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Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones

Chinese Medical Journal 2009年第7期122卷 798-801页

作者： ZHANG Meng-yuan DING Sen-tai Lü Jia-ju LUE Yan-he ZHANG Hui XIA Qing-hua Department of Urology Provincial Hospital Affiliated to ShandongUniversity Jinan Shandong 250021 China Division of Endocrinology Department of Medicine Los AngelesMedical Center and Los Angeles Biomedical Research Institute atHarbor University of California Los Angeles Medical CenterTorrance California 90502 USA

Background Tamsulosin, an alpha-1 receptor antagonist, has been demonstrated effective in promoting distal ureteral stone passage and in reducing pain associated with stone expulsion. This study aimed to evaluate the effect of tamsulosin in comparison with nifedipine and extracorporeal shock wave lithotripsy （ESWL） on the expulsion rate of distal ureteral stones at different sizes. Methods We assigned 314 patients to three categories： Ⅰ, the stone with maximal diameter of 4.0-5.9 mm; Ⅱ, 6.0-7.9 mm, and Ⅲ, 8.0-9.9 mm. Patients in each category were randomly subdivided into three treatment subgroups： group A （nifedipine group）, group B （tamsulosin group）, and group C （ESWL group）. Stone-free rate and the dose of analgesics were recorded weekly during the 4-week follow-up period. Results Three hundred and three patients completed the study. The results showed that nifedipine and tamsulosin treatments promoted a small （4-8 mm, categories Ⅰ and Ⅱ） stone expulsive rate that was comparable with ESWL treatment. Nonetheless, when the stone diameter was 8.0-9.9 mm, ESWL showed a greater stone free rate than nifedipine and tamsulosin treatments; no significant difference existed between the latter two therapies. Although the ESWL treatment group required the least analgesics, tamsulosin treatments required less pain medication than nifedipine （P 〈0.05）. Conclusions Tamsulosin treatment is recommended for patients with the stone diameter smaller than 8 mm because of its feasibility, effectiveness and safety. ESWL is more appropriate than tamsulosin therapy for the patients whose stones are larger than 8 mm.

关键词： tamsulosin distal ureteral stones extracorporeal shockwave lithotripsy expulsive therapy

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Heart failure in the elderly-some aspects in pathophysiology,diagnosis and therapy that require special attention

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Journal of Geriatric Cardiology 2007年第1期4卷 44-49页

作者： Ernst R. Schwarz Division of Cardiology and Comprehensive Transplant center Department of Medicine Cedars Sinai Medical Center & University of California Los Angeles (UCLA) Los Angeles California USA

Approximately 50% of all heart failure patients in the US are above 75 years of age, which is almost similar to most European countries and the Middle and the Far East. Even though aging is an independent molecular process with a multitude of genetic predetermination and biochemical mediations, aging itself does not automatically result in cardiac insufficiency. On the other hand, with increasing age, cardioprotective mechanisms in response to stress are lost, and progressive cardiomyocyte degeneration with replace- ment fibrosis is often seen in older hearts, even though the exact triggers are not completely understood. Older patients with heart failure have distinct features that require special attention in diagnosis as well as therapy. The elderly more frequently suffer from multiple co-morbidities and might have atypical clinical presentations. Several precautions are essential in the treatment of heart failure in the elderly due to co-existing morbidities and the pharmacokinetic and pharmacodynamic changes related to increased age. Also, treatment expectations, compliance, mental status and cognitive function might play a major role regarding optimized treatment and monitoring options in the elderly suffering from heart failure. This review summarizes current issues of heart failure management in the elderly.

关键词： heart failure aging left ventricular function mortality elderly

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Advances of injectable hydrogel-based scaffolds for cartilage regeneration

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Regenerative Biomaterials 2019年第3期6卷 129-140页

作者： Jiawei Li Guojun Chen Xingquan Xu Peter Abdou Qing Jiang Dongquan Shi Zhen Gu Department of Sports Medicine and Adult Reconstructive Surgery Drum Tower HospitalSchool of MedicineNanjing University321 Zhongshan RoadNanjing 210008JiangsuP.R.China Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Jonsson Comprehensive Cancer center University of CaliforniaLos Angeles8-684 Factor BuildingLos AngelesCA 90095USA center for Minimally Invasive Therapeutics University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA

Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial *** to its avascular,aneural and non-lymphatic features,cartilage has limited self-regenerative *** date,the utilization of biomaterials to aid in cartilage regeneration,especially through the use of injectable scaffolds,has attracted considerable *** materials,therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native *** particular,the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of *** review summarizes recent progress in these efforts,including the structural improvement of scaffolds,network cross-linking techniques and strategies for controlled release,which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

关键词： drug delivery tissue engineering injectable hydrogel cartilage regeneration

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington university St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Antiglycation,antioxidant and toxicological potential of polyphenol extracts of alligator pepper,ginger and nutmeg from Nigeria

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 727-732页

作者： Kazeem MI Akanji MA Hafizur Rahman M Choudhary MI Department of Biochemistry University of llorin Department of Biochemistry Lagos State University Dr.Panjwani center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of Karachi

Objective:To evaluate the antioxidant and antiglycation potential of polyphenols from three spices;alligator pepper,ginger and ***:Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay,phyloloxicily test,DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation ***:Results obtained showed that polyphenol extract of ginger has the highest anlioxidant potential with IC_(50)0.075 and 0.070 mg/*** DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC_(50)0.125 mg/***,nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD_(50)4359.70 and 1490μg/mL ***:It can be concluded that the polyphenol extracts of alligator pepper,ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are,safe for consumption.

关键词： Glycation Hyperglycemia Polyphenols Spices Free radicals Antioxidants

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Harmonic 2-forms and positively curved 4-manifolds

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Science China Mathematics 2021年第7期64卷 1613-1620页

作者： Kefeng Liu Jianming Wan Mathematical Science Research center Chongqing University of TechnologyChongqing 400054China Department of Mathematics University of California at Los AngelesLos AngelesCA 90095USA School of Mathematics Northwest UniversityXi'an 710127China

We prove that if a compact Riemannian 4-manifold with positive sectional curvature satisfies a strengthened Kato type inequality,then it is *** also discuss some new insights for compact Riemannian 4-manifolds with po... 详细信息

关键词： positive curvature harmonic forms Hopf conjecture

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Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review

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World Journal of Hepatology 2014年第1期6卷 55-63页

作者： Archita Sood Mariana Castrejón Sammy Saab Department of Medicine Olive View Medical Center Department of Surgery University of California at Los Angeles Medical Center Departments of Medicine and Surgery University of California at Los Angeles Medical Center

AIM: To investigate the diagnosis, pathogenesis, natural history, and management of nodular regenerative hyperplasia(NRH) in patients with human immunodeficiency virus(HIV). METHODS: We performed a systematic review of the medical literature regarding NRH in patients with HIV. Inclusion criteria include reports with biopsy proven NRH. We studied the clinical features of NRH, in particular, related to its presenting manifestation and laboratory values. Combinations of the following keywords were implemented: "nodular regenerative hyperplasia", "human immunodeficiency virus", "noncirrhotic portal hypertension", "idiopathic portal hypertension", "cryptogenic liver disease", "highly active antiretroviral therapy" and "didanosine". The bibliographies of these studies were subsequently searched for any additional relevant ***: The clinical presentation of patients with NRH varies from patients being completely asymptomatic to the development of portal hypertension – namely esophageal variceal bleeding and ascites. Liver associated enzymes are generally normal and synthetic function well preserved. There is a strong association between the occurrence of NRH and the use of antiviral therapies such as didanosine. The management of NRH revolves around treating the manifestations of portal hypertension. The prognosis of NRH is generally good since liver function is preserved. A high index of suspicion is required to make a identify NRH. CONCLUSION: The appropriate management of HIVinfected persons with suspected NRH is yet to be outlined. However, NRH is a clinically subtle condition that is difficult to diagnose, and it is important to be able to manage it according to the best available evidence.

关键词： Human immunodeficiency virus Nodular regenerative hyperplasia Ascites Systematic review Liver complications

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Harmonic maps between compact Hermitian manifolds

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Science China Mathematics 2008年第12期51卷 2149-2160页

作者： LIU KeFeng YANG XiaoKui center of Mathematical Sciences Zhejiang UniversityHangzhou 310027China Department of Mathematical Sciences California University at Los AngelesLos AngelesCA90095-1555USA

In this paper, we generalize the Bochner-Kodaira formulas to the case of Hermitian complex (possibly non-holomorphic) vector bundles over compact Hermitian (possibly non-K?hler) manifolds. As applications, we get the ... 详细信息

关键词： Bochner-Kodaira formulas harmonic maps strongly negative curvature 53C40

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Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens

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Advanced Photonics 2019年第1期1卷 45-57页

作者： Peng Fei Jun Nie Juhyun Lee Yichen Ding Shuoran Li Hao Zhang Masaya Hagiwara Tingting Yu Tatiana Segura Chih-Ming Ho Dan Zhu Tzung KHsiaic Huazhong university of Science and Technology School of Optical and Electronic InformationWuhanChina Huazhong university of Science and Technology Britton Chance Center for Biomedical PhotonicsWuhan National Laboratory for OptoelectronicsWuhanChina university of California Los AngelesDepartment of BioengineeringLos AngelesCaliforniaUnited States university of Texas at Arlington Joint Department of Bioengineering of UT Arlington/UT SouthwesternArlingtonTexasUnited States university of California Los AngelesSchool of MedicineLos AngelesCaliforniaUnited States university of California Los AngelesChemical and Biomolecular Engineering DepartmentLos AngelesCaliforniaUnited States Osaka Prefecture university Nanoscience and Nanotechnology Research CenterResearch Organization for the 21st CenturyOsakaJapan university of California Los AngelesMechanical and Aerospace Engineering DepartmentLos AngelesCaliforniaUnited States

A key challenge when imaging whole biomedical specimens is how to quickly obtain massive cellular information over a large field of view(FOV).We report a subvoxel light-sheet microscopy(SLSM)method enabling high-throughput volumetric imaging of mesoscale specimens at cellular resolution.A nonaxial,continuous scanning strategy is developed to rapidly acquire a stack of large-FOV images with three-dimensional(3-D)nanoscale shifts ***,by adopting a subvoxel-resolving procedure,the SLSM method models these low-resolution,cross-correlated images in the spatial domain and can iteratively recover a 3-D image with improved resolution throughout the *** technique can surpass the optical limit of a conventional light-sheet microscope by more than three times,with high acquisition speeds of gigavoxels per *** fast reconstruction of 3-D cultured cells,intact organs,and live embryos,SLSM method presents a convenient way to circumvent the trade-off between mapping large-scale tissue(>100 mm3)and observing single cell(∼1-μm resolution).It also eliminates the need of complicated mechanical stitching or modulated illumination,using a simple light-sheet setup and fast graphics processing unit-based computation to achieve high-throughput,high-resolution 3-D microscopy,which could be tailored for a wide range of biomedical applications in pathology,histology,neuroscience,etc.

关键词： light-sheet microscopy subvoxel-resolving reconstruction large tissue imaging high-throughput volumetric imaging

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Stiffness heterogeneity-induced double-edged sword behaviors of carcinoma-associated fibroblasts in antitumor therapy

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Science China Materials 2019年第6期62卷 873-884页

作者： Jiantao Fen Shivani Sharma Elizabeth Rao Xiang Li Qiang Zhang Fulong Liao Jie He Dong Han Jianyu Rao Cancer Hospital Chinese Academy of Medical Sciences Department of Pathology and Laboratory Medicine University of CaliforniaLos Angeles California NanoSystems Institute University of CaliforniaLos Angeles Jonhson Comprehensive Cancer Institute University of CaliforniaLos Angeles National center for Nanoscience and Technology Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Carcinoma-associated fibroblasts(CAFs) function as a double-edged sword in tumor progression. However,factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found that the transition was determined by stiffness heterogeneity of the tumor stroma in which tumor cells and CAFs were *** tumor cells were grown on a rigid plastic substrate,supernatants from CAFs inhibited the cytotoxic effects of 5-fluorouracil. In contrast, when tumor cells were grown on a soft substrate(5.3 kPa), supernatants from CAFs grown on a soft substrate increased the cytotoxicity of 5-fluorouracil. The diverse effects of CAFs were mediated by mechanotransduction factors, including stroma stiffness-induced cytokine expression in CAFs and signal transduction associated with stress fiber formation of CAFs. Moreover, we found that the cytokine expression in CAFs was regulated by nuclear Yesassociated protein, which changed according to cell stiffness,as characterized by atomic force microscopy. Overall, these findings suggested that modulating the mechanotransduction of the stroma together with CAFs might be important for increasing the efficacy of chemotherapy.

关键词： stiffness carcinoma-associated fibroblast tumor microenvironment chemotherapy atomic force microscopy

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