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Centimeter-Deep NIR-II Fluorescence imaging with Nontoxic AIE Probes in Nonhuman Primates

research 2020年第1期2020卷 652-665页

作者： Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang Paul C.lauterbur research center for biomedical imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China Department of Radiation Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518055China Department of Chemistry The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal ***,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical ***,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are ***,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence *** important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials.

关键词： Fluorescence Probe breaking

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Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration research 2024年第11期19卷 2351-2353页

作者： Samuel K.H.Sy Ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced biomedical Instrumentation center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Cheung research center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen research center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

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猕猴脑网络组图谱:包含分区、连接和组织学的多层面全新大脑地图

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Science Bulletin 2024年第14期69卷 2241-2259页

作者：陆玉恒崔玥曹龙董振伟程禄祺吴雯王昌硕刘新异刘有通张宝贵李德莹赵舶凯王海艳李开心马亮时维阳李雯马亚伟杜宗昌张佳琪熊辉罗娜刘妍妍侯肖逍韩景路孙洪吉蔡涛彭强冯琳清王骄健 George Paxinos 杨正宜樊令仲蒋田仔 Brainnetome center Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Henan Key Laboratory of imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou 450001China Neuroscience research Australia and The University of New South Wales Sydney NSW 2031Australia Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Primate biomedical research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150080China School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004China Sino-Danish College University of Chinese Academy of ScienceBeijing 100049China research center for Augmented Intelligence Zhejiang LabHangzhou 311100China Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital Yongzhou 425000China

The rhesus macaque(Macaca mulatta)is a crucial experimental animal that shares many genetic,brain organizational,and behavioral characteristics with humans.A macaque brain atlas is fundamental to biomedical and evolutionary ***,even though connectivity is vital for understanding brain functions,a connectivity-based whole-brain atlas of the macaque has not previously been *** this study,we created a new whole-brain map,the Macaque Brainnetome Atlas(MacBNA),based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI *** new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional *** parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained *** a demonstrative application,the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain *** resulting resource includes:(1)the thoroughly delineated Macaque Brainnetome Atlas(MacBNA),(2)regional connectivity profiles,(3)the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset(Brainnetome-8),and(4)multi-contrast MRI,neuronal-tracing,and histological images collected from a single *** can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and ***,it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

关键词： Macaca mulatta Brain atlas Connectivity-based parcellation Diffusion MRI Cytoarchitecture Cross-species comparison

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Neurovascular unit on a chip:the relevance and maturity as an advanced in vitro model

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Neural Regeneration research 2024年第6期19卷 1165-1166页

作者： Sujey Palma-Florez Anna Lagunas Mònica Mir Nanobioengineering Group Institute for Bioengineering of Catalonia(IBEC)Barcelona Institute of Science and Technology(BIST)BarcelonaSpain CIBER-BBN ISCIIIMadridSpain Department of Electronics and biomedical Engineering University of BarcelonaBarcelonaSpain

The brain is a high-energy demanding organ,consuming around 20%of the metabolic energy *** fulfill this demand,cerebral blood flow(CBF)supplies oxygen and glucose continuously through the intricate network of cerebral blood *** for many years brain activity and blood flow were conceived as independent processes,MRI-based functional brain imaging demonstrated that there is a coupling between them.

关键词： cerebral maturity consuming

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INFLUENCE OF LIMITED-PROJECTION ON FLUORESCENCE MOLECULAR TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2012年第3期5卷 59-63页

作者： YUN HE XU CAO FEI LIU JIANWEN LUO JING BAI Department of biomedical Engineering Tsinghua University Beijing 100084P.R.China center for biomedical imaging research Tsinghua University Beijing 100084P.R.China

Challenges remain in imaging fast biological processes in vivo withfluorescence molecular tomography(FMT)due to the long data acquisition *** acquisition with limited projections can greatly reduce the time consumption,but the influence of limited-projection on reconstruction quality is currently *** numerical simulations and a phantom experiment are conducted to analyze this *** a systematic investigation of all the results reconstructed from different numbers of projections,we evaluate the influence of limited-projection data on FMT.A mouse experiment is also performed to validate our work.A general relationship between the number of projections and reconstruction quality is obtained which indicates that the projection number of three is preferred for fast FMT experiment.

关键词： FMT inverse problem limited-projection

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Spectral selective fluorescence molecular imaging with volume holographic imaging system

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Journal of Innovative Optical Health Sciences 2016年第2期9卷 59-69页

作者： Yanlu Lv Jiulou Zhang Fei Liu Junwei Shi Huizhi Guang Jing Bai Jianwen Luo Department of biomedical Engineering School of Medicine Tsinghua University Beijing 100084P.R.China center for biomedical imaging research Tsinghua University Beijing 100084 P.R.China

A compact volume holographic imaging(VHI)method that can detect fluorescence objects located in diffusive medium in spectral selective imaging manner is *** enlargement of lateralfield of view of the VHI system is realized by using broadband illumination and demagnification *** target spectrum of°uorescence emitting from a di®usive medium is probed by tuning the inclination angle of the transmission volume holographic grating(VHG).With the use of the single transmission VHG,fluorescence images with different spectrum are obtained sequentially and precise three-dimensional(3D)information of deep fluorescent objects located in a diffusive medium can be reconstructed from these *** results of phantom experiments demonstrate that two fluorescent objects with a sub-millimeter distance can be resolved by spectral selective imaging.

关键词： Volume holographic grating diffusive medium fluorescence molecular imaging

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Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

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Bioactive Materials 2022年第4期7卷 515-525页

作者： Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen518107China Paul C.lauterbur research center for biomedical imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death,which has been demonstrated to be highly effective in treating malignant *** therapy(SDT)adopts ultrasound(US)as the excitation source to induce the production of reactive oxygen species(ROS),which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical ***,we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO_(2) on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently(Au/BP@MS).The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO_(2)-mediated O_(2) generation and GSH depletion,thus leading to notable inhibition effect on tumor ***,tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.

关键词： Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic

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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

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Nano research 2024年第10期17卷 9044-9051页

作者： Mengdie Chen Anying Zhu Furong Zhu Ziwen Lei Tao Huang Shengnan Du Dongdong Wang Xiaoyu Zhang Huan Min Yingqiu Qi Guangjun Nie Department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450008China Department of General Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Breast Disease The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450003China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety&CAS center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic ***-rich-alpha-2-glycoprotein 1(LRG1)has emerged as a notable target due to its markedly elevated expression in breast tumors,suggesting the viability of LRG1 as a theranostic *** our study,we employed phage display technology to identify a peptide,termed ET,that binds to LRG1 with a dissociation constant of 48.4μ*** modified with fluorescent cyanine dye,the ET peptide showcased effective tumor-targeting imaging across three different primary breast tumor models and a metastatic breast tumor *** also undertook a comprehensive safety evaluation,which verified the good biosafety credentials of ET *** summary,the ET peptide identified in this study shows effective LRG1-targeting ability both in vitro and in vivo,thus exhibiting immense potential for clinical translation.

关键词： breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display peptide tumor targeting

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Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian Jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial Key Laboratory of High Field Magnetic Resonance imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial Engineering Laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

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