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AI for science: Predicting infectious diseases

Journal of Safety Science and Resilience 2024年第2期5卷 130-146页

作者： Alexis Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu Jiaojiao Wang Yue Xiang Da Xie Xi Lu Institute of Automation Chinese Academy of SciencesUniversity of Chinese Academy of SciencesBejing 100090China Systems Engineering Cornll UniversityIthacaNY 14853USA David Eccles School of Business the University of UtahUtahUSA collge of Electrical Engineering Sichuan UniversityChina Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering Southeast UniversityNanjing 210096China

The global health landscape has been persistently challenged by the emergence and re-emergence of infectious *** epidemiological models,rooted in the early 2oth century,have provided foundational in-sights into disease ***,the intricate web of modern global interactions and the exponential growth of available data demand more advanced predictive *** is where AI for Science(AI4S)comes into play,offering a transformative approach by integrating artificial intelligence(Al)into infectious disease *** paper elucidates the pivotal role of AI4s in enhancing and,in some instances,superseding tradi-tional epidemiological *** harnessing AI's capabilities,AI4S facilitates real-time monitoring,sophisticated data integration,and predictive modeling with enhanced *** comparative analysis highlights the stark contrast between conventional models and the innovative strategies enabled by *** essence,Al4S represents a paradigm shift in infectious disease *** addresses the limitations of traditional models and paves the way for a more proactive and informed response to future *** we navigate the complexities of global health challenges,Al4S stands as a beacon,signifying the next phase of evolution in disease prediction,characterized by increased accuracy,adaptability,and efficiency.

关键词： AI for science(AI4S) Data integration Global healthchallenges Infectious disease prediction Predictive modeling Real-timemonitoring

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Tumor targeted and GSH stimuli response a-lactalbumin nanotubes co-delivering doxorubicin and siRNA for cancer therapy

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Journal of Future Foods 2024年第4期4卷 300-308页

作者： Guohua Hou Di Wu Xing Li Bin Liu Research Center of Food Colloids and Delivery of Functionaliny Collge of Food Science and Mutritional EngineeringChina Agriculnrral UniversinBeijimg 10083China Department of Numition cand Heaith China Agricultural UniversityBeijing 100193China Deparoment of Health Sciences and Technology.Eidgenossische Technische Hochschule Zinich Zurich 8092Switzerland

α-Lactalbumin(a-lac),a natural food-sourced protein,exhibits high biocompatibility as delivery systems for small bioactive molecules or ***,their potential clinical application as a delivery system is greatly limited due to the 1ack of targeting to desired tissues,such as ***,a delivery system/nanocarier of nantube(NT)was fabricated by the self-assembly of peptides hydrolyzed from *** the 1oading of anti-tumor agents of doxorubicin(Dox)and siRNA,NTs were conjugated with the tLyp-1 peptide to specifially target the neuropilin 1 receptor,which exists on the membrane of MDA-MB-231 cancer *** micromonphology of NTs was not affected during the processes of 1oading and targeting ***,no significant changes in the size and zeta potential of the tI yp-1/NTs/Dox/siRNA nanocarrier were observed when stored in phosphate buffered saline for 7 days,indicating outstanding ***,both the cellular uptake efficiency and tumor accumulation effects of NTs on MDA-MB-231 breast cancer cells were significantly improved after modification with *** relative viability of MDA-MB-231 cells was decreased by 70.1%in viro after treatmnent with tLyp-1/NTs/Dox/siRNA(5μg/mL Dox).Finally,a synergistic anticancer effect of Dox and siRNA co-loaded in tLyp-1/NTs was achieved in the anticancer treatment of MDA-MB-231 tumor-bearing *** findings indicate that food-sourced protein a-lac nanocarriers could be used for the co-delivery of bioactive molecules and RNA,achieving synergistic and effcient therapeutic effects.

关键词： α-Lactabumin nanotube Nanocarier Tumor-targeted siRNA Synergistic effect

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A design of T-foil and trim tab for fast catamaran based on NSGA-II

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Journal of Hydrodynamics 2020年第1期32卷 161-174页

作者： Qi-dan Zhu Yu Ma collge of Automation Harbin Engineering UniversityHarbin 150001China

This paper proposed an optimization design for a ride control system(RCS)for fast *** ship vertical motions are predicted by 2.5-D *** hydrodynamic characteristics of T-foil and trim tab are given,and the dynamic stability of the system is *** this basis,the ride control system optimization model in regular and irregular waves is established for a specific *** optimal solution is obtained by using non-dominated sorting genetic algorithm-II(NSGA-II).

关键词： Deep neural network channel flow turbulence model Reynolds stress

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Colour and organic removal of biologically treated coffee curing wastewater by electrochemical oxidation method

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Journal of Environmental Sciences 2003年第3期15卷 323-327页

作者： Rajesh S. Bejankiwar K.S. Lokesh T.P. Halappa Gowda Department of Environmental Engineering S. J. Collge of EngineeringDepartment of Environmental Engineering S. J. Collge of EngineeringDepartment of Environmental Engineering S. J. Collge of Engineering Mysore-570023 Karnataka State IndiaMysore-570023 Karnataka State IndiaMysore-570023 Karnataka State India

The treatment of biologically treated wastewater of coffee-curing industry by the electrochemical oxidation using steel anode was investigated. Bench-scale experiments were conducted for activated sludge process on raw wastewater and the treated effluents were further treated by electrochemical oxidation method for its colour and organic content removal. The efficiency of the process was determined in terms of removal percentage of COD, BOD and colour during the course of reaction. Several operating parameters like time, pH and current density were examined to ascertain their effects on the treatment efficiency. Steel anode was found to be effective for the COD and colour removal with anode efficiency of 0.118 kgCOD\5h -1\5A -1\5m -2 and energy consumption 20.61 kWh\5kg -1 of COD at pH 9. The decrease in pH from 9 to 3 found to increase the anode efficiency from 0.118 kgCOD\5h -1\5A -1\5m -2 to 0.144 kWh\5kg -1 of COD while decrease the energy consumption from 20.61 kWh\5kg -1 of COD to 12.86 kWh\5kg -1 of COD. The pH of 5 was considered an ideal from the present treatment process as it avoids the addition of chemicals for neutralization of treated effluents and also economical with respect to energy consumption. An empirical relation developed for relationship between applied current density and COD removal efficiency showed strong predictive capability with coefficient of determination of 96.5%.

关键词： electrochemical oxidation coffee-curing wastewater steel anode COD colour removal

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Fuzzy Multi-Criteria Decision Support System for the Best Anti-Aging Treatment Selection Process through Normal Wiggly Hesitant Fuzzy Sets

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Computers, Materials & Continua 2024年第9期80卷 4947-4972页

作者： Daekook Kang Ramya Lakshmanaraj Samayan Narayanamoorthy Navaneethakrishnan Suganthi Keerthana Devi Samayan Kalaiselvan Ranganathan Saraswathy Dragan Pamucar Vladimir Simic Department of Industrial and Management Engineering Institute of Digital Anti-Aging Health CareInje UniversityGimhae-si50834Republic of Korea Department of Mathematics Bharathiar UniversityCoimbatore641046India Department of SocialWork SRMV Collge of Arts and ScienceCoimbatore641020India Department of Radiology Karpagam Medical College and HospitalCoimbatore641032India Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Department of Industrial Engineering and ManagementYuan Ze UniversityTaoyuan City320315Taiwan Department of Mechanics and Mathematics Western Caspian UniversityBakuAZ1001Azerbaijan Faculty of Transport and Traffic Engineering University of BelgradeBelgrade11000Serbia Department of Computer Science and Engineering College of InformaticsKorea UniversitySeoul02841Republic of Korea

This socialized environment among educated and developed people causes themto focusmore on their appearance and health,which turns them towards medical-related treatments,leading us to discuss anti-aging treatment methods for each age group,particularly for urban people who are interested in *** anti-aging therapies are used to address the alterations brought on by aging in human life without the need for surgery or negative *** anti-aging therapies such as microdermabrasion or dermabrasion,laser resurfacing anti-aging skin treatments,chemical peels,dermal fillers for aged skin,and botox injections are considered in this *** on the criteria of safety risk,investment cost,customer happiness,and side effects,the optimal alternative is *** a result,a NormalWiggly Hesitant Pythagorean Fuzzy Set(NWHPFS)is constructed and used in Multi-Criteria Decision-Making(MCDM)using traditional wavy mathematical *** entropy approach is utilized to determine weight values,and the Normal Wiggly Hesitant Pythagorean-VlseKriterijumska Optimizacija I Kompromisno Resenje(NWHPF-VIKOR)method is utilized to rank alternatives using MCDM *** analysis and comparative analysis were performed to ensure the robustness and reliability of the proposed *** smart final choice will undoubtedly assist Decision Makers(DM)in making the right judgments,and the MCDM approach will undoubtedly assist individuals in understanding the medicine.

关键词： Normal wiggly hesitant pythagorean fuzzy set hesitant pythagorean fuzzy set anti-aging treatment entropy VIse Kriterijumska Optimizacija I Kompromisno Resenje

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A comparative analysis of unsteady and steady Buongiorno’s Williamson nanoliquid flow over a wedge with slip effects

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1767-1777页

作者： R.Chandra Sekhar Reddy P.Sudarsana Reddy Department of Mathematics Rajeev Gandhi Memorial Collge of Engineering&TechnologyNandyalA.P.India

Comparison between unsteady and steady MHD Buongiorno’s model Williamson nanoliquid flow through a wedge with slip effects,chemical reaction and radiation is made in this *** and Brownian motion are also considered in this *** similarity variables are presented to transmute the governing PDEs into the set of non-linear *** most widely authenticated finite element method is implemented to analyze these set of ODEs *** behavior of concentration,temperature and velocity sketches for varied values of relevant parameters is numerically calculated and the outcomes are plotted through *** numerical values of dimensionless rates of mass transfer,heat and velocity are also evaluated and depicted through *** is noted that with upsurging values of angle of wedge parameter,the distributions of temperature of the liquid intensify in both steady and unsteady cases.

关键词： Finite element method Chemical reaction Williamson nanoliquid Thermophoresis Thermal radiation Brownian motion

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SOME PROBLEMS ON FRACTAL GEOMETRY AND TOPOLOGICAL DYNAMICAL SYSTEMS

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Analysis in Theory and Applications 2009年第1期25卷 5-15页

作者： Zuoling Zhou Feng Li lingnan collge Sun Yat-sen University Guangzhou 510275 P. R. China Department of Mathematics and Computer Science Albany State University Albany GA 31705 USA

This paper is a continuation of [14], some new problems on fractal geometry and topological dynamical systems have been posed.

关键词： fractal geometry topological dynamical system

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Epidemiology and genetic characterization of tet(X4)-positive Klebsiella pneumoniae and Klebsiella quasipneumoniae isolated from raw meat in Chengdu City, China

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Biosafety and Health 2024年第2期6卷 116-124页

作者： Weishuai Zhai Yiqing Wang Honghu Sun Bo Fu Qidi Zhang Congming Wu Jianzhong Shen Dejun Liu Yang Wang National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Technology Innovation Center for Food Safety Surveillance and Detection Sanya InstituteChina Agricultural University Sanya 572025China Irradiation Preservation Key Laboratory of Sichuan ProvinceChengdu Institute of Food InspectionChengdu 611135China collge of Veterlnary Medicine Qingdao Agricultural UniversityQingdao 266109China

The rapid spread of mobile tigecycline resistance presents a significant public health threat,particularly with the increasing prevalence of tet(X4)-positive Enterobacterales across various *** study aimed to inves-tigate the epidemic features and transmission dynamics of tet(X4)-positive Klebsiella pneumoniae(***-niae)through the analysis of 206 raw meats,including pork(n=182),beef(n=16),duck(n=5),and chicken(n=3).These samples were collected from schools,markets,and restaurants in Chengdu City,China.A total of 25 isolates were obtained from 13 administrative *** isolates exhibited resistance to tetracycline,tigecycline,ampicillin,chloramphenicol,and *** half of the isolates also demon-strated resistance to streptomycin(80%),sulfamethoxazole/trimethoprim(72%),ciprofloxacin(64%),and ampicillin/sulbactam(56%).Among these strains,14 distinct sequence types(STs)were identified,revealing evidence of inter-regional clonal spread,notably among 9 *** *** analysis revealed the presence of two *** ST5 closely resembling hypervirulent *** from ***,12 isolates were capable of transferring tigecycline resistance to Escherichia coli *** plasmid analysis showed that the tet(X4)-harboring plasmids in *** could be classified into four types,primarily belonging to the IncFIA(HI1)/HI1A/HI1B hybrid plasmid(n=16)and IncFII plasmid(n=7),which significantly contributed to the cross-species dissemination of tet(X4).In summary,this study highlights the prevalence of MDR tet(X4)-positive *** in Chengdu,driven predominantly by clonal expansion and plasmid-mediated horizontal gene *** findings emphasize the importance of contin-uous surveillance of tet(X4)-positive *** in raw meat and the implementation of effective measures to control their spread.

关键词： tet(X4) Tigecycline K.pneumoniae Clonal spread Horizontal transfer

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Superior Ductile and High-barrier Poly(lactic acid)Films by Constructing Oriented Nanocrystals as Efficient Reinforcement of Chain Entanglement Network and Promising Barrier Wall

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Chinese Journal of Polymer Science 2022年第10期40卷 1201-1212,I0009页

作者： Lin Zhou Ping-Ping Xu Shi-Hao Ni Ling Xu Hao Lin Gan-Ji Zhong Hua-Dong Huang Zhong-Ming Li collge of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

It is a daunting task to develop a promising strategy at an industrial scale for simultaneously ameliorating ductility and gas barrier performance of poly(lactic acid)(PLA)films in the application of green *** this work,biaxial stretching and constrained annealing were employed to prepare transparent PLA films with superior ductility and barrier *** oriented nano-sized crystals induced by biaxial stretching were developed into regularαform during constrained annealing,which could not only serve as“nano-barrier wall”to impede the diffusion and dissolution of gas molecules,but also strengthen amorphous chain entanglement network as physical crosslink to enhance *** a result,the as-prepared PLA films exhibited an outstanding comprehensive performance with a low oxygen and water vapor permeability coefficient of 0.733×10^(-14) cm^(3)·cm·cm^(-2)·s^(-1)·Pa^(-1) and 3.82×10^(-14) g·cm·cm^(-2)·s^(-1)·Pa^(-1),respectively,outstanding ductility with elongation at break of 66.0%,high yield strength of 84.2 MPa,and good transparency of more than 80%at 550 *** new insight in the relationship between microscopic amorphous and crystalline structure and macroscopic performance is conducive to alleviating the intrinsic defects of brittle and insufficient barrier PLA films without the aid of any heterogenous modifiers,facilitating their widespread commercialization in the booming sustainable packaging market.

关键词： Poly(lactic acid)films Biaxial stretching Constrained annealing Gas barrier properties Ductility

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Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

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Chinese Journal of Natural Medicines 2020年第9期18卷 704-713页

作者： JING Guang-Chan LIU Di LIU Yu-Qin ZHANG Meng Ren Deparment of Traditional Chinese Medicine Peking Union Medical Collge HospitalPeking Union Medical Collge and Chinese Academy of Medical SciencesBeijing 100730China Deparment 0f cell resource center Institute of Basic Medical SciencePeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Chinese herbal compound Nao-Fu-Cong(NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine(TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ(60 mg·k^(-1))-induced diabetic rats into control group, diabetic model group and NFC groups(low-dose, medium-dose and high-dose). The primary culture of hippocampal neurons were transferred into different culture media on the third day. The cells were then divided into control group, high-glucose group, NFC(low-dose, medium-dose and high-dose) groups, CHOP si-RNA intervention group, JNK pathway inhibitor SP600125 group and oxidative stress inhibitor N-acetylcysteine(NAC) group. NFC significantly improved the cognitive function of diabetic rats, and had neuroprotective effect on hippocampal neurons cultured in high glucose. Further research results showed that NFC could reduce the apoptosis of hippocampal neurons in rats with diabetic cognitive dysfunction. NFC had inhibitory effects on CHOP/JNK apoptosis pathway induced by high glucose, and also decreased the levels of ROS and increased the mitochondrial membrane potential. These suggested that the neuroprotective effect of NFC might be related to the inhibition of CHOP and JNK apoptotic signaling pathways, and the cross pathway between oxidative stress and mitochondrial damage pathway.

关键词： Nao-Fu-Cong Apoptosis High glucose Hippocampal neurons

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