SUMMARY We describe four cases of kidney damage caused by different IFN formulations:IFN-β-related thrombotic microangiopathy,IFN-β-induced systemic lupus erythematosus,and two cases of membranous nephropathy secondary to pegylated-IFN-α*** each case,we carefully excluded any other possible cause of renal *** suspected as the casual relationship between drug and kidney damage,IFN treatment was immediately *** three cases,we observed a complete and persistent remission of clinical and laboratory abnormalities after IFN withdrawal,while the patient who developed thrombotic microangiopathy,despite IFN withdrawal and complement-inhibitor therapy with eculizumab,showed persistent severe renal failure requiring *** This case series highlights the causal relationship between IFN treatment and different types of renal involvement and enables us to delineate several peculiarities of this association.

关键词： Interferon Thrombotic microangiopathy Systemic lupus erythematosus Eculizumab Nephrotoxicity

An overlap syndrome involving autoimmune hepatitis and systemic lupus erythematosus in childhood

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World Journal of Gastroenterology 2007年第19期13卷 2764-2767页

作者： Yusuf Usta Figen Gurakan Zuhal Akcoren Seza Ozen Hacettepe University Faculty of Medicine Department of Pediatrics Section of Gastroenterology Hepatology and Nutrition Sihhiye 06100 Ankara Turkey Hacettepe University Faculty of Medicine Department of Pediatrics Pediatric Pathology Unit Sihhiye 06100 Ankara Turkey Hacettepe University Faculty of Medicine Department of Pediatrics Nephrology and Rheumatology Unit Sihhiye 06100 Ankara Turkey

We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis （AIH） and systemic lupus erythematosus （SLE）. The patient presented with jaundice, hepatosplenomegaly, malaise, polyarthralgia, arthritis and butterfly rash on the face. Laboratory tests revealed severe liver dysfunction, Coombs positive hemolytic anemia and a positive ANA/ anti-dsDNA test. Renal biopsy showed class IIA kidney disease, while liver biopsy showed chronic hepatitis with severe inflammatory activity. The patient satisfied the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with high dose treatment with corticosteroids and azathioprine, however, remission of the liver disease could not be achieved. Repeat biopsy of the liver after three years of therapy revealed ongoing chronic hepatitis with high level of inflammatory activity. The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome.

关键词： Autoimmune hepatitis Systemic lupus erythematosus Overlap syndrome and treatment

Aetiological factors of Budd-Chiari syndrome in Algeria

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World Journal of Hepatology 2015年第6期7卷 903-909页

作者： Nawel Afredj Nawal Guessab Abdelbasset Nani Sid Ahmed Faraoun Ibtissem Ouled Cheikh Rafik Kerbouche Djouhar Hannoun Zine Charef Amir Hayet Ait Kaci Kamel Bentabak Aurélie Plessier Dominique-Charles Valla Valerie Cazals-Hatem Marie-Hélène Denninger Tadjeddine Boucekkine Nabil Debzi Hepatology unit Department of Medicine Mustapha Hospital Radiology unit Centre Pierre and Marie Curie National Institute of Public Health (INSP) Pathology unit CHU Mustapha Pathology unit Centre Pierre and Marie Curie Surgery unit Centre Pierre and Marie Curie Hepatology unit Beaujon Hospital Pathology unit Beaujon Hospital Immunohematology Laboratory Beaujon Hospital

syndrome （BCS） and identify the aetiologies of thisdisease in ***： Patients with BCS, hospitalised in our unitfrom January 2004 until June 2010 were included and theaetiological factors were assessed. Patients presentinga BCS in the setting of advanced-stage cirrhosis or aliver transplantation were excluded from the study. Thediagnosis was established when an obstruction of hepaticvenous outflow （thrombosis, stenosis or compression）was demonstrated. We diagnosed myeloproliferativedisease （MPD） by bone marrow biopsy and V617FJAK2 mutation. Anti-phospholipid syndrome （APLS） wasdetected by the presence of anticardiolipin antibodies,anti-β2 glycoprotein antibodies and lupus *** also detected paroxysmal nocturnal haemoglobinuria（PNH） by flow cytometry. Celiac disease and Beh？etdisease were systematically investigated in our *** anticoagulant protein deficiencies were alsoassessed. We tested our patients for the G20210Amutation at Beaujon Hospital. Imaging procedures wereperformed to determine a local cause of BCS, such as ahydatid cyst or a liver ***： One hundred and fifteen patients wereincluded. Mean follow up： 32.12 mo. Mean age： 34.41years, M/F = 0.64. Chronic presentation was frequent：63.5%. The revealing symptoms for the BCS wereascites （74.8%） and abdominal pain （42.6%）. Themost common site of thrombosis was the hepatic veins（72.2%）. Involvement of the inferior vena cava alonewas observed in 3 patients. According to the radiologicalinvestigations, BCS was primary in 94.7% of the cases（n = 109） and secondary in 5.2% （n = 6）. An aetiologywas identified in 77.4% of the patients （n = 89）; itwas multifactorial in 27% （n = 31）. The predominantaetiology of BCS in our patients was a myeloproliferativedisease, observed in 34.6% of cases. APLS was foundin 21.7% and celiac disease in 11.4%. Other acquiredconditions were： PNH （n = 4）, systemic disease （n = 6）and inflammatory bowel disease （n = 5）. Anticoagulantprotein defici

关键词： Algeria Etiologie Celiac disease Budd-Chiari Thrombosis

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系统性红斑狼疮

英国医学杂志中文版 2006年第4期9卷 236-241页

作者： David P D’Cruz 张卓莉 Louise Coote lupus unit St Thomas' HospitalLondon SE1 7EH

系统性红斑狼疮（SLE）的临床表现可以是慢性致残性的，严重者可以发生重要脏器的功能衰竭，甚至危及生命,早期诊断是改善预后的关键,抗磷脂（Hughes）综合征通常继发于SLE，可以导致病人反复发生血栓和流产，抗疟药、小剂量糖皮质激素... 详细信息

系统性红斑狼疮（SLE）的临床表现可以是慢性致残性的，严重者可以发生重要脏器的功能衰竭，甚至危及生命,早期诊断是改善预后的关键,抗磷脂（Hughes）综合征通常继发于SLE，可以导致病人反复发生血栓和流产，抗疟药、小剂量糖皮质激素和免疫抑制剂的治疗通常有效，新近出现的一些药物，如霉酚酸酯和生物制剂可能为SLE治疗带来更多的选择和希望，外源性补充雌激素导致狼疮复发的风险性可能低于预想的情况，但是仍然会增加血栓形成的危险性，加速性动脉粥样硬化仍然是目前存在的问题。

关键词：系统性红斑狼疮小剂量糖皮质激素动脉粥样硬化血栓形成免疫抑制剂临床表现功能衰竭改善预后早期诊断生物制剂

Antinucleosomal Antibodies and Its Correlation to SLE Manifestations

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 64-72页

作者： Adel A. Elbeialy Hesham M. Eldesouky Noha E. Mosellhy Al-Azhar Faculty of Medicine Rheumatology Cairo Egypt St Thomas Hospital Lupus Unit London United Kingdom Al-Azhar Faculty of Medicine Rheumatology Damietta Egypt Medical student Faculty of Medicine Ain Shams University Cairo Egypt

Subject: SLE is an autoimmune disease with skin, joint, renal, cardiovascular, and nervous manifestations. The disease is classified as an immune complex-mediated disease and is characterized by the production of various autoantibodies. Until now, more than 100 autoantibodies have been identified. Patients and methods: This study was performed on 200 SLE patients. All of them were females and their ages ranged from 20 to 49 years. All participants in this study were subjected to physical examination, thorough history taking including age, sex, age of onset, duration of SLE disease, family history, and SLEDAI. Laboratory investigations included: CBC, ESR, liver function tests, renal function tests, ANA, Anti-dsDNA, CRP, Complements C3, C4, and Anti-NCS. Results: There was a highly significant inverse correlation between anti-NCS antibodies and Hb level, a significant direct correlation between anti-NCS antibodies and 24hr proteinuria, a significant inverse correlation between anti-NCS antibodies and complements (C3 and C4), a significant correlation between anti-NCS antibodies and anti dsDNA antibodies, a significant correlation between anti-NCS and disease activity, SLEDAI, and renal affection. Conclusion: Anti-NCS antibody can be a useful tool in the diagnosis of SLE especially in patients who are negative for anti-ds DNA antibodies.

关键词： SLE Autoantibodies Anti-NCS

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第6期1卷 135-136页

作者： Giulia Leonardi Nicola de Bortoli Massimo Bellini Maria Gloria Mumolo Francesco Costa Angelo Ricchiuti Stefano Bombardieri Santino Marchi Gastroenterology unit Cisanello Hospital University of Pisa Reumatology unit Hospital of Santa Chiara University of Pisa

Chronic intestinal pseudo-obstruction (CIP) is an infre-quent complication of an active systemic lupus erythema-tosus (SLE). We illustrate a case of SLE inactive-related CIP. A 51-year old female with inactive SLE (ECLAM score 2) was hospitalized with postprandial fullness, vomiting, abdominal bloating and abdominal pain. She had had no bowel movements for five days. Plain abdominal X-ray revealed multiple fluid levels and dilated small and large bowel loops with air-fluid levels. Intestinal contrast radiology detected dilated loops. CIP was diagnosed. The patient was treated with prokinetics, octreotide, claritromycin, rifaximin, azathioprine and tegaserod without any clinical improvement. Then methylprednisolone (500 mg iv daily) was started. After the first administration, the patient showed peristaltic movements. A bowel movement was reported after the second administration. A plain abdominal X-ray revealed no air-fluid levels. Steroid therapy was slowly reduced with complete resolution of the symptoms. The patient is still in a good clinical condition. SLE-related CIP is generally reported as a complication of an active disease. In our case, CIP was the only clinical demonstration of the SLE.

关键词： Chronic intestinal pseudo-obstruction Systemic lupus erythematosus

Neuropsychiatric Systemic lupus Erythematosus Complicated with Acute Pericarditis in Patient with Hyperprolactinaemia: A Case Report

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第1期3卷 7-9页

作者： Caterina Naclerio Giovanna Cuomo Gabriele Valentini Chief of Rheumatology unit Second University of Naples Naples Italy Rheumatology unit “M. Scarlato” Hospital Scafati Italy

Neuropsychiatric systemic lupus erythematosus (NP-SLE) is one of the major cause of morbidity in systemic lupus erythematosus patients and its treatment depends on identification of pathogenic mechanisms. We describe the rare case of neuropsychiatric systemic lupus erythematosus (NP-SLE) complicated by pericardial effusion combined to low C4 level persisting and hyperprolactinaemia. A cyclophosphamide therapy showed a good response in a 21-year old woman with disturbances in thought processes and an acute confusional state with sierositis. This paper confirms that a cyclophosphamide therapy contributes to control a disease activity by a mechanism of prolactin level reduction. Other studies occur to evaluate this hypothesis.

关键词： Systemic lupus Erythematosus Neuropsychiatric Systemic lupus Erythematosus Psychosis Pericarditis C4 Level Prolactin