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Proteome Analyses of Hepatocellular Carcinoma

Journal of Clinical and Translational Hepatology 2014年第1期2卷 23-30页

作者： Dominik A.Megger Wael Naboulsi Helmut e.Meyer Barbara Sitek Medizinisches Proteom-Center Ruhr-Universit(a)t Bochum Bochum Germany Medizinisches Proteom-Center Ruhr-Universit(a)t Bochum Bochum Germany leibniz-institut für analytische wissenschaften isas-e.v. Dortmund Germany

Proteomics has evolved into a powerful and widely used bioanalytical technique in the study of cancer,especially hepatocellular carcinoma (HCC).In this review,we provide an up to date ove.v.ew of feasible proteome-analytical techniques for clinical *** addition,we present a broad summaryof proteornic studies of HCC utilizing various technical approaches for the analysis of samples derived from diverse sources like HCC cell lines,animal models,human tissue and body fluids.

关键词： Proteomics Quantitative analysis Hepatocellular carcinoma Biomarker Cell lines Animal models Tissue samples

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Proteome-Based Clustering Approaches reveal Phylogenetic Insights into Amphistegina

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Journal of earth Science 2022年第6期33卷 1469-1479页

作者： Marleen Stuhr Bernhard Blank-Landeshammer Achim Meyer vera Baumeister Jörg rahnenführer Albert Sickmann Hildegard Westphal leibniz Centre for Tropical Marine research(ZMT) BremenGermany leibniz-institut für analytische wissenschaften-isas-e.v. DortmundGermany Austrian Competence Center for feed and food Quality Safety and InnovationWelsAustria Chrestos Concept GmbH&Co KG EssenGermany Department of Statistics TU Dortmund UniversityDortmundGermany Medizinisches Proteom-Center(MPC) Ruhr-Universität BochumBochumGermany Department of Chemistry University of AberdeenOld AberdeenScotlandUK Department of Geosciences Bremen UniversityBremenGermany King Abdullah University of Science and Technology(KAUST) ThuwalSaudi Arabia

foraminifera are highly diverse and have a long evolutionary *** key bioindicators,their phylogenetic schemes are of great importance for paleogeographic applications,but may be hard to recognize *** phylogenetic relationships within the prominent genus Amphistegina are still *** studies on Amphistegina have so far only focused on genetic diversity within single species and suggested a cryptic diversity that demands for further *** molecular sequencing-based approaches,different mass spectrometry-based proteomics approaches are increasingly used to give insights into the relationship between samples and organisms,especially as these do not require reference *** better understand the relationship of amphisteginids and test different proteomics-based approaches we applied de novo peptide sequencing and similarity clustering to several populations of Amphistegina lobifera,*** and *** also analyzed the dominant photosymbiont community to study their influence on holobiont *** analyses indicate that especially de novo peptide sequencing allows to reconstruct the relationship among foraminiferal holobionts,although the detected separation of *** from *** and *** may be partly influenced by their different photosymbiont *** resulting dendrograms reflect the separation in two lineages previously suggested and provide a basis for future studies.

关键词： large benthic foraminifera de novo peptide sequencing tandem mass spectra clustering LC-MS/MS runs proteomics symbiont diversity phylogeography fragilariales

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Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance,neuroinflammation and Alzheimer’s disease

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Translational Neurodegeneration 2022年第1期11卷 931-948页

作者： Alessandro Dario Confettura eleonora Cuboni Mohamed rafeet Ammar Shaobo Jia Guilherme M.Gomes PingAn Yuanxiang raje.v.raman Tingting Li Katarzyna M.Grochowska robert Ahrends Anna Karpova Alexander Dityatev Michael r.Kreutz rG Neuroplasticity Leibniz-Institute for Neurobiology39118 Magde-burgGermany German Center for Neurodegenerative Diseases(DZNe) 39120 MagdeburgGermany Center for Behavioral Brain Sciences Otto Von Guericke University39120 MagdeburgGermany leibniz-institut für analytische wissenschaften-isas-e.v. 44227 DortmundGermany leibniz Group‘Dendritic Organelles and Synaptic function’ Center for Molecular NeurobiologyZMNHUniversity Medical Center Hamburg-Eppendorf20251 Ham-burgGermany Department of Analytical Chemistry Faculty of ChemistryUniversity of Vienna1090 WienAustria Medical faculty Otto-von-Guericke University39120 MagdeburgGermany.

Background:The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer’s *** has been proposed that neuroinflammation might be an inte.v.ning variable,but the underlying mechanisms are currently ***:We utilized primary neurons to induce synaptic insulin resistance as well as a mouse model of high-risk aging that includes a high amyloid load,neuroinflammation,and diet-induced obesity to test hypotheses on underly-ing ***:We found that neddylation and subsequent activation of cullin-rING ligase complexes induced synaptic insulin resistance through ubiquitylation and degradation of the insulin-receptor substrate IrS1 that organizes synap-tic insulin ***,inhibition of neddylation prese.v.d synaptic insulin signaling and rescued memory deficits in mice with a high amyloid load,which were fed with a’western diet’.Conclusions:Collectively,the data suggest that neddylation and degradation of the insulin-receptor substrate is a nodal point that links high amyloid load,neuroinflammation,and synaptic insulin resistance to cognitive decline and impaired synaptic plasticity in high-risk aging.

关键词： Metabolic syndrome Alzheimer’s disease Neddylation Cullins MLN-4924 Insulin IrS1 Amyloid-β TNfα

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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

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Bone research 2024年第3期12卷 611-620页

作者： Brenda Krishnacoumar Martin Stenzel Hilal Garibagaoglu Yasunori Omata rachel L.Sworn Thea Hofmann Natacha Ipseiz Magdalena A.Czubala Ulrike Steffen Antonio Maccataio Cornelia Stoll Christina Böhm Martin Herrmann Stefan Uderhardt robert H.Jenkins Philip r.Taylor Anika Grüneboom Mario M.Zaiss Georg Schett Gerhard Krönke Carina Scholtysek Department of Internal Medicine 3-rheumatology and Immunology Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Deutsches Zentrum für Immuntherapie(DZI) Friedrich-Alexander University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen91054 ErlangenGermany Department of Biopsectroscopy Leibniz Institut für Analytische Wissenschaften-ISAS-e.V.Bunsen-Kirchhoff-Str.11Dortmund 44227Germany Medical faculty University HospitalUniversity Duisburg-EssenEssen 45147Germany Systems Immunity research institute Heath ParkCardiff UniversityCardiff CF144XNUK Optical Imaging Competence Centre(fAU OICe) Exploratory Research UnitFriedrich-Alexander University Erlangen-Nürnberg(FAU)ErlangenGermany Division of Infection&Immunity Heath ParkCardiff UniversityCardiff CF144XNUK Deutsches rheuma-forschungszentrum Berlin BerlinGermany Department of rheumatology and Clinical Immunology Charité-Universitätsmedizin BerlinBerlinGermany

efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing ***,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely *** we identify rANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.

关键词： incomplete exact activation

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Syzygy effects Studies Performed Simultaneously with foucault Pendulums and Torsinds during the Solar eclipses of 13 November 2012 and 10 May 2013

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International Journal of Astronomy and Astrophysics 2014年第1期4卷 39-53页

作者： Dimitrie Olenici Alexander f. Pugach Ilie Cosovanu Cezar Lesanu Jean-Bernard Deloly Danil vorobyov Alexander Delets Stefan-Bogdan Olenici-Craciunescu Association AIrAMA Paris France Astronomical Obse.v.tory Stefan cel Mare University of Suceava Suceava Romania leibniz-institut fur analytische Wisenschaften-isas-e.v Dortmund Germany Main Astronomical Obse.v.tory of National Academy of Sciences Kiev Ukraine Tomsa voda Technological Highschool Solca Romania

Several simultaneous obse.v.tions are presented of Syzygy effects during two solar eclipses, performed with torsinds and foucault pendulums. The experiments/measurements were of a simple nature, conducted in several of places in romania and Ukraine. It is shown that during Syzygy effects both the torsind and the foucault pendulum exhibit specific reactions: the torsind’s disk is rotated, whereas the direction of the swing plane, the period, the eccentricity and the chirality of the ellipse of oscillation of the foucault pendulum are all altered. We term all these perturbations “Syzygy effects” and found that they take place even when the devices are in locations where the eclipse is not visible and even when they are underground. An unusual time shifts?between the responses of the devices and the maximum phase of the eclipse is detected. The importance of simultaneous simple obse.v.tions of astronomical phenomena using these two devices of fundamentally different types is emphasized.

关键词： Paraconical Pendulum Antieclipse effect Torsind

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Tip-enhanced raman Scattering（TerS）on DNA Bases

Tip-enhanced Raman Scattering（TERS）on DNA Bases

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第三十五届国际光谱会议

作者： e.Bailo v.Deckert isas-institute for Analytical Sciences Bunsen-Kirchhoff-Str.11 Dortmund D-44139 Germany isas-institute for Analytical Sciences Bunsen-Kirchhoff-Str.11 Dortmund D-44139 Germany

＜正＞In order to accomplish vibrational spectroscopic measurements with highest lateral resolution on DNA bases,we utilize the tip-enhanced raman scattering *** essence an atomic force microscope （AfM） tip was coated with silver and/or gold,to use localized surface plasmon electromagnetic field and to enhance the raman signals.

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白内障手术Tenon囊下阻滞麻醉与表面麻醉的随机对照试验:患者满意度的比较研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 39-40页

作者： rüschen uschen H. Celaschi D. Bunce C. Carr C. H. rMoorfields 邢咏新 eye Hospital 162 City Road London EC1V 2PD United Kingdom

Background/aim: Sub-Tenon’s block (STB) or topical anaesthesia alone (TOP) are popular techniques employed during cataract surgery. TOP is often preferred b y healthcare providers because of financial or staffing reasons, despite existing evidence that pain during surgery is better controlled with STB. Pain is not the only consideration that determines patient preference for the anaesthesia tec hnique. The authors decided to investigate the issue of patient satisfaction usi ng the recently developed Iowa Satisfaction with Anesthesia Scale (isas). Method : In a randomised controlled pilot trial, 28 patients were enrolled to rece.v. e ither STB with 3 ml of 2%lidocaine and hyaluronidase, or TOP with proxymetacain e 0.5%and amethocaine 1%(Tetracaine) eye drops. Postoperatively patients rated their satisfaction with anaesthesia care by filling in the self administered wr itten questionnaire, the isas. results: One patient in the TOP group dropped out of the study because of intolerable pain. Analysis of the questionnaire results with a two sample Wilcoxon rank sum test showed a significant difference in pat ient satisfaction (pe median satisfaction score was higher in the S TB group 2.77 (interquartile range IQr 2.45 to 3), than in the TOP group 2.04 (I Qr 1.54 to 2.5). Conclusion: In the setting of day case cataract surgery, patien ts report significantly higher satisfaction scores with STB than with TOP alone.

关键词：阻滞麻醉 Tenon 表面麻醉白内障手术随机对照试验满意度评分可更丙美卡因保健机构多卡因

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