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Photoluminescence upgradation of La_(2)MgTiO_(6):2%Dy^(3+) perovskite with monovalent(Li^(+)),divalent(Ba^(2+),Sr^(2+)) and trivalent(Bi^(3+),Sm^(3+))cation sensitization

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Journal of Rare Earths 2025年第1期43卷 47-56,I0002页

作者： V.P.Veena K.Arun C.K.Shilpa S.V.Jasira K.M.Nissamudeen School of Pure and Applied Physics Kannur UniversityPayyanur CampusEdatKannurKrala67 India Department of Nanoscience and Nanotechnology Kannur UniversityPayyanur CampusEdatkannurKerala670327India

Nano phosphors of 2%Dy^(3+)(wt%)doped La_(2)MgTiO_(6) and monovalent/divalent/trivalent co-doped La_(1.98)Dy_(0.02)MgTiO_(6):x%A^(y+)(A^(y+):Li+,Ba^(2+),Sr^(2+),Bi^(3+),and Sm^(3+);0≤x≤2 wt%)were synthesized by combustion *** the XRD data,it is deduced that an increase in the valency of co-dopant increases the crystallinity of the double perovskite orthorhombic nanocrystal *** an increase in co-dopant size,an elevation in optical bandgap is visible with the highest bandgap of 3.835 eV for Bi^(3+).The photo-absorption is monotonically broadened for Sr^(2+),Sm^(3+),and Li+around 200-450 ***351 nm,Dy^(3+)triggered lattice shows major characteristic emission peaks at 480 nm(^(4)F_(9/2)→^(6)H_(15/2)),574 nm(^(4)F_(9/2)→^(6)H_(13/2)),and 670 nm(^(4)F_(9/2)→^(6)H_(11/2)).leading to near white light emission with CIE coordinates(0.341,0.376).Upon co-doping,the PL intensity is significantly increased with maximum emission for trivalent Sm^(3+),followed by divalent Sr^(2+)and monovalent Li+*** increasing excitation wavelength,Sr^(2+)shows a dominated output and it is found that divalent Sr^(2+)is a potential codopant that could enhance luminescence intensity up to 6 times with a Sr^(2+)→Dy^(3+)energy transfer efficiency of 86%.It is specified that the CIE coordinates of Li+co-doped samples show ideal white emission with color coordinates(0.333,0.336).The concluding outcomes signify the noblest rare earth Sm^(3+)co-doping and thus Sm^(3+)→Dy^(3+)energy transfer mechanism is discussed in detail.

关键词： Photoluminescence Perovskite WLED Co-doping Rareearths

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Medical Diagnosis Based on Multi-Attribute Group Decision-Making Using Extension Fuzzy Sets,Aggregation Operators and Basic Uncertainty Information Granule

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 759-811页

作者： Anastasios Dounis Ioannis Palaiothodoros Anna Panagiotou Department of Biomedical Engineering Egaleo Park CampusUniversity of West AtticaAthens12243Greece

Accurate medical diagnosis,which involves identifying diseases based on patient symptoms,is often hindered by uncertainties in data interpretation and *** fuzzy set theories have emerged as effective tools to address these *** this paper,new mathematical approaches for handling uncertainty in medical diagnosis are introduced using q-rung orthopair fuzzy sets(q-ROFS)and interval-valued q-rung orthopair fuzzy sets(IVq-ROFS).Three aggregation operators are proposed in our methodologies:the q-ROF weighted averaging(q-ROFWA),the q-ROF weighted geometric(q-ROFWG),and the q-ROF weighted neutrality averaging(qROFWNA),which enhance decision-making under *** operators are paired with ranking methods such as the similarity measure,score function,and inverse score function to improve the accuracy of disease ***,the impact of varying q-rung values is explored through a sensitivity analysis,extending the analysis beyond the typical maximum value of *** Basic Uncertain Information(BUI)method is employed to simulate expert opinions,and aggregation operators are used to combine these opinions in a group decisionmaking *** results provide a comprehensive comparison of methodologies,highlighting their strengths and limitations in diagnosing diseases based on uncertain patient data.

关键词： Medical diagnosis multi-attribute group decision-making(MAGDM) q-ROFS IVq-ROFS BUI aggregation operators similarity measures inverse score function

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Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families

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Chinese Chemical Letters 2025年第1期36卷 474-477页

作者： Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

Heterodimerization in RTKs is of vital importance in the RTK signaling and cell *** between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to external *** RTKs heterodimerization always occur in the same families and is lack of agonists to activate the heterodimeric RTKs signaling ***,we developed the DNA agonist based on bivalent aptamers for the heterodimerized RTKs of different families,AF/AM-1,which could simultaneously activate FGFR1 and c-Met *** is the first agonist that realizing the heterodimerization and activation of FGFR1 and c-Met,two different RTK *** activation of FGFR1/c-Met heterodimer result in the down-stream signals transduction,such as the phosphorylation of Akt and Erk,inducing the cell migration and *** DNA agonist for RTK heterodimer of different families would have potential applications in the fields of biomedicine.

关键词： DNA Agonist Bivalent aptamers RTKs heterodimer

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Normal faulting and its role in the drainage divide migration in the Karιncalιdag region,Menderes Massif,Western Türkiye

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Journal of Mountain Science 2025年第1期22卷 312-323页

作者： TOPAL Savaş IRFAN Mohammad Pamukkale university Department of Geological EngineeringKınıklıCampusDenizli 20160Türkiye university of Kashmir Department of Earth SciencesSrinagar 190006India

Drainage divide migration refers to the shifting boundaries between adjacent drainage basins over time,driven by processes such as tectonic uplift,differential erosion,stream capture,and lithological *** phenomenon has a significant impact on water flow patterns and basin extents,serving as an indicator of the landscape's response to active tectonic *** of the key drivers of divide migration is asymmetric uplift,which causes divides to shift from areas of lower uplift to regions experiencing higher *** divides are inherently dynamic,evolving over time as drainage networks develop and adjust to changing *** study focuses on the migration of the main drainage divide along Karιncalιda?,located between Bozdo?an and *** employs geomorphic analyses using metrics such as the normalized steepness index(ksn),Chi(χ),and Gilbert *** main divide is categorized into four segments(D1–D4),with the Karacasu Fault,situated along the mountain's north-eastern boundary,identified as the primary factor influencing divide *** factors include the relatively low elevation of Karιncalιda?,uniform lithology,and consistent rainfall patterns across the *** results indicate that the main divide is currently stable,suggesting a balance between uplift and ***,higherχvalues in the D4 segment suggest that future erosion may dominate,potentially causing the divide to migrate toward the Bozdo?an *** findings highlight the dynamic nature of drainage divides and the complex interplay of tectonic,erosional,and lithological processes that shape their *** monitoring and advanced geomorphic analysis are essential for understanding the long-term stability of the divide and its response to future tectonic activity and erosional modifications.

关键词： Drainage divide migration Gilbert metrics Karıncalıdağ Karacasu Fault

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Effects of dietary Lactobacillus postbiotics and bacitracin on the modulation of mucosaassociated microbiota and pattern recognition receptors affecting immunocompetence of jejunal mucosa in pigs challenged with enterotoxigenic F18^(+)Escherichia coli

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Journal of Animal Science and Biotechnology 2025年第1期16卷 282-299页

作者： Marcos Elias Duarte Zixiao Deng Sung Woo Kim Department of Animal Science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA

Background Enterotoxigenic Escherichia coli(***)is a threat to humans and animals that causes intestinal *** resistance has urged alternatives,including Lactobacillus postbiotics,to mitigate the effects of enterotoxigenic *** Forty-eight newly weaned pigs were allotted to NC:no challenge/no supplement;PC:F18^(+)*** chal-lenge/no supplement;ATB:F18^(+)*** challenge/bacitracin;and LPB:F18^(+)*** challenge/postbiotics and fed diets for 28 *** d 7,pigs were orally inoculated withF18^(+)*** d 28,the mucosa-associated microbiota,immune and oxidative stress status,intestinal morphology,the gene expression of pattern recognition receptors(PRR),and intestinal barrier function were *** were analyzed using the MIXED procedure in SAS *** PC increased(P<0.05)Helicobacter mastomyrinus whereas reduced(P<0.05)Prevotella copri and ***-corea compared to *** LPB increased(P<0.05)*** and Dialister succinatiphilus compared with *** ATB increased(P<0.05)Propionibacterium acnes,Corynebacterium glutamicum,and Sphingomonas pseudosanguinis compared to *** PC tended to reduce(P=0.054)PGLYRP4 and increased(P<0.05)TLR4,CD14,MDA,and crypt cell proliferation compared with *** ATB reduced(P<0.05)NOD1 compared with *** LPB increased(P<0.05)PGLYRP4,and interferon-γand reduced(P<0.05)NOD1 compared with *** ATB and LPB reduced(P<0.05)TNF-αand MDA compared with *** TheF18^(+)*** challenge compromised intestinal *** increased beneficial bacteria show-ing a trend towards increasing the intestinal barrier function,possibly by reducing the expression of PRR ***-tobacillus postbiotics enhanced the immunocompetence of nursery pigs by increasing the expression of interferon-γand PGLYRP4,and by reducing TLR4,NOD1,and CD14.

关键词： Escherichia coli Immunocompetence Intestinal health Pattern recognition receptors Pigs

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Disentangling the contributing components of stream water by using environmental tracers

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Journal of Mountain Science 2025年第1期22卷 260-277页

作者： Abul Amir KHAN Naresh Chandra PANT Amity Centre for Air Pollution Control(ACAPC)&Amity Centre for Ocean Atmospheric Science and Technology(ACOAST) Amity University Haryana(AUH)Gurugram-122413India Department of Geology University of DelhiNorth CampusDelhi-11007India

Identifying the various components contributing to river discharge can be *** study relies on stable isotopes and electrical conductivity(EC)of water as tracers to distinguish the different components contributing to total river ***,we have made an effort to comprehend the processes that may influence glacier ice melt as well as the limits of oxygen-based hydrograph *** distinct geographic domains in terms of climates and topographies were *** first study site represents the upper Ganga catchment(central Himalaya),while the second site is located in the Chandra sub-basin in western *** in estimating the proportion of glacier melt in isotope mixing model are likely if end-member isotopic compositions,are not well defined,particularly for *** separation results indicate that snowmelt is the largest contributor to total river flow in both *** contribution of snowmelt to the total runoff of the upper Ganga ranged from~60%to 70%.The estimated contributions of glacier melt varied from 36%to 63%in upper Ganga headwater to 6%to 15%at Devprayag and~8%at *** the Hamtah River,glacier and snowmelt contributions,quantified using a two-component mixing model,ranged from 10%to 14%during the pre-and postmonsoon seasons of *** significant spatial and temporal variability,coupled with overlapping isotopic signatures,suggests complex glacio-fluvial interactions in these *** slow-moving air masses with whirling motion closer to the study area irrespective of the direction,and air parcels coming through Bay of Bengal branch are characterized by depleted isotopic rainfall compared to air masses originating from the Arabian Sea.

关键词： Snowmelt Glacier melt Oxygen isotopes Bhagirathi River Alaknanda River Hamtah

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services university of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA university of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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