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Coverage and determinants of infant postnatal care in Nigeria: A population-based cross-sectional study

儿科学研究(英文) 2024年第1期08卷 27-36页

作者： Egbewale Bolaji Emmanuel Oyedeji Olusola Bump Jesse Sudfeld Christopher Robert Department of Global Health and Population Takemi Program in International Health Harvard T. H. Chan School of Public Health Boston Massachusetts USA Department of Community Medicine College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Pediatrics and Child Health College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria

Importance: In 2019, Nigeria had the largest number of under-5 child deaths globally and many of these deaths occurred within the first week of life. The World Health Organization recommends infant postnatal care (PNC) attendance to support newborn survival; however, utilization of PNC is known to be low in many ***: This study examined coverage and individual-level determinants of infant PNC attendance in ***: Nigeria Demographic Health Survey (NDHS) 2018 data were used to evaluate infant PNC coverage and determinants. Infant PNC was defined as receipt of care within 2 days of birth. Children delivered up to 2 years before the 2018 NDHS were included. We examined predictors of infant PNC with modified Poisson regression models to estimate relative risks (RRs).Results: The national coverage of infant PNC was 37.3% (95% confidence interval [CI]: 35.8%–38.7%). Significant heterogeneity in PNC attendance existed at state and regional levels. Facility delivery was strongly associated with the uptake of PNC (RR: 6.07; 95% CI: 5.60–6.58). Greater maternal education, maternal employment, urban residence, female head of household, and greater wealth were also associated with an increased likelihood of PNC ***: The uptake of infant PNC is low and interventions are urgently needed to promote equity in access and increase demand for PNC in Nigeria.

关键词： Infant postnatal care Epidemiology Coverage Determinants Nigeria

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Contexts and pragmatic strategies of COVID-19 related cartoons in Nigeria

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Language and Semiotic Studies 2024年第2期10卷 267-289页

作者： Ezekiel Opeyemi Olajimbiti Oluwafemi Bolanle Jolaoso Department of English and Literary Studies Federal University LokojaLokojaNigeria Department of English and Literary Studies Ladoke Akintola University of TechnologyOgbomosoNigeria

The global outbreak of the coronavirus pandemic has been experienced differently by people depending on their socio-cultural *** varied experiences are expressed in various forms of communication,including *** paper examines the pragmatic resources inherent in COVID-19-related cartoons depicting the impact of the virus on Nigerian *** COVID-19-related cartoons,circulated on social media,were collected on Twitter and WhatsApp platforms between March and April 2020 as *** and presupposition served as theoretical framework and descriptive research design was *** reveal five socio-contextual domains,religion,health,economy,politics and governance nd family,characterizing the social experiences of Nigerians during the *** the evocation of situational reality,pragmatic sarcasm,punning,and orientation to government insensitivity,the cartoonists evoke pragmatic functions of informing and warning about social behaviours in the religion,family and health domains;recreating situational realities on socioeconomic impacts in the domain of economy;and satirizing government policies and mocking politicians’insincerity in the domain of politics and governance on sociopolitical experiences of Nigerians before and during the *** study concludes cartoons are a strong means of portraying societal realities and people’s experiences comically and graphically.

关键词： multimodality COVID-19-related cartoons sociocultural experience shared situational knowledge context

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Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat:In vitro and in vivo studies

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Chinese Herbal Medicines 2024年第1期16卷 113-120页

作者： Olabinri P.Folashade Ibrahim Damilare Boyenle Tolulope A.Oyedeji Fiyinfoluwa Demilade Ojeniyi Adisa Ayobami Damilare Leonard O.Ehigie Adeola Folasade Ehigie Membrane Biochemistry and Biophysics Research Laboratory Department of BiochemistryLadoke Akintola University of TechnologyOgbomoso 210214Nigeria Computational Biology/Drug Discovery Laboratory Department of BiochemistryLadoke Akintola University of TechnologyOgbomoso 210214Nigeria College of Health Sciences Crescent University AbeokutaAbeokuta 111105Nigeria Department of Biochemistry University of LagosLagos 101017Nigeria

Objective:To assess acute toxicity,the in vitro and in vivo effects of methanol and ethyl acetate extracts(JME and JEE)of Jatonik polyherbal mixture on some mitochondria-related parameters and their effect on the activity of some liver ***:Acute toxicity of JME and JEE was determined using Lorke’s *** vitro and in vivo opening of the mitochondrial membrane permeability transition pore(MMPT pore)was spectrophotometrically *** of malondialdehyde(MDA)as an index of lipid peroxidation and the activity of mitochondrial ATPase was evaluated in vitro and in vivo and the effect of JME and JEE on the activity of liver enzymes such as alkaline phosphatase(ALP),aspartate and alanine aminotransferase(AST and ALT)and gamma-glutamyl transferase(GGT)was also ***:JME had an LD_(50) of 3808 mg/kg b.w whereas JEE had an LD_(50) greater than 5000 mg/kg *** *** the rats have been fed with both extracts,a photomicrograph of a piece of liver tissue showed no apparent symptoms of *** the in vitro and in vivo studies,both extracts prompted intact mitochondria to open their MMPT *** compared to the control,lipid peroxide product release and ATPase activity were significantly increased(P<0.05)in vitro and in *** activities of AST,ALT,and GGT were all reduced at 50 mg/kg when treated with JME,but the activity of AST was considerably enhanced when treated with JEE(P<0.05).The results revealed that both JME and JEE of the Jatonik polyherbal mixture had low toxicity,profound MMPTpore induction,and enhanced ATPase activity,but an increased MDA ***:Jatonik extracts may be a promising target for drug development in diseases where there is dysregulation of apoptosis,however,further studies are needed to better clarify the molecular mechanism involved in these phenomena.

关键词： acute toxicity Ageratum conyzoides Linn. apoptosis Hunteria umbellate(K.Schum.)Hallier f. Lepidium meyenii Walp. mitochondrial ATPase mitochondrial lipid peroxidation mitochondrial membrane permeability transition pore polyherbal mixture Xylopia aethiopica(Dunal)A.Rich

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Audit of Neonatal Jaundice as Experienced at a Mission Hospital in Western Nigeria

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Open Journal of Pediatrics 2024年第1期14卷 50-62页

作者： Joel-Medewase Victor Idowu Department of Paediatrics and Child Health Ladoke Akintola University of Technology Ogbomoso Nigeria

Introduction: Neonatal jaundice (NNJ) is a common disorder in neonates that can impact negatively on the brain and cause death. The peculiarities in aetiology and solutions for different settings are a knowledge gap. This informed the desire to determine local aetiology and solutions for neonatal jaundice in a missionary hospital in Abeokuta, Southwestern Nigeria. Methods: Consecutive consenting babies diagnosed with significant neonatal jaundice were studied between July 2016 and June 2019. Institutional ethical consent was obtained. A proforma was used to obtain socio-demographic data and other relevant information such as age, sex, birthweight, gestational age and history regarding the jaundice. All the information obtained was inputted into a computer and analysed with SPSS version 16. Results: A total of 179 babies with neonatal jaundice comprising of 120 (67.0%) boys and 59 (33.0%) girls with ages ranging between 1 and 12 days (mean 2.7 ± 2.9) were studied. Prematurity, ABO incompatibility, neonatal sepsis and glucose-6-phosphate enzyme deficiency accounted for over 80% of the causes of significant NNJ. Sixty (33.5%) of the 179 babies studied developed acute bilirubin encephalopathy and 11 (6.1%) mortalities were recorded. Higher proportions of babies that were out-born with spontaneous vaginal delivery modes had acute bilirubin encephalopathy (p < 0.05). Mothers with formal education had better outcome compared to mothers without, in terms of mortalities (p < 0.05). Conclusion: Neonatal jaundice is still a significant cause of morbidity and mortality in the neonatal age group. Maternal education is key to good outcome in neonatal jaundice.

关键词： Jaundice Neonates Bilirubinaemia Encephalopathy and Outcomes

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Directives and references in selected coronavirus-motivated internet memes

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Language and Semiotic Studies 2024年第2期10卷 245-266页

作者： Ayo Osisanwo Toluwalope Mary Falade Department of English University of IbadanIbadanNigeria Institute of English Studies Leuphana UniversitätLüneburgGermany Department of English and General Studies Ladoke Akintola UniversityOgbomosoNigeria

The use of directives in communicating the nature of the pandemic and reference to social experiences were promoted using images on social media *** images or memes are used to create awareness and reinforce the criteria for safety during the *** studies on internet memes have concentrated on humor generation,speaker-hearer shared knowledge,neologism,and multimodality among others,with insufficient attention paid to the use of directives and references in such coronavirus-motivated *** paper,therefore,examines how directives and references are employed in conveying expected social responsibilities through coronavirus-motivated internet memes in Nigeria and other socio-cultural *** data,one hundred coronavirus-motivated memes were purposively selected from Facebook,and eight representative memes were subjected to pragmatic analysis using aspects of Jacob Mey’s(***:An introduction,2nd ***:Blackwell Publishing)pragmatic acts theory to unearth insights from *** paper observes that the various spheres of life that are relatable to an online audience help to express what the pandemic is about and enhance the meaning of the pandemic with the context of the use of the memes,giving clearer perspectives on the *** and references are useful tools for conveying social responsibilities to online audience.

关键词： directives references coronavirus internet memes social responsibilities

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Congenital Bilateral Proximal Radio-Ulnar Synostosis in a Nigerian Child

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Open Journal of Pediatrics 2024年第1期14卷 101-107页

作者： Alabi Ayobami Oyetunji Joel-Medewase Victor Idowu Olalere Ayankemi Adenike Joel Iretiayo Titilolu Sayomi Bukola Adetutu Oladibu Olanike Taiye Adetoye Mayowa Mary Ashaolu Oluwakayode Joseph Department of Paediatrics and Child Health Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Radiology Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Radiology University College Hospital Ibadan Nigeria Department of Paediatrics and Child Health LAUTECH Teaching Hospital Ogbomoso Nigeria

Congenital radio-ulnar synostosis (CRUS) is a rare skeletal malformation of the upper limb and the most common congenital functional disorder of the elbow joint, causing limitation in forearm rotational movements, which may lead to difficulties with some activities of daily living. We reported a 4-year-old girl with congenital bilateral proximal radio-ulnar synostosis who presented with functional discomfort due to limitation of the prono-supination movements of the forearms and abnormal gestures when handling objects. She has clinical and radiological features of congenital radio-ulnar synostosis (CRUS). However, the parents declined corrective surgery because of wrong perception of the condition to be normal. This case highlighted the poor health seeking behavior and wrong illness perception prevalent in the developing countries.

关键词： Congenital Radio-Ulnar Synostosis Upper Limb Congenital Anomalies Pro-no-Supination

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The significance of metabolic fingerprinting in carcinogenesis

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Cancer Advances 2024年第1期7卷 1-6页

作者： Ayodele Ademola Adelakun Princess Adekunbi Owokalade Department of Medical Laboratory Science Ladoke Akintola University of TechnologyOgbomoso 210001Nigeria Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria

Carcinogenesis describes the process through which normal cells transform into malignant cells(cancer).There were an estimated 18.1 million new cases of cancer(all cancers combined excluding non-melanoma skin cancer)worldwide in 2020:8.8 million(48%)in females and 9.3 million(52%)in males,giving a male:female ratio of 10:*** may be initiated by the action of biological,physical,or chemical agents that cause a non-lethal,permanent,DNA error on the cell with a consequence of altered cell *** altered cell metabolism include the Warburg effect,altered lipid and amino acid metabolism and production of various *** also results in unique metabolic dependencies that,in some cases,can be targeted with precision medicine and nutrition,including drugs that selectively target metabolic *** fingerprinting has been applied to the study of carcinogenesis and is particularly helpful in early diagnosis,staging and choice of treatment,thus improving health *** technology could therefore be harnessed effectively while combining with other omics technologies.

关键词： cancer metabolomics prognosis diagnosis fingerprint

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L-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu Lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope Deborah Alu Mary Ikuomola Joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of L-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, L-arginine (L), Dichlorvos (D), and L-arginine + Dichlorvos (L + D). Dichlorvos was administered to the D group, L-arginine (100 mg/kg) to the L group, and both L-arginine and dichlorvos to the L + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, L-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with L-arginine supplementation, indicating protection against cardiotoxicity. Moreover, L-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, L-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that L-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos L-Arginine Cardiovascular Function Haematological Parameters Oxidative Stress

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Assessment of Heavy Metal Exposure in Soils of Ihwrekreka Communities, Delta State, Nigeria

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Journal of Geoscience and Environment Protection 2024年第3期12卷 279-303页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede Taofik Adewale Adedosu Uche Udeochu Harrison Agboro Efe Jeffery Isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Delta State Nigeria Department of Chemistry Faculty of Science Ladoke Akintola University Oyo State Nigeria Chemistry Program Division of Science and Mathematics College of Arts and Sciences University of the District of Columbia Washington District of Columbia USA Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven CT USA

Crude oil pollution in the Niger Delta, perpetrated by both local communities and industrial actors, has brought about soil pollution with its consequent ecological, human health and food challenges. The purpose of this research was to examine the concentration and distribution of heavy metals in soil from communities contaminated by crude oil in Niger Delta, and to evaluate the potential health risks to residents from exposure to these contaminants. To achieve this, soil samples were collected from the Ihwrekreka community and analyzed for heavy metal content using inductively coupled plasma mass spectrometry (ICP-MS). The analytical results in mg/kg revealed a significant metals pollution level derived from the oil spill in the soil ranging from 4.85 - 17,078 (Cu), 1.01 - 16.1 (Cd), 0.22 - 36.8 (Cr), 8.28 - 40.9 (Ni), 7.51 - 6474 (Pb), and 8.84 - 12,851 (Zn) respectively. Most of the metals were above the permissible limits of World Health Organization, with Cu, Zn, and Pb as the most contaminating metals. Lead was found to be the main contributor to the hazard index (HI) values for both children and adults in the study area, with its concentration exceeding the permitted limits set by the WHO and the EC. The hazard index (HI) values of Pb, Cu, Zn, Cd, Ni, and Cr were significantly higher than 1. These findings suggest that the release of heavy metals from an oil-contaminated site may pose a risk to human health and the environment.

关键词： Cancer Exposure Pathway Toxic Metals Health Risks

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Substance use and substance use disorders in Africa:An epidemiological approach to the review of existing literature

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World Journal of Psychiatry 2022年第10期12卷 1268-1286页

作者： Olakunle James Onaolapo Anthony Tope Olofinnade Foluso Olamide Ojo Olufunto Adeleye Joshua Falade Adejoke Yetunde Onaolapo Behavioral Neuroscience Unit Neuropharmacology SubdivisionDepartment of PharmacologyLadoke Akintola University of TechnologyOgbomoso 210214 OyoNigeria Department of Pharmacology Therapeutics and ToxicologyLagos State UniversityIkeja 100001LagosNigeria Department of Anatomy Ladoke Akintola University of TechnologyOgbomoso 210214OyoNigeria Department of Mental Health Afe Babalola UniversityAdo-Ekiti 360282EkitiNigeria Behavioral Neuroscience Unit Neurobiology SubdivisionDepartment of AnatomyLadoke Akintola University of TechnologyOgbomoso 210214OyoNigeria

The relationship between man and substances that have abuse potentials,and whose use has been associated with the development or progression of substance use disorders has continued to evolve in terms of geography,economic implications,and *** shows that local plants with psychoactive constituents can get exported worldwide through global travel,commerce,or even *** and globalization also change people’s relationship with substances of abuse;hence,an area that was initially alien to certain substances might evolve to becoming a trafficking hub,and then a destination.A case in point is Africa where a rapidly increasing prevalence of substance use/abuse and substance use disorder among adolescents and young adults is putting enormous strain on the economy,healthcare system,and society at ***,there appears to be a paucity of scientific literature and data on the epidemiology,risk assessment,and contributing factors to substance use and the development of substance use disorders across *** this narrative review,we examine extant literature(PubMed,Google scholar,Medline)for information on the prevalence,trends,and influencers of substance use and the development of substance use *** is with a view of understanding the determinants of substance use and factors that influence the development of substance use disorders in the region,and how this information can be channeled towards developing a comprehensive intervention and treatment program.

关键词： Addiction Cannabis Catha edulis Datura metal Drug dependence Novel psychoactive substances

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