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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Modeling the density gradient of 3D nanofiber scaffolds fabricated by divergence electrospinning

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Advances in Manufacturing 2021年第3期9卷 414-429页

作者： Muhammad Adib Uz Zaman Dilshan Sooriyaarachchi Ying-Ge Zhou George Z.Tan Dong-Ping Du Department of Industrial Manufacturing and Systems EngineeringTexas Tech UniversityLubbockTXUSA

Following recent insights on structure-cell-function interactions and the critical role of the extracellular matrix(ECM),the latest biofabrication approaches have increasingly focused on designing materials with biomimetic *** electrospinning is a novel fabrication method for three-dimensional(3D)nanofiber *** is introduced to produce 3D nanofiber mats that have numerous applications in regenerative medicine and tissue *** of the most important characteristics of 3D nanofiber mats is the density *** study provides a statistical analysis and response surface modeling framework based on experimental data to evaluate the manner by which the geometric designs of double-bevel collectors influence the fiber density ***,variance of analysis and sensitivity analysis were performed to identify parameters that had significant effects,and a response surface model embedded with seven location indicators was developed to predict the spatial distribution of fiber density for different collector *** was concluded that the collector height,bevel angle,and their interactions were significant factors influencing the density *** study revealed the sensitivity of system configuration and provided an optimization tool for process controllability of microstructure gradients.

关键词： Electrospinning 3D nanofiber scaffold Statistical model Design of experiments Response surface method

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A transverse local feedback linearization approach to human head movement control

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Control Theory and Technology 2017年第4期15卷 288-300页

作者： Oki, Takafumi Ghosh, Bijoy K. Department of Mathematics and Statistics Texas Tech University Lubbock U.S.A.

In the mid-nineteenth century, Donders had proposed that for every human head rotating away from the primary pointing direction, the rotational vectors in the direction of the corresponding axes of rotation, is restricted to lie on a surface. Donders＇ intuition was that under such a restriction, the head orientation would be a function of its pointing direction. In this paper, we revisit Donders＇ Law and show that indeed the proposed intuition is true for a restricted class of head-orientations satisfying a class of quadratic Donders＇ surfaces, if the head points to a suitable neighborhood of the frontal pointing direction. Moreover, on a suitably chosen subspace of the 3D rotation group SO（3）, we describe a head movement dynamical system with input control signals that are the three external torques on the head provided by muscles. Three output signals are also suitably chosen as follows. Two of the output signals are coordinates of the frontal pointing direction. The third signal measures deviation of the state vector from the Donders＇ surface. We claim that the square system is locally feedback linearizable on the subspace chosen, and the linear dynamics is decomposed into parts, transverse and tangential to the Donders＇ surface. We demonstrate our approach by synthesizing a tracking and path-following controller. Additionally, for different choices of the Donders＇ surface parameters, head gaits are visualized by simulating different movement patterns of the head-top vector, as the head-pointing vector rotates around a circle.

关键词： Head movement Donders' surface transverse feedback linearization Fick-Gimbal

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A Survey on the Moving Target Defense Strategies:An Architectural Perspective

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Journal of Computer Science & Technology 2019年第1期34卷 207-233页

作者： Jianjun Zheng Akbar Siami Namin Department of Computer Science Texas Tech UniversityLubbockTexas 79409U.S.A.

As the complexity and the scale of networks continue to grow,the management of the network operations and security defense has become a challenging task for network administrators,and many network devices may not be updated timely,leaving the network vulnerable to potential ***,the static nature of our existing network infrastructure allows attackers to have enough time to study the static configurations of the network and to launch well-crafted attacks at their convenience while defenders have to work around the clock to defend the *** asymmetry,in terms of time and money invested,has given attackers greater advantage than defenders and has made the security defense even more *** calls for new and innovative ideas to fix the *** Target Defense (MTD)is one of the innovative ideas which implements diverse and dynamic configurations of network systems with the goal of puzzling the exact attack surfaces available to *** a result,the system status with the MTD strategy is unpredictable to attackers,hard to exploit,and is more resilient to various forms of *** are existing survey papers on various MTD techniques,but to the best of our knowledge,insufficient focus was given on the architectural perspective of MTD strategies or some new technologies such as Internet of Things (IoT).This paper presents a comprehensive survey on MTD and implementation strategies from the perspective of the architecture of the complete network system,covering the motivation for MTD,the explanation of main MTD concepts,ongoing research efforts of MTD and its implementation at each level of the network system,and the future research opportunities offered by new technologies such as Software-Defined Networking (SDN)and Internet of Things (IoT).

关键词： moving target defense network security Software-Defined Networking (SDN)

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Bioinspired and biomimetic membranes for water purification and chemical separation: A review

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Frontiers of Environmental Science & Engineering 2021年第6期15卷 141-173页

作者： Elham Abaie Limeimei Xu Yue-xiao Shen Department of Construction Civil and Environmental EngineeringTexas Tech UniversityLubbockTX 79409USA

Bioinspired and biomimetic membranes that contain biological transport channels or attain their structural designs from biological systems have been through a remarkable development over the last two *** take advantage of the exceptional transport properties of those channels,thus possess both high permeability and selectivity,and have emerged as a promising solution to existing *** the discovery of biological water channel proteins aquaporins(AQPs),extensive efforts have been made to utilize them to make separation membranes–AQP-based membranes,which have been *** exploration of AQPs’unique structures and transport properties has resulted in the evolution of biomimetic separation materials from protein-based to artificial channelbased ***,large-scale,defect-free biomimetic membranes are not available *** paper reviews the state-of-the-art biomimetic membranes and summarizes the latest research progress,platform,and *** it critically discusses the potential routes of this emerging area toward scalable *** conclude that an appropriate combination of bioinspired concepts and molecular engineering with mature polymer industry may lead to scalable polymeric membranes with intrinsic selective channels,which will gain the merit of both desired selectivity and scalability.

关键词： Aquaporins Artificial water channels Biomimetic membranes Chemical separation and water purification

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Free Radical Generation by Selenium Compounds and Their Prooxidant Toxicity

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Biomedical and Environmental Sciences 1997年第2期10卷 260-270页

作者： JULIAN E. SPALLHOLZ(Food and Nutrition, Texas Technology University,lubbock, TX 79404, USA) Texas Technology University Lubbock 79404 USA.

Selemum (Se) and many of its compounds are among the most toxic of nutrients. Selenium toxicity was first described in range animals in the western United States in the 1930's which consumed' selenium accumulator' plants of the genus Astragalus, Xylorrhiza,Oonopsis, and Stanleya. Selenites and selenates from the soil accumulate in these plants primarily as methylated selenium compounds and plants evolve dimethyldiselenide and *** selenium, primarily as selenomethionine and selenocysteine for humans fulfill the dietary requirement for selenoenzymes and proteins. In humans and animals excessive dietary selenium may be toxic. In vitro, selenium compounds such as selenite, selenium dioxide and diselenides react with thiols, such as glutathione, producing superoxide and other reactive oxygen species. This catalytic reaction of selenium compounds with thiols likely accounts for selenium toxicity to cells ex vivo and in vivo where the major glutathione producing organ,the liver, is also the major target organ of selenium *** enzymes and selenoethers that do not readily form a selenide (RSe-) anion and compounds such as Ebselen where selenium is sequestered, are not toxic. Methylation of selenium by both plants and animals serves to detoxify selenium by generating methylselenides. Alternatively, full reduction of Se to elemental selenium (Se0) as done by some bacteria and the formation of heavy metal selenides such as Ag2Se or Hg2Se, results in a non-catalytic nontoxic form of *** catalytic prooxidant attribute of some selenium compounds appears to account for its toxicity when such activity exceeds plant and animal methylation reactions and antioxidant defenses. This prooxidant activity may also account for cellular apoptosis and may provide a useful pharmaceutical application for selenium compounds as antibacterial, antiviral, antifungal and anticancer agents

关键词： Free Radical Generation by Selenium Compounds and Their Prooxidant Toxicity GSH

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Design of a Level-3 electric vehicle charging station using a 1-MW solar system via the distributed maximum power point tracking technique

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Clean Energy 2024年第1期8卷 23-35页

作者： Afshin Balal Michael Giesselmann Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA

Solar power is mostly influenced by solar irradiation,weather conditions,solar array mismatches and partial shading ***,before installing solar arrays,it is necessary to simulate and determine the possible power *** power point tracking is needed in order to make sure that,at any time,the maximum power will be extracted from the photovoltaic ***,maximum power point tracking is not a suitable solution for mismatches and partial shading *** overcome the drawbacks of maximum power point tracking due to mismatches and shadows,distributed maximum power point tracking is util-ized in this *** solar farm can be distributed in different ways,including one DC-DC converter per group of modules or per *** this paper,distributed maximum power point tracking per module is implemented,which has the highest *** technology is applied to electric vehicles(EVs)that can be charged with a Level 3 charging station in<1 ***,the problem is that charging an EV in<1 hour puts a lot of stress on the power grid,and there is not always enough peak power reserve in the existing power grid to charge EVs at that ***,a Level 3(fast DC)EV charging station using a solar farm by implementing distributed maximum power point tracking is utilized to address this ***,the simulation result is reported using MATLAB®,LTSPICE and the System Advisor *** results show that the proposed 1-MW solar system will provide 5 MWh of power each day,which is enough to fully charge~120 EVs each ***,the use of the proposed photovoltaic system benefits the environment by removing a huge amount of greenhouse gases and hazardous *** example,instead of supplying EVs with power from coal-fired power plants,1989 pounds of CO_(2) will be eliminated from the air per hour.

关键词： electric vehicles(EVs) distributed maximum power point tracking solar farm DC fast-charging station step-up DC-DC converter System Advisor Model economic analysis

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COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASED ON THE INTERPRETIVE STRUCTURAL MODELING METHODOLOGY： TRANSDISCIPLINARY APPROACH

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.W. Smith D. Tate W.D. Lawson T.B. Baturalp Department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 Department of Industrial Design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China Department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. With the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

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Anisotropic leaky-like perturbation with subwavelength gratings enables zero crosstalk

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Light(Science & Applications) 2023年第6期12卷 1153-1161页

作者： Md Faiyaz Kabir Md Borhan Mia Ishtiaque Ahmed Nafiz Jaidye Syed Z.Ahmed Sangsik Kim Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA Department of Physics and Astronomy Texas Tech UniversityLubbockTX 79409USA School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141South Korea

Electromagnetic coupling via an evanescent field or radiative wave is a primary characteristic of light,allowing optical signal/power transfer in a photonic circuit but limiting integration density.A leaky mode,which combines both evanescent field and radiative wave,causes stronger coupling and is thus considered not ideal for dense *** we show that a leaky oscillation with anisotropic perturbation rather can achieve completely zero crosstalk realized by subwavelength grating(SWG)*** oscillating fields in the SWGs enable coupling coefficients in each direction to counteract each other,resulting in completely zero *** experimentally demonstrate such an extraordinarily low coupling between closely spaced identical leaky SWG waveguides,suppressing the crosstalk by≈40 dB compared to conventional strip waveguides,corresponding to≈100 times longer coupling *** leaky-SWG suppresses the crosstalk of transverse–magnetic(TM)mode,which is challenging due to its low confinement,and marks a novel approach in electromagnetic coupling applicable to other spectral regimes and generic devices.

关键词： crosstalk coupling enable

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Modeling multicomponent ion transport to investigate selective ion removal in electrodialysis

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Environmental Science and Ecotechnology 2020年第1期1卷 48-56页

作者： Soraya Honarparvar Danny Reible Department of Chemical Engineering Texas Tech UniversityLubbockTX79409-3121USA Department of Civil Environmentaland Construction EngineeringTexas Tech UniversityLubbockTX79409-1023USA

A 2-dimensional multicomponent ion transport model based on Nernst-Planck(NP)equation and electroneutrality assumption is developed for an electrodialysis(ED)cell operated in the ohmic *** flow in channels are assumed incompressible,isothermal,and *** equilibrium and flux continuity are considered at ionexchange membrane(IEM)-solution *** account for tortuosity effects inside membranes,effective ionic diffusion coefficients are calculated using membranes water volume *** developed multicomponent model is used to elucidate the effects of feed solution properties,cell properties,system hydrodynamics,operational conditions,and membrane properties on selective divalent ion removal in the *** results indicate that the selective removal of divalent ions improves with decreasing the cell length,imposed potential,and ionic strength of feed *** mixing in spacer-filled cell also promotes selective divalent ion *** concentrations of fixed charges on the membranes results in greater selectivity toward divalent ions at short cell length and low imposed *** equal concentrations of fixed charges,membranes with high water content are less favorable for selective divalent ion *** developed framework enables the optimum selection of cell design,IEMs,spacer design,and operational conditions to selectively remove ions from multicomponent solutions.

关键词： Electrodialysis Ion transport modeling Multicomponent solution Selective ion removal Scale precipitation

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