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Seroepidemiological Investigation of Lyme disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China

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Biomedical and Environmental Sciences 2013年第3期26卷 185-189页

作者： HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin National Institute for Communicable disease control and prevention Chinese Center for Disease Control and Prevention State Key Laboratory for Infectious disease prevention and control Henan Oil Prospecting Bureau Jilin provincial Centre for disease control and prevention Guizhou provincial Centre for disease control and prevention Qinghai provincial Centre for disease control and prevention Hunan provincial Centre for disease control and prevention Shanxi provincial Centre for disease control and prevention Gansu provincial Centre for disease control and prevention Miyun Centre for disease control and prevention

Objective Lyme disease and Human granulocytic anaplasmosis are tick-borne diseases caused by Borrelia burgdorferi and Anoplasrna phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay （IFA）. Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces （the exception being the Miyun area in Beijing）. The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces.

关键词： Borrelia burgdorferi Anaplasma phagocytophilum Co-infection Residents of forest areas

An NIR-Ⅱ-emissive Ru(Ⅱ) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2025年第1期 5-7页

作者： Chonglu Li Jianbo Zhan Biao Dong Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities, leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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An Epidemic of Hepatitis A--liaoning Province,2020

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China CDC weekly 2020年第30期2卷 570-574页

作者： Jing Sun Yuanqiu Li Xing Fang Yan Wang Yinan Han Yang Liu Jingyuan Cao Wenting Zhou Hui Zheng Wenqing Yao liaoning provincial center for disease control and prevention ShenyangLiaoningChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute of Preventive Medicine China Medical UniversityShenyangLiaoningChina Dalian City center for disease control and prevention DalianLiaoningChina Dandong City center for disease control and prevention DandongLiaoningChina National Institute for Viral disease control and prevention Chinese Center for DiseaseControl and PreventionBeijingChina

What is already known about this topic?Hepatitis A(HA)is caused by acute hepatitis A virus(HAV)infection and was once very common in *** the 2008 introduction of the HA vaccine into the national Expanded Program on Immunization(EPI),the incidence of reported HA in China decreased ***,HA epidemics still occur in liaoning Province every 3–5 years,although with far fewer cases than in the pre-HA-vaccination *** is added by this report?Between January 1,2020 and March 18,2020,the number of reported cases of HA in Dalian and Dandong cities of liaoning Province increased significantly compared with the same period in previous *** cases were sporadic,and cases were seen in nearly every *** increase in HA occurred one month after local fresh seafood became available with most cases being among adults.A casecontrol study showed that consuming raw or undercooked seafood,clams,snapping shrimp,and oysters were significantly associated with the increase in *** are the implications for public health practices?Strengthening health education for residents to avoid consumption of raw seafood and encouraging HAV vaccination of adults aged 20 to 54 years are important to prevent periodic HAV endemic *** multisectoral cooperation must be emphasized on HA surveillance in areas with a high prevalence of HA.

关键词： consuming liaoning vaccination

Rapid and High-throughput Identification of Recombinant Bacteria with Mass Spectrometry Assay

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Biomedical and Environmental Sciences 2014年第4期27卷 250-258页

作者： XIAO Di TAO Xiao Xia WANG Peng LIU Guo Dong GONG Ya Nan ZHANG Hui Fang WANG Hai Bin ZHANG Jian Zhong State Key Laboratory for Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation center for Diagnosis and Treatment of Infectious diseases provincial Key Laboratory for Plague control and prevention Yunnan Provincial Institute for Endemic Diseases Control and Prevention Beijing Municipal center for disease control and prevention Chaoyang District center for disease control and prevention Beijing

Objective To construct a rapid and high-throughput assay for identifying recombinant bacteria based on mass spectrometry. Methods Matrix assisted laser desorption ionization time-of-flight mass spectrometry （MALDI-TOF MS） techniques were used to identify 12 recombinant proteins （10 of Yersinia pestis, 1 of Campylobacter jejuni and 1 of Helicobacter pylori）. A classification model for the various phase of recombinant bacteria was established, optimized and validated, using MALDI-TOF MS-CIinProTools system. The differences in the peptide mass spectra were analyzed by using Biotyper and FIexAnalysis softwares. Results Models of GA, SNN, and QC were established. After optimizing the parameters, the GA recognition model showed good classification capabilities： RC=100%, mean CVA=98.7% （the CVA was 96.4% in phase 1, 100% in phase 2, 98.4% in phase 3, and 100% in phase 4, respectively） and PPV=95}. This model can be used to classify the bacteria and their recombinant, which only requires 3.7x103 cells for analysis. The total time needed is only 10 min from protein extraction to reporting the result for one sample. Furthermore, this assay can automatically detect and test 96 samples concurrently. A total of 48 specific peaks （9, 16, 9, and 14 for the four stages, respectively） was found in the various phase of recombinant bacteria. Conclusion MALDI-TOF MS can be used as a fast, accurate, and high-throughput method to identify recombinant bacteria, which provide a new ideas not only for recombinant bacteria but also for the identification of mutant strains and bioterrorism pathogens.

关键词： Recombinant bacteria MALDI-TOF MS ClinProTools Rapid identification Specific peaks

Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China

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Biomedical and Environmental Sciences 2012年第5期25卷 542-548页

作者： LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao Institute of Communicable disease prevention and control Guizhou Provincial Center for Disease Control and Prevention Guiyang 550004 Guizhou China Institute of Communicable disease prevention and control Chinese Center for Disease Control and Prevention Beijing 102206 China

Abstract Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques （PFGE, MLVA, and MLST）, reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province.

关键词： L. interrogans PFGE MLVA MLST Rattus tanezumi

Trends and Spatial Pattern Analysis of Typhoid and Paratyphoid Fever Incidence — Yunnan Province, China, 1989–2022

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China CDC weekly 2024年第41期6卷 1049-1053,I0001,I0002页

作者： Xiulian Shen Liqiong Zhang Lining Guo Jibo He Weijun Yu Epidemic Surveillance/Public Health Emergency Response center Yunnan Provincial Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Department of Intervention Research Yunnan Institute for Drug AbuseKunming CityYunnan ProvinceChina Hunnan District center for disease control and prevention Shenyang CityLiaoning ProvinceChina Institute for prevention and control of Infection and Infectious diseases Liaoning Provincial Center for Disease Control and PreventionShenyang CityLiaoning ProvinceChina.

Introduction:This study explored the incidence trends and spatial clustering of typhoid and paratyphoid fever(TPF)in Yunnan Province to provide scientific evidence for developing and improving prevention and control ***:Temporal trends were investigated by calculating the annual percent change(APC)and average annual percent change(AAPC),along with their 95%confidence intervals(CIs).The spatial clustering of TPF across Yunnan Province was examined using global Moran’s I and local indicators of spatial association(LISA)***:A total of 206,066 TPF cases were reported in Yunnan Province from 1989 to 2022,with an average annual incidence of 13.98 per 100,000 population and a case fatality rate of 2.5 per 1,*** greatest number of cases was reported during July and *** 25–34-year age group had the highest incidence,and farmers were prominently *** incidence in Yunnan Province showed a significant decrease and spatial *** 2005 to 2022,13 county-level cities/counties/municipal districts in 5 prefectures(cities)in Yunnan Province were identified as statistically significant H-H spatial clusters of TPF incidence.A total of 24 TPF outbreaks were reported in Yunnan Province from 2005 to ***:The incidence of TPF in Yunnan Province showed a significant decrease and spatial *** strategies should focus on highincidence areas,seasons,and populations to reduce the incidence of TPF.

关键词： Spatial prevention district

Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China

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Biomedical and Environmental Sciences 2015年第10期28卷 701-708页

作者： ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu National center for AIDS/STD control and prevention Chinese Center for Disease Control and Prevention Shandong provincial center for disease control and prevention College of Public Health University of South Florida

Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women （15-49 years） increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women （40-49 years）, a slightly increasing trend was identified. The spatial analysis detected ＇hot spots＇ in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas.

关键词： AIDS Women Epidemiology China

Epidemiological Features of Foodborne disease Outbreaks in Catering Service Facilities—China,2010–2020

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China CDC weekly 2023年第22期5卷 479-484页

作者： Donglei Lu Jikai Liu Hong Liu Yunchang Guo Yue Dai Junhua Liang Lili Chen Lizi Xu Ping Fu Ning Li Shanghai Municipal center for disease control and prevention ShanghaiChina China National center for Food Safety Risk Assessment BeijingChina Jiangsu provincial center for disease control and prevention Nanjing CityJiangsu ProvinceChina Guangdong provincial center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Zhejiang provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Anhui provincial center for disease control and prevention Hefei CityAnhui ProvinceChina

Introduction:In terms of food preparation settings,catering service facilities have been identified as locations with the highest incidence of foodborne disease outbreaks in *** 2010,the China National center for Food Safety Risk Assessment has established the Foodborne disease Outbreak Surveillance System(FDOSS)to monitor foodborne disease ***,data from the FDOSS has provided a more accurate depiction of the epidemic characteristics of outbreaks within these ***:From 2010 to 2020,the FDOSS gathered data related to the prevalence of outbreaks,cases,hospitalizations,and deaths linked to foodborne disease outbreaks in catering service *** study examined the temporal and geographical distribution,pathogenic factors,and contributing variables of these outbreaks over the course of the ***:From 2010 to 2020,China’s catering service facilities reported 18,331 outbreaks,which resulted in 206,718 illnesses,68,561 hospitalizations,and 201 *** second and third quarters of the year accounted for 76.12%of the outbreaks and 72.93%of the *** primary pathogenic factors were pathogenic organisms,which caused 4,883(26.64%)outbreaks,94,047(45.50%)cases,32,170(46.92%)hospitalizations,and 21(10.45%)*** were 5,607(30.59%)outbreaks in restaurants,2,876(15.69%)outbreaks from street vendors,and 2,560(13.97%)outbreaks in employee canteens in ***:The implementation of relevant control methods,including health education and promotion,is critical for addressing foodborne diseases in catering service *** food safety training sessions for restaurant personnel and managers are essential to ensuring the effective management of these health risks.

关键词： Service restaurant facilities

Dimethylacetamide-induced Hepatic Injury in Vitro: Mechanism and Potential Preventive Strategy

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Biomedical and Environmental Sciences 2016年第2期29卷 153-157页

作者： LIU Xin GONG Wei XU Yan Qiong ZHU Bao Li Institute of Occupational disease prevention Jiangsu Provincial Center for Disease Prevention and Control

N,N-Dimethylacetamide （DMAc） is a widely used organic solvent in modern chemical industry with low to moderate hepatotoxicity to occupational health of employees. But so far, there are fewer and less conclusive data concerning its pathogenic mechanism in detail. In current study, the toxicity of DMAc was firstly investigated on human normal hepatocytes （LO-2）, using a series of molecular biology measurements to ananlyze the effect and mechanism of DMAc-induced hepatic cell injury and explore effective prophylactic measures. We found that DMAc triggered LO-2 apoptosis in a obviously dose-dependent manner, caused by increased ROS generation and activation of Bcl-2 pathway. Significantly, glutathione （GSH） rather than vitamin C （Vit C） could partially inhibit DMAc-induced apoptosis thus showing potential as a effective precaution for workers.

关键词： GSH Figure Dimethylacetamide-induced Hepatic Injury in Vitro Mechanism and Potential Preventive Strategy 33258 NAC