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Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products

Engineering 2020年第11期6卷 1217-1221页

作者： Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Science 8 Peking Union Medical CollegeBejjing 100730.China National Engineering Research Center of Light Alloys Net Forming&State Key Laboratony of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Notional Engineering Research Center of Mg Materials and Applicarions and School of Materials Science 8r Engineering.Shanghai Jlao Tong University Shanghai 200240China Department of Spine Surgery Beijing Jishuitan HospitalBeijing 100035China Center for Troanslational Medicine Research and Development Institute of Biomedical and Health EngineeringShenzhen Insitute of Advanced Technology.Chinese Academy of SciencesShenzhen 518055China Guangdong Engineering Laboratony of Biomaterials Additive Manufacturing Guangdong 518055China Musculoskeletal Research Laboratory of the Department of Orthopedics 8 Traumatology and Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Center for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstiuteShenzhen 518057.China Hong Kong Branch of National Precious Metals Material Engineering Research Center Department of Material Science and EngineeringCity Untiversity of Hong KongHong Kong 999077.China Department of Mechanical Engineering ity Untiversity of Hong Kong.Hong Kong 9977 China School of Pharmacy.Shanghai Jiao Tong University Shanghai 200240China China State Instute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical IndustryShonghai 201203China Shanghai Innovation Instinute for Materials Shanghai 200444.China State Key Laboratory of High-Performance Ceramies and Superfine Microstructure Shanghai Institute of CeramicsChinese Acadermy 0f SciencesShanghai 200050Ch

*** and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)*** and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common *** example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of *** most widely used materials in biomedicine are *** homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.

关键词： composites printing additive

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Low intensity mechanical signals promote proliferation in a cell-specific manner:Tailoring a non-drug strategy to enhance biomanufacturing yields

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Mechanobiology in Medicine 2024年第4期2卷 59-68页

作者： M.Ete Chan Christopher Ashdown Lia Strait Sishir Pasumarthy Abdullah Hassan Steven Crimarco Chanpreet Singh Vihitaben S.Patel Gabriel Pagnotti Omor Khan Gunes Uzer Clinton T.Rubin Department of Biomedical Engineering College of Engineering and Applied SciencesRenaissance School of MedicineStony Brook UniversityStony BrookNY11794-5280USA Medical Scientist Training Program Renaissance School of MedicineStony Brook UniversityStony BrookNY11794USA Department of Endocrine Neoplasia and Hormonal Disorders MD Anderson Cancer CenterHoustonTX77030USA Department of Mechanical and Biomedical Engineering College of EngineeringBoise State UniversityBoiseID83725-205USA Center for Biotechnology New York State Center for Advanced Technology in Medical BiotechnologyStony Brook UniversityStony BrookNY11794-5281USA

Biomanufacturing relies on living cells to produce biotechnology-based therapeutics,tissue engineering constructs,vaccines,and a vast range of agricultural and industrial *** the escalating demand for these bio-based products,any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the *** these goals are primarily achieved using biological or chemical strategies,harnessing cell mechanosensitivity represents a promising–albeit less studied–physical pathway to promote bioprocessing endpoints,yet identifying which mechanical parameters influence cell activities has remained *** tested the hypothesis that mechanical signals,delivered non-invasively using low-intensity vibration(LIV;ny unique signal configuration was not equally influential across a range of cell *** frequency,intensity,duration,refractory period,and daily doses of LIV increased proliferation in Chinese Hamster Ovary(CHO)-adherent cells(t79%in 96 hr)using a particular set of LIV parameters(0.2 g,500 Hz,330 min/d,2 hr refractory period),yet this same mechanical input suppressed proliferation in CHO-suspension cells(13%).Another set of LIV parameters(30 Hz,0.7 g,260 min/d,2 hr refractory period)however,were able to increase the proliferation of CHO-suspension cells by 210%and T-cells by 20.3%.Importantly,we also reported that T-cell response to LIV was in-part dependent upon AKT phosphorylation,as inhibiting AKT phosphorylation reduced the proliferative effect of LIV by over 60%,suggesting that suspension cells utilize mechanism(s)similar to adherent cells to sense specific LIV *** image velocimetry combined with finite element modeling showed high transmissibility of these signals across fluids(>90%),and LIV effectively scaled up to T75 ***,when LIV is tailored to the target cell populati

关键词： Biomanufacturing Cell proliferation Mechanical stimulation Biomechanics Adherent cells Suspension cells Stem cells Vibration

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Surgical left atrial appendage occlusion during cardiac surgery： A systematic review and meta-analysis

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World Journal of Cardiology 2018年第11期10卷 242-249页

作者： Varunsiri Atti Mahesh Anantha-Narayanan Mohit K Turagam Scott Koerber Sunil Rao Juan FViles-Gonzalez Rakesh MSuri Poonam Velagapudi Dhanunjaya Lakkireddy David G Benditt Department of Medicine Michigan State University-Sparrow Hospital East Lansing MI 48912 United States Division of Cardiovascular diseases Department of Medicine University of Minnesota Minneapolis MN 55455 United States Helmsley Electrophysiology Center Icahn School of medicine at Mount Sinai New York City NY 10029 United States Department of Cardiac Electrophysiology Medical University of South Carolina Charleston SC 29425 United States Department of Cardiovascular diseases Genesys Heart Institute Ascension Genesys Hospital Grand Blanc MI. Baptist Health South Florida Professor of Medicine at Wertheim College of Medicine Miami FL 33176. Cleveland Clinic Foundation and Cleveland Clinic Abu Dhabi Department of Thoracic and Cardiovascular Surgery. Cleveland Clinic Cleveland OH 44195 United States Structural Heart and Valve Center Center for Interventional Vascular Therapy Division of Cardiology Columbia University Medical Center New York City NY 10027 United States Kansas City Heart Rhythm Institute and Research Foundation Kansas City MO 64132 United States

AIM To evaluate the safety and efficacy of surgical left atrial appendage occlusion(s-LAAO) during concomitant cardiac *** We performed a comprehensive literature search through May 31 st 2018 for all eligible studies comparing s-LAAO vs no occlusion in patients undergoing cardiac surgery. Clinical outcomes during follow-up included: embolic events, stroke, all-cause mortality, atrial fibrillation(AF), reoperation for bleeding and postoperative complications. We further stratified the analysis based on propensity matched studies and AF *** Twelve studies(n = 40107) met the inclusion criteria.s-LAAO was associated with lower risk of embolic events(OR: 0.63, 95%CI: 0.53-0.76; P long-term benefits of s-LAAO are warranted.

关键词： Left atrial appendage Left atrial appendageocclusion Embolic events Stroke Adverse events

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Homologous and Heterologous Covid-19 Booster Vaccinations

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四川生理科学杂志 2021年第11期43卷 2022-2022页

作者： Robert L Atmar From the Departments of Medicine and Molecular Virology and Microbiology Baylor College of Medicine Houston (R.L.A. H.M.E.S.) and Sealy Institute for Vaccine Sciences University of Texas Medical Branch Galveston (R.E.R.) the Center for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore (K.E.L. M.E.D. K.M.N.) and the Division of Microbiology and Infectious Diseases (S.C. S.U.N. P.C.R. J.H.B.) and the Vaccine Research Center (A.B.M. S.E.O.) National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Kaiser Permanente Washington Health Research Institute (L.A.J.) the Departments of Medicine (C.J. T.M.B. M.J. McElrath) and Laboratory Medicine and Pathology (C.J. C.M.P.) University of Washington the Vaccine and Infectious Disease Division (C.J. C.M.P. C.P.D.I. E.R.B. M.J. McElrath) and the Statistical Center for HIV/AIDS Research and Prevention (D.S. J.A.Z.) Fred Hutchinson Cancer Research Center and Seattle Children’s Research Institute (R.N.C.) and the Department of Pediatrics (R.N.C.) University of Washington School of Medicine Seattle the Department of Medicine Division of Infectious Diseases University of Rochester Rochester (A.R.B. D.D.) NYU Langone Vaccine Center and Division of Infectious Diseases and Immunology Department of Medicine NYU Grossman School of Medicine New York (M.J. Mulligan A.C.K.) and NYU Langone Hospital–Long Island Vaccine Center Research Clinic and the Division of Infectious Disease Department of Medicine NYU Long Island School of Medicine Mineola (M.B.) — all in New York the Departments of Pediatrics (C.A.R.) Microbiology and Immunology (M.S.S.) and Medicine (S.E. D.S.S.) the Center for Childhood Infections and Vaccines (C.A.R.) Hope Clinic of Emory Vaccine Center (S.E.) Emory Vaccine Center and Yerkes National Primate Research Center (M.S.S.) Emory University School of Medicine Emory University and Children’s Healthcare of Atlanta (C.A.R.) — all in Atlanta the De

Background:Although the three vaccines against coronavirus disease 2019(Covid-19)that have received emergency use authorization in the United States are highly effective,breakthrough infections are *** are needed on the serial use of homologous boosters(same as the primary vaccine)and heterologous boosters(different from the primary vaccine)in fully vaccinated recipients.

关键词： vaccine breakthrough vaccines

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胸腔镜与开胸肺叶切除的长期生存比较：基于SEER数据库的倾向匹配比较分析

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英国医学杂志中文版 2015年第5期18卷 243-243页

作者： Subroto Paul associate professor Abby J Isaacs senior analyst Tom Treasure professor Nasser K Altorki professor Art Sedrakyan associate professor and director 周礼馨 Department of Health Policy and Research Patient Centered Comparative Effectiveness Program New York Presbyterian Hospital-Weill ComeUMedical College New York NY 10065 USA Department of Cardiothoracic Surgery New York Presbyterian Hospital-Weill Cornell Medical College New Yolk NY 10065 USA Clinical Operational Research Unit University College London London UK 北京大学人民医院胸外科

目的比较微创肺叶切除和开胸肺叶切除术后的远期生存。方法倾向匹配比较分析。背景监测、流行病学及最终结果（SEER）数据库。参与者2007至2009年所有接受肺叶切除的肺癌患者。主要结局测量微创胸腔镜手术对总生存率、无病生存率和肿瘤... 详细信息

目的比较微创肺叶切除和开胸肺叶切除术后的远期生存。方法倾向匹配比较分析。背景监测、流行病学及最终结果（SEER）数据库。参与者2007至2009年所有接受肺叶切除的肺癌患者。主要结局测量微创胸腔镜手术对总生存率、无病生存率和肿瘤特异生存率的影响。结果从2007至2009年，共6008例患者接受了肺叶切除，其中开胸手术4715例（78％）。总体中位年龄74（四分位数间距70～78）岁，中位随访时间为40个月。通过匹配分析，两组均纳入1195例患者，结果提示两组患者的3年总生存率、无病生存率和肿瘤相关生存率均没有统计学差异（总生存率：70．6％比68．1％，P=0．55；无病生存率：86．2％比85．4％，P=0．46；肿瘤相关生存率：92．0％比89．5％，P=0．05）。结论本研究通过倾向匹配分析提示胸腔镜肺叶切除术与开胸肺叶切除术在总生存、无病生存和肿瘤特异生存方面没有显著差异。胸腔镜肺叶切除术后的结局不劣于开胸手术。

关键词： SEER 匹配使用数据库医保腔镜肺

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应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告

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中华男科学杂志 2009年第7期15卷 584-592页

作者：程跃彭弋峰刘毅东田龙吕年青苏新军严泽军胡嘉盛 Richard LEE Howard KIM David C. SOKAL 李石华宁波大学医学院附属宁波市第一医院泌尿中心浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 上海交通大学医学院附属仁济医院泌尿科上海200127 首都医科大学附属北京朝阳医院泌尿科北京100034 江苏省计划生育科学技术研究所江苏南京210036 Center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA Family Health International Research Triangle ParkNC 27709USA

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环... 详细信息

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称"商环,ShangRing")包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18～58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。

关键词：包皮环切术中国商环标准化方案并发症男性成年人

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中国建立男性包皮环切手术标准化和培训的重要性

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中华男科学杂志 2009年第5期15卷 390-394页

作者：李石华吕年青程跃彭弋峰田龙刘毅东贲昆龙徐建春 Richard LEE Howard KIM David C.SOKAL Center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA 江苏省计划生育科学技术研究所江苏南京210036 宁波大学医学院附属宁波市第一医院泌尿科浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 首都医科大学附属北京朝阳医院泌尿科北京100034 上海交通大学医学院附属仁济医院泌尿科上海200127 昆明康涛生物技术有限公司云南昆明650106 昆明医学院第一附属医院男性科云南昆明650106 Family Health International Research Triangle ParkNC 27709USA

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(H... 详细信息

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(HPV)、单纯疱疹病毒2型(HSV-2)和其他性传播疾病(STD)的感染率。虽然男性包皮环切技术有许多,但是没有标准化的手术方案和培训计划。研究表明,男性包皮环切技术的标准化与培训计划的实施可以大大降低并发症发生率。并发症发生率高是实施男性包皮环切服务的一个主要障碍。我们建议,在推广男性包皮环切之前应建立手术标准和培训计划。

关键词：包皮环切术 HIV感染性传播疾病

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