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与亨廷顿病严重程度相关的小胶质细胞激活:一项临床及PET研究

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 61-62页

作者： Pavese N. Gerhard A. P. Piccini 朱振中 Hammersmith Hospital Cyclotron Bldg. DuCane Road w12 0nn london United Kingdom Dr.

Characterization of the Drosophila Atlastin Interactome Reveals VCP as a Functionally Related Interactor

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Journal of Genetics and Genomics 2013年第6期40卷 297-306页

作者： Niamh C.O'Sullivan Nina Dräger Cahir J.O'Kane 4th Floor Burlington Danes BuildingDepartment of MedicineImperial College LondonW12 ONNUnited Kingdom Department of Genetics University of CambridgeDowning StreetCambridge CB2 3EHUnited Kingdom

At least 25 genes,many involved in trafficking,localisation or shaping of membrane organelles,have been identified as causative genes for the neurodegenerative disorder hereditary spastic paraplegia（HSP）.One of the most commonly mutated HSP genes,atlastin-1, encodes a dynamin-like GTPase that mediates homotypic fusion of endoplasmic reticulum（ER） ***,the molecular mechanisms of atlastin-1-related membrane fusion and axonopathy remain *** better understand its mode of action,we used affinity purification coupled with mass spectrometry to identify protein interactors of atlastin in *** of 72 identified proteins revealed that the atlastin interactome contains many proteins involved in protein processing and transport,in addition to proteins with roles in mRNA binding,metabolism and mitochondrial *** highest confidence interactor from mass spectrometry analysis, the ubiquitin-selective AAA-ATPase valosin-containing protein（VCP）,was validated as an atlastin-interacting protein,and VCP and atlastin showed overlapping subcellular ***,VCP acted as a genetic modifier of atlastin：loss of VCP partially suppressed an eye phenotype caused by atlastin overexpression,whereas overexpression of VCP enhanced this *** interactions between atlastin and VCP suggest a functional relationship between these two proteins,and point to potential shared mechanisms between HSP and other forms of neurodegeneration.

关键词： Endoplasmic reticulum Hereditary spastic paraplegias Atlastin Valosin-containing protein

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Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 341-350页

作者： Dechao Feng Yuhan Xiao Jie wang Ruicheng wu Zhouting Tuo Koo Han Yoo wuran wei Dilinaer wusiman Zhipeng wang Dengxiong Li Yubo Yang william C.Cho Mang Ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Science University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of Comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for *** this situation,we summarized the current research actuality and problems in this field using the bibliometric *** in the PubMed and web of Science databases were ***,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of *** from USA,Germany,Italy,China and England have greater studies than *** three publication institutions are University of California System,UDICE-French Research Universities and University of Texas *** research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κ*** conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in *** established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

关键词： Aging circadian rhythm human cancer bibliometric analysis oxidative stress

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming wang Yan wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

Inhibiting lysosomal aldolase: a magic bullet for AMPK activation in treating metabolic disease?

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Life Metabolism 2022年第3期1卷 209-210页

作者： David Carling MRC london Institute of Medical Sciences Imperial CollegeLondon W120NNUK

In a tour-de-force study by Zhang et *** published in Nature Metabolism,a newly identified aldolase inhibitor,Aldometanib,is shown to activate lysosomal AMP-activated protein kinase(AMPK).Remarkably,mice treated with Aldometanib have increased insulin sensitivity,lowered blood glucose,and decreased hepatic steatosis and fibrosis,and are long-lived,effects of which all appear to be mediated via activation of lysosomal *** is a central regulator of mammalian energy homeostasis,and activation of AMPK regulates a wide range of biological processes that are linked to multiple health benefits,associated with an increased healthy lifespan[1].Designing efficacious AMPK activators for clinical use that show long-term safety profiles has proved challenging,but the potential reward for such drugs would be substantial.

关键词： lysosomal homeostasis drugs

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动态增强超声评估早期临床试验新的治疗方法对血管的影响

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国际医学放射学杂志 2012年第5期 494-495页

作者： E.Leen M.Averkiou M.Arditi P.Burns D.Bokor T.Gauthier 陈桂玲 Imaging Department Imperial College London NHS TrustHammersmith Hospital CampusDu Cane RoadLondon W12 0NNUK

摘要影像学在准确监测靶向肿瘤血管的癌症治疗药物抑制其生长及播散的疗效中起着关键作用。动态对比增强超声是一种利用真正的血管内对比剂进行肿瘤血管定量的方法,并具有无创、适用范围广、便捷、成本低、高度敏感和可重复性等优点。2... 详细信息

摘要影像学在准确监测靶向肿瘤血管的癌症治疗药物抑制其生长及播散的疗效中起着关键作用。动态对比增强超声是一种利用真正的血管内对比剂进行肿瘤血管定量的方法,并具有无创、适用范围广、便捷、成本低、高度敏感和可重复性等优点。2010年5月,在实验性癌症医学中心影像网络的倡议和主办下,来自英国、欧洲和北美的专家进行了为期2天的专题研讨会。

关键词：超声对比剂灌注量化血管靶向治疗治疗效果评估

Development of acoustic computer simulation for performance spaces: A systematic review and meta-analysis

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Building Simulation 2022年第10期15卷 1729-1745页

作者： Chao wang Jian Kang School of Architecture Tianjin UniversityTianjin 300072China UCL Institute for Environmental Design and Engineering The BartlettUniversity College London(UCL)Central House14 Upper Woburn PlaceLondon WC1H0NNUK

This article aims to review the development of acoustic computer simulation for performance spaces. The databases of web of Science and Scopus were searched for peer-reviewed journal articles published in English between 1960 and 2021, using the keywords for “simulation”, “acoustic”, “performance space”, “measure”, and their synonyms. The inclusion criteria were as follows: (1) the searched article should be focused on the field of room acoustics (reviews were excluded);(2) a computer simulation algorithm should be used;(3) it should be clearly stated that the simulated object is a performance space;and (4) acoustic measurements should be used for comparison with the simulation. Finally, twenty studies were included. A standardised data extraction form was used to collect the modelling information, software/algorithm, indicators for comparison, and other information. The results revealed that the most used acoustic indicators were early decay time (EDT), reverberation time (T30), strength (G), and definition (D50). The accuracy of these indicators differed greatly. For non-iterative simulation, the simulation accuracies of most indicators were outside their respective just noticeable differences. Although a larger sample size was required for further validation, simulations of T30, EDT, and D50 all showed an increase in accuracy with increasing time from 1979 to 2020, except for G. In terms of frequency, the simulation was generally less accurate at lower frequencies, which occurred at T30, G, D50 and T20. However, EDT accuracy did not exhibit significant frequency sensitivity. The prediction accuracy of inter-aural cross-correlation coefficients (IACC) was even higher at low frequencies than it was at high frequencies. The average value of most indicators showed a clear systematic deviation from zero, providing hints for future algorithm improvements. Limitations and the risks of bias in this review were discussed. Finally, various types of benchmark tests were sug

关键词： acoustic simulation accuracy systematic review performance space iterative simulation

Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy

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world Journal of Gastroenterology 2006年第19期12卷 2969-2978页

作者： VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson Hepatology Section Division of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom Imaging Sciences DepartmentClinical Sciences DivisionFaculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Imaging Sciences Department Clinical Sciences Division Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Hepatology Section Division of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom

Hepatic encephalopathy （HE） is a common neuropsychiatric abnormality, which complicates the course of patients with liver disease and results from hepatocellular failure and/or portosystemic shunting. The manifestations of HE are widely variable and involve a spectrum from mild subclinical disturbance to deep coma. Research interest has focused on the role of circulating gut-derived toxins, particularly ammonia, the development of brain swelling and changes in cerebral neurotransmitter systems that lead to global CNS depression and disordered function. Until recently the direct investigation of cerebral function has been difficult in man. However, new magnetic resonance imaging （MRI） techniques provide a non-invasive means of assessment of changes in brain volume （coregistered MRI） and impaired brain function （fMRI）, while proton magnetic resonance spectroscopy （^1H MRS） detects changes in brain biochemistry, including direct measurement of cerebral osmolytes, such as myoinositol, glutamate and glutamine which govern processes intrinsic to cellular homeostasis, including the accumulation of intracellular water. The concentrations of these intracellular osmolytes alter with hyperammonaemia. MRS-detected metabolite abnormalities correlate with the severity of neuropsychiatric impairment and since MR spectra return towards normal after treatment, the technique may be of use in objective patient monitoring and in assessing the effectiveness of various treatment regimens.

关键词： Hepatic encephalopathy Magnetic resonance imaging Magnetic resonance spectroscopy Diffusion weighted imaging Arterial spin labeling Functional MRI

Bandwidth limits of luminescent solar concentrators as detectors in free-space optical communication systems

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Light(Science & Applications) 2021年第1期10卷 29-40页

作者： Mark Portnoi Paul Anthony Haigh Thomas JM acdonald Filip Ambroz Ivan PParkin Izzat Darwazeh loannis Papakonstantinou Photonic Innovations Lab Department of Electronic and Electrical EngineeringUniversity College LondonLondon WC1E 7JEUK School of Engineering University of NewcastleNewcastle NE17RUUK Department of Chemistry Imperial College LondonLondon W12 OBZUK Department of Chemistry University College LondonLondon WC1H OAJUK Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

Luminescent solar concentrators(LSCs)have recently emerged as a promising receiver technology in free-space optical communications due to their inherent ability to collect light from a wide field-of-view and concentrate it into small areas,thus leading to high optical *** high-speed communication systems integrating LSCs in their detector blocks have already been demonstrated,with the majority of efforts so far being devoted to maximising the received optical power and the system's ***,LSCs may pose a severe bottleneck on the bandwidth of such communication channels due to the comparably slow timescale of the fluorescence events involved,a situation further aggravated by the inherent reabsorption in these systems,and yet,an in-depth study into such dynamic effects remains absent in the *** fill this gap,we have developed a comprehensive analytical solution that delineates the fundamental bandwidth limits of LSCs as optical detectors in arbitrary free-space optical links,and establishes their equivalence with simple RC low-pass electrical ***,we demonstrate a time-domain Monte Carlo simulation platform,an indispensable tool in the multiparameter optimisation of LSC-based receiver *** work offers vital insight into LSC system dynamic behaviour and paves the way to evaluate the technology for a wide range of applications,including visible light communications,high-speed video recording,and real-time biological imaging,to name a few.

关键词： communication integrating devoted