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Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： shan-shan Xu Li-Hai Hao Yan-Meng Guan Hemodialysis Center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(sHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic *** calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular *** case report describes a maintenance hemodialysis patient with refractory sHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular *** sUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus *** developed sHPT,and an electrocardiogram revealed a first-degree atrioventricular ***,she underwent parathyroidectomy(PTX)with ***,a few years later,she developed sHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was *** This case revealed that metastatic cardiac calcification can result in complete atrioventricular *** parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular *** is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

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World Journal of Clinical Cases 2024年第7期12卷 1296-1304页

作者： Dan Wu Qiong Wang shuai Yan Xia sun Ya Qin Ming Yuan Nan-Yao Wang Xian-Ting Huang Department of Oncology Jiangyin People's HospitalWuxi 214400Jiangsu ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant *** decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more ***-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic *** data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune *** sUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFs)of 10 *** 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 ***,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was *** patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)*** patient died in February *** 2 also took two prior lines of chemotherapy and then local radiotherapy combined with *** confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third *** the patient had COVID-19 in December 2022,fruquintinib was *** patient died in January 2023 due to disease *** Both cases achieved a PFs benefit from later-line single-agent fruquintinib *** its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

关键词： Pancreatic cancer Anti-vascular endothelial growth factor receptor Fruquintinib Case report

3D printed grafts with gradient structures for organized vascular regeneration

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International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao Fu Zhuang Li Zhaojie Zhang Meng Zhu Qing Gao shaofei Wu Guosheng Fu Yong He Jiayin Fu state Key Laboratory of Fluid Power and Mechatronic systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China school of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China school of Mechanical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(sDVGs) in clinical practice due to thrombosis and stenosi... 详细信息

synthetic vascular grafts suitable for small-diameter arteries(still no commercially available small-diameter vascular grafts(sDVGs) in clinical practice due to thrombosis and stenosis after in vivo *** designing sDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(sML).To facilitate rapid sML regeneration,a high-resolution 3D printing method was used to create a novel bilayer sDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of sML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate sML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide sDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of sML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

A dual-route optical emission spectroscopy diagnostic with wide spectral range and high wavelength resolution on HL-2A tokamak

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Plasma science and Technology 2024年第3期26卷 25-30页

作者：陈越高继昆龙婷聂林高金明马尧黄渊田文静刘延民朱晓东庄革钟武律许敏 school of Physical sciences School of Nuclear Sciences and TechnologyUniversity of Science and Technology of ChinaHefei 230026People's Republic of China southwestern Institute of Physics Chengdu 610041People's Republic of China Tsinghua University Beijing 100084People's Republic of China

A dual-route optical emission spectroscopy(D-OEs)diagnostic is newly developed to monitor the optical emission from the X-point plasma region on the HL-2 A *** diagnostic is composed of an imaging system,a beam-splitting system for dual-route measurements,fiber bundles,a spectrometer system,and a control and acquisition *** route is used to obtain wide-spectral-range spectra,and the other route is used to acquire high-wavelengthresolution line *** spectral resolution of the wide-range spectrometers is 0.8 nm with a coverage of 800 nm(@200-1000 nm).The spectral resolution of the high-resolution spectrometer is 0.01 nm with a coverage of 6 nm(@200-660 nm).The spatial resolution of each route of D-OEs is about 4 cm with 11 *** temporal resolution is 16 ms at maximum in the single-channel ***-range spectra(containing Balmer series and a Fulcher band)and highly resolved Ha line shapes are obtained by D-OEs in the hydrogen glow discharge in the lab.D-OEs measurements are carried out in the high-density deuterium experiments of *** electron density n_(e)and deuterium temperature T_(D) in the X-point multifaceted asymmetric radiation from the edge(MARFE)region are derived simultaneously by fitting the measured D_(a) *** density n_(e)is observed to increase from~8.7×10^(18)m^(-3)to~7.8×10^(19)m^(-3),and the temperature T_(D)drops from~14.4 eV to~2.3 eV after the onset of MARFE in the discharge#38260.

关键词： optical emission spectroscopy Balmer series tokamak

Lung ultrasound score evaluation of the effect of pressure-controlled ventilation volume-guaranteed on patients undergoing laparoscopicassisted radical gastrectomy

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1717-1725页

作者： Jian Tan Cheng-Ming Bao Xiao-Yuan Chen Department of Critical Care Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina Department of Ultrasound Medicine Lishui District People's HospitalNanjing 211200Jiangsu ProvinceChina

BACKGROUND Laparoscopic-assisted radical gastrectomy(LARG)is the standard treatment for early-stage gastric carcinoma(GC).However,the negative impact of this proce-dure on respiratory function requires the optimized intraoperative management of patients in terms of *** To investigate the influence of pressure-controlled ventilation volume-guaranteed(PCV-VG)and volume-controlled ventilation(VCV)on blood gas analysis and pulmonary ventilation in patients undergoing LARG for GC based on the lung ultrasound score(LUs).METHODs The study included 103 patients with GC undergoing LARG from May 2020 to May 2023,with 52 cases undergoing PCV-VG(research group)and 51 cases undergoing VCV(control group).LUs were recorded at the time of entering the operating room(T0),20 minutes after anesthesia with endotracheal intubation(T1),30 minutes after artificial pneumoperitoneum(PP)establishment(T2),and 15 minutes after endotracheal tube removal(T5).For blood gas analysis,arterial partial pressure of oxygen(PaO_(2))and partial pressure of carbon dioxide(PaCO_(2))were *** airway pressure(P_(peak)),plateau pressure(Pplat),mean airway pressure(P_(mean)),and dynamic pulmonary compliance(C_(dyn))were recorded at T1 and T2,1 hour after PP establishment(T3),and at the end of the operation(T4).Postoperative pulmonary complications(PPCs)were ***-and postoperative serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were measured by enzyme-linked immunosorbent *** Compared with those at T0,the whole,anterior,lateral,posterior,upper,lower,left,and right lung LUs of the research group were significantly reduced at T1,T2,and T5;in the control group,the LUs of the whole and partial lung regions(posterior,lower,and right lung)decreased significantly at T2,while at T5,the LUs of the whole and some regions(lateral,lower,and left lung)increased *** comparison with the control group,the whole and regional LUs of the research group were reduc

关键词： Lung ultrasound score Pressure-controlled ventilation volume-guaranteed Laparoscopic-assisted radical gastrectomy Blood gas analysis indexes Pulmonary ventilation

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-Xin Fu Feng Duan Mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese people's Liberation Army Medical school Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April *** survival(Os)and progression-free survival(PFs)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median Os was 26.43 months(95%CI:17.00-35.87),and the median PFs was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior Os and PFs than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

Efficacy and safety of minimally invasive laparoscopic surgery under general anesthesia for ovarian cancer

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World Journal of Clinical Cases 2024年第9期12卷 1569-1577页

作者： Xian Qin Chen Chen Yang Liu Xian-Hong Hua Jia-Yi Li Meng-Jie Liang Fang Wu Department of Anesthesiology The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of Obstetrics and Gynecology The First People's Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Ovarian cancer is one of the most common malignant tumors in female reproductive system in the world,and the choice of its treatment is very important for the survival rate and prognosis of *** open surgery is the main treatment for ovarian cancer,but it has the disadvantages of big trauma and slow *** the continuous development of minimally invasive technology,minimally invasive laparoscopic surgery under general anesthesia has been gradually applied to the treatment of ovarian cancer because of its advantages of less trauma and quick ***,the efficacy and safety of minimally invasive laparoscopic surgery under general anesthesia in the treatment of ovarian cancer are still *** To explore the efficacy and safety of general anesthesia minimally invasive surgery in the treatment of ovarian *** The clinical data of 90 patients with early ovarian cancer in our hospital were analyzed *** to the different surgical treatment methods,patients were divided into study group and control group(45 cases in each group).The study group received minimally invasive laparoscopic surgery under general anesthesia for ovarian cancer,while the control group received traditional open surgery for ovarian *** European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30),clinical efficacy and safety of the two groups were *** The intraoperative blood loss,length of hospital stay,postoperative gas evacuation time,and postoperative EORTC QLQ-C30 score of the study group were significantly better than those of the control group(Pstoperative complications in the study group was significantly lower than in the control group(Ps had no significant differences in the preoperative adrenocorticotropic hormone(ACTH),androstenedione(AD),cortisol(Cor),cluster of differentiation 3 positive(CD3+),and clu

关键词： Early-stage ovarian cancer Efficacy Minimally invasive Laparoscopy safety surgery

Observation of Doppler shift f_(D) modulated by the internal kink mode using conventional reflectometry in the EAsT tokamak

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Plasma science and Technology 2024年第3期26卷 1-9页

作者：李恭顺张涛耿康宁文斐叶凯萱徐立清朱翔张学习钟富彬周振杨书琪周子强喻琳兰婷王守信提昂张寿彪刘海庆李国强高翔 the EAsT Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People's Republic of China University of science and Technology of China Hefei 230026People's Republic of China

In this paper we present a new experimental observation using a conventional reflectometry technique,poloidal correlation reflectometry(PCR),in the Experimental Advanced superconducting Tokamak(EAsT).The turbulence spectrum detected by the PCR system exhibits an asymmetry and induced Doppler shift f_(D)during the internal kink mode(IKM)rotation *** Doppler shift f_(D)is the target measurement of Doppler reflectometry,but captured by conventional *** show that the Doppler shift f_(D)is modulated by the periodic changes in the effective angle between the probing wave and cutoff layer normal,but not by plasma *** fishbone mode and saturated long-lived mode are typical IKMs,and this modulation phenomenon is observed in both ***,the value of the Doppler shift f_(D)is positively correlated with the amplitude of the IKM,even when the latter is ***,the positive and negative frequency components of the Doppler shift f_(D)can be asymmetric,which is related to the plasma configuration.A simulated analysis is performed by ray tracing to verify these *** results establish a clear link between f_(D)and IKM rotation,and are helpful for studying the characteristics of IKM and related physical phenomena.

关键词： microwave reflectometry Doppler shift internal kink mode

Third-Trimester spontaneous Uterine Rupture After Ultrasound-Guided High-Intensity Focused Ultrasound Therapy

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Maternal-Fetal Medicine 2024年第1期6卷 57-59页

作者： Juanjuan Yang Jiayi Zhang Yun shi Jie shui Hongying Qian Department of Obstetrics Suzhou Ninth People's HospitalSuzhou 215000China

To editor:Uterine rupture,despite its low incidence,is a severe obstetric complication that is associated with adverse maternal and neonatal *** uterine scarring is a known risk factor for uterine *** scars can form from hysterotomy after abdominal/hysteroscopic myomectomy,cesarean delivery,or hysteroscopic *** the past few decades,ultrasound-guided high-intensity focused ultrasound(UsgHIFU)has emerged as a non-invasive therapeutic tool and has found wide application for the safe and effective management strategy of uterine fibroids and adenomyosis.

关键词： Uterine rupture Pregnancy Cesarean delivery Ultrasound-guided high-intensify focused ultrasound(UsgHIFU)