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Brain Urea as a Potential Biomarker of Neoplasm Progression

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Journal of Biosciences and Medicines 2024年第4期12卷 1-13页

作者： Larisa Mikhailovna Obukhova Elena Ivanovna Erlykina Igor Aleksandrovich Medyanik Artem Sergeevich Grishin Angelina Mikhailovna Shutova Federal state Budgetary Educational Institution of Higher Education The &#8220Privolzhsky Research Medical University&#8221 of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia National Research lobachevsky state University of Nizhny Novgorod Nizhny Novgorod Russia

Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.

关键词： Glioma Peritumoral Zone Urea Gliomal Molecular Genetic Markers Ki-67 MGMT

In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan university Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

Frilled Lizard Optimization: A Novel Bio-Inspired Optimizer for Solving Engineering Applications

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Computers, Materials & Continua 2024年第6期79卷 3631-3678页

作者： Ibraheem Abu Falahah Osama Al-Baik Saleh Alomari Gulnara Bektemyssova Saikat Gochhait Irina Leonova OmParkash Malik Frank Werner Mohammad Dehghani Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Software Engineering Al-Ahliyya Amman UniversityAmman19328Jordan Faculty of Science and Information Technology Software EngineeringJadara UniversityIrbid21110Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Symbiosis Institute of Digital and Telecom Management Constituent of Symbiosis International Deemed UniversityPune412115India Neuroscience Research Institute Samara State Medical UniversitySamara443001Russia Faculty of Social Sciences Lobachevsky UniversityNizhny Novgorod603950Russia Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran

This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural *** draws its inspiration from the sit-and-wait hunting strategy of these *** algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after *** assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark *** functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test ***’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative *** simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search *** balanced approach enables FLO to outperform several competing algorithms in numerous test ***,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization ***,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.

关键词： Optimization engineering bio-inspired metaheuristic frilled lizard exploration exploitation

Generation of synchronized x-rays and mid-infrared pulses by Doppler-shifting of relativistically intense radiation from near-critical-density plasmas

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Matter and Radiation at Extremes 2023年第2期8卷 6-13页

作者： Nikita A.Mikheytsev Artem V.Korzhimanov lobachevsky state university of nizhny novgorod 603022 Nizhny NovgorodRussia Federal Research Center Institute of Applied Physics of the Russian Academy of Sciences 603950 Nizhny NovgorodRussia

It is shown that when relativistically intense ultrashort laser pulses are reflected from the boundary of a plasma with a near-critical density,the Doppler frequency shift leads to generation of intense radiation in both the high-frequency(up to the x-ray)and low-frequency(mid-infrared)*** efficiency of energy conversion into the wavelength range above 3μm can reach several percent,which makes it possible to obtain relativistically intense pulses in the mid-infrared *** pulses are synchronized with high harmonics in the ultraviolet and x-ray ranges,which opens up opportunities for high-precision pump–probe measurements,in particular,laser-induced electron diffraction and transient absorption spectroscopy.

关键词： pump intense relativistic

The theory of information images： Modeling based on diffusion equations

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International Journal of Biomathematics 2016年第6期9卷 139-150页

作者： Alexandr Y. Petukhov Sofia A. Polevaya Vladimir G. Yakhno lobachevsky nizhny novgorod state university 23 gagarin avenue 603950 Nizhniy Novgorod Russia

This work represents a formalized description of information and communicative interactions of individuals on the basis of theory of information images (II). It also demonstrates how important it is to choose the models type adequate to the systems under research. It also introduces an explication of the possibility to create the model of information and communication interactions that can illustrate transmission of information between two and more individuals. Methods and approaches suggested in this paper allow us to compare different levels of the described processes depending on the chosen architecture of the model; the methods and approaches mentioned in the current work can be also used to simulate the processes of distortion and generation of information images while information and communication social interaction. Expansion and addition of information images theory in terms of transmission of information among individuals enables us to speak about the space of individual II. The existence of such a space and creation of correct formalized model help us to explain a number of characteristic phenomena of human thinking processes. As a result of this research, the authors introduce an equation that describes the spatial and structural evolution of individual II. There is also an example of modeling on the basis of this theory taking into account the results of the experiment (bilingual Stroop test).

关键词：信息传递扩散方程图像建模模型选择空间结构形式化模型体系结构

Modeling of information images dynamics through the communicative field method

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International Journal of Biomathematics 2016年第4期9卷 147-154页

作者： Alexandr Y. Petukhov S. A. Polevaya lobachevsky nizhny novgorod state university 23 gagarin avenue Nizhniy Novgorod 603950 Russia

This work presents a formalized description of information and communicative interactions of individuals on the basis of the communicative field (CF) method. It also contains explication of the possibility to create model of information and communication interactions, which is able to illustrate both interactions between two and more individuals. Methods and approaches which are suggested in this paper can correctly simulate the processes of distortion and generation of information images (IIs) with information and communication social interaction. Expansion and addition of IIs theory in terms of the transmission of information between individuals allows us to speak about the space of IIs. This space helps to explain a number of characteristic phenomena of human thinking.

关键词：信息传输动态建模图像 IIS 行为模型相互作用生成过程人类思维

New luminescent 10-oxybenzoquinolate complexes of rare earth metals

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Journal of Rare Earths 2023年第8期41卷 1135-1143,I0001页

作者： Tatyana V.Balashova Svetlana K.Polyakova Vasily A.Ilichev Andrey A.Kukinov Roman V.Rumyantcev Georgy K.Fukin Ivan D.Grishin Artem N.Yablonskiy Alexander F.Shestakov Mikhail N.Bochkarev G.A.Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences Tropinina Street49603950Nizhny NovgorodRussian Federation nizhny novgorod state university Gagarina Avenue 23/2603950Nizhny NovgorodRussian Federation Institute for Physics of Microstructures of Russian Academy of Sciences Akademicheskaya Street 7603950Nizhny NovgorodRussian Federation Institute of Problems of Chemical Physics of Russian Academy of Sciences Academician Semenov Avenue1ChernogolovkaMoscow Region142432Russian Federation

A series of Sc,Y,Ce,Pr,Nd,Sm,Eu,Gd,Tb,Ho,Er,Tm and Yb complexes with oxybenzoquinoline ligands(BQ) was synthesized by the reactions of 10-hydroxybenzo[h]quinoline with cyclopentadienides or tris(trimethylsilyl)amides of rare earth *** structure,as well as the photo-and electroluminescent(PL,EL) properties of these complexes in solutions and solid state were *** solutions,complexes of sodium and lanthanides exhibit double peaked ligand-centered PL of enol and keto forms of BQ with a quantum yield of 1%-8%.In the solid state the complexes of Sm,Eu,Ho,Nd,Er,and Yb along with the ligand-centered PL also exhibit a moderate-intensity metal-centered PL which is characteristic of the corresponding Ln^(3+) ***(BQ)_(3) complex shows bright green EL which has intensity comparable to the best results observed for scandium complexes with other organic ligands.

关键词： Lanthanides Photoluminescence(PL) Electroluminescence(EL) 10-hydroxybenzo[h]quinoline X-ray structure Organic light-emitting diodes(OLEDs)

A review on magneto-optical ceramics for Faraday isolators

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Journal of Advanced Ceramics 2023年第5期12卷 873-915页

作者： Lixuan Zhang Dianjun Hu Ilya LSnetkov Stanislav Balabanov Oleg Palashov Jiang Li Transparent Ceramics Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Institute of Applied Physics of the Russian Academy of Sciences Nizhny Novgorod 603950Russia lobachevsky state university of nizhny novgorod Nizhny Novgorod 603950Russia G.G.Devyatykh Institute of Chemistry of High-Purity Substances Russian Academy of SciencesNizhny Novgorod 603951Russia

As a promising magneto-optical(MO)material applied in Faraday isolators,magneto-optical ceramics possess excellent comprehensive properties and have attracted much attention these ***,we review the fabrication and properties of magneto-optical ceramics including garnet,sesquioxide,and A_(2)B_(2)O_(7) *** of the ceramics have been proved to possess applicable performance,while further studies are still needed for most of the magneto-optical *** at the application for isolators,the research status,existing problems,and development trends of magneto-optical ceramics are shown and discussed in this review.

关键词： magneto-optical(MO)ceramics Faraday isolators optical quality thermo-optical effects

Plant hormesis and Shelford’s tolerance law curve

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Journal of Forestry Research 2021年第5期32卷 1789-1802页

作者： Elena A.Erofeeva Department of Ecology Lobachevsky State University of Nizhny Novgorod23 Gagarina PrNizhni NovgorodRussian Federation 603950

Shelford’s law of tolerance is illustrated by a bell-shaped curve depicting the relationship between environmental factor/factors’intensity and its favorability for species or *** is a fundamental basis of ecology when considering the regularities of environment impacts on living systems,and applies in plant biology,agriculture and forestry to manage resistance to environmental limiting factors and to enhance *** recent years,the concept of hormesis has been increasingly used to study the dose-response relationships in living organisms of different complexities,including *** requires the need for an analysis of the relationships between the hormetic dose-response model and the classical understanding of plant reactions to environments in terms of Shelford’s law of *** paper analyses various dimensions of the relationships between the hormetic model and Shelford’s tolerance law curve under the influence of natural environmental factors on plants,which are limiting for plants both in deficiency and *** analysis has shown that Shelford’s curve and hormetic model do not contradict but instead complement each *** hormetic response of plants is localized in the stress zone of the Shelford’s curve when adaptive mechanisms are disabled within the ecological *** the same time,in a species range,the ecological optimum is the most favorable combination of all or at least the most important environmental factors,each of which usually deviates slightly from its optimal *** mechanisms cannot be completely disabled in the optimum,and hormesis covers optimum and stress *** can modify the plant tolerance range to environmental factors by preconditioning and makes limits of plant tolerance to environmental factors flexible to a certain *** turn,as a result of tolerance range evolution,quantitative characteristics of hormesis(width and magnitude of hormetic zone)as well as the range of stimulatin

关键词： Hormetic dose-response Environmental limiting factor Plant stress Phenotypic plasticity Adaptive response