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Asian Journal of Andrology 2013年第3期15卷 391-394页

作者： Miroslav L Djordjevic Vladimir Kojovic School of Medicine University of Belgrade Belgrade 11000 Serbia

We evaluated penile prosthesis implantation with tunica albuginea-relaxing incisions without grafting in the treatment of Peyronie＇s disease associated with erectile dysfunction. Between April 2005 and June 2011, 62 patients underwent surgery due to severe Peyronie＇s disease associated with erectile dysfunction. Malleable and inflatable penile prostheses were inserted in 49 and 13 cases, respectively. Penile prostheses were inserted into the corpora cavernosa using the standard ventral approach. After lifting the neurovascular bundle, the tunica albuginea was incised and opened at the plaque region to correct the deformities and to lengthen the penis. Subsequently, the wide neurovascular bundle was replaced, and all incisions of the tunica albuginea were covered to prevent corporal grafting. In the median follow-up of 35 months （range 14-82 months）, the penis was completely straightened in 59 （95%） patients. Numbness of the glans, which the patients found initially upsetting, decreased or disappeared spontaneously 3-6 months later. Penile prosthesis implantation with tunica albuginea incisions is a viable alternative in the treatment of Peyronie＇s disease because the extensive dissection of the neurovascular bundle allows a good approach to the plaque and provides excellent covering of the incised tunica albuginea without additional grafting.

关键词： erectile dysfunction neurovascular bundle penile prosthesis Peyronie's disease tunica albuginea

Association between innate immunity gene polymorphisms and neonatal sepsis development:a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第10期18卷 654-670页

作者： Tamara Sljivancanin Jakovljevic Jelena Martic Jelena Jacimovic Nadja Nikolic Jelena Milasin Tanja Lazić Mitrović Department of Neonatology The Obstetrics and Gynecology Clinic“Narodni Front”BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia Department of Neonatology Mother and Child Health Care Institute of Serbia“Dr Vukan Cupic”BelgradeSerbia Central Library School of Dental MedicineUniversity of BelgradeBelgradeSerbia Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgradeSerbia

Background The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis *** A comprehensive literature search,reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines,was performed with no language *** derived using the PICO(population,intervention,comparison and outcomes)strategy,with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without *** were analyzed using Review *** Cochran–Mantel–Haenszel test was used to calculate odds ratios with 95%confidence *** was tested using the I2 *** From a total of 9428 possibly relevant articles,33 qualified for inclusion in this systematic *** to the STrengthening the REporting of Genetic Association Studies,23 studies were found to be of moderate quality,while 10 were of low *** results showed an association of the mannose-binding lectin(MBL)exon 1 genetic polymorphism with the risk of culture-proven ***-like receptor(TLR)4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven *** certainty of evidence per GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)varied from very low to *** bias was not *** Out of the 11 investigated single-nucleotide polymorphisms,this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 *** is an evident need for larger well-designed,multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.

关键词： Genetic Immunity Innate Neonatal sepsis Polymorphism

Immobilization of laccase from Myceliophthora thermophila on functionalized silica nanoparticles: Optimization and application in lindane degradation

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Chinese Journal of Chemical Engineering 2020年第4期28卷 1136-1144页

作者： Jelena Bebic Katarina Banjanac Marija Corović Ana Milivojevic Milica Simovic Aleksandar Marinkovic Dejan Bezbradica Directorate of Measures and Precious Metals Mike Alasa 1411000 BelgradeSerbia Innovation Centre of Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000 BelgradeSerbia Department of Biochemical Engineering and Biotechnology Faculty of Technology and MetallurgyUniversity of BelgradeKarnegijeva 411000 BelgradeSerbia Department of Organic Chemistry Faculty of Technology and MetallurgyUniversity of BelgradeKarnegijeva 411000 BelgradeSerbia

This work is focused on immobilization of laccase from Myceliophthora thermophila expressed in Aspergillus oryzae(Novozym 51003?laccase)on amino modified fumed nano-silica(AFNS)and the possible use in ***,for the first time,factors affecting the immobilization of Novozym 51003?laccase on AFNS were investigated for defining the immobilization mechanism and optimizing the utilization of AFNS as support for laccase *** highest specific activity(13.1 IU·mg-1 proteins)was achieved at offered 160 mg per g of AFNS and for the same offered protein concentration the highest activity immobilization yield,reaching68.3%after the equilibrium time,at optimum pH 5.0,was *** immobilization occurs by adsorption as monolayer enzyme binding in 40 min,following pseudo-first-order *** possible use of obtained immobilized preparation was investigated in degradation of pesticide *** 24 h,lindane concentration was reduced to 56.8%of initial concentration and after seven repeated reuses it retained 70%of the original activity.

关键词： Silica nanoparticles Laccase Enzyme immobilization Lindane Bioremediation

Effi ciency of phosphorus accumulation by plankton,periphyton developed on submerged artifi cial substrata and metaphyton:in-situ observation in two shallow ponds

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Journal of Oceanology and Limnology 2021年第3期39卷 928-945页

作者： Marija PEĆIĆ Slađana POPOVIĆ Vesna MILUTINOVIĆ Gordana SUBAKOV SIMIĆ Ivana TRBOJEVIĆ Dragana PREDOJEVIĆ Institute of Botany and Botanical Garden‘Jevremovac’ Faculty of BiologyUniversity of BelgradeBelgrade 11000Serbia Institute of Chemistry Technology and MetallurgyScientific InstitutionNational InstituteCenter for Ecology and TechnoeconomicsUniversity of BelgradeBelgrade 11000Serbia Institute of Public Health of belgrade Belgrade 11000Serbia

Phosphorus overenrichment of shallow ponds prevailing in wetlands leads to their eutrophication causing the collapse of those vulnerable *** potential of phosphorus accumulation by periphyton developed on artificial substrata has been investigated in two shallow ponds(Bara?ka and?iroki Rit)in northwest Serbia and compared to the same ability of plankton and *** periphyton substrate carrier has been submerged from May to *** continuously(CS)and monthly developed(MS)periphyton were *** component of all investigated communities has been qualitatively *** accumulation of only 14.7 mg TP/m^(2) was recorded in three-month exposed periphyton *** exposed from July to August reached maximal 12.7 mg TP/m^(2).Plankton community that was characterized by more diverse and abundantly developed algal component was more effective in phosphorus accumulation(0.7 mg/g dry weight)in comparison with dominantly inorganic and diatom-dominated periphyton in Bara?*** conditions caused by recent revitalization(dredging organic matter and mud from pond basin—redigging)as well as rapid desiccation of?iroki Rit disabled making an unambiguous conclusion about the efficiency of phosphorus accumulation among different communities,but suggested slight potential of phosphorus harvesting by metaphyton in this *** to the shorter exposure time that brings the reduced risk of unpredictable changes in the ecosystem,as well as the considerable amount of accumulated phosphorus,large-scale application of one-month exposed periphyton developed on artificial substrates would be more advisable for phosphorus harvesting in nutrient affected shallow ponds.

关键词： periphyton phosphorus accumulation shallow ponds (phyto)plankton metaphyton eutrophication

Approximation of thermoelasticity contact problem with nonmonotone friction

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Applied Mathematics and Mechanics(English Edition) 2010年第1期31卷 77-86页

作者： Ivan ESTAK Boko S. JOVANOVI Faculty of Mine and Geology University of Belgrade Faculty of Mathematics University of Belgrade

The paper presents the formulation and approximation of a static thermoelasticity problem that describes bilateral frictional contact between a deformable body and a rigid foundation. The friction is in the form of a nonmonotone and multivalued law. The coupling effect of the problem is neglected. Therefore, the thermic part of the problem is considered independently on the elasticity problem. For the displacement vector, we formulate one substationary problem for a non-convex, locally Lipschitz continuous functional representing the total potential energy of the body. All problems formulated in the paper are approximated with the finite element method.

关键词： static thermoelastic contact nonmonotone multivalued friction hemivari-ational inequality substationary problem finite element approximation

Classical behaviour of various variables in an open Bose-Hubbard system

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Chinese Physics B 2011年第12期20卷 63-71页

作者： Nikola Buri Institute of Physics University of BelgradeP O BOX 6811000 BelgradeSerbia

Quantum dispersions of various sets of dynamical variables of an open Bose-Hubbard system in a classical limit are studied. To this end, an open system is described in terms of stochastic evolution of its quantum pure states. It is shown that the class of variables that display classical behaviour crucially depends on the type of noise. This is relevant in the mean-field approximation of open Bose-Hubbard dynamics.

关键词： quantum trajectories decoherence classical limit

Influences of synthesis methods and modifier addition on the properties of Ni-based catalysts supported on reticulated ceramic foams

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International Journal of Minerals,Metallurgy and Materials 2014年第8期21卷 806-812页

作者： Vesna Nikolic Zeljko Kamberovic Zoran Antic Marija Korac Miroslav Sokic Vesna Maksimovic Innovation Center of the Faculty of Technology and Metallurgy University of Belgrade Karnegijeva 4 11120 Belgrade Serbia Faculty of Technology and Metallurgy University of Belgrade Karnegijeva 4 11120 Belgrade Serbia Innovation Center of the Faculty of Chemistry University of Belgrade Studentski trg 12-16 11000 Belgrade Serbia Institute for Technology of Nuclear and other Raw Materials Bulevar Frans d'Eperea 86 11000 Belgrade Serbia Institute for Nuclear Sciences ‘Vinca’ Mike Petrovica Alasa 12-14 11001 Belgrade Serbia

A method of synthesizing Ni-based catalysts supported on α-Al2O3-based foams was developed. The foams were impregnated with aqueous solutions of metal chlorides under an air atmosphere using an aerosol route. Separate procedures involved calcination to form oxides and drying to obtain chlorides on the foam surface. The synthesized samples were subsequently reduced with hydrogen. With respect to the Ni/Al2O3 catalysts, the chloride reduction route enabled the formation ofa Ni coating without agglomerates or cracks. Further research included catalyst modification by the addition of Pd, Cu, and Fe. The influences of the additives on the degree of reduction and on the low-temperature reduction effectiveness （533 and 633 K） were examined and compared for the catalysts obtained from oxides and chlorides. Greater degrees of reduction were achieved with chlorides, whereas Pd was the most effective modifier among those investigated. The reduction process was nearly complete at 533 K in the sample that contained 0.1wt% Pd. A lower reduction temperature was utilized, and the calcination step was avoided, which may enhance the economical and technological aspects of the developed catalyst production method.

关键词： catalysts nickel ceramic foams modification aerosol process catalytic properties

Alternative routes to equivalent classical models of a quantum system

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Chinese Physics B 2012年第12期21卷 51-56页

作者： M.Radonji Slobodan Prvanovi Nikola Buri Institute of Physics University of Belgrade

Coarse-graining of some sort is a fundamental and unavoidable step in any attempt to derive the classical mechanical behavior from the quantum *** utilize the two-mode Bose-Hubbard model to illustrate how different coarse-grained systems can be naturally associated with a fixed quantum system if it is compatible with different dynamical *** coarse-grained systems generate different evolutions of the same physical quantities,and the difference becomes negligible only in the appropriate macro-limit.

关键词： two-mode Bose-Hubbard model coarse-grained system Hamilton operator system dynamical algebra

Carotenoids: New Applications of “Old” Pigments

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1041-1062页

作者： Stefan M.Kolašinac Zora P.DajićStevanović Sofija N.Kilibarda AleksandarŽ.Kostić Faculty of Agriculture University of BelgradeChair of AgrobotanyBelgrade11080Serbia Faculty of Agriculture University of BelgradeChair of Chemistry and BiochemistryBelgrade11080Serbia

Carotenoids represent a large group of mainly red,orange,and yellow natural metabolites mainly involved in regulation of many metabolic *** are beneficial for human *** study describes the importance,chemical composition and functioning of *** is well known that carotenoids support pigments acting in light absorbance mechanisms during photosynthesis,and are known to protect the chlorophyll molecules from oxidative stress and reactive oxygen species(ROS)*** are involved in signaling processes in plants,responses to environmental stresses,pollination,germination and reproduction,and development *** nutrients of strong antioxidant activity that is primarily linked to their polyene molecular structure,the carotenoids are reported as immune-enhancement and anticancer agents,which are also involved in prevention of eye-,gastric and neurocognitive disorders,and in regulation of obesity and *** the wide prospective applications of carotenoids as pharmaceuticals and nutraceuticals,there are some critical aspects associated with carotenoids’bioavailability and challenges in their *** mostly refers to the needs for identification and cloning of genes responsible for carotenoid biosynthesis and transformation and related development of transgenic carotenoid-rich *** the recent years,technologies of micro-and nanoencapsulation have addressed the needs of carotenoid entrapping to enhance their bioavailability,solubility and chemical stability,and to ensure the target delivery and manifestation of their strong antioxidant and other biological *** standard and some advanced analytic tools for carotenoid determination(e.g.,High performance liquid chromatography-HPLC,Liquid chromatography–mass spectrometry-LC-MS,Ultra high performance liquid chromatography-UHPLC,High-performance thin-layer chromatography-HPTLC and others),the vibrational spectroscopy techniques,primaril

关键词： Antioxidant and biological activity biosynthesis of carotenoids encapsulation raman spectroscopy role in plants

Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats

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Biomedical and Environmental Sciences 2019年第7期32卷 508-519页

作者： KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana Immunotoxicology group Department of Ecology Institute for Biological Research 'Sinisa Stankovic ' University of Belgrade 142 Bulevar despota Stefana Belgrade 11000 Serbia Institute of Zoology Faculty of Biology University of Belgrade 16 Studentskitrg Belgrade 11000 Serbia Innovation center of the Faculty of Chemistry University of Belgrade 12-16 Studentskitrg 11000 Belgrade Serbia Institute of Physiology and Biochemistry Faculty of Biology University of Belgrade 16 Studentskitrg Belgrade 11000 Serbia

Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.

关键词： Rats Oral cadmium administration Lungs Cytokine response