检索结果-南通市图书馆

World Journal of Engineering and Technology 2018年第1期6卷 176-200页

作者： Myung Su Yi Chung Min Hyun Jeom Kee Paik Department of Naval Architecture and Ocean Engineering Pusan National University Busan Korea Central Research Institute Samsung Heavy Industries Co. Ltd. Geoje Korea The Korea Ship and Offshore Research Institute (The Lloyd’s Register Foundation Research Centre of Excellence) Pusan National University Busan Korea Department of Mechanical Engineering University College London London UK

The objective of the present paper is to develop nonlinear finite element method models for predicting the weld-induced initial deflection and residual stress of plating in steel stiffened-plate structures. For this purpose, three-dimensional thermo-elastic-plastic finite element method computations are performed with varying plate thickness and weld bead length (leg length) in welded plate panels, the latter being associated with weld heat input. The finite element models are verified by a comparison with experimental database which was obtained by the authors in separate studies with full scale measurements. It is concluded that the nonlinear finite element method models developed in the present paper are very accurate in terms of predicting the weld-induced initial imperfections of steel stiffened plate structures. Details of the numerical computations together with test database are documented.

关键词： Steel Stiffened-Plate Structures Weld-Induced Initial Distortion Weld-Induced Residual Stress Nonlinear Finite Element Method Three-Dimensional Ther-mo-Elastic-Plastic Finite Element Analysis Full Scale Measurements

Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-Cheol Son Moon-Jong Han Woo-Jin Kim Soo-Hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun Shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute ltd.

AIM: To determine intestinal permeability,the serum tumor necrosis factor (TNF)-α level and urine nitric oxide (NO) metabolites are altered in liver cirrhosis (LC) with or without ascites. METHODS: Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol (PEG) 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay (ELISA) and Greiss reaction method,respectively. RESULTS: The intestinal permeability index wassignif icantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites (0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03,P < 0.05) and correlated with urine nitrite excretion (r = 0.98). Interestingly,the serum TNF-α concentra-tion was significantly higher in LC without ascites than in control subjects or in LC with ascites (198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL,P < 0.05). Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites (1170.9 ± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L,P < 0.05). CONCLUSION: Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites,but the serum TNF-α concentration was not related to LC with ascites.

关键词：肠内渗透性肿瘤氧化氮肝硬化腹水

Energy Technologies as Power Storage and Generation towards the Business Model in Sustainable Society

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2010年第7期4卷 1-6页

作者： Noboru Sato samsung SDI Co. Ltd. 3-1-1 Roppongi Minato-ku Tokyo 1068532 Japan

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第11期36卷 609-617页

作者： Kyung-Hee Lee Tae Won Kim Jung-Hun Kang Jin-Soo Kim Jin-Seok Ahn Sun-Young Kim Hwan-Jung Yun Young-Jun Eum Sung Ae Koh Min Kyoung Kim Yong Sang Hong Jeong Eun Kim Gyeong-Won Lee Department of Hematology-Oncology Yeungnam University Medical Center Daegu 42415 South Korea Department of Oncology Asan Medical Center University of Ulsan Seoul 05505 South Korea Department of Hematology-Oncology Gyeongsang National University Hospital Jinju 52727 South Korea Department of Internal Medicine SMG-SNU Boramae Medical Center Seoul 07061 South Korea Division of Hematology-Oncology Department of Medicine Samsung Medical Center Seoul 06351 South Korea Department of Hematology.Oncology National Cancer Center Ilsan 10408 South Korea Department of Hematology-Oncology Chungnam National University Hospital Daejeon 35015 South Korea Medical Affairs Mundipharma Korea Ltd Seoul 04637 South Korea Department of Oncology Asan Medical Center University of Ulsan College of Medicine 388.1 Pungnap-dong Songpa-gu Seoul 138.736 South Korea

Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean ***: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 *** primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety ***: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety ***: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatmen

关键词： Constipation Naloxone Oxycodone Quality of life Safety

Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2019年第1期39卷 271-278页

作者： Ji-Yeon Kim Seri Park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine81 Irwon-roGangnam-guSeoul 06351South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and TechnologySungkyunkwan UniversitySeoul 06351South Korea Department of Internal Medicine Seoul National University HospitalCancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Medical Oncology Department of Internal MedicineYonsei University College of MedicineSeoul 03722South Korea Center for Breast Cancer National Cancer CenterGoyang 10408South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Deparment of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC.

关键词： Metastatic breast cancer Eribulin Paclitaxel Neuropathy Quality of life Functional assessment of cancer therapy-taxane questionnaires

用于便携式终端和电子设备的柔感涂层用基于聚丁二烯多元醇和聚烯酸的涂料组合物及其制备方法

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

涂料技术与文摘 2008年第1期29卷 35-35页

作者： Kang, Do-Heang samsung Electronics Co. Ltd.韩国

提供了一种具有优异耐变色性、耐热性、耐黄变性和防污性的用于便携式终端和电子设备的柔感涂料组合物。该涂料组合物含低聚物组合物（由聚丁二烯多元醇和聚烯酸混合制得）和添加到该低聚物组合物中的各种添加剂。该涂料组合物可用于涂... 详细信息

提供了一种具有优异耐变色性、耐热性、耐黄变性和防污性的用于便携式终端和电子设备的柔感涂料组合物。该涂料组合物含低聚物组合物（由聚丁二烯多元醇和聚烯酸混合制得）和添加到该低聚物组合物中的各种添加剂。该涂料组合物可用于涂覆便携式终端和电子设备表面。

关键词：涂料组合物便携式终端电子设备聚丁二烯多元醇制备方法烯酸涂层

Non-destructive thickness characterisation of 3D multilayer semiconductor devices using optical spectral measurements and machine learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Advanced Manufacturing) 2021年第1期2卷 1-11页

作者： Hyunsoo Kwak Sungyoon Ryu Suil Cho Junmo Kim Yusin Yang Jungwon Kim Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141South Korea Memory Metrology&Inspection Technology Team Memory Manufacturing Technology CenterSamsung Electronics Co.Ltd.Gyeonggi-do 18448South Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141South Korea

Three-dimensional(3D)semiconductor devices can address the limitations of traditional two-dimensional(2D)devices by expanding the integration space in the vertical direction.A 3D NOT-AND(NAND)flash memory device is presently the most commercially successful 3D semiconductor *** vertically stacks more than 100 semiconductor material layers to provide more storage capacity and better energy efficiency than 2D NAND flash memory *** the manufacturing of 3D NAND,accurate characterisation of layer-by-layer thickness is critical to prevent the production of defective devices due to non-uniformly deposited *** date,electron microscopes have been used in production facilities to characterise multilayer semiconductor devices by imaging cross-sections of ***,this approach is not suitable for total inspection because of the wafer-cutting ***,we propose a non-destructive method for thickness characterisation of multilayer semiconductor devices using optical spectral measurements and machine ***>200-layer oxide/nitride multilayer stacks,we show that each layer thickness can be non-destructively determined with an average of approximately 1.6Åroot-mean-square *** also develop outlier detection models that can correctly classify normal and outlier *** is an important step towards the total inspection of ultra-high-density 3D NAND flash memory *** is expected to have a significant impact on the manufacturing of various multilayer and 3D devices.

关键词： NAND multilayer character

CistromeMap:A knowledgebase and web server for ChlP-Seq and DNase-Seq studies in mouse and human

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CistromeMap:A knowledgebase and web server for ChlP-Seq and ...

OH Diffusion in Silica Glass Preform During Jacketing Process by Oxy-Hydrogen Burner

第五届全国生物信息学与系统生物学学术大会暨国际生物信息...

作者： Bo Qin Meng Zhou Ying Ge Len Taing Tao Liu Qian Wang Su Wang Junsheng Chen Lingling Shen Xikun Duan Shengen Hu Wei Li Henry Long Yong Zhang X.Shirley Liu Department of Bioinformatics School of Life Science and TechnologyTongji University Center for Functional Cancer Epigenetics Dana-Farber Cancer InstituteBostonMA02115USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard School of Public Health450 Brookline AveBostonMA02115USA Department of Information Technology China Novartis Institutes for BioMedical Research Co.Ltd. Division of Biostatistics Dan L Duncan Cancer Center and Department of Molecular and Cellular BiologyBaylor College of MedicineOne Baylor PlazaHoustonTX 77030USA

Transcription and chromatin regulators,and histone modifications play essential roles in gene expression *** have created CistromeMap as a web server to provide a comprehensive knowledgebase of all of the publicly available ChIP-Seq and DNase-Seq data in mouse and human. In total,CistromeMap contains 2711 ChlP-Seq datasets for transcription and chromatin regulators,2355 for histone modifications and variants,412 DNase-Seq,and 996 control *** systematically annotated the following metadata for each sample:cell line/ population,cell type,tissue origin,strain(for mouse),disease state,factor name,PubMed ID (for published data),data source,reference,and last *** on the original literature and online information about official gene symbol,cell line and tissue origin,we created our own ontology for better annotation and *** transcription and chromatin regulators,POLR2A,CTCF,ESR1,RELA,and EP300 are the most often profiled ChlP-Seq *** histone marks,H3K4me3,H3K27me3,H3K4mel,H3K36me3 and H3K9me3 ChlP-Seq are the most common,which together accounts for over 70%of all of the histone ChlP-Seq *** details of the above statistics are available at http://***. ***/pc/dcstats/,and will be automatically updated as more ChIP-Seq and DNase-Seq data become available.

关键词： knowledgebase ChlP-Seq DNase-Seq systematic annotation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 76-77页

作者： B.H.Kim S.R.Han U. C.Paek W.-T.Han S. K.Oh Department of Information and Communications Kwangju Institute of Science and Technology (K-JIST) I Oryong-dong Buk-gu Gwangju 500-712 South KoreaDepartment of Information and Communications Kwangju Institute of Science and Technology (K-JIST) I Oryong-dong Buk-gu Gwangju 500-712 South KoreaDepartment of Information and Communications Kwangju Institute of Science and Technology (K-JIST) I Oryong-dong Buk-gu Gwangju 500-712 South KoreaDepartment of Information and Communications Kwangju Institute of Science and Technology (K-JIST) I Oryong-dong Buk-gu Gwangju 500-712 South KoreaEngineering and R & D group Optical Communication Product Division Information & Communication Business Samsung Electronics Co. LTD. # 94-1 Imsoo-dongGumiGyeong-Buk 730-350 South Korea

Radial distribution of OH diffusion in silica glass preform during jacketing process using a oxy-hydrogen burner was investigated by FTIR spectroscopy. The OH peaks at the jacketing boundary and the surface of the pre... 详细信息

关键词： OH Diffusion in Silica Glass Preform During Jacketing Process by Oxy-Hydrogen Burner on for by MCVD in

羟考酮/纳洛酮控释片与羟考酮控释片治疗韩国癌性疼痛患者的疗效及安全性的随机对照研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

癌症 2018年第5期37卷 179-187页

作者： Kyung-Hee Lee Tae Won Kim Jung-Hun Kang Jin-Soo Kim Jin-Seok Ahn Sun-Young Kim Hwan-Jung Yun Young-Jun Eum Sung Ae Koh Min Kyoung Kim Yong Sang Hong Jeong Eun Kim Gyeong-Won Lee Department of Hematology-Oncology Yeungnam University Medical Center Department of Oncology Asan Medical Center University of Ulsan Department of Oncology Asan Medical Center University of Ulsan College of Medicine Department of Hematology-Oncology Gyeongsang National University Hospital Department of Internal Medicine SMG-SNU Boramae Medical Center Division of Hematology-Oncology Department of Medicine Samsung Medical Center Department of Hematology-Oncology National Cancer Center Department of Hematology-Oncology Chungnam National University Hospital Medical Affairs Mundipharma Korea Ltd

背景与目的羟考酮/纳洛酮控释片(controlled?release oxycodone/naloxone,OXN?CR)通过羟考酮发挥阿片类药物诱导的镇痛效果,同时纳洛酮可降低阿片类药物引起的便秘的发生率。本研究旨在评价与羟考酮控释片(controlled?release oxycodone... 详细信息

背景与目的羟考酮/纳洛酮控释片(controlled?release oxycodone/naloxone,OXN?CR)通过羟考酮发挥阿片类药物诱导的镇痛效果,同时纳洛酮可降低阿片类药物引起的便秘的发生率。本研究旨在评价与羟考酮控释片(controlled?release oxycodone,OX?CR)相比,OXN?CR在控制韩国患者癌性疼痛中的非劣效性。方法本项随机、开放标签、平行分组、IV期研究中,我们从韩国的7个肿瘤学/血液学中心招募了年龄20岁及以上、具有中重度癌性疼痛的患者[疼痛数字评价量表(numeric rating scale,NRS)疼痛评分≥4分]。意向治疗人群(intention天20 mg/10 mg,每天最大?to用?treat,ITT)随机(1:1)分为OXN?CR和OX?CR组。OXN?CR组:起始用药量为每药量80 mg/40 mg,用药4周。OX?CR组:起始用药量为20 mg/d,最大用药量为80 mg/d,用药4周。本研究的主要疗效终点为NRS疼痛评分从基线到第4周的变化,其非劣效性界值为-1.5。次要终点包括应急镇痛药摄入量、患者报告的排便习惯改变、缓泻药摄入量、生活质量(quality of life,QoL)及安全性评价。结果 128例患者组成的ITT人群中,7例因缺失主要疗效数据、4例因不符合资格标准被排除疗效分析。在第4周时,OXN?CR组(n=58)和OX?CR组(n=59)患者NRS疼痛评分的平均变化无显著性差异(-1.586 vs.-1.559,P=0.948)。组间差异的单侧95%置信区间(-0.776-0.830)的下限超过非劣效性边界(P <0.001)。OXN?CR和OX?CR两组患者在应急镇痛药摄入量、排便习惯改变、缓泻药摄入量、QoL和安全性评价方面均无显著差异。结论就治疗4周后减轻患者疼痛的效果而言,OXN?CR的疗效非劣于OX?CR,两者具有相似的安全性。对于OXN?CR在长期疼痛控制和缓解便秘方面的疗效,则需在更多韩国癌性疼痛患者人群中开展进一步的研究。

关键词：便秘纳洛酮羟考酮生活质量安全性