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Weighted Linear Loss Large Margin Distribution Machine for Pattern Classification

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Chinese Journal of Electronics 2024年第3期33卷 753-765页

作者： Ling LIU Maoxiang CHU Rongfen GONG Liming LIU Yonghui YANG School of Electronic and Information Engineering University of Science and Technology Liaoning

Compared with support vector machine,large margin distribution machine(LDM) has better generalization *** central idea of LDM is to maximize the margin mean and minimize the margin variance *** the computational complexity of LDM is *** order to reduce the computational complexity of LDM,a weighted linear loss LDM(WLLDM) is *** framework of WLLDM is built based on LDM and the weighted linear *** weighted linear loss is adopted instead of the hinge loss in *** modification can transform the quadratic programming problem into a simple linear equation,resulting in lower computational ***,WLLDM has the potential to deal with large-scale *** WLLDM is similar in principle to the LDM algorithm,which can optimize the margin distribution and achieve better generalization *** WLLDM algorithm is compared with other models by conducting experiments on different *** results show that the proposed WLLDM has better generalization performance and faster training speed.

关键词： Training Support vector machines Pattern classification Transforms Fasteners Mathematical models Vectors

Role of albumin-bilirubin score in non-malignant liver disease

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World Journal of Gastroenterology 2024年第9期30卷 999-1004页

作者： Shi-Xue Xu Fan Yang Nan Ge Jin-Tao Guo Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The albumin-bilirubin(ALBI)score,which was proposed to assess the prognosis of patients with hepatocellular carcinoma,has gradually been extended to other liver diseases in recent years,including primary biliary cholangitis,liver cirrhosis,hepatitis,liver transplantation,and liver *** ALBI score is often compared with classical scores such as the Child-Pugh and model for end-stage liver disease scores or other noninvasive prediction *** is widely employed because of its immunity to subjective evaluation indicators and ease of obtaining detection *** increasing number of studies have confirmed that it is highly accurate for assessing the prognosis of patients with chronic liver disease;additionally,it has demonstrated good predictive performance for outcomes beyond survival in patients with liver diseases,such as decompensation *** article presents a review of the application of ALBI scores in various non-malignant liver diseases.

关键词： Albumin-bilirubin score Liver cirrhosis Primary biliary cholangitis Hepatitis Liver transplantation Liver injury

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating Link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei LIN School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： Duo-Lun Gao Meng-Ran Lin Nan Ge Jin-Tao Guo Fan Yang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

Constructing long-cycling crystalline C_(3)N_(4)-based carbonaceous anodes for sodium-ion battery via N configuration control

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Carbon Energy 2024年第1期6卷 159-171页

作者： Ying Wang Hongguan Li Shuanlong Di Boyin Zhai Ping Niu Antonios Kelarakis Shulan Wang Li Li School of Metallurgy Northeastern UniversityShenyangLiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoningChina Department of Chemistry College of ScienceNortheastern UniversityShenyangLiaoningChina School of Natural Sciences UCLan Research Centre for Smart MaterialsUniversity of Central LancashirePrestonUK Foshan Graduate School of Innovation Northeastern UniversityFoshanGuangdongChina

Carbon nitrides with two-dimensional layered structures and high theoretical capacities are attractive as anode materials for sodium-ion batteries while their low crystallinity and insufficient structural stability strongly restrict their practical *** carbon nitrides with conductive carbon may relieve these ***,little is known about the influence of nitrogen(N)configurations on the interactions between carbon and C_(3)N_(4),which is fundamentally critical for guiding the precise design of advanced C_(3)N_(4)-related ***,highly crystalline C_(3)N_(4)(poly(triazine imide),PTI)based all-carbon composites were developed by molten salt *** importantly,the vital role of pyrrolic-N for enhancing charge transfer and boosting Na+storage of C_(3)N_(4)-based composites,which was confirmed by both theoretical and experimental evidence,was spot-highlighted for the first *** elaborately controlling the salt composition,the composite with high pyrrolic-N and minimized graphitic-N content was *** from the formation of highly crystalline PTI and electrochemically favorable pyrrolic-N configurations,the composite delivered an unusual reverse growth and record-level cycling stability even after 5000 cycles along with high reversible capacity and outstanding full-cell capacity *** work broadens the energy storage applications of C_(3)N_(4) and provides new prospects for the design of advanced all-carbon electrodes.

关键词： anode highly crystalline C_(3)N_(4) N configuration sodium-ion batteries ultra-long cyclic stability

Nicotine up-regulates SLC7A5 expression depending on TRIM29 in non-small cell lung cancer

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Genes & Diseases 2024年第2期11卷 582-584页

作者： Dahua Liu Haolin Ren Guimin Wen Pu Xia Biological Anthropology Institute College of Basic Medical ScienceJinzhou Medical UniversityJinzhouLiaoning 121000China Department of Radiology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Community Nursing College of NursingJinzhou Medical UniversityJinzhouLiaoning 121000China

Non-small cell lung cancer(NSCLC)is a malignant tumor that poses a serious threat to human ***(LUAD)and squamous cell carcinoma(LUSC)are two common types of *** originate from glandular and squamous cells of the bronchial epithelium,*** gene changes during tumorigenesis is conducive to the selection of suitable treatment methods for ***98 is a heterodimeric transmembrane glycoprotein,which is composed of a heavy chain and a light chain.1 cD98 heavy chain(CD98hc),also known as 4F2hc or SLC3A2,is an 85kDa type ll transmembraneglycoprotein,which consists of a cytoplasmic region(NH2 terminal),a single chain transmembrane region,and a huge extracellular region(COOH terminal).1 CD98hc can combine with the CD98 light chain,LAT1(SLC7A5),to form CD98 protein through disulfide bonds.1 SLC7A5 is a 12 times transmembrane helix bundle protein composed of 501-535 amino acid residues1.

关键词： lung cancer NSCLC

OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1- p62/SQSTM1 complex

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World Journal of Gastroenterology 2024年第15期30卷 2155-2174页

作者： Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Clinical Laboratory Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina The Institute of Integrative Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina The Institute of Laboratory Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Central Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of ***-1,which is derived from the bulbs of Ornithogalum saundersiae Baker,exerts a wide range of pharmaco-logical *** To explore whether OSW-1 can induce necroptosis in colorectal cancer(CRC)cells,thereby expanding its range of clinical *** We performed a sequence of functional experiments,including Cell Counting Kit-8 assays and flow cytometry analysis,to assess the inhibitory effect of OSW-1 on CRC *** utilized quantitative proteomics,employing tandem mass tag label-ing combined with liquid chromatography-tandem mass spectrometry,to analyze changes in protein *** bioinformatic analysis was conducted to elucidate the biological processes associated with the identified *** electron microscopy(TEM)and immunofluorescence studies were also performed to examine the effects of OSW-1 on ***,western blotting,siRNA experiments,and immunoprecipitation were employed to evaluate protein interactions within CRC *** The results revealed that OSW-1 exerted a strong inhibitory effect on CRC cells,and this effect was accompanied by a necroptosis-like morphology that was observable via ***-1 was shown to trigger necroptosis via activation of the RIPK1/RIPK3/MLKL ***,the accumulation of p62/SQSTM1 was shown to mediate OSW-1-induced necroptosis through its interaction with *** We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway,and that this effect is mediated by the RIPK1-p62/SQSTM1 complex,in CRC *** results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.

关键词： OSW-1 Necroptosis RIPK1 P62/SQSTM1 Colorectal cancer

Current trends and hotspots of depressive disorders with colorectal cancer:A bibliometric and visual study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3687-3704页

作者： Zi-Wei Yan Ying-Nan Liu Qian Xu Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in liaoning Education Department The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Laboratory of GI Cancer Etiology and Prevention in liaoning Province The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Depression is strongly associated with colorectal cancer(CRC).Few bibliometric analyses have systematically summarized the research focus and recent progress in this *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and *** Articles on depression in CRC patients were collected from the Web of Science Core *** and VOSviewer software were used to visualize bibliometric *** From 2001 to 2022,Supportive Care in Cancer,the United States,Tilburg University,and Mols were the most productive and influential journal,country,institution,and author ***-occurrence cluster analysis of keywords placed quality of life,anxiety,and psychological stress in the center of the visual network *** clustering was performed for the clusters with studies of the relevant mechanism of action,which showed that:(1)Cytokines have a role essential for the occurrence and development of depressive disorders in CRC;(2)MicroRNAs have a role essential for the development of depressive disorders in CRC;(3)Some anticancer drugs have pro-depressant activity;and(4)Selective serotonin reuptake inhibitors have both antitumor and antidepressant *** Life quality and psychological nursing of the cancer population were key *** roles of cytokines and microRNAs,the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

关键词： Depression Colorectal cancer Bibliometric analysis Cytokines Drugs Mechanism

Experimental and simulation research on hollow AZ31 magnesium alloy three-channel joint by hot extrusion forming with sand mandrel

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Journal of Magnesium and Alloys 2024年第1期12卷 98-109页

作者： Shi Shengnan Wang Hongyu Teng Fei Jiang Lei Sun Juncai Sun Jie Zhang Shunhu Transportation Engineering College Dalian Maritime UniversityDalianLiaoning 106026China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoning 110819China Shagang School of Iron and Steel Soochow UniversitySuzhouJiangsu 215021China

Magnesium alloy is one of the lightest metal structural *** weight is further reduced through the hollow ***,the hollow structure is easily damaged during *** order to maintain the hollow structure and to transfer the stresses during the high temperature deformation,the sand mandrel is *** this paper,the hollow AZ31 magnesium alloy three-channel joint is studied by hot extrusion *** as one of solid granule medium is used to fill the hollow magnesium *** extrusion temperatures are 230℃ and 300℃,*** process parameters(die angle,temperature,bottom thickness,sidewall thickness,edge-to-middle ratio in bottom,bottom shape)of the hollow magnesium alloy are analyzed based on the results of experiments and the finite element *** results are shown that the formability of the hollow magnesium alloy will be much better when the ratio of sidewall thickness to the bottom thickness is 1:*** when edge-to-middle ratio in bottom is about 1:1.5,a better forming product can be *** best bottom shape in these experiments will be convex based on the forming *** grain will be refined obviously after the *** the microstructures will be shown as *** these lines will be well agreement with the mold in the corner.

关键词： AZ31 magnesium alloy Three-channel joint Sand Experiments and the finite element Die angle

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