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Biomedical and Environmental sciences 2024年第2期37卷 221-227页

作者： ZHANG Wei YUAN si Long QIANG Jing Chao HUANG He LI Da sUN Ying ZHANG Hong Gang Department of Vascular surgery The First People’s Hospital of LianyungangLianyungang 222005JiangsuChina Jiangsu Key Laboratory of Marine Pharmaceutical Compound screening College of PharmacyJiangsu Ocean UniversityLianyungang 222005JiangsuChina Jinzhou Medical University postgraduate training base(lianyungang First People’s Hospital) Lianyungang 222005JiangsuChina

In critical care medicine,sepsis is a dangerous systemic condition that is highly prevalent and is associated with high morbidity and mortality rates^([1]).The high mortality rate associated with sepsis is closely related to multi-organ dysfunction,with heart injury being particularly critical and considered the starting point of multi-organ injury^([2]).

关键词： mortality Apoptosis TLR4

Research on the prognostic value of adjusting intraperitoneal threedimensional quality evaluation mode in laparoscopic cholecystectomy patients

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World Journal of Gastrointestinal surgery 2024年第4期16卷 1078-1086页

作者： Yuan Zhou Zhan-Qing Chen Operating Room Lianyungang Hospital of Traditional Chinese MedicineLianyungang 222000Jiangsu ProvinceChina Operating Room The Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical UniversityLianyungang 222000Jiangsu ProvinceChina

BACKGROUND Benign gallbladder diseases have become a high-prevalence condition not only in China but also *** main types of benign gallbladder diseases include gallbladder polyps,acute and chronic cholecystitis,and gallstones,with gallstones being the most common,accounting for over 70%of *** the mortality rate of benign gallbladder diseases is low,they carry obvious potential *** have shown that an increased incidence of benign gallbladder diseases can increase the risk of cardiovascular diseases and gallbladder cancer,resulting in a substantial disease burden on patients and their *** To assess the medical utility of the Configuration-Procedure-Consequence(CPC)three-dimensional quality evaluation model in modulating the prognosis of laparoscopic cholecystectomy *** A total of 98 patients who underwent laparoscopic cholecystectomy in our hospital from February 2020 to January 2022 were selected as the *** to the random number table method,they were divided into a study group and a control group,with 49 patients in each *** control group received routine perioperative care,while the study group had the addition of the CPC three-dimensional quality *** postoperative recovery-related indicators(time to first flatus,time to oral intake,time to ambulation,hospital stay),stress indicators(cortisol and adrenaline levels),distinctions in anxiety and REsULTs The time to first flatus,time to oral intake,time to ambulation,and hospital stay of the study group patients were obviously lower than those of the control group patients,with statistical significance(Pst day after admission,there were no obvious distinctions in cortisol and adrenaline levels in blood samples,as well as in the self-Rating Anxiety scale(sAs)and self-Rating Depression scale(sDs)scores between the study group and the control group(P>0.05).However,on the 3rd day after surgery,the cortisol and adrenaline leve

关键词： Configuration-Procedure-Consequence Three-dimensional quality evaluation Laparoscopic Cholecystectomy Recovery process Anxiety and depression Complications

Transforming Adolescent smiles:Correcting skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical science 2024年第3期44卷 657-666页

作者： Wen-jie FAN Jia-qi ZHANG Jia-qi ZHAN Li HU Li-li CHEN Department of stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China school of stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda college of Nanjing Medical University/The First People’s Hospital of lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice

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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming GUO Jiatian ZHAO Jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI Fang CHEN Chong HOU Mingzhuang LV Nanning XU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)***(CsL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain *** study aimed to substantiate CsL’s chondroprotective effects and unravel its underlying *** investigated CsL’s impact on chondrocytes under both normal and inflammatory *** vitro,CsL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)*** vivo,intra-articular injection of CsL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA ***,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CsL-mediated antioxidative functions and exacerbated the progression of *** study is the first to elucidate the role of CsL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial sIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng Nanning Lv Yong Xu Xuesong Zhu Huilin Yang Qin shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMsCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMsCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMsCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

A wealth distribution model with a non-Maxwellian collision kernel

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Chinese Physics B 2024年第7期33卷 224-231页

作者：孟俊周霞赖绍永 college of Mathematics and statistics Kashi UniversityKashi 844006China college of Mathematics and Physics Mianyang Teacher's CollegeMianyang 621000China school of Mathematics Southwestern University of Finance and EconomicsChengdu 611130China

A non-Maxwellian collision kernel is employed to study the evolution of wealth distribution in a multi-agent *** collision kernel divides agents into two different groups under certain conditions. Applying the kinetic theory of rarefied gases, we construct a two-group kinetic model for the evolution of wealth distribution. Under the continuous trading limit, the Fokker–Planck equation is derived and its steady-state solution is obtained. For the non-Maxwellian collision kernel, we find a suitable redistribution operator to match the taxation. Our results illustrate that taxation and redistribution have the property to change the Pareto index.

关键词： kinetic theory non-Maxwellian collision kernel wealth distribution Pareto index

A review of ethnobotanical studies reveals over 500 medicinal plants in Mindanao,Philippines

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Plant Diversity 2024年第5期46卷 551-564页

作者： Joeime F.Meñiza Monica M.Pasco Jemer A.Alimbon Department of teacher Education UM Tagum CollegeTagum City8100Davao del Norte Philippines

Medicinal plants have long been used to treat various diseases in both indigenous and non-indigenous populations of Mindanao,***,we extracted data from ethnobotanical studies to compile a comprehensive list of these medicinal plants and identify how and for what purpose they are most commonly *** identified 530 verified medicinal plant species across 372 genera in 118 *** two most frequently cited species were Euphorbia hirta and Psidium *** most represented family was Fabaceae and the most represented genus was Ficus.A total of 28 medicinal plant species are designated as threatened at the national or global level;of these,11 are endemic to the *** plant preparations most commonly use leaves for oral administration to treat various diseases such as digestive issues,including *** study underscores the need for further ethnobotanical investigations,particularly in areas lacking *** also emphasizes the need for conservation of threatened and endemic medicinal plants to ensure sustainable utilization of this valuable resource.

关键词： Ethnobotany Medicinal plants Mindanao Philippines

Ethnographic Research on the Formation Path of Preschool Children’s Peer Cultures

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Frontiers of Education in China 2024年第2期19卷 174-203页

作者： LIN Lan JIN Xiangjun college of teacher Education Ningbo UniversityNingbo 315211China

As a major branch of children’s studies and a clear manifestation of adherence to a child-oriented position,research on children’s peer cultures is of significant value for understanding the true world of *** an ethnographic approach,this study conducts in-depth field observations in three kindergartens to explore how preschool children create their peer *** results indicate that the children in three kindergartens created a series of meaningful symbols within their respective kindergarten settings during peer interaction and formed their peer *** study finds that:Firstly,children’s peer cultures encompass five core themes,namely,self-presentation,friendly interaction,conflict and segregation,collective play routines,and secondary adjustments to classroom ***,the development of children’s selves,shared play among children,interpretive reconstruction of adult cultures,and inclusiveness of school cultures are inherent sources of strength,core driving force,mechanisms for the path,and external environmental factors of the formation of children’s peer ***,children gain membership in the cultures to which they belong through collective participation in social ***,children produce peer cultures and contribute to the renewal of adult cultures by creatively appropriating information and knowledge from the adult *** this connection,it is essential for kindergartens to support the development of children’s peer cultures.

关键词： children’s peer cultures ethnography children’s studies

Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

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Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo Kou shouqiang Zhang Tianqi Cao Hanqing Wu Jing Zhou Department of Chemistry Capital Normal UniversityBejing100048China college of teacher Education Capital Normal University Beijing100048China

The tumor microenvironment(TME)differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials(NaLuF_(4):Yb,Er)with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network(MPN)*** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy(CT)drug EGCG,which can cause apoptosis,Cu_(x)s_(y)is generated by combining Cu^(2+)with H_2s overexpressed in human colorectal cancer cells and can be used for photothermal therapy(PTT).Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Tumor microenvironment Metal-polyphenol networks synergistic therapy Rare earths Nanomaterials

stability Analysis of a Class of Nonlinear Fractional Differential systems With Riemann-Liouville Derivative

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IEEE/CAA Journal of Automatica sinica 2024年第8期11卷 1883-1885页

作者： Ruoxun Zhang shiping Yang shiwen Feng college of teacher Education Xingtai UniversityXingtai 054001China college of Physics and Information Engineering Hebei Normal UniversityShijiazhuang 050016China

Dear Editor,This letter investigates the stability of n-dimensional nonlinear fractional differential systems with Riemann-Liouville *** using the Mittag-Leffler function,Laplace transform and the Gronwall-Bellman lemma,one sufficient condition is attained for the asymptotical stability of a class of nonlinear fractional differential systems whose order lies in(0,2).According to this theory,if the nonlinear term satisfies some conditions,then the stability condition for nonlinear fractional differential systems is the same as the ones for corresponding linear *** examples are provided to illustrate the applications of our result.

关键词： Liouville Riemann nonlinear