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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU Department of Epidemiology&Key Laboratory of cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

Dietary cooking oils and cardiometabolic measurements in an elderly Chinese population

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Journal of Geriatric Cardiology 2024年第6期21卷 642-650页

作者： Xin-Yu WANG Chao-Ying MIAO Xiao-Fei YE Wen-Yuan-Yue WANG Jia-Bo ZHU Yi ZHOU Yan LI Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of cardiovascular Medicine Centre for Epidemiological Studies and Clinical TrialsThe Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To investigate three features of dietary cooking oil intake,namely,the consumption,cooking style,and composition of fatty acids in relation to several cardiometabolic measurements in an elderly Chinese *** The elderly(≥65 years)participants for this study were recruited from two community health centers in the urban area of Shanghai.A questionnaire was administered to collect information on dietary oil consumption(low,medium and high)and cooking styles(fry or stir-fry ***)and the composition of fatty acids(poly-unsaturated ***-unsaturated).The cardiometabolic measurements included anthropometry,blood pressure,fasting plasma glucose and serum *** The 1186 study participants had a mean age of 70.9±5.4 *** mean dietary oil consumption was 35.0 g/d,being low(<25 g/d),medium(25-49 g/d)and high(≥50 g/d)in 485,467 and 234 participants,*** proportion of the fry or stir-fry cooking style and oils rich in mono-unsaturated fatty acids was 30.4%and 27.4%,*** before and after adjustment for sex,age,current smoking and alcohol intake,dietary oil consumption was significantly(P≤0.02)and positively associated with the prevalence of treated hypertension and fasting plasma glucose *** similar adjustments as above and additional adjustment for dietary oil consumption,the fry or stir-fry cooking style was significantly(P≤0.048)and positively associated with body mass index,but inversely with systolic and diastolic blood pressure and serum low-density lipoprotein cholesterol,and the dietary intake of oils rich in mono-unsaturated fat acids was significantly(P≤0.02)and positively associated with diastolic blood pressure,serum triglycerides,total cholesterol and low-density lipoprotein cholesterol,and the prevalence of hypertriglyceridemia and *** This study showed that both the consumption and composition of fatty acids of the dietary oils mattered with regard to sev

关键词： cooking elderly unsaturated

EVOLUTION AND INTERACTION OFδ-WAVES IN THE ZERO-PRESSURE GAS DYNAMICS SYSTEM

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Acta Mathematica Scientia 2024年第5期44卷 1801-1836页

作者： Abhishek DAS K.T.JOSEPH centre for Data science Institute of Technical Education and Research(ITER)Siksha‘O’Anusandhan(Deemed to be University)BhubaneswarOdisha751030India centre for Applicable Mathematics Tata Institute of Fundamental ResearchSharada NagarBangalore560065KarnatakaIndia

Evolution and interaction of plane waves of the multidimensional zero-pressure gas dynamics system leads to the study of the corresponding one dimensional *** this paper,we study the initial value problem for one dimensional zero-pressure gas dynamics *** the first equation is the Burgers equation and the second one is the continuity *** consider the solution with initial data in the space of bounded Borel *** we prove a general existence result in the algebra of generalized functions of *** we study in detail special solutions withδ-measures as initial *** study interaction of waves originating from initial data concentrated on two point sources and interaction with classical shock/rarefaction *** gives an understanding of plane-wave interactions in the multidimensional *** use the vanishing viscosity method in our analysis as this gives the physical solution.

关键词： zero-pressure gas dynamics delta-waves interaction of waves

LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

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science China(Life sciences) 2024年第8期67卷 1601-1619页

作者： Hua Yang Lina Xuan Shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei Jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

Theoretical Analysis of the Buckling Behaviors of Inhomogeneous Shape Memory Polymer Composite Laminates Considering Prestrains

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Acta Mechanica Solida Sinica 2024年第2期37卷 271-284页

作者： Hanxing Zhao Pengyu Cao Fengfeng Li Xin Lan Liwu Liu Yanju Liu Jinsong Leng centre of Composite Materials and Structures Harbin Institute of Technology(HIT)Harbin150080China Department of Astronautical science and Mechanics Harbin Institute of Technology(HIT)Harbin150001China

The mismatch in thermal expansion coefficients between the fiber-rich and resin-rich regions of a shape memory polymer composite(SMPC)laminate,along with the residual strain during SMPC fabrication,results in buckling deformation of the inhomogeneous *** paper presents a macroscopic model for buckling of an inhomogeneous SMPC laminate under initial biaxial *** linear and nonlinear buckling analyses are carried out using the energy *** influences of prestrain biaxiality,temperature,and ply angle on the buckling wavelength,critical buckling prestrain,and buckling amplitude are *** results demonstrate that the critical buckling wavelength of the SMPC laminate is independent of the prestrain,while the amplitude is almost independent of *** addition,the optimal fiber stacking configuration with the maximum critical buckling prestrains of inhomogeneous SMPC laminates is determined by a genetic algorithm.

关键词： Shape memory polymer composite Buckling behavior Inhomogeneous laminate Biaxial prestrains

High-Performance Inverted Perovskite Solar Cells with Sol-Gel-Processed Sliver-Doped NiOx Hole Transporting Layer

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Energy & Environmental Materials 2024年第4期7卷 205-214页

作者： Haibin Wang Zhiyin Qin Xinjian Li Chun Zhao Chao Liang School of Advanced Technology Xi'an Jiaotong-Liverpool University Department of Electrical Engineering and Electronics University of Liverpool School of Humanities and Social sciences Xi'an Jiaotong-Liverpool University Key Laboratory of Materials Physics of Ministry of Education School of Physics and Microelectronics Zhengzhou University MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Physics National Innovation Platform (Center) for Industry-Education Integration of Energy Storage Technology Xi'an Jiaotong University

Nickel oxide （NiOx） has been established as a highly efficient and stable holetransporting layer （HTL） in perovskite solar cells （PSCs）.However,existing deposition methods for NiOxhave been restricted by high-vacuum processes and fail to address the energy level mismatch at the NiOx/perovskite interface,which has impeded the development of PSCs.

关键词： Ag-NiOX/NiOX hole transporting layer inverted perovskite solar cells

Interfacial growth of N,S-codoped mesoporous carbon onto biomass-derived carbon for superior potassium-ion storage

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Nano Research 2024年第4期17卷 2619-2627页

作者： Na Huang Cheng Tang Hao Jiang Jie Sun Aijun Du Haijiao Zhang Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China School of Chemistry and Physics and centre for Materials science Queensland University of TechnologyBrisbaneQLD 4001Australia Shanghai Engineering Research Center of Hierarchical Nanomaterials Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Carbonaceous materials have been recognized as one of the most promising anode materials for potassium-ion batteries(PIBs)due to their abundant raw materials,controllable structure,superior conductivity,and good chemical ***,the large radius of K ions and the low potassium content of intercalation compounds result in the sluggish storage kinetics and low reversible capacity of carbon *** this work,we present a unique heteroatom-doped carbon composite(denoted as NS-MC/SC)through a facile interfacial assembly route and simple heat-treatment process,where NS-MC is well grafted onto the biomass-derived spore carbon(SC).This unique structural design endows it with abundant mesoporous channels,expanded layer spacing,and highly doped N and *** these merits,the NS-MC/SC anode in PIBs exhibits a high reversible capacity of 350.4 mAh·g^(-1) at 100 mA·g^(-1) after 300 cycles,and an outstanding cycling ***,in-situ Raman spectra further verify the high reversibility of K ions insertion/***,theoretical simulations also reveal that the N,S dual-doping is an efficient approach for improving the potassium-ion storage performance of NS-MC/SC.

关键词： mesoporous carbon(MC) biomass-derived carbon(BC) N S co-doping interfacial assembly potassium-ion batteries(PIBs)

High critical current density in Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong Lv Teng-Fei Zhang Zhao-Tong Hu Guang-Lin Xia Ze-Ya Huang Zhen-Hua Liu Li-Hua Que Cai-Ting Yuan Fang-Qin Guo Takayuki Ichikawa Xue-Bin Yu College of Materials science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials science Fudan UniversityShanghai200433China Graduate School of Advanced science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) Lithium-sulfur batteries

Two-stage aging treatment to accelerate aging kinetics without impairing strength in B_4C/7A04Al composite

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science China(Technological sciences) 2024年第8期67卷 2485-2492页

作者： CHEN YunTao MA GuoNan ZHU ShiZe WANG Dong XIAO BoLv MA ZongYi Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials science and Engineering University of Science and Technology of ChinaShenyang 110016China centre of Excellence for Advanced Materials Dongguan 523808China

Aging treatments are the key process to obtain satisfactory strength for 7xxxAl alloys and their composites. However, traditional single-stage(SS) aging is time-consuming to reach a peak strength condition. In this study, an efficient 120℃ + 160℃ two-stage(TS) aging treatment was proposed on a B_4C/7A04Al composite fabricated via powder metallurgy(PM) technology, which could acquire similar peak-aging strength but only took about 15% of the time compared to traditional 120℃ SS aging. The evolution of precipitation during the TS aging was investigated, as well as those of the 7A04Al alloys for comparison. In the second stage aging process, the higher aging temperature accelerated the nucleation of η′ phases inside the grains and thus increased the density of precipitates. Moreover, the short aging time limited the coarsening of precipitates and the broadening of precipitatefree zones. The above factors were beneficial for quickly obtaining satisfactory precipitation strengthening effects. The B_4C/7A04Al composite exhibited slower aging kinetics than the 7A04Al alloy in the TS aging. Mg elements consumption by the chemical reaction between B impurities introduced by B_4C particles and the Al matrix was considered to potentially retard the aging kinetics of the B_4C/7A04Al composite. Nevertheless, the precipitation sequence was not affected.

关键词： aluminum matrix composites aging treatment powder metallurgy mechanical properties precipitation