检索结果-南通市图书馆

Antileishmanial potential of a marine sponge Haliclona oculata against experimental visceral leishmaniasis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Coastal Life Medicine 2015年第3期3卷 187-192页

作者： Vijai Lakshmi Prashant Khare Pragya Misra Mahendra Nath Srivastava Anuradha Dube Divisions of Medicinal&Process Chemistry CSIR-Central Drug Research InstituteLucknow-226001India Divisions of Parasitology CSIR-Central Drug Research InstituteLucknow-226001India Divisions of Botany CSIR-Central Drug Research Institute Lucknow-226001India

Objective:To evaluate the antileishmanial activity of a marine spongeHaliclona ***:The crude methanol extract was prepared from the freshly collected sponge and its three fractions were also prepared by maceration *** antileishmanial activity of these extract and fractions was tested againstLeishmania ***:The antileishmanial activity was tested bothin vitroand in *** crude methanol extract exerted almost complete inhibition of promastigotes(81.0%±6.9%)and 78.8%±5.2%inhibition of intracellular amastigotes at 100μg/mL with IC_(50)values of 29.5μg/mL and 40.6μg/mL,*** treatment of 500 mg/kg(p.o.)of the crude methanol extract for 5 d for Leishmania donovani infected hamsters resulted in 78.35%±10.20%inhibition of intracellular *** a lower dose(250 mg/kg),it exhibited poor *** the fractions,highestin vitro(>75%)and in vivo(84.3%±10.2%)antileishmanial activity was observed in n-chloroform fraction with IC_(50)values of 54.2μg/mL and 61μg/mL against promastigotes and intracellular amastigotes,*** fraction andn-butanol(both insoluble and soluble)fractions were found inactivein vitroand in ***:Our findings indicate that this marine sponge has the potential to provide new insight toward development of an effective antileishmanial agent and,hence,more exhaustive studies are needed for exploiting the vast marine resources of the world to combat the scourge of several parasitic diseases.

关键词： Antileishmanial activity In vitroand in vivo Marine sponge Haliclona oculata Leishmania donovani

Evaluation of Cytogenetic Effects of Isoproturon on the Root Meristem Cells of Allium sativum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2001年第3期14卷 214-219页

作者： L. K. S. CHAUHAN, P. N. SAXENA, AND S. K. GUPTA1Cell Biology Section, Industrial Toxicology Research Centre, P. B. No. 80, M. G. Marg, lucknow- 226001, India\ \ Industrial Toxicology Research Centre 印度 226001

Objective\ To validate the use of Allium sativum as a reliable test model for genotoxicity, isoproturon, a substituted phenylalkylurea herbicide, was evaluated on the root meristem cells by this plant system. Method\ Test concentrations were selected by determining EC50 and root tips were exposed to various concentrations for 6 or 24 hr. EC50 concentration was calculated to be 70.8 ppm for the root growth. In addition to root growth retardation exposure to isoproturon induced morpholoogical changes like discolouration and stiffness of roots. Results\ Exposure to various experimental concentrations of isoproturon (35-280 ppm), including EC50, significantly and dose-dependently inhibited the mitotic index and induced chromosome breaks/mitotic aberrations at 6 or 24 hr. Conclusion\ The frequency of aberrations was found to be decreased in a dose dependant manner at 24 or 48 hr post exposure, however in comparison of control cells the frequency of aberrations was considerably high which indicates genotoxicity potentials of isoproturon. Further, present study also suggests that Allium sativum is a sensitive, efficient, and reliable test system for measuring the genotoxicity potential of environmental chemicals.

关键词： Phenylurea Compounds Chromosome Aberrations DNA Damage Dose-Response Relationship, Drug Garlic Herbicides Lethal Dose 50 Methylurea Compounds Mitosis Mutagenicity Tests Plant Roots Sensitivity and Specificity

Epithelial plasticity and cancer stem cells:Major mechanisms of cancer pathogenesis and therapy resistance

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2017年第8期9卷 118-126页

作者： Minal Garg Department of Biochemistry University of LucknowLucknow 226007India

Epithelial-mesenchymal transition(EMT) has been linked with aggressive tumor biology and therapy resistance. It plays central role not only in the generation of cancer stem cells(CSCs) but also direct them across the multiple organ systems to promote tumor recurrence and metastasis. CSCs are reported to express stem cell genes as well as specific cell surfacemarkers and allow aberrant differentiation of *** facilitates cancer cells to leave primary tumor, acquire migratory characteristics, grow into new environment and develop radio-chemo-resistance. Based on the current information, present review discusses and summarizes the recent advancements on the molecular mechanisms that derive epithelial plasticity and its major role in generating a subset of tumor cells with stemness properties and pathophysiological spread of tumor. This paper further highlights the critical need to examine the regulation of EMT and CSC pathways in identifying the novel probable therapeutic *** improved therapeutic strategies based on the co-administration of inhibitors of EMT, CSCs as well as differentiated tumor cells may provide improved antineoplastic response with no tumor relapse.

关键词： Epithelial-mesenchymal transition Anticancer therapies Cancer stem cells Molecular pathogenesis Tumor relapse

A stage structured model of malaria transmission and efficacy of mosquito larvicides in its control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Modeling, Simulation, and Scientific Computing 2014年第4期5卷 201-226页

作者： Manju Agarwal Archana S.Bhadauria Department of Mathematics&Astronomy lucknow University Lucknow 226007 Uttar PradeshIndia

In this paper,we analyze a stage structured mathematical model for the transmission of malaria and its control by killing mosquitoes in larvae(immature)*** the Mosquito and human populations are divided into susceptible and infective ***-ceptible class of mosquito population is further divided into mature and *** model is analyzed by using stability theory of nonlinear ordinary differential *** reproduction ratio is derived which is found to be the decreasing function of maturation delay and larvicidal *** addition,it is observed that biting rate of mosquito,transmission efficiency of parasitic infection from infective human to mosquito and critical value of maturation delay are the key parameters determining the stability switch in the *** simulation is also carried out to confirm the analytical results obtained in the paper.

关键词： Mosquitoes adults immature mature bifurcation larvicides

Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 283-288页

作者： Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap MargP.O.Box No.436Lucknow 226001Uttar PradeshIndia Department of Pharmacology Goel Institute of Pharmacy & SciencesFaizabad Road(Near Indira Canal) Lucknow 227105Uttar PradeshIndia

Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(***) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal ***:Five groups of six rats each were selected for the *** extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated *** serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the ***:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of *** ***,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose *** addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver ***:The results of this study slrongly indicate that ethanolic extract of *** has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats.

关键词： Ziziphus oenoplia(Rhamnaceae) Rifampicin Isoniazid Hepatotoxicity

Synergism of co-delivered nanosized antioxidants displayed enhanced anticancer efficacy in human colon cancer cell lines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2017年第2期2卷 82-95页

作者： Lipika Ray Manish Kumar Pal Ratan Singh Ray CSIR-Indian Institute of Toxicology Research P.O.Box No.80M.G.MargLucknowUP226001India Academy of Scientific and Innovative Research New Delhi 110001India

Combination of chemopreventive and/or therapeutic agents is the imminent smart approach to cope upwith cancer because it may act on multiple targets through different pathways. In the present study, wehave synthesized multiple chemopreventive and/or therapeutic agents (Curcumin, Quercetin andAspirin) loaded nanoparticles by simple cation-anion interaction among the amine groups of chitosan(CS) and phosphate groups of sodium hexametaphosphate (SHMP). These nanosized bioactive materials(CS-SHMP-CQA-NPs) were well characterized and found most effective in colon cancer cell line (HCT-116)compared to other cancer cell lines. Triplex chemopreventive and/or therapeutic agents-loaded NPs weresynergistically inducing apoptosis in HCT-116 cells compared to two-chemopreventive agents-loadedNPs as evident by an increase in sub-G1 cells (percent), and chromatin condensation along with thedecrease in mitochondrial membrane potential (MMP). Interestingly, ChoueTalalay analysis revealedthat CS-SHMP-CQA-NPs showed strong synergistic effect in its all doses. Thus, our study demonstratesthat nanoparticles based bioactive materials significantly inhibit the growth of HCT-116 cells and thuscould be a promising approach for colon cancer chemoprevention.

关键词： Chemoprevention Therapeutic agent Colon cancer Synergistic effect Apoptosis

Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第10期12卷 738-744页

作者： Sunil K.Jaiswal Mukesh K.Dubey Sanjib Das Ch.V.Rao Department of Pharmacy Rameshwaram Institutes of Technology & Management Department of Pharmaceutical Sciences Dibrugarh University Pharmacognosy & Ethnopharmacology Div. National Botanical Research Institute (CSIR)Rana Pratap MargLucknow 226001Uttar PradeshIndia

AIM: To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves(BPE) against different gastric ulcer models in rats. METHOD: The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress(CRS), and pylorus ligation(PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model. RESULTS: BPE showed a dose-dependent ulcer protective effect in PL(18.67%–66.26% protection), aspirin(24.65%–63.25% protection), CRS(20.77%–59.42% protection), and EtOH(16.93%–77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO(P < 0.01–0.001), SOD(P < 0.01–0.001), and an increase in CAT(P < 0.01–0.001), activity in the CRS-induced model. CONCLUSION: The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential.

关键词： Barleria prionitis Iridoid HPTLC Anti-ulcer activity Antioxidant enzymes

Intrinsic advantages of Cheilomenes sexmaculata over two coexisting Coccinella species （Coleoptera：Coccinellidae）

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insect Science 2005年第3期12卷 179-184页

作者： OMKAR AHMADPERVEZ GEETANJALIMISHRA SHEFALISRIVASTAVA SATYENDRAK.SINGH AVANISHK.GUPTA Ladybird Research Laboratory Department of ZoologyUniversity of LucknowLucknowIndia

Development, survival and reproductive performance of coexisting ladybird species, viz. Cheilomenes sexmaculata, Coccinella septempunctata, and Coccinella transversalis, of the tribe Coccinellini were studied and compared to assess their coexistence and ecological relationships. High values of life history parameters, viz. developmental rate,immature survival, fecundity, egg viability, reproductive rate and conversion of efficiency of ingested food were recorded for C. sexmaculata followed by C. transversalis and *** suggesting that the former has intrinsic advantages over the latter two species. This could possibly counterbalance its disadvantages, like relatively smaller size and weight, thereby making it competitive. The developmental period increased with increase in body size. Exceptionally high fecundity after single mating has been recorded in C. sexmaculata. The egg viability, however, was lower than in both Coccinella species.

关键词： cheilomenes sexmaculata coccinella septempunctata coccinella transversalis size reproductive rate bioconversion efficiency

Survival, development and life tables of two congeneric ladybirds in aphidophagous guilds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2006年第2期13卷 119-126页

作者： AVANISH K. GUPTA SHEFALI SRIVASTAVA GEETANJALI MISHRA KALPANA SINGH OMKAR Ladybird Research Laboratory Department of Zoology University of Lucknow Lucknow India

Two congeneric aphidophagous ladybirds, Coccinella septempunctata and Coccinella transversalis, were reared on three aphid species, Lipaphis erysimi, Myzus persicae and Aphis nerii, to estimate the effect of prey quality and intra- and interspecific interactions on their survival and development of life stages. Mortality of first instar ladybirds of both species was highest feeding on A. nerii. Preimaginal mortafity was lowest when feeding on L. erysimi （C. septempunctata, 1.6% and C. transversalis, 3.2%）, and highest when feeding on A. nerii （ C. septempunctata, 6.2% and C. transversalis, 8.2%）. Comparatively higher weight and larger size of C. septempunctata along with the lower levels of mortality recorded suggested that it is more likely to have acted as an intraguild predator than C. transversalis. High recorded mortality of C. transversalis is attributed to probable intraguild predation on account of its smaller size. The major sources of mortality were probably cannibalism, intraguild predation and other unknown factors. Lower prey quality increased the incidence of cannibalism and intraguild predation, especially in C. transversalis. The investigation suggests an intrinsic competitive advantage for C. septempunctata over C. transversalis in guilds of three aphid species.

关键词： Coccinella septempunctata Coccinella transversalis ladybirds life table,aphids cannibalism intraguild predation