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Management of vitamin D deficiency in young women with 1-year follow up

Open Journal of Preventive Medicine 2012年第3期2卷 312-317页

作者： C. Perdrix O. Large R. Fauché C. Dupraz MF. Legoaziou Associate Professor. collège des enseignants généralistes Université Claude Bernard LYON1 general practitioner LYOn lecturer. collège des enseignants généralistes Université Claude Bernard LYON 1

Vitamin D deficiency is very frequently observed among young women. This study reports the follow up of 68 women over a period of 1 year. The objective of this study was to observe doses of vitamin D can correct and preserve blood levels of vitamin D near 75 nmol/L. It was found that large amounts of vitamin D are needed to correct and then maintain vitamin D blood levels (≥530,000 units), particularly in veiled women (~720,000 units). Parathyroid hormone (PTH) levels decreased as blood levels of vitamin D increased. Quality of life measured with the SF12? Health Survey questionnaire, improved when the patients’ vitamin D deficiencies were corrected. This work highlights the need for the development of guidelines to treat and correct vitamin D deficiency for the long term in young adult women.

关键词： Hypovitaminosis D Treatment Adult Women Follow Up

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numerical modeling of centrifuge cyclic lateral pile load experiments

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Earthquake Engineering and Engineering Vibration 2009年第1期8卷 61-76页

作者： nikos gerolymos Sandra Escoffier george gazetas Jacques garnier Civil Engineering National Technical UniversityAthens Greece Laboratoire Central des Ponts et Chaussées Nantes France Lecturer Laboratoire Central des Ponts et Chaussées Nantes France

To gain insight into the inelastic behavior of piles, the response of a vertical pile embedded in dry sand and subjected to cyclic lateral loading was studied experimentally in centrifuge tests conducted in Laboratoire Central des Ponts et Chaussees. Three types of cyclic loading were applied, two asymmetric and one symmetric with respect to the unloaded pile. An approximately square-root variation of soil stiffness with depth was obtained from indirect in-flight density measurements, laboratory tests on reconstituted samples, and well-established empirical correlations. The tests were simulated using a cyclic nonlinear Winkler spring model, which describes the full range of inelastic phenomena, including separation and re-attachment of the pile from and to the soil. The model consists of three mathematical expressions capable of reproducing a wide variety of monotonic and cyclic experimentalp-y curves. The physical meaning of key model parameters is graphically explained and related to soil behavior. Comparisons with the centrifuge test results demonstrate the general validity of the model and its ability to capture several features of pile-soil interaction, including： soil plastification at an early stage of loading, ＂pinching＂ behavior due to the formation of a relaxation zone around the upper part of the pile, and stiffness and strength changes due to cyclic loading. A comparison of the p-y curves derived from the test results and the proposed model, as well as those from the classical curves of Reese et al. （1974） for sand, is also presented.

关键词： centrifuge test Winkler model p-y curves cyclic loading pile-soil separation/gapping nonlinear response experimental validation

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