检索结果-南通市图书馆

Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis

Cellular & Molecular Immunology 2022年第11期19卷 1263-1278页

作者： Xiao Shan Penghui Hu Lina Ni long Shen Yanan Zhang Zemin Ji Yan Cui Meihua Guo Haoan Wang Liyuan Ran Kun Yang Ting Wang Lei Wang Bin Chen Zhi Yao Vingjie Wu Qiujing Yu Tianjin Institute of Immunology Key Laboratory of Immune Microenvironment and Disease of the Ministry of EducationThe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsTianjin Key Laboratory of Inflammation BiologyDepartment of ImmunologySchool of Basic Medical SciencesTianjin Medical University Division of Infectious Disease Second Hospital of Tianjin Medical UniversityTianjin300070China Institute for Genome Engineered Animal Models of Human Diseases National Center of Genetically Engineered Animal Models for International ResearchDalian Medical UniversityDalian116044LiaoningChina Shandong Provincial hospital School of Laboratory Animal and Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University and Shandong Academy of Medical SciencesJinan250021ShandongChina The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Department of Pharmacology and Tianjin Key Laboratory of Inflammation BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Tianjin Institute of Immunology Key Laboratory of Immune Microenvironment and Disease of the Ministry of EducationDepartment of ImmunologySchool of Basic Medical SciencesTianjin Medical UniversityTianjinChina Department of Molecular Pathobiology New York University College of DentistryNew YorkNY10010USA

Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key enzyme phosphoglycerate dehydrogenase in the serine biosynthesis pathway or by exogenous serine and glycine restriction, robustly enhances the polarization of interferon-γ-activated macrophages (M(IFN-γ)) but suppresses that of interleukin-4-activated macrophages (M(IL-4)) both in vitro and in vivo. Mechanistically, serine metabolism deficiency increases the expression of IGF1 by reducing the promoter abundance of S-adenosyl methionine-dependent histone H3 lysine 27 trimethylation. IGF1 then activates the p38-dependent JAK–STAT1 axis to promote M(IFN-γ) polarization and suppress STAT6-mediated M(IL-4) activation. This study reveals a new mechanism by which serine metabolism orchestrates macrophage polarization and suggests the manipulation of serine metabolism as a therapeutic strategy for macrophage-mediated immune diseases.

关键词： Serine metabolism PHGDH Macrophage polarization SAM IGF1 p38

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Telemonitoring and hemodynamic monitoring to reduce hospitalization rates in heart failure： a systematic review and meta-analysis of randomized controlled trials and real-world studies

引用

Journal of Geriatric Cardiology 2018年第4期15卷 298-309页

作者： Gary Tse Cynthia Chan Mengqi Gong Lei MENG Jian ZHANG Xiao-Ling SU Sadeq Ali-Hasan-Al-Saegh Abhishek C Sawant George Bazoukis Yun-long XIA Ji-Chao Zhao Alex Pui Wai Lee Leonardo Roever Martin CS Wong Adrian Baranchuk Tong Liu Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University Tianjin China State Key Laboratory of Cardiovascular Disease Heart Failure Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of Cardiology Qinghai Provincial People's Hospital Xining China Cardiovascular Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran Division of Cardiology State University of New York at Buffalo Buffalo NY USA The Second Department of Cardiology Laboratory of Cardiac Electrophystology Evangehsmos General Hospital of Athens Athens Greece Department of Cardiovascular Medicine the First Affiliated Hospital of Dalian Medical University Dalian China Auckland Bioengineering Institute the University of Auckland Auckland New Zealand Department of Clinical Research Federal University of Uberlandia Uberlandia MG Brazil JC School of Public Health and Primary Care Faculty of Medicine the Chinese University of Hong Kong Hong Kong China Division of Cardiology Kingston General Hospital Queen 's University Kingston Ontario Canada

BackgroundHeart 失败是导致重复住院的一个重要问题。Telemonitoring 并且血液动力学的监视在减少住院率表明了成功，然而并非所有研究报导了重要效果。系统的评论和元分析是在在心 *** 与 ResultsPubMed 和 Cochrane 图书馆减少住院检... 详细信息

BackgroundHeart 失败是导致重复住院的一个重要问题。Telemonitoring 并且血液动力学的监视在减少住院率表明了成功，然而并非所有研究报导了重要效果。系统的评论和元分析是在在心 *** 与 ResultsPubMed 和 Cochrane 图书馆减少住院检验 telemonitoring 和无线血液动力学的监视设备的有效性的这的目的被寻找直到 1 为调查了 telemonitoring 或在住院上的血液动力学的监视的效果的文章的 st 2017年5月评价在心失败。在 31,501 个病人(吝啬的年龄：68 #

关键词：血液动力学评论系统随机化世界试用控制评价

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Erratum to “Novel Wavelet-Based Segmentation of Prostate CBCT Images with Implanted Calypso Transponders” [International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 6 (2017) 336-343]

引用

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 376-376页

作者： Yingxia Liu Ziad Saleh Yulin Song Maria Chan Xiang Li Chengyu Shi Xin Qian Xiaoli Tang Shandong Communication and Media college Jinan China Medical Physics Department Memorial Sloan Kettering Cancer Center New York NY USA Radiation Oncology North Shore Long Island Jewish Health System New Hyde Park NY USA

The original online version of this article (Liu, Y.X., Saleh, Z., Song, Y.L., Chan, M., Li, X., Shi, C.Y., Qian, X. and Tang, X.L (2017) Novel Wavelet-Based Segmentation of Prostate CBCT Images with Implanted Calypso Transponders. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 6, 336-343. doi: 10.4236/ijmpcero.2017.63030) was published without acknowledging our support. The authors wish to add the acknowledgments.

关键词： Erratum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

long-term safety of laser in situ keratomileusis in eyes with thin corneas： 5-year follow-up

引用

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1227-1233页

作者： Yao-Wen Song Rui He Jack X.Ma Douglas D.Koch Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology and VisualScience Key Laboratory Beijing 100730 China Shanxi Eye hospital Taiyuan 030002 Shanxi ProvinceChina Mc Govern Medical School University of Texas Health Science Center at Houston TX 75835 USA Cullen Eye Institute Department of Ophthalmology Baylor College of Medicine Houston TX 75844 USA

AIM： To investigate the long term（≥5 y） efficacy, predictability, and safety of laser in situ keratomileusis（LASIK） in eyes with thin corneas [central corneal thickness（CCT）〈500 μm]. METHODS： A total of 339 patients met the criteria of this study. Finally, 175 eyes of 89 patients who had thin corneas and underwent LASIK≥5 y ago returned to our clinic and included in this study. Preoperative parameters recorded included uncorrected visual acuity（UCVA）, corrected distance visual acuity（CDVA）, manifest refraction, CCT and corneal topography. At returning visits, in addition to visual acuity and manifest refraction, ultrasound CCT and corneal topography were performed. Optical coherence tomography was used to measure the CCT, LASIK flap thickness, and residual stromal bed thickness（RSBT）. Safety index, efficacy index, percentage of eyes within ±0.5 D and ±1.0 D of refraction, percent tissue altered（PTA）, and percentage stromal bed thickness（PSBT） were calculated. RESULTS： The safety index was 1.09 and efficacy index was 0.99. The percentages of eyes within ±0.5 D and ±1.0 D were 71.2% and 87.7%, respectively. The mean PTA was 40%±6%（range 20% to 55%）; 76 eyes（43.4%） had PTA 〈40% and 99 eyes（56.6%） had PTA≥40%. The mean RSBT was 303±27 μm（range 240 to 390 μm）, and 2 eyes had RSBT〈250 μm. The mean PSBT was 61%±9%（range 51% to 85%）. No eyes developed ectasia. CONCLUSION： In this cohort with the PSBT of 50% or more, LASIK is safe with follow-up for at least 5 y.

关键词： LASIK thin cornea long-term safety percent tissue altered percentage stromal bed thickness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

世界核心医学期刊文摘(神经病学分册) 2006年第12期 21-21页

作者： Noskin O. Jafarimojarrad E. Libman R.B. Nelson J.L. 郭俊 Dr.Department of Neurology Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew Hyde ParkNY 11040United States

Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a “thunder clap”headache and focal neurologic *** of unknown etiology,it has been reported in association with vasoactive sympathomimetic *** authors report Call-Fleming syndrome in two patients with history of antidepressant *** the association is hypothetical,the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache,focal deficits,and evidence of cerebral ischemia during antidepressant use.

关键词：抗抑郁综合征综合病症 Call-Fleming 药物

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

aTME:走向繁荣还是中途夭折?

引用

Gastroenterology Report 2020年第1期8卷 1-4,I0001页

作者： Liang Kang Patricia Sylla Sam Atallah Massaki Ito Steven D.Wexner Jian-Ping Wang Department of Colorectal Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Colon and Rectal Surgery Department of SurgeryIcahn School of Medicine at Mount SinaiNew YorkNYUSA The college of Medicine Endo-Surgical Center of FloridaDepartment of Colorectal SurgeryFlorida HospitalOrlandoFLUSA Colorectal and Pelvic Surgery Division Department of Surgical OncologyNational Cancer Center Hospital EastKashiwaChibaJapan Department of Colorectal Surgery Cleveland Clinic FloridaWestonFLUSA

Since Sylla et al.[1]introduced transanal total mesorectal excision(taTME)in 2010,there has been rapid global uptake of this approach,predicated upon the postulated advantage of improved visualization of and access to the deep pelvic *** approach has been proposed for locally adries have demonstrated the procedural safety and short-and long-term oncologic adequacy of taTME in carefully selected patients,when performed by experienced high-volume taTME surgeons[1–7].

关键词： anatomy carefully experienced

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection

引用

Nano-Micro Letters 2021年第3期13卷 177-193页

作者： Yusi Peng Chenglong Lin Li long Tanemura Masaki Mao Tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John RLombardi Yong Yang State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050People’s Republic of China Graduate School of the Chinese Academy of Sciences No.19(A)Yuquan RoadBeijing 100049People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641People’s Republic of China Department of Frontier Materials Nagoya Institute of TechnologyNagoya 466‑8555Japan State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032People’s Republic of China City college CUNYNew YorkNYUSA

The outbreak of coronavirus disease 2019 has seriously threatened human *** and sensitively detecting SARSCoV-2 viruses can help control the spread of ***,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor ***,it is worthwhile to search novel semiconductor-based substrates with excellent SERS *** we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic *** SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 532 ***,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike ***,its detection limit is as low as 5×10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel *** research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

关键词： Nb2C and Ta2C MXenes SERS sensitivity PICT resonance SARS-CoV-2 S protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

引用

Nano-Micro Letters 2021年第7期13卷 105-117页

作者： Yong Yang Yusi Peng Chenglong Lin Li long Jingying Hu Jun He Hui Zeng Zhengren Huang Zhi-Yuan Li Masaki Tanemura Jianlin Shi John R.Lombardi Xiaoying Luo State Key Laboratory of High-Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050People’s Republic of China Graduate School of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032People’s Republic of China Anhui Provincial Center for Disease Control and Prevention Hefei 12560AnhuiPeople’s Republic of China Public Health Research Institute of Anhui Province Hefei 12560AnhuiPeople’s Republic of China Shanghai Yangpu hospital of Traditional Chinese Medicine Shanghai 200090People’s Republic of China Department of Frontier Materials Nagoya Institute of TechnologyNagoya 466-8555Japan Department of Chemistry The City College of New York160 Convent AvenueNew YorkNY 10031USA

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 ***,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus *** a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS ***,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of ***,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus.

关键词： SERS SARS-CoV-2 Human ACE2 “Virus-trap”nanostructure Single-virus detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair

引用

Bone Research 2021年第3期9卷 349-359页

作者： Rui Shao Zhong Zhang Zhan Xu Huiling Ouyang Lijun Wang Hongwei Ouyang Matthew Greenblatt Xi Chen Weiguo Zou Shanghai Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell SciencesChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang University-University of Edinburgh InstituteZhejiang UniversityHangzhouZhejiangChina China Orthopedic Regenerative Medicine Group HangzhouZhejiangChina Department of Pathology and Laboratory Medicine Weill Cornell MedicineNew YorkNYUSA Department of Molecular and Cellular Biology Lester and Sue Smith Breast CenterDan L.Duncan Cancer CenterBaylor College of MedicineHoustonTXUSA

Chondrocyte differentiation is a critical process for endochondral ossification,which is responsible for long bone development and fracture *** progress has been made in understanding the transcriptional control of chondrocyte differentiation;however,epigenetic regulation of chondrocyte differentiation remains to be further ***1 is a H3K36(histone H3 at lysine 36)***,we showed that mice with Nsd1 deficiency in Prx1+mesenchymal progenitors but not in Col2+chondrocytes showed impaired skeletal growth and fracture healing accompanied by decreased chondrogenic *** combined RNA sequencing(RNA-seq)and chromatin immunoprecipitation sequencing(ChIP-seq)analysis,we identified sex determining region Y box 9(Sox9),the key transcription factor of chondrogenic differentiation,as a functional target gene of ***,NSD1 regulates Sox9 expression by modulating H3K36me1 and H3K36me2 levels in the Sox9 promoter region,constituting a novel epigenetic regulatory mechanism of ***,we found that NSD1 can directly activate the expression of hypoxia-inducible factor 1α(HIF1α),which plays a vital role in chondrogenic differentiation through its regulation of Sox9 ***,the results of our study reveal crucial roles of NSD1 in regulating chondrogenic differentiation,skeletal growth,and fracture repair and expand our understanding of the function of epigenetic regulation in chondrogenesis and skeletal biology.

关键词： skeletal impaired healing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

早期莱姆病

引用

世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 1-2页

作者： Wormser G.P. 冯义国 Munger Pavilion New York Medical CollegeValhallaNY 10595United States Dr.

A 26-year-old woman with a summer home on long island,New York,had a low-grade fever,malaise,arthralgias,headache,and neck pain one week after removing a tick from her *** reveals a nontender oval(8 by 12 cm),homogeneously erythematous lesion at the site of the tick bite,consistent with erythema *** should this case be managed? What if she had presented earlier,just after removing the tick?

关键词：莱姆病游走性红斑蜱叮咬关节痛颈痛纽约长岛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：