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Discrepancies between self-reported Checkf update medication in adherence and indirect measurement adherence among patients undergoing antiretroviral therapy:a systematic review

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Infectious diseases of Poverty 2024年第4期13卷 1-13页

作者： Rujun Liao Zihuan Tang Na Zhang Lin Hu Zongqi Chang Jiayi Ren Xuefei Bai inhong Shi Sisi Fan Rong Pei Liang Du Tao Zhang center of Infectious diseases Research Center of Clinical Epidemiology and Evidence-Based MedicineInnovation Insititute for Integration of Medicine and EngineeringWest China HospitalSichuan UniversityChengdu 610041SichuanPeople's Republic of China Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041SichuanPeople's Republic of China Sichuan center for disease control and prevention Chengdu 610041SichuanPeople's Republic of China School of Public Health Chengdu University of Traditional Chinese MedicineChengdu 611130SichuanPeople's Republic of China

Background Given the critical importance of medication adherence in HIV/AIDS treatment,this study aims to com-pare medication adherence measured by self-report(SR)and indirect measurement among antiretroviral therapy(ART)patients,exploring the differences of adherence results measured by different *** We systematically searched PubMed,Embase,and the Cochrane Library to identify all relevant literature published up to November 22,2023,without language restrictions,reporting adherence to ART measured by both SR and indirect measurement methods,while also analyzing individual and group adherence *** between SR and indirect measurement results were assessed using the Mann-Whitney U test or Wilcoxon signed-rank test,with correlations evaluated using the Pearson correlation *** one-to-one comparisons,meta-epidemiological one-step analysis was conducted,and network meta-analysis techniques were applied to compare results obtained through specific adherence assessment tools reported in the identified *** The analysis encompassed 65 original studies involving 13,667 HIV/AIDS patients,leading to 112 one-to-one comparisons between SR and indirect measurement *** significant differences were observed between SR and indirect measurement tools regarding both individual and group adherence(P<0.05),with Pear-son correlation coeffcients of 0.843 for individual adherence and 0.684 for group *** meta-epide-miological one-step analysis,SR-measured adherence was determined to be 3.94%(95%Cl:-4.48-13.44%)higher for individual adherence and 16.14%(95%Cl:0.81-18.84%)higher for group adherence compared to indirectly measured *** analysis indicated that factors such as the year of reporting and geographic region appeared to influence the discrepancies between SR and indirect ***,network meta-analysis revealed that for both individual and group adherence,the results obt

关键词： HIV AIDS Antiretroviral therapy Medication adherence Self-report Meta-epidemiological one-step analysis Networkmeta-analysis

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Molecular epidemiology of Mycobacterium tuberculosis in Gansu province of China

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Chinese Medical Journal 2012年第19期125卷 3458-3464页

作者： TIAN Li-li SI Hong-yan MU Tao-jun FAN Wen-bing WANG Jing JIANG Wei-min Li Qing YANG Biao ZHANG Ying ZHU Bing-dong Lanzhou center for Tuberculosis Research & Institute of Pathogenic Biology School of Basic Medical Sciences Lanzhou University Lanzhou Gansu 730000 China center for disease prevention and control of Gansu Province Lanzhou Gansu 730000 China Department of Molecular Microbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA

Background Mycobacterial interspersed repetitive units-variable number tandem repeat （MIRU-VNTR） and Beijing family typing based on detecting the deletion of RD105 sequence are two common genotyping methods used to study the molecular epidemiologic characteristics of Mycobacterium （M.） tuberculosis. We collected 218 strains of M. tuberculosis between 2004 and 2006 in the Linxia Hui Autonomous prefecture of Gansu province in Northwest China. Methods MIRU-VNTR analysis and Beijing family typing based on detecting the deletion of RD105 sequence were used to type the 218 strains, and their typing power was evaluated to look for practical and efficient genotyping methods suitable for the region. Results The MIRU typing yielded 115 distinct genotypes, including 98 unique isolates and 17 different clusters containing 120 isolates （55.05%）; the cluster rate was 47.25%. By detecting the deletion of RD105 sequence, 188 of 218 （86.23%） isolates belonged to Beijing family. Combination of Beijing family typing and MIRU typing yielded 118 distinct patterns, including 101 unique isolates and 17 clusters containing 117 isolates （54.13%）. The largest cluster contained 58 strains with MIRU genotype of 223325173533 which contained 50 strains belonging to Beijing family and 8 strains belonging to non-Beijing family. Conclusions The Beijing family strains occupied a large proportion and the Beijing family MIRU genotype 223325173533 is a dominant strain in Linxia of Gansu. Combining detecting the deletion of RD105 and MIRU typing together provides a simple, fast, and effective method which is low in cost and might be practical and suitable for M. tuberculosis aenotvDina in China.

关键词： Mycobacterium tuberculosis mycobacterial interspersed repetitive unit genotyping Beijing family epidemiology

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Deworming of stray dogs and wild canines with praziquantel-laced baits delivered by an unmanned aerial vehicle in areas highly endemic for echinococcosis in China

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Infectious diseases of Poverty 2017年第1期6卷 1054-1059页

作者： Qing Yu Ning Xiao Shi-jie Yang Shuai Han Department of Echinococcosis National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention207 Rui Jin Er RoadShanghai 200025China Key Laboratory of Parasite and Vector Biology National health and Family Planning CommissionShanghaiChina WHO Collaborating center for Tropical diseases ShanghaiChina

Background:Canines,the definitive hosts for the parasites causing alveolar(AE)and cystic echinococcosis(CE),are the main source of this infections playing the key role in the *** ten-year mortality rate of AE is extremely high(94%)if the patients are not given sustained *** aim of this field study is to explore the possibility of delivery of praziquantel-laced baits using unmanned aerial vehicles(UAVs)aimed at deworming wild canines in the endemic ***:UAVs were compared to manual bait delivery in the 1-km^(2)test areas followed by testing of canine faeces using an Echinococcus coproantigen ELISA test in the ensuing *** outcomes of the two approaches were compared with respect to time of delivery and overall ***:Compared to manual bait delivery,delivery by UAVs saved up to 67%of the overall *** times more staff was needed for the former approach compared to the latter and,time wise,UAV bait delivery saved 350%compared to manual bait delivery on *** regard to investment needed,the use of UAVs showed an efficiency 2.5 times better than manual bait *** to the area served by UAVs,the average positive rate for the canine faecal samples was more than 38%higher in the area served ***:The technique of bait delivery with praziquantel using UAVs for canine deworming has a strong potential with regard to savings of manpower,time and overall cost in areas highly endemic for echinococcosis.

关键词： Echinococcosis Wild canine definitive hosts control:Unmanned aerial vehicle Delivery Baits Qinghai-Tibet Plateau China

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Visceral leishmaniasis in northwest China from 2004 to 2018:a spatio-temporal analysis

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Infectious diseases of Poverty 2020年第6期9卷 29-41页

作者： Canjun Zheng Liping Wang Yi Li Xiao-Nong Zhou Chinese center for diseases control and prevention(China CDC) Beijing102206China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing100081China Chinese center for diseases control and prevention National Institute of Parasitic DiseasesShanghai200025China

Background: Although visceral leishmaniasis(VL),a disease caused by parasites,is controlled in most provinces in China,it is still a serious public health problem and remains fundamentally uncontrolled in some northwest provinces and autonomous *** objective of this study is to explore the spatial and temporal characteristics of VL in Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region in China from 2004 to 2018 and to identify the risk areas for VL ***:: Spatiotemporal models were applied to explore the spatio-temporal distribution characteristics of VL and the association between VL and meteorological factors in western China from 2004 to *** information of patients from the National diseases Reporting Information System operated by the Chinese center for disease control and prevention was defined according to the address code from the surveillance ***: During our study period,nearly 90%of cases occurred in some counties in three western regions(Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region),and a significant spatial clustering pattern was *** our spatiotemporal model,the transmission risk,autoregressive risk and epidemic risk of these counties during our study period were also well *** number of VL cases in three regions of western China concentrated on a few of *** in Kashi prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic ***: The number of VL cases in three regions of western China concentrated on a few of *** in Kashi prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic *** findings will strengthen the VL control programme in China.

关键词： Visceral leishmaniasis Spatio-temporal analysis Spatial regression China

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专题报告-S2药物和污染物的毒理学和遗传易感性

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中国药理学与毒理学杂志 2006年第3期20卷 167-169页

作者： LIN Guo-Fang DU Hui CHEN ji-Gang LU Hong-Chao GUO Wei-Chao ZHANG Xin-Jiang SHEN Jian-Hua Shanghai Institute for Biological Sciences Instituteof Plant Physiology and Ecology Chinese Academy ofSciences Shanghai 200032 China prefecturecenter for disease prevention and control Guiyang562400 China Municipal center for disease Pre-vention and control Shanghai 200236 China Division of Dermatology Affiliated Hospital ZhengyiMedical College Zhengyi 563003 China

A total of 2402 patients of arseniasis in a few villages in Southwest Guizhou Autonomous prefecture, China, represents a unique case of endemic arseniasis related with indoor combustion of high arsenic coal. This study aimed to investigate the possible involvement of hereditary factors in the risk modulation of arseniasis in two clans of different ethnic origin living in one village for generations.

关键词： SYMPOSIA-S2 Toxicology Genetic Susceptibility Drugs Pollutants

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Predicting the number of visceral leishmaniasis cases in Kashgar, Xinjiang, China using the ARIMA-EGARCH model

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Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 81-90页

作者： Hu-ling Li Rong-jiong Zheng Qiang Zheng Wei Jiang Xue-liang Zhang Wei-ming Wang Xing Feng Kai Wang Xiao-bo Lu College of Public Health Xinjiang Medical UniversityUrumqi 830011P.R.China Department of Infectious diseases the first Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054P.R.China Xinjiang center for disease control and prevention Urumqi830002P.R.China Department of Medical Engineering and Technology Xinjiang Medical UniversityUrumqi 830011P.R.China School of Mathematics Science Huaiyin Normal UniversityHuaian 223300 P.R.China

Objective:To forecast the visceral leishmaniasis cases using autoregress integrated moving average(ARIMA)and hybrid ARIMAEGARCH model,which offers a scientific basis to control visceral leishmaniasis spread in Kashgar prefecture of Xinjiang,***:The data used in this paper are monthly visceral leishmaniasis cases in the Kashgar prefecture of Xinjiang from 2004 to *** sample data between 2004 and 2015 were used for the estimation to choose the best model and the sample data in 2016 were used for the *** series of visceral leishmaniasis started on 1 January 2004 and ended on 31 December 2016,consisting of 1790 observations reported in Kashgar ***:For Xinjiang,the total number of reported cases were 2187,the male-to-female ratio of cases was 1:*** aged between 0 and 10 years accounted for 82.72%of all reported cases and the largest percentage of visceral leishmaniasis cases was detected among scattered children who accounted for 68.82%.The monthly incidences fitted by ARIMA(2,1,2)(1,1,1)12 model were consistent with the real data collected from 2004 to ***,the predicted cases failed to comply with the observed case number;we then attempted to establish a hybrid ARIMA-EGARCH model to fit visceral ***,the ARIMA(2,1,2)(1,1,1)12-EGARCH(1,1)model showed a good estimation when dealing with volatility clustering in the data ***:The combined model has been determined as the best prediction model with the root-mean-square error(RMSE)of 7.23%in the validation phase,which means that this model has high validity and rationality and can be used for short-term prediction of visceral leishmaniasis and could be applied to the prevention and control of the disease.

关键词： Visceral leishmaniasis ARIMA model Hybrid ARIMA-EGARCH Forecasting

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Cost-effectiveness analysis of the prevention of mother-to-child transmission of HIV

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Infectious diseases of Poverty 2022年第3期11卷 97-97页

作者： Shui-ling Qu Ai-ling Wang Hong-mei Yin Jin-qi Deng Xiao-yan Wang Ye-huan Yang Xiao-ping Pan Tong Zhang 不详 National center for Women and Children’s Health Chinese Center for Disease Control and PreventionNo.12 Dahuisi RoadHaidian DistrictBeijing100081China Capital Institute of Pediatrics No.2 Yabao RoadChaoyang DistrictBeijing100020China

Background:The number of HIV-positive pregnant women accounted for about 10% of China’s total over the past few years in liangshan prefecture, Sichuan province in China. Although cost-effectiveness of the PMTCT of HIV have been evaluated in other previous studies, no specific study has been conducted in liangshan prefecture, nor has the expenses paid individually by HIV-positive pregnant women been included. The purpose of this study was to evaluate both the short-term and long-term cost-effectiveness of PMTCT of HIV in liangshan prefecture from the social ***:From December 2018 to January 2019, individual expenses and the other costs were collected: individual expenses of 133 recruited HIV-positive pregnant women registered in the National Information System of prevention of Mother-to-Child Transmission of HIV, Syphilis, and HBV, and the other costs from local maternal and child healthcare hospitals, centers for disease control and prevention, and general hospitals. The costs, the number of pediatric infections averted from being HIV infected were analyzed. And, Life years gained by pediatric infections averted were calculated by using a life table. Besides, Direct benefit was calculated through a Markov mode. Furthermore, One-way sensitivity analysis was conducted for key variables affecting the benefit–cost ***:The estimated number of pediatric infections averted was *** total cost was USD 114.1 million, including direct medical costs, direct non-medical costs, and indirect costs, which were USD 54.2 million, USD 53.4 million, and USD 6.5 million, respectively. 630.6 person-years discounted to 2017 were gained at a 3% annual rate, and cost per life year gained was USD 1809.50. Direct benefits were USD 198.4 million, indirect benefits USD 82.5 million, and the benefit–cost ratio was 1.5. The sensitivity analysis showed that if PMTCT costs hypothetically ranged from USD 85.6 million to USD 142.6 million, benefit–cost ratio would vary f

关键词： Cost-effectiveness PMTCT HIV Benefit-cost ratio Individual cost

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Immediate and long-term outcomes after treat-all among people living with HIV in China:an interrupted time series analysis

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Infectious diseases of Poverty 2023年第4期12卷 29-42页

作者： Xinsheng Wu Guohui Wu Ping Ma Rugang Wang Linghua Li Yinghui Sun Junjie Xu Yuwei Li Tong Zhang Quanmin Li Yuecheng Yang Lijing Wang Xiaoli Xin Ying Qiao Bingxue Fang Zhen Lu Xinyi Zhou Yuanyi Chen Qi Liu Gengfeng Fu Hongxia Wei Xiaojie Huang Bin Su Hui Wang Huachun Zou Shenzhen Campus of Sun Yat-sen University No.66Gongchang RoadGuangming DistrictShenzhen518107GuangdongPeople’s Republic of China School of Public Health(Shenzhen) Sun Yat-sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhen518107GuangdongPeople’s Republic of China Institute for AIDS/STD control and prevention Chongqing Center for Disease Control and PreventionChongqingPeople’s Republic of China Department of Infectious diseases Tianjin Second People’s HospitalTianjinPeople’s Republic of China Tianjin Association of STD/AIDS prevention and control TianjinPeople’s Republic of China Dalian Public Health Clinical center DalianPeople’s Republic of China Infectious disease center Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouPeople’s Republic of China Clinical Research Academy Peking University Shenzhen HospitalPeking UniversityShenzhenPeople’s Republic of China Clinical and Research center for Infectious diseases Beijing Youan HospitalCapital Medical UniversityNo.8 XitoutiaoYouanmenwaiFeng Tai DistrictBeijing100069People’s Republic of China Dehong prefecture center for disease control and prevention DehongPeople’s Republic of China Shijiazhuang Fifth Hospital ShijiazhuangPeople’s Republic of China No.6 People’s Hospital of Shenyang ShenyangPeople’s Republic of China No.2 Hospital of Hohhot HohhotPeople’s Republic of China Department of STD/AIDS control and prevention Jiangsu Provincial Center for Disease Control and PreventionNanjingPeople’s Republic of China Department of Infectious disease The Second Hospital of NanjingNanjing University of Chinese Medicine1-1 Zhongfu RoadNanjing210036JiangsuPeople’s Republic of China National Clinical Research Centre for Infectious diseases The Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of SouthernUniversity of Science and TechnologyBulan Road 29#Longgang DistrictShenzhen518112GuangdongPeople’s Republic of China School of Public Health Fudan University130 Dongan RoadXuhu

Background In 2003,China implemented free antiretroviral therapy(ART)for people living with HIV(PLHIV),establishing an eligibility threshold of CD4<200 cells/μ***,the entry criteria were revised in 2012(eligibility t... 详细信息

Background In 2003,China implemented free antiretroviral therapy(ART)for people living with HIV(PLHIV),establishing an eligibility threshold of CD4centers for disease control and prevention and ten major infectious disease hospitals specialized in HIV care in *** used Poisson and quasi-Poisson segmented regression models to estimate the immediate and long-term impact of treat-all on three key indicators:monthly proportion of 30-day ART initiation,mean CD4 counts(cells/μl)at ART initiation,and mean estimated time from infection to diagnosis(year).We built separate models according to gender,age,route of transmission and *** Monthly data on ART initiation and collection were available for 75,516 individuals[gender:83.8%males;age:median 39 years,interquartile range(IQR):28-53;region:18.5%Northern China,10.9%Northeastern China,17.5%Southern China,49.2%Southwestern China].In the first month of treat-all,compared with the contemporaneous counterfactual,there was a significant increase in proportion of 30-day ART initiation[+12.6%,incidence rate ratio(IRR)=1.126,95%CI:1.033-1.229;P=0.007]and mean estimated time from infection to diagnosis(+7.0%,IRR=1.070,95%CI:1.021-1.120;P=0.004),while there was no significant change in mean CD4 at ART initiation(IRR=0.990,95%CI:0.956-1.026;P=0.585).By December 2019,the three outcomes were not significantly different from expected *** the stratified analysis,compared with the con

关键词： HIV Antiretroviral therapy Treat-all CD4

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Human neutralizing antibodies isolated from a Zika patient and their molecular determinants

Human neutralizing antibodies isolated from a Zika patient a...

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第十一届全国免疫学学术大会

作者： Wang Qihui Yang Huabing Liu Xiaoqing Dai Lianpan Ma Tong Qi Jianxun Wong Gary Peng Ruchao Liu Sheng Li Junfu Li Shihua Song Jian Liu Jianying He Jianhua Yuan Hui Xiong Ying Liao Yong Li Jianhua Yang Jianping Tong Zhou Griffin Bryan Bi Yuhai Liang Mifang Xu Xiaoning Qin Chuan Cheng Gong Wang Peiyi Qiu Xiangguo Kobinger Gary Shi Yi Yan Jinghua Gao Fu CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of Microbiology Chinese Academy of Sciences Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Third People’s Hospital School of Life Sciences Anhui University Jiangxi province center for disease control and prevention Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences CAS center for Influenza Research and Early-warning (CASCIRE) Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China Collaborative Innovation center for Diagnosis and Treatment of Infectious diseases School of Medicine Tsinghua University Shanghai Institute of Applied Physics Chinese Academy of Sciences Ganzhou prefecture center for disease control and prevention Special Pathogens Program National Microbiology Laboratory Public Health Agency of Canada National Institute for Viral disease control and prevention Chinese Center for Disease Control and Prevention (China CDC) MRC Human Immunology Unit University of Oxford Key Laboratory of Human diseases Comparative Medicine Ministry of Health Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences Faculty of Biological Science University of Leeds College of Life Sciences University of Chinese Academy of Sciences Savaid Medical School University of Chinese Academy of Sciences

Zika virus infections are associated with fetal microcephaly,neurological complications and constitute a public health ***,we report the isolation of 13 specific,human-origin monoclonal antibodies from an imported Zika case to *** of the isolated antibodies(Z23 and Z3L1)demonstrate potent Zika-specific neutralization in vitro without binding or neutralizing activity against Zika’s closest relative Dengue virus(DENV)1-4,

关键词： Zika virus envelope protein human neutralizing MAbs B cell sequencing crystal structure Cryo-EM

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Experimental Trichinella spiralis infection in Hezuo Pig and immune response analysis

Experimental Trichinella spiralis infection in Hezuo Pig and...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Tingting Li Nianzhang Zhang Wenhui Li Li Li Jianmin Cui Hongbin Yan Zigang Qu Yangyang Wanzhong Jia Baoquan Fu State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu Province Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Jiangsu Co-innovation center for prevention and control of Important Animal Infectious disease

Trichinellosis caused by Trichinella spiralis is a serious foodborne parasitic zoonosis. Pork and other animal meat are identified as the most important source of infection for humans. Hezuo pig is a sort of primitive local pig, which is from natural domestication and artificial selection. The plateau such as Gannan Tibetan Autonomous prefecture of Gansu Province, is the main distribution area of Hezuo pig. Because of the free-range systems, Hezuo pig is liable to be attacked by Trichinella spiralis. Furthermore, the pork from Hezuo pig as one of the main source of meat, the residents can be infected by Trichinella spiralis because of the altitude environment and their dietary habit. The aim of the present work is to study the infectivity of Trichinella spiralis Tibet strain to Hezuo pig and the changes of cytokine levels in sera. A total of 9 Hezuo pigs were divided into four groups, including three experimental groups(two pigs in each group) and one control group(three pigs). The pigs in the experimental groups were inoculated with 200, 2000 or 20,000 muscle larvae of Trichinella isolate from Tibet respectively. During the 107 days post-infection, the blood samples were collected at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 63, 70, 100 and 107 post-infection, and the sera were isolated to evaluate the anti-Trichinella Ig G kinetics by ELISA using excretory/secretory antigens and the cytokine levels by the microarray. The results of ELISA showed that the level of antibodies was corresponded with the inoculum dose before the days 56 post-infection, and the pigs receiving high dosage of larvae obtained higher level of antibodies than that receiving low dosage of larvae. The level of antibodies of the pigs receiving 2000 and 20,000 muscle larvae increased sharply after day 21 post-infection, while the pigs receiving 200 larvae increased after day 28 post-infection. Ten cytokines were detected by microarray in the serum, which includes four Th1 cytokines(IFN-γ, IL-1β, IL-

关键词： Trichinella spiralis experimental infection Hezuo pig immunoresponse

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