检索结果-南通市图书馆

Noncontact ultrasound sensing based on Mach-Zehnder homodyne interferometer for photoacoustic imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第3期22卷 101-106页

作者：龙星胡毅成王一冰李长辉 Department of biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China National biomedical imaging center Peking UniversityBeijing 100871China

We present a novel noncontact ultrasound(US)and photoacoustic imaging(PAI)system,overcoming the limitations of traditional coupling *** a long coherent length laser,we employ a homodyne free-space Mach-Zehnder setup with zero-crossing triggering,achieving a noise equivalent pressure of 703 Pa at 5 MHz and a-6 dB bandwidth of 1 to8.54 *** address the phase uncertainty inherent in the homodyne *** the noncontact US probe enables photoacoustic computed tomography(PACT).Phantom studies demonstrate imaging performance and system stability,underscoring the potential of our system for noncontact US sensing and PAI.

关键词： noncontact ultrasound sensing photoacoustic imaging Mach–Zehnder interferometer

Model-driven CT reconstruction algorithm for nano-resolution x-ray phase contrast imaging

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第7期33卷 646-650页

作者：谭雨航蔡学宝杨杰成苏婷郑海荣梁栋朱佩平葛永帅 research center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Paul C lauterbur research center for biomedical imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The low-density imaging performance of a zone plate-based nano-resolution hard x-ray computed tomography(CT)system can be significantly improved by incorporating a grating-based Lau interferometer. Due to the diffraction, however,the acquired nano-resolution phase signal may suffer splitting problem, which impedes the direct reconstruction of phase contrast CT(nPCT) images. To overcome, a new model-driven nPCT image reconstruction algorithm is developed in this study. In it, the diffraction procedure is mathematically modeled into a matrix B, from which the projections without signal splitting can be generated invertedly. Furthermore, a penalized weighted least-square model with total variation(PWLSTV) is employed to denoise these projections, from which nPCT images with high accuracy are directly *** experiments demonstrate that this new algorithm is able to work with phase projections having any splitting distances. Moreover, results also reveal that nPCT images of higher signal-to-noise-ratio(SNR) could be reconstructed from projections having larger splitting distances. In summary, a novel model-driven nPCT image reconstruction algorithm with high accuracy and robustness is verified for the Lau interferometer-based hard x-ray nano-resolution phase contrast imaging.

关键词： splitting phase image reconstruction algorithm grating interferometer

Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第1期5卷 377-384页

作者： Renfa Liu Huanyu Yang Shuai Qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian Department of biomedical Engineering College of Future TechnologyNational Biomedical Imaging CenterPeking UniversityBeijingChina Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijingChina

Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and ***,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ***,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal *** antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 *** micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem *** a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem *** research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.

关键词： antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy

Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of biomedical imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

在线全文

学校读者我要写书评

暂无评论

Bone research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The research center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core imaging center and Bioimaging Data Curation center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage research center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

Positron Emission Tomography imaging of Synaptic Dysfunction in Parkinson’s Disease

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第6期40卷 743-758页

作者： Jiaqi Niu Yan Zhong Chentao Jin Peili Cen Jing Wang Chunyi Cui Le Xue Xingyue Cui Mei Tian Hong Zhang Department of Nuclear Medicine and PET center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Institute of Nuclear Medicine and Molecular imaging Zhejiang UniversityHangzhou310009China Key Laboratory of Medical Molecular imaging of Zhejiang Province Hangzhou310009China College of biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310014China Key Laboratory for biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou310014China Huashan Hospital and Human Phenome Institute Fudan UniversityShanghai200040China

Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex *** formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine *** loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological *** emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular *** synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical *** this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

关键词： Parkinson’s disease Positron emission tomography Synapse dysfunction Alpha-synuclein Dopamine system Non-dopamine system

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology research center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of biomedical imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano research 2024年第1期17卷 270-281页

作者： Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&center for Molecular imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of *** by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor *** detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic ***,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic *** importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用于常见疾病成像的纳米材料造影剂

Science China Materials 2024年第4期67卷 1288-1291页

作者：邢洁李子厚姚俊列吴爱国 Ningbo Key Laboratory of biomedical imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and Application Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices Ningbo Cixi Institute of Biomedical Engineering Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Advanced Energy Science and Technology Guangdong Laboratory

生物医学精准诊断对于疾病的有效治疗十分重要.纳米基成像造影剂具有灵敏度高、特异性强、生物相容性好等特点,在生物医学成像诊断中具有巨大的临床转化潜力.目前,尽管研究者们构筑了大量的纳米基探针材料作为疾病诊断造影剂,但纳米材... 详细信息

生物医学精准诊断对于疾病的有效治疗十分重要.纳米基成像造影剂具有灵敏度高、特异性强、生物相容性好等特点,在生物医学成像诊断中具有巨大的临床转化潜力.目前,尽管研究者们构筑了大量的纳米基探针材料作为疾病诊断造影剂,但纳米材料造影剂在临床转化方面仍然面临极大的挑战.这里我们主要概述了不同生物医学成像类型的纳米基造影剂所面临的问题,并针对这些难题提出了应对方案和未来的研究重点,最后对纳米基造影剂的临床转化前景进行了展望.

关键词：造影剂生物医学成像疾病诊断应对方案生物相容性纳米材料临床转化有效治疗